Abstract：
:The study was undertaken to examine regional differences in the concentrations of five regulatory peptides in the human colonic mucosa. Biopsies were obtained during routine colonoscopy from 33 patients whose colonic mucosa was macroscopically and histologically normal. Regulatory peptides were extracted, and measured by specific radioimmunoassays. Concentrations of three peptides that are present predominantly in endocrine cells within colonic mucosa increased significantly towards the rectum: Mean concentrations of peptide YY, enteroglucagon, and somatostatin were about three times greater in the rectum than in the cecum. However, concentrations of two peptides that are present in mucosal nerve fibers diminished significantly towards the rectum: Mean rectal concentrations of vasoactive intestinal peptide and peptide histidine methionine were both about 0.6 of mean cecal concentrations. Concentrations of all five peptides were lower in biopsies taken from colonic polyps than in normal colonic mucosa. Regional differences in colonic mucosal concentrations of regulatory peptides probably reflect differences in the physiological functions of different parts of the colon.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Calam J,Ghatei MA,Domin J,Adrian TE,Myszor M,Gupta S,Tait C,Bloom SRdoi
10.1007/BF01537267subject
Has Abstractpub_date
1989-08-01 00:00:00pages
1193-8issue
8eissn
0163-2116issn
1573-2568journal_volume
34pub_type
杂志文章abstract：:We observed five cases of unusual extraperitoneal presentation of diverticulitis during an 11 year period. During that time, a total of 263 patients were operated for diverticulitis. Patients 1-4 presented with an inflammatory spread of diverticulitis through the abdominal wall; in patient 5 multiple abscesses were pr...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297073
更新日期：1993-11-01 00:00:00
abstract：:The effects of cisapride on upper gut motility were studied in seven healthy volunteers by means of a novel intraluminal electromyographic technique in a placebo-controlled study. In the interdigestive state, cisapride (10 mg intravenous bolus injection) markedly increased the number of spike bursts. The most obvious ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/BF01535939
更新日期：1988-12-01 00:00:00
abstract：:Colonic mucus is decreased in a rat model of spastic constipation, and some types of water-insoluble dietary fiber increase colonic mucus when consumed by rats for several weeks. However, little is known about the effect of water-soluble dietary fiber on the colonic mucus. The aim of the present study was to investiga...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1010644021888
更新日期：2001-07-01 00:00:00
abstract：:Leptin is an adipocyte-derived hormone involved in the homeostasis of body composition. An imbalance in leptin regulation has been observed in patients with liver cirrhosis. We aimed to assess serum and ascitic leptin levels in a group of patients with decompensated liver cirrhosis and to evaluate the relationship of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000017451.48031.b6
更新日期：2004-02-01 00:00:00
abstract：:Manometry is considered the gold standard for evaluating sphincter of Oddi dysfunction. It has recently been demonstrated that the ultrasound (US) secretin test proposed a few years ago as a noninvasive test for the study of sphincter of Oddi dysfunction yields a substantial percentage of pathological findings in pati...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026658618605
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:It is unclear whether the quality of bowel preparation affects colonoscopic detection of non-polypoid colorectal neoplasms (NP-CRNs). AIM:To evaluate the impact of bowel-cleansing quality on detection of NP-CRNs. METHODS:We performed a retrospective analysis of asymptomatic screening colonoscopy cases afte...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3628-6
更新日期：2015-08-01 00:00:00
abstract：:Bleeding from esophagogastric varices is a potentially deadly complication in patients with hepatosplenic schistosomiasis. The aim of this study is to establish indicators of variceal bleeding. We studied 40 patients with compensated hepatosplenic schistosomiasis and varices, analyzing four endoscopic (variceal size, ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005501930808
更新日期：2000-05-01 00:00:00
abstract：:Vagal control of pyloric resistance was evaluated in anesthetised pigs by recording gastropyloroduodenal motility and transpyloric flow during emptying of a liquid nonnutrient meal. Vagotomy did not modify pyloric resistance or the characteristics of the flow pulses. Electrical stimulation of the distal stumps of cerv...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02300364
