Effects of oral calcium blocker, diltiazem, on esophageal contractions. Studies in volunteers and patients with nutcracker esophagus.

abstract：:Acid inhibition after proton pump inhibitors in children is variable, and to measure it by a noninvasive method may help to tailor treatment. To study gastric acid inhibition after a single dose of PPI, by measuring urinary acid output (UAO), which decreases as parietal cells release acid into the stomach during a mea...

journal_title：Digestive diseases and sciences

authors： Oderda G,Rapa A,Chiorboli E,Ronchi B,Zavallone A,Strigini L

更新日期：2002-08-01 00:00:00

abstract：:Gastroparesis often precludes gastric enteral nutrition (EN) in critically ill patients. Our aim was to determine the feasibility of bedside microendoscopic placement of nasointestinal feeding tubes to facilitate enteral nutrition in critically ill patients with poor gastric emptying. Nine mechanically ventilated pati...

journal_title：Digestive diseases and sciences

authors： Taylor SJ,Przemioslo R,Manara AR

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND AND STUDY AIMS:Use of ultrathin (ut) endoscopes is sometimes limited by their design (outer diameter, tip angulation and image quality). New ut-endoscopes are being designed to address these limitations. A new ut-endoscope, XGIF-PV70N5 (Olympus America Inc.), with an outer diameter of 5.5 mm, 4-way angulatio...

journal_title：Digestive diseases and sciences

authors： Agrawal D,Wong RC,Isenberg G,Faulx A,Chak A

更新日期：2011-03-01 00:00:00

abstract：:Hepatolithiasis is a major disease in Asia but differences in operative incidence between countries have not been examined. A retrospective study was conducted in Taiwan, Hong Kong, and Singapore, and the results were compared with those in Japan with the aim of defining factors involved in the etiology of the conditi...

journal_title：Digestive diseases and sciences

authors： Nakayama F,Soloway RD,Nakama T,Miyazaki K,Ichimiya H,Sheen PC,Ker CG,Ong GB,Choi TK,Boey J

更新日期：1986-01-01 00:00:00

abstract：:Bombesin or gastrin-releasing peptide prevents gastric injury by an unknown mechanism. Since exogenous gastrin is a gastroprotective agent, this study was undertaken to test the hypothesis that gastroprotection by bombesin involves release of endogenous gastrin. Subcutaneous bombesin (10-100 microg/kg) dose dependentl...

journal_title：Digestive diseases and sciences

authors： Mercer DW,Cross JM,Chang L,Lichtenberger LM

更新日期：1998-04-01 00:00:00

abstract：:The aim of the study was to determine inter- and intrapatient variation of Helicobacter pylori strains based on genomic fingerprinting and cagA (cytotoxin-associated gene A) status. Ten bacterial colonies from each of 10 patients with gastric cancer (GC), 10 with duodenal ulcer (DU), and 10 with gastritis (GI) were us...

journal_title：Digestive diseases and sciences

authors： Enroth H,Nyrén O,Engstrand L

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Major modification of the 7th tumor-node-metastasis (TNM) staging system for hepatocellular carcinoma (HCC) was divided into 6th stage IIIA to 7th IIIA (multiple tumors, any>5 cm) and IIIB (tumors involving a major vessel). This study aimed to validate 6th and 7th TNM systems in prognostic prediction, then a...

journal_title：Digestive diseases and sciences

authors： Kee KM,Wang JH,Lin CY,Wang CC,Cheng YF,Lu SN

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this study was to investigate interdigestive cycling and postprandial release of pancreatic polypeptide (PP) in relation to exocrine pancreatic function in chronic pancreatitis (CP). We investigated nine patients with mild-moderate CP (MCP), eight patients with severe CP and steathorrea (SCP), and 17 he...

journal_title：Digestive diseases and sciences

authors： Pieramico O,Nelson DK,Glasbrenner B,Malfertheiner P

更新日期：1994-01-01 00:00:00

abstract：:The authors have developed a primate model for evaluating cytoprotection against alcohol-induced injury in gastric mucosa pretreated with antiulcer agents. In the present study, groups of squirrel monkeys received either a single oral dose of misoprostol (500 or 200 micrograms/kg), cimetidine (3 or 6 mg/kg), placebo, ...

journal_title：Digestive diseases and sciences

authors： Liss RH,Letourneau RJ,Schepis JP

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND/AIM:We have previously reported that bee venom (BV) has a protective role against acute pancreatitis (AP). However, the effects of apamin, the major compound of BV, on AP have not been determined. The aim of this study was to evaluate the effects of apamin on cerulein-induced AP. METHODS:AP was induced via ...

journal_title：Digestive diseases and sciences

authors： Bae GS,Heo KH,Park KC,Choi SB,Jo IJ,Seo SH,Kim DG,Shin JY,Kang DG,Lee HS,Song HJ,Shin BC,Park SJ

