Interferon inhibits progression of liver fibrosis and reduces the risk of hepatocarcinogenesis in patients with chronic hepatitis C: a retrospective multicenter analysis of 652 patients.

abstract：:The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). The mechanism is not known, and a potent and specific GRP-R antagonist BIM26226, which has low affinity for NMB-R, wa...

journal_title：Digestive diseases and sciences

authors： Chu KU,Ishizuka J,Battey JF,Uchida T,Beauchamp RD,Townsend CM Jr,Thompson JC

更新日期：1996-11-01 00:00:00

abstract：:Our purpose was to determine if the presence of duodenal diverticula predisposes to the development of pancreaticobiliary disease. Between May 1999 and February 2001, 381 patients were examined by endoscopic retrograde cholangiopancreaticography. Of these patients, 51 had periampullary diverticula. In 27 patients the ...

journal_title：Digestive diseases and sciences

authors： Yildirgan MI,Başoğlu M,Yilmaz I,Atamanalp SS,Balik AA,Aydinli B,Oztürk G

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND AND AIM:The liver has a high capacity of its regeneration. Most hepatic cells are quiescent unless otherwise stimulated such as their injury or ablation. A previous study suggest that pre-activated hepatic cells have a positive effect on their regeneration. In this study, we examined whether the pre-activate...

journal_title：Digestive diseases and sciences

authors： Arioka Y,Ito H,Ando T,Ogiso H,Hirata A,Hara A,Seishima M

更新日期：2015-06-01 00:00:00

abstract：:The CCK-A (cholecystokinin-A) receptor is selectively expressed by human pancreatic adenocarcinomas, suggesting a possible role in pancreatic tumorigenesis. In animals, pancreatic CCK receptor expression varies during ontogeny and neoplastic transformation. This study examined the temporal expression of CCK receptors ...

journal_title：Digestive diseases and sciences

authors： Weinberg DS,So C,Ruggeri B,Biswas S,Barber M,Waldman S

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Despite national campaigns and other efforts to improve colorectal cancer (CRC) screening, participation rates remain below targets set by expert panels. We hypothesized that availability and practice patterns of healthcare providers may contribute to this gap. METHOD:Using data of the Medical Expenditure P...

journal_title：Digestive diseases and sciences

authors： Gawron AJ,Staub J,Bielefeldt K

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Sorafenib, a drug that inhibits Raf serine/threonine kinases mediating cell proliferation and receptor tyrosine kinases involved in angiogenesis, is approved for treatment of advanced hepatocellular carcinoma. AIMS:To explore the efficacy and safety of sorafenib for treating advanced HCC, and to identify cl...

journal_title：Digestive diseases and sciences

authors： Xie B,Wang DH,Spechler SJ

更新日期：2012-05-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is characterized by elevated serum IgA concentrations, the presence of circulating immune complexes containing IgA, and IgA deposits along sinusoids in the liver. When combined with the presupposed IgA-clearance function of the liver, a causal association between IgA abnormalities and the...

journal_title：Digestive diseases and sciences

authors： van de Wiel A,Valentijn RM,Schuurman HJ,Daha MR,Hené RJ,Kater L

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Intraductal ultrasonography (IDUS) is a useful procedure for diagnosing microlithiasis in the bile duct but it is not easy to differentiate between tiny echogenicity and real microlithiasis. We compared the echogenicity seen on IDUS and the findings of bile microscopy (BM) of bile that was collected in the c...

journal_title：Digestive diseases and sciences

authors： Kim BJ,Kang P,Lee JK,Sinn DH,Lee KH,Lee KT,Rhee JC,Lim JH

更新日期：2010-03-01 00:00:00

abstract：:The purpose of this study was to characterize the diagnostic process, frequency of associated disorders, family history, and impact of a gluten-free diet in individuals with celiac disease. All members of the Canadian Celiac Association (n=5240) were surveyed with a questionnaire. Respondents included 2681 adults with...

journal_title：Digestive diseases and sciences

authors： Cranney A,Zarkadas M,Graham ID,Butzner JD,Rashid M,Warren R,Molloy M,Case S,Burrows V,Switzer C

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:According to the Japanese Esophageal Society (JES) guidelines, risk factors for lymph node (LN) metastasis in the muscularis mucosa (MM)/submucosa to a depth of up to 200 μm (SM1) in cases of esophageal squamous cell carcinomas (ESCCs) include the presence of lymphatic invasion (ly), venous invasion (v), inf...

