Abstract：
:Immune (gamma) interferon is a substance produced by immunologically activated mononuclear cells. Besides its antiviral activity, interferon gamma has a crucial role in immunoregulation, by acting directly upon lymphocytes and monocytes, and interacting with other soluble mediators of the immune response. Studies of the interferons system in inflammatory bowel disease have been limited, and little information is available on the generation of interferon during immunological events occurring in the human gut. To investigate the capacity of intestinal mucosal mononuclear cells to produce interferon gamma, lamina proprial mononuclear cells, isolated from Crohn's disease, ulcerative colitis, and control patients, were incubated with interleukin 2 or phytohemagglutinin, and the amounts of interferon gamma present in the culture supernatants were measured by a virus cytopathic effect inhibition assay. Under identical stimulatory conditions, culture supernatants of cells derived from actively involved mucosa of inflammatory bowel disease specimens contained two- to fivefold less interferon gamma than those of cells from control tissue. However, the amount of interferon gamma present in supernatants of cells from uninvolved inflammatory bowel disease mucosa was similar to that found in control supernatants. These results indicate that, in patients with active Crohn's disease and ulcerative colitis, mononuclear cells produce decreased amounts of interferon gamma in the intestinal mucosa. The exact significance of these findings is unclear, but because of the importance of interferon gamma in a variety of cell-mediated immune phenomena, its impaired availability might be relevant to the pathogenesis of inflammatory bowel disease.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Lieberman BY,Fiocchi C,Youngman KR,Sapatnekar WK,Proffitt MRdoi
10.1007/BF01536683subject
Has Abstractpub_date
1988-10-01 00:00:00pages
1297-304issue
10eissn
0163-2116issn
1573-2568journal_volume
33pub_type
杂志文章abstract：:The aim of the study was to determine inter- and intrapatient variation of Helicobacter pylori strains based on genomic fingerprinting and cagA (cytotoxin-associated gene A) status. Ten bacterial colonies from each of 10 patients with gastric cancer (GC), 10 with duodenal ulcer (DU), and 10 with gastritis (GI) were us...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026658301825
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Recent data suggest the involvement of both the adaptive and the innate immune system in celiac disease (CD). However, little is known about the immune phenotype of children with CD and its alteration upon dietary intervention. AIMS:We characterized the prevalence of major interacting members of the adaptiv...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1363-6
更新日期：2011-03-01 00:00:00
abstract：:We studied the anorectal manometric and urodynamic pattern of seven patients who had right and/or left frontal lobe injury to investigate the possibility that the frontal lobe area plays an important role in control of anorectal motility as it does for the urinary bladder. We found that the disturbances of anorectal m...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536767
更新日期：1990-02-01 00:00:00
abstract：:Twelve partially gastrectomized subjects who have consecutively undergone total biliary diversion for severe bilious vomiting were studied before and after operation in order to assess the effects of surgery on gastric histology and enterogastric reflux. Before and six months after operation, the following protocol wa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536682
更新日期：1988-10-01 00:00:00
abstract：:The frequent association of stromal tumors with neurofobromatosis raises high suspicion of a possible correlation between the two entities. The aim of this study was to analyze clinicopathologic features of patients with concomitant neurofibromatosis and gastrointestinal stromal tumors and to discuss the molecular bas...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000037806.14471.a2
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Long non-coding RNAs have been acknowledged as the crucial regulators in the progression of human cancers, including gastric cancer (GC). Small nucleolar RNA host gene 10 (SNHG10) has been identified as an oncogene in several cancer types. Nonetheless, it is unclear whether SNHG10 exerts functions in GC cell...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06576-w
更新日期：2020-09-12 00:00:00
abstract：:In order to investigate whether the human exocrine pancreas is capable of adapting to a diet with a high-carbohydrate, low-fat, and normal protein content, 10 healthy subjects were given a continuous intraduodenal infusion of such a dietary composition (8760 kJ in 2400 ml/day) via a portable infusion pump over a perio...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01347884
更新日期：1985-03-01 00:00:00
abstract：:The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtim...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s10620-006-9111-7
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Despite national campaigns and other efforts to improve colorectal cancer (CRC) screening, participation rates remain below targets set by expert panels. We hypothesized that availability and practice patterns of healthcare providers may contribute to this gap. METHOD:Using data of the Medical Expenditure P...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06541-7
更新日期：2021-01-01 00:00:00
abstract：:This study investigates whether topical prostaglandins protect isolated gastric mucosa against injury provoked by acidified "barrier-breaking" agents. Intracellular pH (pHi), apical cell membrane potential (Vcm) and intraepithelial resistances in isolated Necturus antral mucosa were measured using double-barreled liqu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005465528158
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Tyrosine phosphorylation and dephosphorylation by protein tyrosine kinases and phosphatases (PTPs), respectively, play crucial roles in cellular signal transduction. Protein phosphatase non-receptor type 11 (PTPN11) is a positive signaling PTP that activates RAS and ERK signaling. Also, the PTPN11 binds with...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0924-z
更新日期：2010-06-01 00:00:00
abstract：:Metronidazole has been used to treat pouchitis, but there are no controlled data that show it is effective. Chronic unremitting pouchitis is a form of the disorder particularly difficult to manage. Diarrhea is the main symptom of pouchitis, which results from acute inflammation of the mucosa of an ileal reservoir. To ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02093783
