Widespread changes in neurotransmitter expression and number of enteric neurons and interstitial cells of Cajal in lethal spotted mice: an explanation for persisting dysmotility after operation for Hirschsprung's disease?

abstract：:Our objective was to investigate the expression of HMGA1 mRNA and protein in hepatocellular carcinoma (HCC) and the correlation between its expression and clinical pathological characteristics and prognosis. HMGA1 expression was determined at both the mRNA level and the protein level in 30 HCC tissues and their corres...

journal_title：Digestive diseases and sciences

authors： Chang ZG,Yang LY,Wang W,Peng JX,Huang GW,Tao YM,Ding X

更新日期：2005-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a highly morbid and prevalent cancer globally. While high quality evidence for mortality benefit of HCC surveillance is lacking, early detection of HCC is likely beneficial as prognosis is highly correlated with tumor stage. High risk populations, including patients with cirrhosis and...

journal_title：Digestive diseases and sciences

authors： Deng LX,Mehta N

更新日期：2020-12-01 00:00:00

abstract：:Ehlers-Danlos syndrome (EDS) type IV is an autosomal dominant connective tissue disease caused by mutations in the type III collagen gene resulting in extreme tissue fragility. Affected individuals are at risk of dramatic and often fatal complications, mostly spontaneous arterial, uterine, or colonic ruptures. Phenoty...

journal_title：Digestive diseases and sciences

authors： Gelbmann CM,Köllinger M,Gmeinwieser J,Leser HG,Holstege A,Schölmerich J

更新日期：1997-08-01 00:00:00

abstract：:To study the clinicopathologic features of hepatitis C viremic patients negative for hepatitis C antibodies (anti-HCV) by current second-generation assay, we categorized 139 consecutive histologically verified patients with chronic non-A, non-B hepatitis into three groups: 121 (87%) were positive for second-generation...

journal_title：Digestive diseases and sciences

authors： Kao JH,Lai MY,Hwang YT,Yang PM,Chen PJ,Sheu JC,Wang TH,Hsu HC,Chen DS

更新日期：1996-01-01 00:00:00

abstract：:This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNM...

journal_title：Digestive diseases and sciences

authors： Ding WJ,Fang JY,Chen XY,Peng YS

更新日期：2008-08-01 00:00:00

abstract：:Leptin is an adipocyte-derived hormone involved in the homeostasis of body composition. An imbalance in leptin regulation has been observed in patients with liver cirrhosis. We aimed to assess serum and ascitic leptin levels in a group of patients with decompensated liver cirrhosis and to evaluate the relationship of ...

journal_title：Digestive diseases and sciences

authors： Giannini E,Romagnoli P,Tenconi GL,Botta F,Malfatti F,Chiarbonello B,Mamone M,Barreca T,Testa R

更新日期：2004-02-01 00:00:00

abstract：:One hundred nineteen children, either French or from the Ivory Coast, aged 1-8 years, were submitted to pancreatic function testing by duodenal aspiration. Trypsin, chymotrypsin, lipase, phospholipase, amylase, volume, bicarbonate, chloride, and calcium were estimated before and after an intravenous injection of 1 CU ...

journal_title：Digestive diseases and sciences

authors： Sauniere JF,Sarles H,Attia Y,Lombardo A,Yoman TN,Laugier R,Manlan K,Sahel J

更新日期：1986-05-01 00:00:00

abstract：:Inhibitors of gastric acid secretion are efficient drugs in the treatment of acid-related diseases. However, by reducing gastric acidity, hypergastrinemia develops. Gastrin regulates its target cell, the enterochromaffin (ECL) cell, both functionally and tropicaly. Long-term hypergastrinemia in whatever species studie...

journal_title：Digestive diseases and sciences

authors： Waldum HL,Gustafsson B,Fossmark R,Qvigstad G

更新日期：2005-10-01 00:00:00

abstract：:Development of type 1 insulin-dependent diabetes mellitus has been recently reported in patients who underwent interferon-alpha (IFN-alpha) therapy because of chronic viral hepatitis. Furthermore IFN-alpha seems to be involved in the immunological events that lead to beta-cell destruction and development of type 1 dia...

journal_title：Digestive diseases and sciences

authors： di Cesare E,Previti M,Russo F,Brancatelli S,Ingemi MC,Scoglio R,Mazzù N,Cucinotta D,Raimondo G

更新日期：1996-08-01 00:00:00

abstract：:Radionuclide gastric solid-phase emptying was studied in 10 subjects with diabetic gastroparesis comparing the acute intravenous administration of cisapride (2.5, 5, 10 mg), placebo, and metoclopramide (10 mg). No hemodynamic or electrocardiographic changes were noted. While both cisapride and metoclopramide normalize...

