Vagal control of transpyloric flow and pyloric resistance.

abstract：:Minimal lesions of the small bowel are mucosal changes characterized by an increased number of intraepithelial lymphocytes (with or without crypt hyperplasia) and normal villous architecture. Such changes are associated with a wide spectrum of conditions, ranging from food intolerances to infections, and from drugs to...

journal_title：Digestive diseases and sciences

authors： Volta U,Caio G,Ghirardi C,Lungaro L,Mansueto P,Carroccio A,De Giorgio R

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Much of the economic burden of Crohn's disease (CD) is related to surgery. Twenty percent of patients with CD have isolated colonic disease. While permanent end ileostomy (EI) is generally the procedure of choice for patients with refractory CD colitis, single-center experiences suggest that restorative proc...

journal_title：Digestive diseases and sciences

authors： Taleban S,Van Oijen MG,Vasiliauskas EA,Fleshner PR,Shen B,Ippoliti AF,Targan SR,Melmed GY

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Interferon regulatory factor 9 (IRF9) acts as a negative regulator of sirtuin-1 (SIRT1) to participate in many diseases. However, the role of SIRT1 and IRF9 in hyperlipidemia acute pancreatitis associated with kidney injury is unclear. AIMS:To explore the function of SIRT1 and IRF9 in hyperlipidemia acute p...

journal_title：Digestive diseases and sciences

authors： Liu Y,Sun Y,Xue BH,Wang XD,Yu WL

更新日期：2020-05-28 00:00:00

abstract：:The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian gastrointestinal tract that can impact physiologic and pathologic processes. However, our understanding of the underlying mechanism for the dynamic interaction between host and gut microbiota is still in its infancy. The highly evolved ep...

journal_title：Digestive diseases and sciences

authors： Ye J,Wu W,Li Y,Li L

更新日期：2017-05-01 00:00:00

abstract：:Alkaline sphingomyelinase (Alk-SMase) is a key enzyme in the intestinal tract for digestion of dietary sphingomyelin (SM), which generates lipid messengers with cell-cycle regulating effects. The enzyme is significantly decreased in ulcerative colitis and colon cancer. Based on this information, we wanted to investiga...

journal_title：Digestive diseases and sciences

authors： Andersson D,Kotarsky K,Wu J,Agace W,Duan RD

更新日期：2009-07-01 00:00:00

abstract：:Solitary rectal ulcer syndrome (SRUS) is sufficiently uncommon that the clinician or general pathologist may lack familiarity with the disorder and may confuse it with other inflammatory bowel diseases. To evaluate the role of collagen staining in facilitating the differential diagnosis of SRUS, an initial open review...

journal_title：Digestive diseases and sciences

authors： Levine DS,Surawicz CM,Ajer TN,Dean PJ,Rubin CE

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Heat shock protein 70-2 (HSP70-2) has a cytoprotective role in various conditions and also protects the gastric mucosa. Recently, polymorphism of HSP70-2 at position 1267 was suggested to be associated with carcinogenesis. We investigated the association of this polymorphism with the risk of gastric cancer i...

journal_title：Digestive diseases and sciences

authors： Shibata T,Arisawa T,Tahara T,Yoshioka D,Maruyama N,Fujita H,Kamiya Y,Nakamura M,Nagasaka M,Iwata M,Takahama K,Watanabe M,Hirata I,Nakano H

更新日期：2009-01-01 00:00:00

abstract：:We describe a 28-yr-old woman who presented with severe, recurrent cholangitis due to Caroli's disease in association with congenital hepatic fibrosis. Cystic dilatation of the segmental bile ducts was diffuse, but predominated in the right lobe and left medial segment of the liver. Extended right lobectomy was follow...

journal_title：Digestive diseases and sciences

authors： Ramond MJ,Huguet C,Danan G,Rueff B,Benhamou JP

更新日期：1984-04-01 00:00:00

abstract：:Acetic acid-induced pan colitis in rats leads not only to colonic injury but also to a bystander ileal injury, characterized by decreased fluid and electrolyte absorption without associated histological injury or infiltration of inflammatory cells. To examine the nature of this decreased ileal fluid and electrolyte ab...

journal_title：Digestive diseases and sciences

authors： Cui N,Madsen KL,Friend DR,Stevenson BR,Fedorak RN

更新日期：1996-02-01 00:00:00

abstract：:The present study reports the results of intravenous cyclosporine in 32 patients with refractory and/or severe attacks of ulcerative colitis (UC). Twenty of 32 patients responded to intravenous cyclosporine; cyclosporine was clinically effective and improved colonic lesions. However, one colonic perforation and one po...