更新日期：1994-06-01 00:00:00
abstract：BACKGROUND:Intraductal ultrasonography (IDUS) is a useful procedure for diagnosing microlithiasis in the bile duct but it is not easy to differentiate between tiny echogenicity and real microlithiasis. We compared the echogenicity seen on IDUS and the findings of bile microscopy (BM) of bile that was collected in the c...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0770-z
更新日期：2010-03-01 00:00:00
abstract：:We measured the effects of cimetidine on antibiotic concentrations in the luminal portion of gastric mucosa. Guinea pigs were premedicated with cimetidine 4 mg/kg intramuscularly. Clindamycin, an antibiotic previously characterized under physiologic pH conditions, was administered intramuscularly and levels measured i...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300082
更新日期：1991-01-01 00:00:00
abstract：:Two hundred forty-six patients with a wide range of upper gastrointestinal tract disorders were investigated for the presence of Campylobacter pylori infection in esophagus, gastric antrum, and duodenum. C. pylori was identified in 52% of patients in at least one site, and microbiological and histological techniques w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536269
更新日期：1989-03-01 00:00:00
abstract：:On the basis of previous studies in our laboratory we postulated that the ethanol-induced alteration in jejunal morphology was the result of its effect on the microcirculation. The present study was undertaken to examine the validity of this hypothesis. Accordingly, the effects of intraluminal ethanol perfusion (3.0 a...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01311730
更新日期：1983-11-01 00:00:00
abstract：:The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01550972
更新日期：1988-07-01 00:00:00
abstract：:Endoscopic injection sclerotherapy is known to cause a variety of motility abnormalities, but the correlation between these changes and symptomatology has not been clearly defined. To assess the effects of endoscopic sclerosis of varices on esophageal function and symptoms, we prospectively studied esophageal motility...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318367
更新日期：1985-01-01 00:00:00
abstract：:In cases of difficult biliary cannulation, transpancreatic sphincterotomy (TPS) can be an alternative approach of biliary access. However, its success and safety profile have not been studied in detail. A systematic review and meta-analysis were performed to study the overall cannulation success and adverse events of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,meta分析
doi：10.1007/s10620-019-05640-4
更新日期：2019-09-01 00:00:00
abstract：:We present the case of a 60-year-old male patient, who had several episodes of melena during the last years. One month ago he had a new episode of digestive bleeding, and an endoscopic study was performed that showed at 35 cm from the dental arcade a polypoid, pedunculated lesion, with a diameter of 5 cm and a submuco...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087691
更新日期：1994-12-01 00:00:00
abstract：:The study was undertaken to examine regional differences in the concentrations of five regulatory peptides in the human colonic mucosa. Biopsies were obtained during routine colonoscopy from 33 patients whose colonic mucosa was macroscopically and histologically normal. Regulatory peptides were extracted, and measured...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537267
更新日期：1989-08-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026107429546
更新日期：2003-10-01 00:00:00
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02208587
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:MicroRNAs (miRNAs) in exosomes represent disease-specific profiles and are applied as biomarkers in oncology. However, in functional dyspepsia (FD), the role of exosomal miRNAs has not been fully elucidated. AIMS:To investigate exosomal miRNAs as potential biomarkers of FD using liquid biopsy. METHODS:This...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06096-7
更新日期：2020-12-01 00:00:00
abstract：:To investigate the possible role of pepsin in ulceration induced by hydrogen ion back-diffusion, the ratio of alkali-labile pepsinogen to total pepsinogen was studied during the course of aspirin- and taurocholate-induced gastric ulceration in comparison with the changes in the ion permeability and histological findin...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01338527
更新日期：1980-11-01 00:00:00
abstract：:We have developed a breath test to measure solid gastric emptying using a standardized scrambled egg test meal (250 kcal) labeled with [14C]octanoic acid or [13C]octanoic acid. In vitro incubation studies showed that octanoic acid is a reliable marker of the solid phase. The breath test was validated in 36 subjects by...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02300385
更新日期：1994-12-01 00:00:00
abstract：:Little information on functional status and well-being is available in patients with functional gastrointestinal disease. We aimed to evaluate whether quality of life is poorer in patients with functional dyspepsia. A consecutive sample of 73 patients with functional dyspepsia completed a validated questionnaire prior...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02064375
更新日期：1995-03-01 00:00:00
abstract：:The molecular mechanisms of Helicobacter pylori associated tumor development are poorly understood. The spectra of genetic alterations in neoplasms may provide clues to the molecular carcinogenesis of a tumor and may be relevant for the prognosis of the patients. We investigated the p53 mutation pattern and the protei...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1013275706401
更新日期：2002-01-01 00:00:00
abstract：:Patients with pernicious anemia have an estimated risk of gastric adenocarcinoma that ranges from three- to fivefold greater than that of the general population. It has been reported that NK cells may be involved in immunosurveillance against tumor spread. The natural killer cell activity of peripheral blood mononucle...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02285205
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Gastroparesis is a heterogeneous disorder. Patient characteristics and treatment responsiveness may differ based on the extent of delay in gastric emptying. AIMS:Characterize gastroparesis patients based on the degree of delay in gastric emptying, and assess the relationship of patient demographics, symptom...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06258-7
更新日期：2020-04-18 00:00:00
