Natural antibiotic expression in celiac disease--correlation with villous atrophy and response to a gluten-free diet.

Abstract:

:As infection influences the pathogenesis and presentation of celiac disease, we investigated the expression of natural antibiotics in this condition. Twenty-three adults were prospectively studied: 10 controls and 13 subjects with untreated celiac disease. Distal duodenal biopsies were taken at baseline and after 6 months of a gluten-free diet and assessed for the expression of natural antibiotics. Epithelial human beta-defensin 1 in subjects with celiac disease had a median of 0.02 unit at baseline, compared with 0.34 unit in controls (P < 0.001). It correlated negatively with the degree of villous atrophy (r = -0.64, P = 0.019) and rose to 0.04 unit on the gluten-free diet (P = 0.035 vs. baseline, P < 0.001 vs. controls). The expression of other antibiotics was unchanged. The expression of epithelial natural antibiotics is limited in celiac disease.

journal_name

Dig Dis Sci

authors

Taha AS,Faccenda E,Angerson WJ,Balsitis M,Kelly RW

doi

10.1007/s10620-005-2575-z

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

791-5

issue

4

eissn

0163-2116

issn

1573-2568

journal_volume

50

pub_type

杂志文章
  • Effect of opiates on gastroduodenal motility following surgical operation.

    abstract::Following surgical operations, opiate analgesics are widely used to control pain. This situation was used to investigate patterns of human gastroduodenal motility and the effect of opiate analgesics on this motility during the early postoperative period. Gastric contractions were absent for 6--12 hr following surgery ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01314760

    authors: Ingram DM,Catchpole BN

    更新日期:1981-11-01 00:00:00

  • Transcytotic vesicle fusion is reduced in cholestatic rats: redistribution of phospholipids in the canalicular membrane.

    abstract::Cholestasis, which affects phospholipid trafficking, therefore would be expected to alter canalicular membrane phospholipid composition and fluidity, as well as fatty acid composition of membrane phospholipid. These alterations may affect transcytotic vesicle fusion and would be expected to cause variety of cholestati...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026639716440

    authors: Hyogo H,Tazuma S,Kajiyama G

    更新日期:1999-08-01 00:00:00

  • A rare gastric outlet anomaly: pyloric ostium on incissura angularis.

    abstract::Congenital gastric outlet anomalies are rarely seen defects resulting from early embryologic development of foregut. We report a case of congenital pyloric outlet anomaly in a 60-year-old man with mild postprandial epigastric discomfort of approximately 3 months' duration. Endoscopic examination of the stomach showed ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9228-8

    authors: Uraz S,Aygün C,Konduk T,Celebi A,Sentürk O,Hülagü S

    更新日期:2007-04-01 00:00:00

  • Effects of octapeptide-cholecystokinin, secretin, and glucagon on intestinal mucosal growth in parenterally nourished rats.

    abstract::Nutrients in the lumen of the small intestine may cause the release of enteric hormones which directly or indirectly stimulate intestinal mucosal growth. Male Sprague-Dawley rats with either an intact small bowel or following jejunal resection were maintained on total parenteral nutrition (TPN). C-terminal octapeptide...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01313582

    authors: Weser E,Bell D,Tawil T

    更新日期:1981-05-01 00:00:00

  • Effectiveness of concomitant enteral nutrition therapy and infliximab for maintenance treatment of Crohn's disease in adults.

    abstract:BACKGROUND:One of the problems associated with infliximab (IFX) treatment for Crohn's disease (CD) is loss of response during maintenance therapy. AIMS:The aim of this multicenter, retrospective, cohort study was to determine whether enteral nutrition (EN) added to the IFX therapy regimen is effective for maintaining ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2374-2

    authors: Hirai F,Ishihara H,Yada S,Esaki M,Ohwan T,Nozaki R,Ashizuka S,Inatsu H,Ohi H,Aoyagi K,Mizuta Y,Matsumoto T,Matsui T

    更新日期:2013-05-01 00:00:00

  • Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption.

    abstract:BACKGROUND:Gut inflammation is prevalent in chronic kidney disease (CKD) and likely contributes to systemic inflammation via disruption of the epithelial tight junction with subsequent endotoxin and bacterial translocation. AIMS:To study the expression profile of inflammatory and tight junction proteins in the colon f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3428-4

    authors: Lau WL,Liu SM,Pahlevan S,Yuan J,Khazaeli M,Ni Z,Chan JY,Vaziri ND

    更新日期:2015-05-01 00:00:00

  • Pneumothorax following ERCP: report of four cases and review of the literature.