journal_title：Digestive diseases and sciences

authors： Carbonnel F,Boruchowicz A,Duclos B,Soulé JC,Lerebours E,Lémann M,Belaïche J,Colombel JF,Cosnes J,Gendre JP

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Hepatic encephalopathy (HE) is a serious neuropsychiatric complication in both acute and chronic liver disease. AIMS:To establish the utility of a portable noninvasive method to measure ammonia in the breath of healthy subjects and patients with HE. METHODS:The study included 106 subjects: 44 women and 62 ...

journal_title：Digestive diseases and sciences

authors： Adrover R,Cocozzella D,Ridruejo E,García A,Rome J,Podestá JJ

更新日期：2012-01-01 00:00:00

abstract：:The motor function of the gallbladder after partial distal gastrectomy for gastric carcinoma (Billroth-I reconstruction) and its relationship to the motor function of the stomach was investigated using a double-isotope method. In this method, [99mTc]N-54-pyridoxyl-5-methyltryptophan ([99mTc]PMT) was utilized as a trac...

journal_title：Digestive diseases and sciences

authors： Hamasaki T,Hamanaka Y,Adachi A,Suzuki T

更新日期：1995-04-01 00:00:00

abstract：:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently develop hepatic encephalopathy. Metabolic etiology of encephalopathy is less often considered in these patients. Although paraneoplastic hypercalcemia may be associated with several malignant tumors, it has also been described in HCC [1-4], and may caus...

journal_title：Digestive diseases and sciences

authors： Tudela P,Soldevila B,Mòdol JM,Domènech E

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Lipopolysaccharide binding protein (LBP) is involved in the modulation of acute liver injury and failure caused by acetaminophen (APAP). Although the biological activity of LBP is concentration dependent, little is known about its levels in acute liver failure. METHODS:Serum and hepatic LBP were me...

journal_title：Digestive diseases and sciences

authors： Su GL,Fontana RJ,Jinjuvadia K,Bayliss J,Wang SC

更新日期：2012-04-01 00:00:00

abstract：:Alterations in both gastric emptying (GE) and small bowel motility have been reported in irritable bowel syndrome (IBS); the relationship, however, between these different measures of upper gut motor function in IBS has not been assessed. The aims of this study were therefore: (1) to compare the prevalence and charact...

journal_title：Digestive diseases and sciences

authors： Evans PR,Bak YT,Shuter B,Hoschl R,Kellow JE

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:While the short-term benefits of exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) are well documented, the longer-term outcomes are less clear. AIM:This retrospective study aimed to ascertain the outcomes for up to 24 months following EEN in a group of child...

journal_title：Digestive diseases and sciences

authors： Lambert B,Lemberg DA,Leach ST,Day AS

更新日期：2012-08-01 00:00:00

abstract：:The destruction of the integrity of the gastric epithelial barrier underlies the pathology of many gastric diseases, including gastric tumors. The Helicobacter pylori virulence factor CagA is one of the main destroyers of the gastric epithelial barrier. There are differences among CagA proteins that originate from dif...

journal_title：Digestive diseases and sciences

authors： Wu J,Xu S,Zhu Y

更新日期：2013-07-01 00:00:00

abstract：:Achalasia is the best described motor disorder of the esophagus. Associations with familial glucocorticoid deficiency and alacrima (triple A syndrome) have been described in the pediatric population, but no attention has been paid to the possibility of this association in adults. Tear production was assessed in 20 pat...

journal_title：Digestive diseases and sciences

authors： Verma S,Brown S,Dakkak M,Bennett JR

更新日期：1999-05-01 00:00:00

abstract：:Pulmonary injury with leukocyte infiltration is a frequent occurrence in obstructive cholangitis patients. We wished to evaluate the roles of reactive oxygen species and vascular cell adhesion molecule-1 (VCAM-1) in this distant organ failure. Wild type (WT) and transgenic (SODtg) mice overexpressing superoxide dismut...

journal_title：Digestive diseases and sciences

authors： Morise Z,Ueda M,Kitajima M,Epstein CJ,Granger DN,Grisham MB

更新日期：2002-03-01 00:00:00

abstract：:This study set out to evaluate the effects of dietary fiber on cancer development in the large bowel under in vivo experimental conditions as similar as possible to those under which this cancer develops in vivo in humans. Forty-eight Sprague-Dawley rats were divided into three groups that were fed either a nonfiber d...

journal_title：Digestive diseases and sciences

authors： Iwane S,Nakaji S,Ohta M,Tamura K,Sakamoto J,Munakata A,Sugawara K

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Esophageal epithelial microRNAs may be used to diagnose Barrett's esophagus (BE) and possibly monitor its progression to esophageal adenocarcinoma (EAC). AIMS:We reviewed studies that have investigated this to identify microRNAs with high biomarker potential for screening and disease monitoring in BE. METH...