更新日期：1994-12-01 00:00:00
abstract：BACKGROUND AND AIMS:Colorectal cancer (CRC) screening with a fecal immunochemical test (FIT) reduces CRC mortality; however, the acceptance rate of a colonoscopy in patients with a positive FIT was not high. The aim of this study was therefore to determine whether a telephone reminder call could increase the acceptance...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1720-0
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Eosinophilic esophagitis (EoE) is associated with tissue remodeling that can result in esophageal mucosal fragility, and esophageal dilation for patients with EoE is known to cause painful mucosal lacerations. Clinicians have been admonished that patients with EoE may be exceptionally predisposed to perforat...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-010-1165-x
更新日期：2010-06-01 00:00:00
abstract：:Hepatolithiasis is a major disease in Asia but differences in operative incidence between countries have not been examined. A retrospective study was conducted in Taiwan, Hong Kong, and Singapore, and the results were compared with those in Japan with the aim of defining factors involved in the etiology of the conditi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01347905
更新日期：1986-01-01 00:00:00
abstract：:Upper gastrointestinal endoscopy was performed for the evaluation of infectious esophagitis in 19 consecutive subjects evaluated prospectively before orthotopic liver transplantation (OLTx), in a separate group of 27 subjects post-OLTx, and in 21 subjects following orthotopic renal transplantation (ORTx). None of the ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01535788
更新日期：1988-09-01 00:00:00
abstract：:The effects of ecabet sodium (ecabet), 12-sulfodehydroabietic acid monosodium salt, on gastric mucin biosynthesis in rat antrum were compared with those in the corpus. Intragastric administration of ecabet significantly increased [3H]glucosamine incorporation into antral mucin as well as into corpus mucin during five ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005469913079
更新日期：2000-03-01 00:00:00
abstract：:Management of severe refractory functional gastrointestinal disorders (FGIDs) is difficult. Quetiapine, an atypical antipsychotic, may benefit patients by mitigating associated anxiety and sleep disturbances, augmenting the effect of antidepressants, and providing an independent analgesic effect. Outpatient records fr...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-009-0723-6
更新日期：2009-06-01 00:00:00
abstract：:The study investigated the effect of either nocturnal acid suppression by the H2 antagonist nizatidine 300 mg at night or prolonged acid suppression by the proton- pump inhibitor omeprazole 20 mg in the morning, during four weeks, on intragastric pH profile, occurrence of bacterial growth in gastric fluid and biopsies...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02093609
更新日期：1996-10-01 00:00:00
abstract：BACKGROUND:Marijuana may be used by some patients with gastroparesis (Gp) for its potential antiemetic, orexigenic, and pain-relieving effects. AIMS:The aim of this study was to describe the use of marijuana by patients for symptoms of Gp, assessing prevalence of use, patient characteristics, and patients' perceived b...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05963-2
更新日期：2020-08-01 00:00:00
abstract：:To investigate the pathophysiological basis of Courvoisier's law, the gallbladder size and pliability were measured in chronic calculous cholecystitis with (7 patients) or without (25 patients) common duct obstruction, in periampullary malignancy (6 patients), and in the normal state (3 patients). The duration and lev...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01393358
更新日期：1983-01-01 00:00:00
abstract：:A retrospective multicenter analysis of 652 patients with chronic hepatitis C who have been treated with interferon (IFN) was performed to assess the effects of IFN on the clinical course and development of HCC. During a mean follow-up of 54.8 months, hepatocellular carcinoma (HCC) developed in 7.0% of the patients. T...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究
doi：10.1023/a:1013244326874
更新日期：2002-01-01 00:00:00
abstract：:The purpose of this study was to establish if estrogen-induced hepatocyte proliferation in vitro involves the cell cycle regulators cyclin D1, p21(Cip1), and p27(Kip1). Male rat hepatocytes were cultured in presence of 17-beta-estradiol (E2) +/- ICI-182780, a pure estrogen antagonist, and [3H]-thymidine, as required. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-3173-4