更新日期：2013-10-01 00:00:00

abstract：:We retrospectively reviewed the role of ursodeoxycholic acid in infants having nonsurgical cholestasis attending the Hepatology Clinic, New Children Hospital, Cairo University, Egypt, from 1985 until 2005. Files of 496 infants with neonatal hepatitis and 97 with intrahepatic bile duct paucity were included; of them 24...

journal_title：Digestive diseases and sciences

authors： Kotb MA

更新日期：2009-10-01 00:00:00

abstract：:Diffuse esophageal spasm is an uncommon motility disorder that is found in less than 5% of patients undergoing esophageal motility testing for dysphagia. It is defined manometrically by the presence of 20% or more simultaneous contractions in the distal esophageal body with normal peristalsis. This motility abnormalit...

journal_title：Digestive diseases and sciences

authors： Sperandio M,Tutuian R,Gideon RM,Katz PO,Castell DO

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:The high mobility group protein A2 (HMGA2) is an architectural transcription factor that plays an important role in the development and progression of many malignant neoplasms. High expression of HMGA2 in gastric cancer correlates with invasiveness of cancer and is an independent prognostic factor. The reaso...

journal_title：Digestive diseases and sciences

authors： Zha L,Zhang J,Tang W,Zhang N,He M,Guo Y,Wang Z

更新日期：2013-03-01 00:00:00

abstract：:Acid inhibition increases gastric mucosal susceptibility to damage by luminal acid. This might be due to reduced metabolic CO2 and bicarbonate whereas, during normal acid, secretion cytoprotective CO2/HCO3- production parallels acid production. Metabolic activity and mucosal damage caused by luminal acid perfusion was...

journal_title：Digestive diseases and sciences

authors： Glauser M,Bauerfeind P,Feil W,Riegler M,Fraser R,Blum AL

更新日期：1996-05-01 00:00:00

abstract：:Musashi-1 (Msi-1), a mammalian neural RNA-binding protein, has been found to play important roles in the maintenance of stem cell states and differentiation in neural stem cells and mouse intestinal cells. We explored Msi-1 expression and its potential implications in the human stomach. Reverse transcription-PCR revea...

journal_title：Digestive diseases and sciences

authors： Murata H,Tsuji S,Tsujii M,Nakamura T,Fu HY,Eguchi H,Asahi K,Okano H,Kawano S,Hayashi N

更新日期：2008-02-01 00:00:00

abstract：:Basal gastric acid output was analyzed prospectively in 110 patients with endoscopically documented duodenal ulcer disease to determine the frequency of gastric acid hypersecretion in patients with bleeding versus nonbleeding ulcers. Thirty-eight patients with stigmata of an actively or recently bleeding duodenal ulce...

journal_title：Digestive diseases and sciences

authors： Collen MJ,Kalloo AN,Sheridan MJ

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Wnt-β-catenin signaling is essential for homeostasis of intestinal stem cells in mice and is thought to promote intestinal crypt fission. AIMS:The aim of this study was to investigate Wnt-β-catenin signaling in intestinal crypts of human infants. METHODS:Duodenal biopsies from nine infants (mean, range 0.9...

journal_title：Digestive diseases and sciences

authors： Dudhwala ZM,Drew PA,Howarth GS,Moore D,Cummins AG

更新日期：2019-01-01 00:00:00

abstract：:Sonic Hedgehog (Shh) signaling has been extensively studied for its role in developmental biology and cancer biology. The association between Shh and cancer development in general is well established but the functional role of Shh in the development and progression of gastric cancer specifically is largely unknown. Bo...

journal_title：Digestive diseases and sciences

authors： Martin J,Donnelly JM,Houghton J,Zavros Y

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Sorafenib is a proven first-line treatment recommended for hepatocellular carcinoma (HCC) patients with portal vein invasion (PVI). However, multiple treatment modalities are used in clinical practice as a first-line option. This study is a prospective, observational, multicenter, cohort study evalu...

journal_title：Digestive diseases and sciences

authors： Sinn DH,Lee HW,Paik YH,Kim DY,Kim YJ,Kim KM,Bae SH,Kim JH,Seo YS,Jang JY,Jang BK,Yim HJ,Kim HJ,Lee BS,Kim BH,Kim IH,Cho EY,Lee JI,Suh KS

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:The objectives of this study were, firstly, to determine the diversity of the host's gut microbiota in irritable bowel syndrome (IBS) using a culture-independent method (DGGE of the 16S rRNA gene) and, secondly, to examine mucosal biopsies of IBS patients and compare them to their own fecal microbiota. METHODS...

