Abstract:
:To investigate the possible role of pepsin in ulceration induced by hydrogen ion back-diffusion, the ratio of alkali-labile pepsinogen to total pepsinogen was studied during the course of aspirin- and taurocholate-induced gastric ulceration in comparison with the changes in the ion permeability and histological findings. The results obtained were as follows. (1) The increase in the ulcer index was observed between 1 and 2 hr with intragastric aspirin and between 2 and 4 hr with intragastric taurocholate. (2) The back-diffusion of luminal hydrogen ions, observed as a significant decrease in hydrogen ion net flux, occurred immediately in both cases with aspirin and with taurocholate. (3) A significant increase in the ratio of alkali-labile to total pepsinogen in the homogenate of gastric mucosa was observed at 30 min with aspirin and at 60 min with taurocholate. (4) Histological examination revealed the degeneration of mucosal cells spreading from the luminal surface into the mucosa, which fell off after 120 min with aspirin. These findings indicate that the activated pepsin is involved in the ulcer formation caused by the hydrogen ion back-diffusion, although the origin of the activated pepsin is not clear at the present time.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Ohe K,Yokoya H,Kitaura T,Kunita T,Miyoshi Adoi
10.1007/BF01338527subject
Has Abstractpub_date
1980-11-01 00:00:00pages
849-56issue
11eissn
0163-2116issn
1573-2568journal_volume
25pub_type
杂志文章abstract::Studies of the T-cell-receptor repertoire and oligoclonal expansion of lamina propria T cells in patients with Crohn's disease suggest restricted antigen processing in this disease. We examined HPLC elution profiles of HLA-DR-bound peptides isolated from human intestine. Surgical samples of colon and ileum were obtain...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1019689332601
更新日期:2002-09-01 00:00:00
abstract::Extraintestinal symptoms are often found in patients with irritable bowel syndrome (IBS). Recent studies suggest that IBS is associated with bronchial hyperresponsiveness. But it is still arguable that the bronchial hyperresponsiveness is associated with IBS patients. The purpose of this study is to investigate the po...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2916-y
更新日期:2005-09-01 00:00:00
abstract::Hepatitis B virus (HBV) infection is a major etiology of chronic liver disease worldwide. In the past decade, nonalcoholic fatty liver disease (NAFLD) has emerged as a common liver disorder in general population. Accordingly, the patient number of chronic hepatitis B (CHB) concomitant with NAFLD grows rapidly. The pre...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3772-z
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To evaluate the safety and efficacy of performing ampullary balloon dilation (ABD) following endoscopic sphincterotomy (ES). METHODS:Retrospective review of patients that underwent ABD at Thomas Jefferson University from 2000 to 2007. In all cases, dilation was performed with Hurricane RX hydrostatic balloons ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0376-x
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:Bacterial translocation is a frequent complication in portal hypertension related to cirrhosis in the human clinical area. The aim of this study was to verify the existence of intestinal bacterial translocation to mesenteric lymph nodes in male Wistar rats with triple partial portal vein ligation during short- ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-1001-3
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abstract::The secondary bile acid deoxycholic acid is believed to be a promoter of large bowel cancer, in part by inducing colonic epithelial proliferation. The effects of deoxycholic acid on [3H]thymidine incorporation by the human colon cancer cell line HT29 and two differentiated subclones were measured and compared. The sub...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018806431866
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abstract::New studies monitoring ambulatory esophageal pressures during food ingestion often compare results to normal values obtained from supine liquid swallows. We compared distal esophageal peristaltic and lower esophageal sphincter (LES) pressures in 15 normal subjects during six liquid swallows in the upright and supine p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536799
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Lipopolysaccharide binding protein (LBP) is involved in the modulation of acute liver injury and failure caused by acetaminophen (APAP). Although the biological activity of LBP is concentration dependent, little is known about its levels in acute liver failure. METHODS:Serum and hepatic LBP were me...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2046-2
更新日期:2012-04-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0870-9
更新日期:2010-05-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02212692
更新日期:1995-08-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3285-1
更新日期:2015-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-007-0178-6
更新日期:2008-10-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-020-06134-4
更新日期:2021-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296145
