[*C]octanoic acid breath test to measure gastric emptying rate of solids.


:We have developed a breath test to measure solid gastric emptying using a standardized scrambled egg test meal (250 kcal) labeled with [14C]octanoic acid or [13C]octanoic acid. In vitro incubation studies showed that octanoic acid is a reliable marker of the solid phase. The breath test was validated in 36 subjects by simultaneous radioscintigraphic and breath test measurements. Nine healthy volunteers were studied after intravenous administration of 200 mg erythromycin and peroral administration of 30 mg propantheline, respectively. Erythromycin significantly enhanced gastric emptying, while propantheline significantly reduced gastric emptying rates. We conclude that the [*C]octanoic breath test is a promising and reliable test for measuring the gastric emptying rate of solids.


Dig Dis Sci


Maes BD,Ghoos YF,Rutgeerts PJ,Hiele MI,Geypens B,Vantrappen G




Has Abstract


1994-12-01 00:00:00




12 Suppl








  • Changes in serum hepatitis C virus RNA titer and response to interferon therapy in patients with chronic hepatitis C.

    abstract::Response to interferon (IFN) therapy for chronic hepatitis C has been determined by the alteration of serum alanine aminotransferase (ALT) values. However, eradication of hepatitis C virus (HCV) could be another aim of the therapy. Thus, we serially measured serum HCV RNA levels during therapy and for at least 12 mont...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Aiyama T,Yoshioka K,Hirofuji H,Kusakabe A,Yamada M,Tanaka K,Kakumu S

    更新日期:1994-10-01 00:00:00

  • Efficacy of 5-aminosalicylic acid enemas versus hydrocortisone enemas in ulcerative colitis.

    abstract::A controlled trial has been carried out in order to compare the efficacy of enemas containing a high dosage of 5-ASA (4 g) versus enemas containing hydrocortisone 100 mg. The trial was conducted on 86 patients, 44 of whom received 5-ASA and 42 received hydrocortisone. The results were favorable in terms of clinical, s...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Campieri M,Gionchetti P,Belluzzi A,Brignola C,Migaldi M,Tabanelli GM,Bazzocchi G,Miglioli M,Barbara L

    更新日期:1987-12-01 00:00:00

  • Interferon inhibits progression of liver fibrosis and reduces the risk of hepatocarcinogenesis in patients with chronic hepatitis C: a retrospective multicenter analysis of 652 patients.

    abstract::A retrospective multicenter analysis of 652 patients with chronic hepatitis C who have been treated with interferon (IFN) was performed to assess the effects of IFN on the clinical course and development of HCC. During a mean follow-up of 54.8 months, hepatocellular carcinoma (HCC) developed in 7.0% of the patients. T...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究


    authors: Takimoto M,Ohkoshi S,Ichida T,Takeda Y,Nomoto M,Asakura H,Naito A,Mori S,Hata K,Igarashi K,Hara H,Ohta H,Soga K,Watanabe T,Kamimura T

    更新日期:2002-01-01 00:00:00

  • Esophageal inflammatory fibroid polyp. Endoscopic and radiologic features.

    abstract::We present the case of a 60-year-old male patient, who had several episodes of melena during the last years. One month ago he had a new episode of digestive bleeding, and an endoscopic study was performed that showed at 35 cm from the dental arcade a polypoid, pedunculated lesion, with a diameter of 5 cm and a submuco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bosch O,González Campos C,Jurado A,Guijo I,Miro C,Renedo G,Porres JC

    更新日期:1994-12-01 00:00:00

  • Racial differences in epidemiology of irritable bowel syndrome alone, un-investigated dyspepsia alone, and "overlap syndrome" among african americans compared to Caucasians: a population-based study.

    abstract::There is A paucity of data on racial differences in epidemiology of irritable bowel syndrome (IBS) alone and un-investigated dyspepsia (UD) alone compared to "overlap syndrome" (OS). We conducted a random survey (n = 990). Subjects completed a questionnaire which included Rome II criteria for IBS and functional dyspep...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Minocha A,Chad W,Do W,Johnson WD

    更新日期:2006-01-01 00:00:00

  • Effect of base precursors on water and electrolyte transport during oral hydration solution perfusion in secreting rat intestine.

    abstract::In situ steady-state, single-pass small intestine perfusions in rats were carried out to compare the effect of the bicarbonate and citrate World Health Organization oral rehydration solutions and a base precursor-free solution on intestinal water and electrolyte transport after inducing intestinal secretion with purif...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Rolston DD,Mathan VI