journal_title：Digestive diseases and sciences

authors： McHugh S,Lico S,Diamant NE

更新日期：1992-07-01 00:00:00

abstract：:Anorectal manometry was performed in 40 women, who consulted for functional disorders of the lower gastrointestinal tract and had been sexually abused. Anismus, defined as a rise in anal pressure during straining, was observed in 39 of 40 abused women, but in only six of 20 healthy control women (P < 0.0001). Other pa...

journal_title：Digestive diseases and sciences

authors： Leroi AM,Berkelmans I,Denis P,Hémond M,Devroede G

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Neuromediators produced by enteric nervous system regulate inflammatory processes via interacting with enteric immune system. Role of γ-aminobutyric acid (GABA), which is also a neuromediator, has been implicated in autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, where...

journal_title：Digestive diseases and sciences

authors： Aggarwal S,Ahuja V,Paul J

更新日期：2017-10-01 00:00:00

abstract：:As infection influences the pathogenesis and presentation of celiac disease, we investigated the expression of natural antibiotics in this condition. Twenty-three adults were prospectively studied: 10 controls and 13 subjects with untreated celiac disease. Distal duodenal biopsies were taken at baseline and after 6 mo...

journal_title：Digestive diseases and sciences

authors： Taha AS,Faccenda E,Angerson WJ,Balsitis M,Kelly RW

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Ileocolic anastomosis is an essential step in the treatment to restore continuity of the gastrointestinal tract following ileocolic resection in patients with Crohn's disease (CD). However, the association between anastomotic type and surgical outcome is controversial. AIMS:The aim of this meta-analysis is ...

journal_title：Digestive diseases and sciences

authors： He X,Chen Z,Huang J,Lian L,Rouniyar S,Wu X,Lan P

更新日期：2014-07-01 00:00:00

abstract：:Twelve patients with recurrent polyserositis (RP, familial Mediterranean fever) on colchicine prophylaxis (1.0-2.0 mg daily) for three years or more were evaluated for the presence of gastrointestinal effects possibly attributable to the drug. Two patients had bulky stools, two others had transient diarrhea, and one h...

journal_title：Digestive diseases and sciences

authors： Ehrenfeld M,Levy M,Sharon P,Rachmilewitz D,Eliakim M

更新日期：1982-08-01 00:00:00

abstract：:The effects of chronic normovolemic anemia on gastric microcirculation and gastric mucosal susceptibility to ethanol-induced gastric damage were investigated in anesthetized rats. Blood exchange by a plasma expander during four consecutive days rendered the animals anemic with a 34% decrease in the baseline hematocrit...

journal_title：Digestive diseases and sciences

authors： Marroni N,Casadevall M,Panés J,Piera C,Jou JM,Pique JM

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Intestinal Behcet's disease (BD) is a specific subtype of BD. Effective drug therapy for intestinal BD remains elusive. AIMS:To investigate long-term outcomes and identify predictors of sustained response in intestinal BD patients receiving infliximab (IFX) treatment. METHODS:The medical records were revie...

journal_title：Digestive diseases and sciences

authors： Zou J,Ji DN,Cai JF,Guan JL,Bao ZJ

更新日期：2017-02-01 00:00:00

abstract：:Primary hepatic lymphoma is a rare disease. We report five cases here and summarize clinical and pathologic features of our own and reported cases from Western countries and Japan. The total number of cases was 68. The age of patients ranged from 7 to 87 years (median 55) with a male-to-female ratio of 3.1:1. Chronic ...

journal_title：Digestive diseases and sciences

authors： Ohsawa M,Aozasa K,Horiuchi K,Kataoka M,Hida J,Shimada H,Oka K,Wakata Y

更新日期：1992-07-01 00:00:00

abstract：:Liver from neonatal rats injected with LD50 E. coli endotoxin was studied by light and electron microscopy. By 2 hr, there was margination and migration of polymorphonuclear leukocytes. Single cell necrosis was seen after 8 hr. At 16 hr, there were numerous necrotic foci in the mid-zonal region of hepatic lobules, as ...

journal_title：Digestive diseases and sciences

authors： Young RS,Woods C,Towfighi J

更新日期：1986-06-01 00:00:00

abstract：:Octreotide is a crucial drug used for treating patients with chylous ascites; however, there have been few reports related to octreotide that are being used in cirrhotic patients. Thus, this thesis is designed to determine the effects of octreotide on patients with chylous ascites after liver cirrhosis. Eight patients...