更新日期:1987-07-01 00:00:00
abstract::Low or minimal doses of aspirin are widely used for prevention of cardiovascular diseases. Aspirin is known to produce severe adverse gastrointestinal effects, such as bleeding and perforation. Less is known about the risk associated with minidose aspirin. Our aim was to assess the possible association of upper gastro...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2906-0
更新日期:2005-09-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3823-5
更新日期:2016-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01318426
更新日期:1984-09-01 00:00:00
abstract::The effects of Sulglycotide were evaluated in a pilot study of active H. pylori+ atrophic gastritis. Ten informed patients (mean age 51 +/- 13 years) entered a double-blind study. Five received Sulglycotide 400 mg three times a day for one year, the other 5, placebo. At 0, 30, 90, 270, and 360 days of treatment, patie...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02208579
更新日期:1996-01-01 00:00:00
abstract::The value of a "bread-barium" swallow for diagnosis of disordered esophageal motility was examined in 53 patients, 20 of whom complained of dysphagia, 20 retrosternal chest pain, and 13 heartburn; a further 19 subjects served as controls. Esophageal manometry in the patients with dysphagia and chest pain revealed majo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295808
更新日期:1983-12-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-017-4662-3
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-011-1697-8
更新日期:2011-10-01 00:00:00
abstract::In the pathogenesis of gastroesophageal reflux disease (GERD), gastric acid is considered to be one of the most important factors, but little is known about the degree of gastric acid secretion in GERD patients. In this study, we evaluated it in GERD patients and control subjects by 24-h intragastric pH, and serologic...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/b:ddas.0000030090.84412.2a
更新日期:2004-05-01 00:00:00
abstract::Clinical features and liver biopsy findings were studied in six patients with nonalcoholic steatohepatitis associated with hyalin. A comparative study was made on the ultrastructure of the hyalin in one patient with nonalcoholic steatohepatitis and in one patient with alcoholic hepatitis. The patients, all over 50 yea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296754
更新日期:1982-04-01 00:00:00
abstract::In previous studies, the majority of patients with the cholestatic liver diseases, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), had increased hepatic copper (Cu) levels even in early stages of disease. We prospectively measured hepatic copper content by atomic absorption spectrophotometry ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087659
更新日期:1994-11-01 00:00:00
abstract::The bile acids in brown pigment stones and gallbladder bile were fractionated into free acids, glycine and taurine conjugates, and sulfates using diethylaminohydroxypropyl Sephadex LH-20 (DEAP-LH-20) column chromatography and were quantitated by gas chromatography. Twenty-eight cases of brown pigment stones were studi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01537218
更新日期:1990-01-01 00:00:00
abstract::Minimal hepatic encephalopathy (MHE) describes patients with chronic liver disease or cirrhosis who have no clinical symptoms of brain dysfunction but perform worse on psychometric tests compared with healthy subjects. The pathogenesis of hepatic encephalopathy is controversial although ammonia has been found to induc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-006-9687-y
更新日期:2007-11-01 00:00:00
abstract::Serum biochemical tests were observed for about three weeks following oral cholecystography with fractionated high doses (6 g) of iopanoic acid (Telepaque) or sodium ipodate (Biloptin) in 24 and 29 patients, respectively. Both agents produced similar effects. No significant changes were seen in renal or hepatic functi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308063
更新日期:1980-05-01 00:00:00
abstract::We have previously reported impressive results in using a gonadotropin-releasing hormone analog, leuprolide acetate (Lupron), in the treatment of moderate to severe symptoms (especially abdominal pain and nausea) in patients with functional bowel disease (FBD). Pain is the hallmark of patients with FBD, and there is n...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1023/a:1018888631286
更新日期:1998-06-01 00:00:00
abstract::Bone loss is an established complication of cholestatic liver cirrhosis, while little is known about bone mass and metabolism in noncholestatic liver cirrhosis. The aim of the present study is, therefore, to evaluate bone mass and mineral metabolism in patients with liver cirrhosis secondary to viral hepatitis. Bone m...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005568406664
更新日期:2000-07-01 00:00:00
abstract::Lipopolysaccharide (LPS) is implicated in the pathology of acute liver injury and can induce lethal liver failure when simultaneously administered with D-galactosamine (D-GalN). At the present time, nonlethal liver failure, the liver injury of clinical implication, is incompletely understood following challenge by low...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-9994-y
更新日期:2008-05-01 00:00:00