Abstract:
:As infection influences the pathogenesis and presentation of celiac disease, we investigated the expression of natural antibiotics in this condition. Twenty-three adults were prospectively studied: 10 controls and 13 subjects with untreated celiac disease. Distal duodenal biopsies were taken at baseline and after 6 months of a gluten-free diet and assessed for the expression of natural antibiotics. Epithelial human beta-defensin 1 in subjects with celiac disease had a median of 0.02 unit at baseline, compared with 0.34 unit in controls (P < 0.001). It correlated negatively with the degree of villous atrophy (r = -0.64, P = 0.019) and rose to 0.04 unit on the gluten-free diet (P = 0.035 vs. baseline, P < 0.001 vs. controls). The expression of other antibiotics was unchanged. The expression of epithelial natural antibiotics is limited in celiac disease.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Taha AS,Faccenda E,Angerson WJ,Balsitis M,Kelly RWdoi
10.1007/s10620-005-2575-zsubject
Has Abstractpub_date
2005-04-01 00:00:00pages
791-5issue
4eissn
0163-2116issn
1573-2568journal_volume
50pub_type
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