journal_title：Digestive diseases and sciences

authors： Zhou DX,Zhou HB,Wang Q,Zou SS,Wang H,Hu HP

更新日期：2009-08-01 00:00:00

abstract：:We have studied three patients with chronic HBV infection who had a superimposed bout of type A hepatitis. The patients recovered uneventfully without observing a change in their clinical course afterwards. In one patient we observed transient disappearance of DNA polymerase during type A hepatitis; we have postulated...

journal_title：Digestive diseases and sciences

authors： Conteas C,Kao H,Rakela J,Weliky B

更新日期：1983-08-01 00:00:00

abstract：:An important histologic feature of inflammatory bowel disease (IBD) is infiltration of the colonic mucosa with neutrophils. To investigate the nature of the chemotactic agents responsible for this infiltration, colonic mucosa from three normals and nine patients with inflammatory bowel disease (seven ulcerative coliti...

journal_title：Digestive diseases and sciences

authors： Lobos EA,Sharon P,Stenson WF

更新日期：1987-12-01 00:00:00

abstract：:Slow transit constipation (STC) is a severe motility disorder, which in the majority of cases is of unknown etiology. In some, symptoms arise de novo in childhood, but a proportion of patients present in later life, including after pelvic surgery or childbirth. Our aims were: (1) to describe our current knowledge of t...

journal_title：Digestive diseases and sciences

authors： Knowles CH,Scott SM,Lunniss PJ

更新日期：2001-02-01 00:00:00

abstract：INTRODUCTION:A significant proportion of patients with Crohn's disease (CD) lose response to antibodies directed against tumor necrosis factor α (TNF). Prior TNF-antagonist failure is associated with lower rates of response to subsequent TNF-antagonist therapy. In patients failing two anti-TNF agents, a choice exists b...

journal_title：Digestive diseases and sciences

authors： Ananthakrishnan AN,Hur C,Korzenik JR

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Endoscopic submucosal dissection (ESD) criteria are histologically categorized by early gastric cancer (EGC) with differentiated- and undifferentiated-type histology. However, EGC is histologically heterogenous and there have been no separate criteria for EGC with mixed-type histology [EGC-MH; differentiated...

journal_title：Digestive diseases and sciences

authors： Bang CS,Yang YJ,Lee JJ,Baik GH

更新日期：2020-01-01 00:00:00

abstract：:Continuous noninvasive measurement of local blood flow at one or more chosen sites will be useful during experiments on the liver, during liver surgery, or after hepatic transplantation. We have compared a Clark-type flow-dependent oxygen electrode having a 3-mm-diameter cathode applied to the surface of rabbit liver ...

journal_title：Digestive diseases and sciences

authors： Piasecki C,Seifalian AM

更新日期：1990-03-01 00:00:00

abstract：:Immune (gamma) interferon is a substance produced by immunologically activated mononuclear cells. Besides its antiviral activity, interferon gamma has a crucial role in immunoregulation, by acting directly upon lymphocytes and monocytes, and interacting with other soluble mediators of the immune response. Studies of t...

journal_title：Digestive diseases and sciences

authors： Lieberman BY,Fiocchi C,Youngman KR,Sapatnekar WK,Proffitt MR

更新日期：1988-10-01 00:00:00

abstract：BACKGROUND:The US Food and Drug Administration currently approves three types of anti-tumor necrosis factor α (anti-TNFα) therapy for treatment of moderate to severe Crohn's disease. There are no guidelines to clarify which of the drugs may be better suited to individual clinical scenarios. AIMS:We gathered national d...

journal_title：Digestive diseases and sciences

authors： Swaminath A,Lebwohl B,Capiak KM,Present DH

更新日期：2011-04-01 00:00:00

abstract：:The synthetic prostanoid, Ro 22-6923, was studied for its effects on canine gastric secretion. Histamine-stimulated acid secretion was inhibited for up to 8 hr after an orally administered dose of 0.25 mg/kg Ro 22-6923. In the Amdrup (modified Pavlov) pouch model, Ro 22-6923 significantly inhibited food-stimulated aci...

journal_title：Digestive diseases and sciences

authors： Gaginella TS,Bertko RJ,Müller RK,Gallo-Torres H,Sullivan AC

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Eosinophilic esophagitis (EoE) is defined by a minimum of 15 eosinophils (eos) per high-powered field (HPF) on esophageal biopsy, along with esophageal symptoms and the exclusion of gastroesophageal reflux (GERD). The clinical significance of fewer eosinophils is unknown. METHODS:Fifty-nine adult patients w...

journal_title：Digestive diseases and sciences

authors： Ravi K,Talley NJ,Smyrk TC,Katzka DA,Kryzer L,Romero Y,Arora AS,Alexander JA

更新日期：2011-07-01 00:00:00