    abstract::We report four patients with pneumothorax as a complication of ERCP with sphincterotomy. With conservative treatment all patients recovered. Previously, 16 comparable cases have been reported in the literature. The main risk factor for this rare complication seems (pre-cut) sphincterotomy. Pneumothorax is usually righ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-012-2150-3

    authors: Schepers NJ,van Buuren HR

    更新日期:2012-08-01 00:00:00

  • Gastric dysrhythmias following pylorus-preserving pancreaticoduodenectomy. Possible mechanism for early delayed gastric emptying.

    abstract::Transient delayed gastric emptying is reported as a frequent complication following pancreas-preserving pancreaticoduodenectomy (PPW). We placed serosal electrodes on the stomach of a patient undergoing PPW. Myoelectric recordings were obtained postoperatively and correlated with simultaneous radionuclide liquid gastr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536411

    authors: Hocking MP,Harrison WD,Sninsky CA

    更新日期:1990-10-01 00:00:00

  • Involvement of alpha(2)-adrenoceptors in the gastric protective effect of nitroglycerin against acidified ethanol-induced mucosal injury.

    abstract::Clinical observations reveal that alcohol intake is associated with an increase in upper gastrointestinal hemorrhage requiring hospitalization and that nitroglycerin or long-acting nitrates lower this risk. Nitroglycerin, a gastric vasodilator that can increase gastric fluid volume, protects the rodent stomach against...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9692-1

    authors: Leung FW,Chan CC

    更新日期:2007-11-01 00:00:00

  • siRNA directed against survivin enhances pancreatic cancer cell gemcitabine chemosensitivity.

    abstract::Survivin is known to be overexpressed in various human malignancies, including pancreatic cancer, and to cause resistance to radiation and chemotherapy, so the regulation of this molecule could be a new strategy for treating pancreatic cancer. In our study, a short interfering RNA (siRNA) plasmid expression vector aga...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0329-4

    authors: Liu WS,Yan HJ,Qin RY,Tian R,Wang M,Jiang JX,Shen M,Shi CJ

    更新日期:2009-01-01 00:00:00

  • Distribution of HCV genotypes in patients with end-stage renal disease according to type of dialysis treatment.

    abstract::The objective of this study was to investigate the effects of types of dialysis treatments on hepatitis C virus infection and the epidemiologic properties of hepatitis C virus (HCV) infection at three Baskent University hospitals, in Ankara, Adana, and Izmir, Turkey, in 655, 326, and 118 patients with end-stage renal ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-005-9025-9

    authors: Selcuk H,Kanbay M,Korkmaz M,Gur G,Akcay A,Arslan H,Ozdemir N,Yilmaz U,Boyacioglu S

    更新日期:2006-08-01 00:00:00

  • Pancreaticopleural fistula: report of two cases and review of the literature.

    abstract::Pancreaticopleural fistulas are a rare complication of pancreatitis. We report two cases from our institution and review 37 cases of pancreaticopleural fistulas identified in the literature. Endoscopic retrograde cholangiopancreatography was more sensitive compared to computed tomography in demonstrating pancreaticopl...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-3073-7

    authors: Oh YS,Edmundowicz SA,Jonnalagadda SS,Azar RR

    更新日期:2006-01-01 00:00:00

  • Gallbladder motility, gallstones, and the surgeon.

    abstract::Cholecystectomy is one of the commonest surgical procedures in the Western world, with more than half a million procedures performed annually in the United States alone. In recent years, studies of gallstone pathogenesis and gallbladder disease have increasingly focused on abnormal gallbladder motility in the pathogen...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/BF02063233

    authors: Patankar R,Ozmen MM,Bailey IS,Johnson CD

    更新日期:1995-11-01 00:00:00

  • Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.

    abstract::This study evaluated the gastroprotective activity of DA-6034 against various ulcerogens including ethanol, aspirin, indomethacin, stress, and acetic acid. The basic mechanisms of DA-6034 as a defensive factor such as mucus secretion and endogenous prostaglandin E(2) synthesis were determined. Rats with gastric lesion...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9657-4

    authors: Choi SM,Shin JH,Kang KK,Ahn BO,Yoo M

    更新日期:2007-11-01 00:00:00

  • Biomagnetic 3-dimensional spatial and temporal characterization of electrical activity of human stomach.