journal_title：Digestive diseases and sciences

authors： Mallick R,Patnaik SK,Wani S,Bansal A

更新日期：2016-04-01 00:00:00

abstract：:Animal studies have shown that calcium blocking drugs decrease lower esophageal sphincter pressure and inhibit peristaltic amplitude and duration. In a single-dose acute study, we compared the effects of a new oral calcium blocker, diltiazem (90, 120, 150 mg) with placebo in five volunteers and 10 patients with chest ...

journal_title：Digestive diseases and sciences

authors： Richter JE,Spurling TJ,Cordova CM,Castell DO

更新日期：1984-07-01 00:00:00

abstract：:Theoretically, relative distal common bile duct obstruction due to sphincter of Oddi dysfunction may be a cause of poor gallbladder evacuation observed on quantitative cholescintigraphy. In this study, the relationship of sphincter of Oddi dysfunction to the gallbladder ejection fraction by quantitative cholescintigra...

journal_title：Digestive diseases and sciences

authors： Ruffolo TA,Sherman S,Lehman GA,Hawes RH

更新日期：1994-02-01 00:00:00

abstract：:Since celiac disease screening by traditional IgA anti-endomysial antibody test is limited by high costs of monkey esophagus commercial kits as well as by rising ethical problems related to the endangered species, the identification of an inexpensive and commonly available substrate for this antibody determination is ...

journal_title：Digestive diseases and sciences

authors： Volta U,Molinaro N,de Franceschi L,Fratangelo D,Bianchi FB

更新日期：1995-09-01 00:00:00

abstract：:Gastrointestinal motor dysfunction persists in a large number of children subjected to surgical treatment for Hirschsprung's disease, indicating abnormalities in the remaining intestine. The aim of the study was to detect possible alterations in frequency and topographic distribution of enteric neurons and interstitia...

journal_title：Digestive diseases and sciences

authors： Sandgren K,Larsson LT,Ekblad E

更新日期：2002-05-01 00:00:00

abstract：:This study was designed to assess the central nervous system actions of human calcitonin (hCalc) and human calcitonin gene-related peptide (hCGRP) on meal-stimulated gastric acid secretion in awake beagle dogs. hCalc (0.1-1.0 nmol/kg) and hCGRP (0.01-1.0 nmol/kg) injected into the third cerebral ventricle significantl...

journal_title：Digestive diseases and sciences

authors： Lenz HJ,Brown MR

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Estradiol-17β-D-glucuronide (E17G) induces cholestasis in vivo, endocytic internalization of the canalicular transporters multidrug resistance-associated protein 2 (Abcc2) and bile salt export pump (Abcb11) being a key pathomechanism. Cyclic AMP (cAMP) prevents cholestasis by targeting these transporters bac...

journal_title：Digestive diseases and sciences

authors： Zucchetti AE,Barosso IR,Boaglio AC,Luquita MG,Roma MG,Crocenzi FA,Sánchez Pozzi EJ

更新日期：2013-06-01 00:00:00

abstract：:In previous open studies, misoprostol and metronidazole reduced nonsteroidal anti-inflammatory drug-induced intestinal permeability changes and inflammation respectively. We assessed the effects of indomethacin treatment (50 mg three times a day) for one week with either coadministered metronidazole (400 mg twice a da...

journal_title：Digestive diseases and sciences

authors： Davies GR,Wilkie ME,Rampton DS

更新日期：1993-03-01 00:00:00

abstract：:Colonic diverticula have been generally accepted as a source of massive hemorrhaging. Little is known, however, about fecal occult blood loss from colonic diverticula and diverticulosis. We retrospectively investigated the possibility of minor bleeding in 737 diverticula cases diagnosed from April 1989 to May 1994. Th...

journal_title：Digestive diseases and sciences

authors： Ohyama T,Sakurai Y,Ito M,Sezai S,Kamisaka K,Abe T,Ikegami F,Kobayashi Y

更新日期：1998-07-01 00:00:00

abstract：:Cholecystokinin (CCK) decreases lower esophageal sphincter pressure (LESP) in man. Cholestyramine, a nonabsorbable bile salt binding resin, stimulates endogenous CCK secretion. We have investigated the effect of oral ingestion of 16 g cholestyramine without and with infusion of the CCK receptor antagonist CR1505 (loxi...

journal_title：Digestive diseases and sciences

authors： Masclee AA,Jansen JB,Rovati LC,Lamers CB

更新日期：1993-10-01 00:00:00