journal_title：Digestive diseases and sciences

authors： Mizumoto T,Hiyama T,Oka S,Yorita N,Kuroki K,Kurihara M,Yoshifuku Y,Sanomura Y,Urabe Y,Murakami Y,Arihiro K,Tanaka S,Chayama K

更新日期：2018-06-01 00:00:00

abstract：:On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of lif...

journal_title：Digestive diseases and sciences

authors： Ponce J,Argüello L,Bastida G,Ponce M,Ortiz V,Garrigues V

更新日期：2004-06-01 00:00:00

abstract：:Basal gastric acid output was analyzed prospectively in 110 patients with endoscopically documented duodenal ulcer disease to determine the frequency of gastric acid hypersecretion in patients with bleeding versus nonbleeding ulcers. Thirty-eight patients with stigmata of an actively or recently bleeding duodenal ulce...

journal_title：Digestive diseases and sciences

authors： Collen MJ,Kalloo AN,Sheridan MJ

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Percutaneous gastrostomy (PEG) is a common inpatient procedure. Prior data from National Inpatient Sample (NIS) in 2006 reported a mortality rate of 10.8% and recommended more careful selection of PEG candidates. This study assessed for improvement in the last 10 years in mortality rate and complica...

journal_title：Digestive diseases and sciences

authors： Stein DJ,Moore MB,Hoffman G,Feuerstein JD

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:Percutaneous endoscopic gastrostomy (PEG) is a commonly performed procedure for patients with severe dysphagia leading to malnutrition. Improved knowledge of risk factors for PEG-related complications might decrease patient discomfort and healthcare costs. AIM:The aim of the present study was to investigate...

journal_title：Digestive diseases and sciences

authors： Lee SP,Lee KN,Lee OY,Lee HL,Jun DW,Yoon BC,Choi HS,Kim SH

更新日期：2014-01-01 00:00:00

abstract：:The impact of treatment on progression of fibrosis in autoimmune hepatitis (AIH) is unknown. We assessed the changes in liver fibrosis before and after treatment among these patients. Nineteen AIH patients who had paired liver biopsies were studied. Of these, seven had been treated with 6 months of cyclosporine A and ...

journal_title：Digestive diseases and sciences

authors： Mohamadnejad M,Malekzadeh R,Nasseri-Moghaddam S,Hagh-Azali S,Rakhshani N,Tavangar SM,Sedaghat M,Alimohamadi SM

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Esophageal epithelial microRNAs may be used to diagnose Barrett's esophagus (BE) and possibly monitor its progression to esophageal adenocarcinoma (EAC). AIMS:We reviewed studies that have investigated this to identify microRNAs with high biomarker potential for screening and disease monitoring in BE. METH...

journal_title：Digestive diseases and sciences

authors： Mallick R,Patnaik SK,Wani S,Bansal A

更新日期：2016-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) arises from a number of cirrhosis-related and non-cirrhosis-related exposures and is one of the leading causes of cancer-related deaths worldwide. Achieving a durable cure currently relies on either resection or transplantation, but since most patients will be diagnosed with inoperable d...

journal_title：Digestive diseases and sciences

authors： Saffo S,Taddei TH

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:The impact of antithrombotic treatment on the findings of small-bowel capsule endoscopy for patients with obscure gastrointestinal bleeding remains contentious. We aimed to determine the effect of these agents on small-bowel video capsule endoscopy positive findings. METHODS:MEDLINE, Cochrane Library, and...

journal_title：Digestive diseases and sciences

authors： Tziatzios G,Gkolfakis P,Papanikolaou IS,Triantafyllou K

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:While gastroesophageal reflux disease (GERD) is common in Middle Eastern countries, little data exists on the epidemiology of Barrett's esophagus (BE). AIMS:We aimed to determine the prevalence of BE among patients undergoing esophagogastroduodenoscopy (EGD) in a cohort of Saudi patients. METHODS:We retros...

journal_title：Digestive diseases and sciences

authors： Alsahafi M,Mimish H,Salem F,Hijazi M,Aljahdli E,Jawa H,Bazarah S,Bokhary R,Qari Y,Mosli M

更新日期：2020-08-04 00:00:00

abstract：:The protein ornithine decarboxylase antizyme (AZ) is inhibitory to both polyamine transport and synthesis. Experiments were performed to examine the distribution and regulation of AZ mRNA in cells of the small intestinal epithelium, a tissue exposed to high concentrations of extracellular polyamines and high levels of...