    更新日期:1992-01-01 00:00:00

  • Can Sertraline and Nortriptyline Protect the Neurons in Submucosal and Myenteric Plexuses of Rat's Colon Against Stress?

    abstract:BACKGROUND:The colon is partly controlled by myenteric and submucosal plexuses, which respond to stress and lead to some gastrointestinal disorders. These plexuses play roles in irritable bowel syndrome. Patients suffering from this syndrome can be treated with some antidepressants, including sertraline and nortriptyli...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Noorafshan A,Yousefi M,Hosseini L,Karbalay-Doust S

    更新日期:2019-09-01 00:00:00

  • Remission of severe aplastic anemia associated with hepatitis B virus infection after viral clearance: potential role of lamivudine.

    abstract::Although viral hepatitis infection is known to be associated with aplastic anemia, a causal link between viral hepatitis and aplastic anemia has not been convincingly demonstrated. A case of hepatitis B-associated severe aplastic anemia is described which only partially responded to conventional immunosuppressive trea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Bozkaya H,Yurdaydin C,Törüner M,Arat M,Bozdayi AM,Erekul S,Cinar K,Koç H,Uzunalimoğlu O

    更新日期:2002-08-01 00:00:00

  • Prognostic Factors for Acute Transjugular Intrahepatic Portosystemic Shunt Occlusion Using Expanded Polytetrafluoroethylene-Covered Stent.

    abstract:BACKGROUND:The expanded polytetrafluoroethylene (ePTFE)-covered stent has been widely used in the transjugular intrahepatic portosystemic shunt (TIPS) procedure. However, the epidemiologic data of acute TIPS occlusion (ATO) and the underlying mechanisms are scarce. AIMS:The purpose of this study was to evaluate the in...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Wang X,Luo X,Zhao M,Song J,Li X,Yang L

    更新日期:2020-10-01 00:00:00

  • Comparison of effects of nifedipine, propantheline bromide, and the combination on esophageal motor function in normal volunteers.

    abstract::Both intracellular calcium ions and neural input are important in esophageal smooth muscle contraction. The aim of this study was to compare the effects of well-tolerated doses of the calcium-channel blocker, nifedipine (20 mg sublingually/buccally) with the anticholinergic, propantheline bromide (15 mg orally) and th...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hongo M,Traube M,McCallum RW

    更新日期:1984-04-01 00:00:00

  • N-Butyrate rectal transport in cirrhotic patients.

    abstract::Data about colonic mucosa transport of short-chain fatty acids in cirrhotic patients are still lacking. The aim of the present study was to compare the rectal mucosa transport of n-butyrate and its effect on transport of other electrolytes and endoluminal pH in normal subjects and in cirrhotic patients by using a rect...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Onori L,Pimpo MT,Palumbo GC,Gili L,Marchetti G,Saltarelli P,Aggio A,Frieri G

    更新日期:2001-10-01 00:00:00

  • Diverticulosis and the risk of interval colorectal cancer.

    abstract:BACKGROUND:Diverticulosis, a prevalent condition at screening colonoscopy, has been associated with colorectal cancers that develop after a clearing colonoscopy, or interval cancers. AIMS:To quantify the overall risk of diverticulosis in the development of interval cancers and examine this association in relevant subg...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Cooper GS,Xu F,Schluchter MD,Koroukian SM,Barnholtz Sloan JS

    更新日期:2014-11-01 00:00:00

  • Helicobacter pylori CagA: a critical destroyer of the gastric epithelial barrier.

    abstract::The destruction of the integrity of the gastric epithelial barrier underlies the pathology of many gastric diseases, including gastric tumors. The Helicobacter pylori virulence factor CagA is one of the main destroyers of the gastric epithelial barrier. There are differences among CagA proteins that originate from dif...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审


    authors: Wu J,Xu S,Zhu Y

    更新日期:2013-07-01 00:00:00

  • Frailty Assessment Predicts Acute Outcomes in Patients Undergoing Screening Colonoscopy.

    abstract:BACKGROUND:Colonoscopy is associated with multiple adverse outcomes. With an aging population undergoing colorectal cancer screening, few modalities exist to assess the patient risk prior to colonoscopy. Frailty, the age-related decline in reserve and function across multiple organ systems, predicts poor surgical outco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Taleban S,Toosizadeh N,Junna S,Golden T,Ghazala S,Wadeea R,Tirambulo C,Mohler J

    更新日期:2018-12-01 00:00:00

  • Evaluation of cytoprotection against ethanol-induced injury in gastric mucosa pretreated with misoprostol, cimetidine, or placebo.