journal_title：Digestive diseases and sciences

authors： Codling C,O'Mahony L,Shanahan F,Quigley EM,Marchesi JR

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Chronic megacolon is a rare disease of the colonic motor function characterized by a permanent increase in colonic diameter. METHODS:We reviewed electronic medical records of all patients diagnosed with chronic megacolon from 1999 to 2014 at Mayo Clinic. Our aim was to summarize clinical and motility featur...

journal_title：Digestive diseases and sciences

authors： O'Dwyer RH,Acosta A,Camilleri M,Burton D,Busciglio I,Bharucha AE

更新日期：2015-08-01 00:00:00

abstract：:Liver from neonatal rats injected with LD50 E. coli endotoxin was studied by light and electron microscopy. By 2 hr, there was margination and migration of polymorphonuclear leukocytes. Single cell necrosis was seen after 8 hr. At 16 hr, there were numerous necrotic foci in the mid-zonal region of hepatic lobules, as ...

journal_title：Digestive diseases and sciences

authors： Young RS,Woods C,Towfighi J

更新日期：1986-06-01 00:00:00

abstract：:In this study we investigated the relative vascular response of different locations of the gastrointestinal tract to continuous intravenous infusion of isoproterenol (0.1 microgram kg-1 min-1 for 10 min). The vascular response of some nonsplanchnic organs was also examined. Blood flow of the arteries was measured by e...

journal_title：Digestive diseases and sciences

authors： Harrison DA,Dinda PK,Beck IT

更新日期：1988-11-01 00:00:00

abstract：:Gastric distension has been used to evaluate gastric sensory function in humans, but the methodology is poorly validated and studies in vivo comparing different distension protocols are lacking. We aimed to compare the influence of the mode of gastric distension on sensation and gastric compliance utilizing a barostat...

journal_title：Digestive diseases and sciences

authors： Holtmann G,Gschossmann J,Guerra G,Goebell H,Talley NJ

更新日期：1995-12-01 00:00:00

abstract：:The aim of the present study was to study the effect and mechanism of action of intraduodenal and intrajejunal dai-kenchu-to, an herbal medicine clinically effective for uncomplicated postoperative adhesive intestinal obstruction, on upper gastrointestinal motility. Five mongrel dogs were equipped with four strain-gau...

journal_title：Digestive diseases and sciences

authors： Jin XL,Shibata C,Naito H,Ueno T,Funayama Y,Fukushima K,Matsuno S,Sasaki I

更新日期：2001-06-01 00:00:00

abstract：:There is growing recognition of the importance of assessing patient perceptions of treatment, especially patient satisfaction. The Gastroesophageal Reflux Disease (GERD) Treatment Satisfaction Questionnaire (GTSQ) was developed to assess satisfaction with GERD medication. A web-based survey, which included the GTSQ an...

journal_title：Digestive diseases and sciences

authors： Shikiar R,Flood E,Siddique R,Howell J,Dodd SL

更新日期：2005-11-01 00:00:00

abstract：:Lansoprazole, a proton pump inhibitor, exerts prominent antiulcer activity via both antisecretory and mucosal protective actions. Although the antisecretory action has been explained by inactivation of (H+, K+)-ATPase in parietal cells, the mode of mucosal protective action remains to be elucidated. In the present stu...

journal_title：Digestive diseases and sciences

authors： Inada I,Satoh H

更新日期：1996-04-01 00:00:00

abstract：INTRODUCTION:Crohn's disease (CD) follows a relapsing and remitting course incurring cumulative bowel damage over time. The question of whether or not the timing of the initiating biologic therapy affects long-term disease progression remains unanswered. Herein, we calculated rates of change in the Lémann index-which q...

journal_title：Digestive diseases and sciences

authors： Panchal H,Wagner M,Chatterji M,Taouli B,McBride R,Patterson JR,Ungaro R,Dubinsky M,Cho J,Sachar DB

更新日期：2019-11-01 00:00:00

abstract：:Nos2 knockout mice were compared to wild-type mice for susceptibility to colitis in response to a diet supplemented with deoxycholate, a bile acid increased in the colon of individuals on a high-fat diet. Wild-type mice fed a fat-related diet, supplemented with 0.2% DOC, develop colonic inflammation associated with in...

journal_title：Digestive diseases and sciences

authors： Bernstein H,Holubec H,Bernstein C,Ignatenko NA,Gerner E,Dvorak K,Besselsen D,Blohm-Mangone KA,Padilla-Torres J,Dvorakova B,Garewal H,Payne CM

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Gastrointestinal motility disorder is an important pathological basis for functional dyspepsia (FD). Epigastric ache and discomfort are the main symptoms of FD, and ghrelin deficiency is closely related to the occurrence and development of FD. While electroacupuncture (EA) alleviated the symptoms of FD patie...

journal_title：Digestive diseases and sciences

authors： Tang L,Zeng Y,Li L,Wang J,Peng D,Zhang T,Zhang H,An X

更新日期：2020-06-01 00:00:00