    abstract::Biomagnetic measurements are based on the noninvasive recording of magnetic signals produced by biological sources such as nervous system and muscle. The aim of this study was to obtain multichannel magnetic field recordings from the human gastrointestinal tract and to localize the sources of these signals three-dimen...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018852208687

    authors: Allescher HD,Abraham-Fuchs K,Dunkel RE,Classen M

    更新日期:1998-04-01 00:00:00

  • Omeprazole inhibits natural killer cell functions.

    abstract::This study was designed to determine the possible effects of omeprazole on human natural killer cells. Peripheral venous blood samples were taken from 20 peptic ulcer patients before and at the 14th and the 28th days of omeprazole treatment. Mononuclear cells were removed from blood and their capability of making conj...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9869-2

    authors: Alkim H,Unal S,Okur H,Imir T

    更新日期:2008-02-01 00:00:00

  • Analysis of the T1288R mutation of the Wilson disease ATP7B gene in four generations of a family: possible genotype-phenotype correlation with hepatic onset.

    abstract::Wilson disease, an autosomal recessive disorder due to mutations of the ATP7B gene, is characterized by copper accumulation and toxicity in the liver and subsequently in other organs, mainly the brain and cornea. A new missense mutation (T1288R) of the ATP7B gene has recently been discovered in a Wilson disease patien...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9666-3

    authors: Leggio L,Malandrino N,Loudianos G,Abenavoli L,Lepori MB,Capristo E,De Virgiliis S,Gasbarrini G,Addolorato G

    更新日期:2007-10-01 00:00:00

  • Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer.

    abstract:BACKGROUND:New molecular biology-based methods of bacterial identification are expected to help elucidate the relationship between colorectal cancer (CRC) and intestinal microbiota. Although there is increasing evidence revealing the potential role of microbiota in CRC, it remains unclear whether microbial dysbiosis is...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2526-4

    authors: Ohigashi S,Sudo K,Kobayashi D,Takahashi O,Takahashi T,Asahara T,Nomoto K,Onodera H

    更新日期:2013-06-01 00:00:00

  • Expression of EGF-receptor related protein (ERRP) decreases in gastric mucosa during aging and carcinogenesis.

    abstract::Aging and gastrointestinal malignancies, including that of the stomach are associated with increased activation of EGF-receptor (EGFR). Although the intracellular events that regulate this process are poorly understood, we hypothesize that loss of ERRP (EGFR-related protein; GenBank accession number AF187818), a recen...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1023078924686

    authors: Majumdar AP,Du J,Hatfield JS,Levi E,Adsay V,Schmelz EM,Nagothu KK,Jaszewski R,Kucuk O,Sarkar FH

    更新日期:2003-05-01 00:00:00

  • Comparison of effects of upright versus supine body position and liquid versus solid bolus on esophageal pressures in normal humans.

    abstract::New studies monitoring ambulatory esophageal pressures during food ingestion often compare results to normal values obtained from supine liquid swallows. We compared distal esophageal peristaltic and lower esophageal sphincter (LES) pressures in 15 normal subjects during six liquid swallows in the upright and supine p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536799

    authors: Sears VW Jr,Castell JA,Castell DO

    更新日期:1990-07-01 00:00:00

  • Weight loss induced by gastric implant in rats. Effects of capsaicin sensory denervation.

    abstract::To study the efficacy and mechanism of action of the intragastric bubble, 1- to 5-ml silicone bubbles were surgically implanted into the stomachs of 10- to 12-week-old female rats. To test the hypothesis that the satiety effects of the implant are mediated by visceral sensory nerves, a subgroup was treated as neonates...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01300286

    authors: Northway MG,Geisinger KR,Gilliam JH,MacLean DB

    更新日期:1992-07-01 00:00:00

  • Gastrointestinal endoscopic terminology coding (GET-C): a WHO-approved extension of the ICD-10.

    abstract::Technological developments have greatly promoted interest in the use of computer systems for recording findings and images at endoscopy and creating databases. The aim of this study was to develop a comprehensive WHO-approved code system for gastrointestinal endoscopic terminology. The International Classification of ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9272-4

    authors: Groenen MJ,Hirs W,Becker H,Kuipers EJ,Van Berge Henegouwen GP,Fockens P,Ouwendijk RJ

    更新日期:2007-04-01 00:00:00

  • Altered Metabolic Profile of Triglyceride-Rich Lipoproteins in Gut-Lymph of Rodent Models of Sepsis and Gut Ischemia-Reperfusion Injury.