    abstract::The authors have developed a primate model for evaluating cytoprotection against alcohol-induced injury in gastric mucosa pretreated with antiulcer agents. In the present study, groups of squirrel monkeys received either a single oral dose of misoprostol (500 or 200 micrograms/kg), cimetidine (3 or 6 mg/kg), placebo, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Liss RH,Letourneau RJ,Schepis JP

    更新日期:1986-02-01 00:00:00

  • Pancreas Divisum Increases the Risk of Recurrent Acute Pancreatitis in Patients with rs12338 Polymorphism in the Cathepsin B Gene.

    abstract:OBJECTIVES:Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD. DESIGN:We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Pat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Talukdar R,Aslam M,Reddy DN,Nabi Z,Shava U,Ravikanth VV,Avanthi S,Govardhan B

    更新日期:2020-08-04 00:00:00

  • Effects of beta-adrenoceptor stimulation on rectosigmoid motility in man.

    abstract::Effects of selective beta-adrenoceptor agonists on rectosigmoid motility during prolonged rectal distension were studied in 12 healthy volunteers in a double-blind, randomized fashion. Continuous distension was performed with a balloon in the proximal part of the rectum. Pressure was recorded by this balloon and by a ...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lyrenäs E,Abrahamsson H,Dotevall G

    更新日期:1985-06-01 00:00:00

  • Unusual Sites of Necrotic Collections in Acute Necrotizing Pancreatitis: Association with Parenchymal Necrosis and Clinical Outcomes.

    abstract:BACKGROUND:The presence of necrotic collection in acute necrotizing pancreatitis (ANP) at intra-abdominal sites other than the retroperitoneum has not been systematically studied. AIM:To investigate unusual sites of necrotic collections at computed tomography (CT) and to evaluate association with pancreatic necrosis a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Gupta P,Virk M,Gulati A,Muktesh G,Shah J,Samanta J,Mandavdhare H,Sharma V,Dutta U,Kochhar R

    更新日期:2020-08-10 00:00:00

  • Immunohistochemical Assessment of CD30+ Lymphocytes in the Intestinal Mucosa Facilitates Diagnosis of Pediatric Ulcerative Colitis.

    abstract:BACKGROUND:Diagnosis of pediatric inflammatory bowel diseases (IBD) remains challenging. We aimed at the value of immunohistochemical assessment of CD30+ lymphocytes in the intestinal mucosa in differential diagnosis between pediatric Crohn's disease (CD) and ulcerative colitis (UC) and its utility as a predictor of fu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Fabian O,Hradsky O,Drskova T,Mikus F,Zamecnik J,Bronsky J

    更新日期:2018-07-01 00:00:00

  • Early disturbance of microvascular function precedes chemotherapy-induced intestinal injury.

    abstract::Intestinal injury 4-48 hr after cytotoxic therapy (etoposide phosphate, 100 mg/kg body weight [bw], intravenously [i.v.]) was studied in rats using ligated intestinal loops. Chromium-51 ethylenediaminetetraacetic acid ((51)Cr-EDTA) and rubidium-86 chloride ((86)RbCl) were deposited intraluminally to determine the exte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Abel E,Ekman T,Warnhammar E,Hultborn R,Jennische E,Lange S

    更新日期:2005-09-01 00:00:00

  • Bronchial hyperresponsiveness in irritable bowel syndrome.

    abstract::Extraintestinal symptoms are often found in patients with irritable bowel syndrome (IBS). Recent studies suggest that IBS is associated with bronchial hyperresponsiveness. But it is still arguable that the bronchial hyperresponsiveness is associated with IBS patients. The purpose of this study is to investigate the po...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Jun DW,Lee OY,Yoon HJ,Lee HL,Yoon BC,Choi HS,Lee MH,Lee DH,Kee CS

    更新日期:2005-09-01 00:00:00

  • During thioacetamide-induced acute liver failure, the proliferative response of hepatocytes to thyroid hormone is maintained, indicating a potential therapeutic approach to toxin-induced liver disease.

    abstract::In toxic liver injury, proliferation of preexisting hepatocytes helps restore liver mass and function. While loss of liver mass per se stimulates hepatocyte proliferation, exogenous mitogens have a potential role in enhancing liver regeneration. The aim of this study was to characterize the effects of the mitogen, tri...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Malik R,Saich R,Rahman T,Hodgson H

    更新日期:2006-12-01 00:00:00

  • Comparative effects of adjuvant cimetidine and omeprazole during pancreatic enzyme replacement therapy.