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Little is known on practice patterns of endoscopists for the management of Barrett's esophagus (BE) over the last decade. AIMS:Our aim was to assess practice patterns of endoscopists for the diagnosis, surveillance and treatment of BE. METHODS:All members of the Italian Society of Digestive Endoscopy (SIED...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06615-6
更新日期：2020-09-28 00:00:00
abstract：:This study investigated the effects of intravenous morphine on gastric antral and duodenal motility in healthy volunteers. Intravenous morphine (both infusion and bolus) increased duodenal motility, typically as bursts of contractions similar to phase III of the migrating motor complex. Intravenous infusion of morphin...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026684132254
更新日期：1999-11-01 00:00:00
abstract：:The aim of the study was to assess the value of quantitative attenuation values (Hounsfield units) and of gallstone pattern by computerized tomography in predicting response to bile acid therapy. We carried out a prospective study in a multicenter setting on 90 consecutive outpatients with radiolucent gallstones. All ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF02208664
更新日期：1995-09-01 00:00:00
abstract：:Gastric stasis and duodenogastric reflux have each been implicated in the pathogenesis of various upper gastrointestinal disorders. However, the relationship between intragastric bile and gastric emptying has not been explored. In each of nine healthy volunteers (seven men and two women, ages 22-47 years), gastric emp...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01535751
更新日期：1988-03-01 00:00:00
abstract：:A gangliocytic paraganglioma (GP) is an extremely rare neurogenic tumor nearly located in the second portion of the duodenum and has been regarded as benign. We report a case of duodenal GP in a 53-year-old man. The GP arose in the second portion of the duodenum and was shown by histological examination to consist of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9370-3
更新日期：2007-06-01 00:00:00
abstract：:The major host defense mechanisms against bacterial overgrowth in the small bowel are the normal propulsive activity of the bowel itself and gastric acid secretion. Microbial interactions are a major factor in regulating the indigenous bacterial flora. Studies of the bacterial enzymes of the gut suggest that changes i...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01295996
更新日期：1986-09-01 00:00:00
abstract：:Five cases of granular cell tumor of the esophagus are reported. In four cases, the tumor was an asymptomatic, incidental finding. In one case, a larger granular cell tumor presented with dysphagia and required local surgical excision. Long-term follow-up in three cases revealed no evidence of tumor progression. Esoph...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536687
更新日期：1988-10-01 00:00:00
abstract：:Idiopathic chronic constipation has been correlated to neural abnormalities that consist of a reduced number of myenteric plexus neurons and a decreased concentration of VIP-positive nerve fibers within the circular muscle. Recent studies hypothesized the involvement of nitric oxide in motility disorders of the human ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02063253
更新日期：1995-11-01 00:00:00
abstract：:The effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion were evaluated in a pylorus-ligated rat model. Oral administration of salicylate (50 mg/kg), aspirin (50 mg/kg), and indomethacin (3.5 mg/kg) significantly increased ulcerogenesis over the basal value by six- to sevenfold, but ib...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02063956
更新日期：1995-01-01 00:00:00
abstract：:The intestine-specific caudal-related homeobox transcription factor Cdx2 is widely accepted to play a key role in intestinal development and differentiation in mammals. We studied the role of Cdx2 in the development of Barrett's esophagus (BE). In previous studies, we have shown a sequence of morphological changes of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-005-2452-9
更新日期：2005-03-01 00:00:00
abstract：:Consistent regression of intestinal metaplasia in Barrett's esophagus has not been achieved with medical or surgical interventions. In this case report, a patient with Barrett's esophagus of stable length had half the circumference of the Barrett's epithelium ablated with laser therapy while on a high-dose proton-pump...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01307557
更新日期：1993-02-01 00:00:00