    abstract:BACKGROUND:Triglyceride-rich lipoproteins are important in dietary lipid absorption and subsequent energy distribution in the body. Their importance in the gut-lymph may have been overlooked in sepsis, the most common cause of critical illness, and in gut ischemia-reperfusion injury, a common feature of many critical i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-018-5270-6

    authors: Hong J,Nachkebia S,Tun SM,Petzer A,Windsor JA,Hickey AJ,Phillips AR

    更新日期:2018-12-01 00:00:00

  • Hepatitis C virus infection in institutionalized psychiatric patients: possible role of transmission by razor sharing.

    abstract::The objective of this study was to determine if HCV can be transmitted from patient to patient in psychiatric institutions and to determine possible routes of infection. We did a cross-sectional survey of 196 Japanese psychiatric patients tested for HCV and HBV markers and 400 age- and sex-matched controls. Anti-HCV w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005472812403

    authors: Sawayama Y,Hayashi J,Kakuda K,Furusyo N,Ariyama I,Kawakami Y,Kinukawa N,Kashiwagi S

    更新日期:2000-02-01 00:00:00

  • Practice patterns in the use of anti-tumor necrosis factor alpha agents in the management of Crohn's disease: a US national practice survey comparing experts and non-experts.

    abstract:BACKGROUND:The US Food and Drug Administration currently approves three types of anti-tumor necrosis factor α (anti-TNFα) therapy for treatment of moderate to severe Crohn's disease. There are no guidelines to clarify which of the drugs may be better suited to individual clinical scenarios. AIMS:We gathered national d...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1530-9

    authors: Swaminath A,Lebwohl B,Capiak KM,Present DH

    更新日期:2011-04-01 00:00:00

  • Effect of bile and pancreatic juice on adenoviral-mediated gene delivery: implications on the feasibility of gene delivery through ERCP.

    abstract::Current research in gene delivery to the liver is focused on the intravenous, intraarterial, intraportal, or intratumoral route. Another possible route for gene delivery is via the common bile duct through endoscopic retrograde cholangiopancreatography (ERCP). Whether bile and pancreatic juice have any effect on gene ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005431703317

    authors: Xie X,Forsmark CE,Lau JY

    更新日期:2000-02-01 00:00:00

  • Helicobacter pylori protection against reflux esophagitis.

    abstract:BACKGROUND AND AIM:Negative association has been reported between presence of Helicobacter pylori and developing gastroesophageal reflux disease (GERD) and its complications. The aim of this study was to determine whether H. pylori (HP) can be protective against GERD in an African American (AA) population. METHODS:Fro...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2349-3

    authors: Ashktorab H,Entezari O,Nouraie M,Dowlati E,Frederick W,Woods A,Lee E,Brim H,Smoot DT,Ghadyari F,Kamangar F,Razjouyan H

    更新日期:2012-11-01 00:00:00

  • A survey of irritable bowel syndrome in Vietnam using the Rome criteria.

    abstract::Prevalence estimates for irritable bowel syndrome from surveys in Western countries are 4.4% to 22%, generally higher in women than men, and only a minority seek health care. There are few studies of bowel patterns in Asian countries. We conducted a survey of a nonpatient population in Ho Chi Minh City, Vietnam, to de...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-9005-0

    authors: Zuckerman MJ,Nguyen G,Ho H,Nguyen L,Gregory GG

    更新日期:2006-05-01 00:00:00

  • Hepatic stimulator substance alleviates toxin-induced and immune-mediated liver injury and fibrosis in rats.

    abstract:BACKGROUND:Liver fibrosis is a common scarring response to chronic liver injury. It is a precursor to cirrhosis and liver carcinoma. Hepatic stimulator substance (HSS), a known liver-specific but species-nonspecific growth factor, has been shown to protect hepatocytes from various toxins. METHODS:We have investigated ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2168-6

    authors: Yi X,Song M,Yuan Y,Zhang X,Chen W,Li J,Tong M,Liu G,You S,Kong X

    更新日期:2012-08-01 00:00:00

  • Prognostic index for survival in patients after treatment for primary hepatocellular carcinoma.

    abstract::We retrospectively evaluated clinical factors affecting long-term survival after treatment for hepatocellular carcinoma (HCC) to predict the reliability of the prognosis of patients with HCC. We analyzed 157 patients who received treatment for HCC. The prognostic index (PI) was evaluated using the Cox regression model...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9137-x

    authors: Kogo M,Kano A,Kiuchi Y,Mitamura K,Yoneyama K

    更新日期:2007-09-01 00:00:00