    abstract::In a double-blind, randomized crossover study, the hypotheses were tested that more powerful inhibition of gastric acid secretion by adjuvant omeprazole further improves the efficacy of pancreatic enzyme replacement therapy compared to adjuvant cimetidine and that excluding the influence of pH-related factors, by virt...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bruno MJ,Rauws EA,Hoek FJ,Tytgat GN

    更新日期:1994-05-01 00:00:00

  • Induced mucosal penetration and transfer to portal blood of luminal horseradish peroxidase after exposure of mucosa of guinea pig small intestine to ethanol and lysolecithin.

    abstract::The effect of luminal 150 mmol saline, 0.05-0.2% (w/v) lysolecithin, and 5-20% (v/v) ethanol was studied on the mucosal morphology of the proximal small intestine in conscious guinea pigs as well as on the mucosal penetration and transfer to portal venous blood of luminal horseradish peroxidase (HRP). No ultrastructur...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Talbot RW,Foster JR,Hermon-Taylor J,Grant DA

    更新日期:1984-11-01 00:00:00

  • Geographical Disparities of Outcomes of Hepatocellular Carcinoma in France: The Heavier Burden of Alcohol Compared to Hepatitis C.

    abstract:BACKGROUND:Data on alcohol-related HCC are limited. AIMS:Our aim was to describe the incidence, management, and prognosis of alcohol compared to Hepatitis C (HCV)-related HCC at a national level. METHODS:Incident cases of HCC were identified in French healthcare databases between 2009 and 2012 and analyzed retrospect...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Costentin CE,Sogni P,Falissard B,Barbare JC,Bendersky N,Farges O,Goutte N

    更新日期:2020-01-01 00:00:00

  • Chronic active hepatitis associated with liver-kidney microsomal antibody of an autoimmune type. Two familial cases.

    abstract::We report the findings in two sisters with active cirrhosis and an anti-liver-kidney microsomal antibody (anti-LKM) of the autoimmune type. This unusual disease is characterized by the presence of high levels of antibodies that react with the smooth and rough endoplasmic reticulum of the liver and other tissues. Our p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Buffet C,Homberg JC,Pelletier G,Turner K,Etienne JP

    更新日期:1986-11-01 00:00:00

  • Activation of beta-catenin in the stem cell region of crypts during growth of the small intestine in infant rats.

    abstract::The Wnt/beta-catenin pathway has been proposed as promoting intestinal stem cell division. Wnt ligands activate cytoplasmic beta-catenin and increase nuclear translocation of beta-catenin that binds to the Tcf-4 transcription factor. The aim of this study was to investigate beta-catenin expression in the stem cell reg...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Camac KS,Thompson FM,Cummins AG

    更新日期:2007-05-01 00:00:00

  • Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats.

    abstract::Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow's milk yoghurt (CY; fermented with Lactobacillus john...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Southcott E,Tooley KL,Howarth GS,Davidson GP,Butler RN

    更新日期:2008-07-01 00:00:00

  • Clinical response is associated with elevated plasma interleukin-1 receptor antagonist during selective granulocyte and monocyte apheresis in patients with ulcerative colitis.

    abstract::Depletion of granulocytes and monocytes (GM) by selective apheresis (GMA) with an Adacolumn exerts an anti-inflammatory effect in patients with ulcerative colitis (UC) or rheumatoid arthritis. However, the mechanism of the anti-inflammatory effect of GMA is not fully understood yet. We investigated the effect of GMA o...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章


    authors: Sakimura K,Omori T,Iwashita E,Yoshida T,Tsuzuki Y,Fujimori K,Konishi F,Yoshida Y,Anzai H,Suzuki H,Sugawara S,Takeda Y,Hiraishi K,Saniabadi AR,Ide T,Miura S,Ota S

    更新日期:2006-09-01 00:00:00

  • Preoperative Pulmonary Function Tests Predict Aspiration Pneumonia After Gastric Endoscopic Submucosal Dissection.

    abstract:BACKGROUND:ESD allows higher rates of en-bloc and R0 resections, but has occasionally complications such as aspiration pneumonia. Factors associated with aspiration pneumonia are not completely understood. AIMS:To analyze the relationship between aspiration pneumonia and preoperative factors including pulmonary functi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章


    authors: Matsumi A,Takenaka R,Ando C,Sato Y,Takei K,Yasutomi E,Okanoue S,Oka S,Kawai D,Kataoka J,Takemoto K,Tsugeno H,Fujiki S,Kawahara Y

    更新日期:2017-11-01 00:00:00