journal_title：Digestive diseases and sciences

authors： Gill JE,Christian JF,Seidel ER

更新日期：2002-07-01 00:00:00

abstract：:Phlebosclerosis of the mesenteric vein is a rare condition causing chronic intestinal ischemia, it has only been reported in Japan. A 56-year-old man with liver cirrhosis and hepatic tumor presented with phlebosclerosis of mesenteric vein without any abdominal symptoms. He was admitted for examination of suspected hep...

journal_title：Digestive diseases and sciences

authors： Oshitani N,Matsumura Y,Kono M,Tamori A,Higuchi K,Matsumoto T,Seki S,Arakawa T

更新日期：2002-12-01 00:00:00

abstract：:The major heat shock protein, HSP70, is known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperone." However, the influence of HSP70 on gastric mucosal healing under physical stimulation or stress is not completely understood. Rat gastric mucosal cells (R...

journal_title：Digestive diseases and sciences

authors： Odashima M,Otaka M,Matsuhashi T,Jin M,Horikawa Y,Ohba R,Itoh H,Watanabe S

更新日期：2007-11-01 00:00:00

abstract：:The effects of cisapride on upper gut motility were studied in seven healthy volunteers by means of a novel intraluminal electromyographic technique in a placebo-controlled study. In the interdigestive state, cisapride (10 mg intravenous bolus injection) markedly increased the number of spike bursts. The most obvious ...

journal_title：Digestive diseases and sciences

authors： Coremans G,Janssens J,Vantrappen G,Chaussade S,Ceccatelli P

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Postmenopausal women have a higher risk of nonalcoholic steatohepatitis (NASH) along with an increase in age, and vitamin D deficiency occurs in some patients with NASH. AIM:We performed ovariectomy (OVX) surgery on female mice to mimic menopause, fed them a choline-deficient high-fat (CDHF) diet to induce ...

journal_title：Digestive diseases and sciences

authors： Ma L,Ishigami M,Honda T,Yokoyama S,Yamamoto K,Ishizu Y,Kuzuya T,Hayashi K,Hirooka Y,Goto H

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:The majority of ghrelin producing cells (GPC) are present in the fundic gland of the stomach and recognized as X/A like cells. The detailed distribution of GPC in the stomach is still unknown in healthy and pathological subjects. METHODS:We investigated the detailed distribution of GPC in the stomach, especi...

journal_title：Digestive diseases and sciences

authors： Takiguchi S,Adachi S,Yamamoto K,Morii E,Miyata H,Nakajima K,Yamasaki M,Kangawa K,Mori M,Doki Y

更新日期：2012-05-01 00:00:00

abstract：:Intravenous administration of platelet-activating factor (PAF) induces extensive damage in rat gastric mucosa. The aim of the present study was to examine whether the presence or absence of acid in the gastric lumen could modify the PAF-induced gastric damage. The effects of inhibition of basal and pentagastrin-stimul...

journal_title：Digestive diseases and sciences

authors： Piqué JM,Pérez Ayuso RM,Bilbao J,Terés J

更新日期：1991-12-01 00:00:00

abstract：:Colorectal cancer results in significant morbidity and mortality in the United States. Screening is a critical component of cancer prevention. However, research has suggested that physicians may inconsistently adhere to surveillance guidelines. Since residency training can significantly impact upon future practice pat...

journal_title：Digestive diseases and sciences

authors： Borum ML

更新日期：1997-06-01 00:00:00

abstract：:Nongranulomatous chronic idiopathic enterocolitis is characterized by sudden onset of severe watery diarrhea, malabsorption, exudative enteropathy, frequent appearance of shallow ulcerations, and variable degrees of villus atrophy. In the absence of infectious and pharmacologic causes, the presence of a predominantly ...

journal_title：Digestive diseases and sciences

authors： Soergel KH

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Human hepatocellular carcinoma (HCC) is one of the most common fatal cancers and an important health problem worldwide, but its mechanism is still unclear. Microtubule (MT) kinesin motor proteins orchestrate a variety of cellular processes (e.g. mitosis, motility and organelle transportation) and have been i...

journal_title：Digestive diseases and sciences

authors： Huang X,Liu F,Zhu C,Cai J,Wang H,Wang X,He S,Liu C,Yao L,Ding Z,Zhang Y,Zhang T

更新日期：2014-04-01 00:00:00

abstract：:A 24-year-old white woman presented with abdominal discomfort associated with a firm, nonpulsatile hepatic mass. Radiological examination, which included radionuclide liver scan, abdominal ultrasonography, computed tomography, and hepatic angiography, demonstrated a large, globular, multilocular cyst arising from the ...

journal_title：Digestive diseases and sciences

authors： Marcial MA,Hauser SC,Cibas ES,Braver J

更新日期：1986-08-01 00:00:00