Gastroprotective effects of DA-6034, a new flavonoid derivative, in various gastric mucosal damage models.

abstract：:Our objective was to investigate the expression of HMGA1 mRNA and protein in hepatocellular carcinoma (HCC) and the correlation between its expression and clinical pathological characteristics and prognosis. HMGA1 expression was determined at both the mRNA level and the protein level in 30 HCC tissues and their corres...

journal_title：Digestive diseases and sciences

authors： Chang ZG,Yang LY,Wang W,Peng JX,Huang GW,Tao YM,Ding X

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Partially covered metal stents (PCMS) have been increasingly used for both malignant and benign biliary indications. This study reports their complications and subsequent management. METHODS:Over 5 years, all patients receiving biliary PCMS were followed prospectively until stent-related dysfunction or deat...

journal_title：Digestive diseases and sciences

authors： Ho H,Mahajan A,Gosain S,Jain A,Brock A,Rehan ME,Ellen K,Shami VM,Kahaleh M

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The underlying mechanisms of nonalcoholic steatohepatitis (NASH) are poorly understood, and little is known about hepatocellular apoptosis in NASH. Cyclooxygenase (COX)-2, the key enzyme in eicosanoid metabolism, is highly expressed in NASH. COX-2 can also regulate the release of mediators of inf...

journal_title：Digestive diseases and sciences

authors： Cheng Q,Li N,Chen M,Zheng J,Qian Z,Wang X,Huang C,Xu S,Shi G

更新日期：2013-10-01 00:00:00

abstract：:Low or minimal doses of aspirin are widely used for prevention of cardiovascular diseases. Aspirin is known to produce severe adverse gastrointestinal effects, such as bleeding and perforation. Less is known about the risk associated with minidose aspirin. Our aim was to assess the possible association of upper gastro...

journal_title：Digestive diseases and sciences

authors： Sapoznikov B,Vilkin A,Hershkovici M,Fishman M,Eliakim R,Niv Y

更新日期：2005-09-01 00:00:00

abstract：:The study was undertaken to examine regional differences in the concentrations of five regulatory peptides in the human colonic mucosa. Biopsies were obtained during routine colonoscopy from 33 patients whose colonic mucosa was macroscopically and histologically normal. Regulatory peptides were extracted, and measured...

journal_title：Digestive diseases and sciences

authors： Calam J,Ghatei MA,Domin J,Adrian TE,Myszor M,Gupta S,Tait C,Bloom SR

更新日期：1989-08-01 00:00:00

abstract：:While transilluminating guinea pig gastric wall, we noticed foci of irregular compression of submucosal veins and arteries, featuring parallel bands across arteries, with complete cessation of blood flow, mucosal pallor, and shrinkage of the area. Other features demonstrated that this was not due to artifactual pressu...

journal_title：Digestive diseases and sciences

authors： Piasecki CK,Thrasivoulou C

更新日期：1993-07-01 00:00:00

abstract：:To investigate the colonic adenoma-adenocarcinoma progression sequence, DNA ploidy analysis was performed on hyperplastic polyps to adenocarcinomas. DNA ploidy data were then compared with immunocytochemical staining for proliferating cell nuclear antigen (PCNA). In hyperplastic polyps to villous adenomas, all cases w...

journal_title：Digestive diseases and sciences

authors： Tomita T

更新日期：1995-05-01 00:00:00

abstract：:On the basis of previous studies in our laboratory we postulated that the ethanol-induced alteration in jejunal morphology was the result of its effect on the microcirculation. The present study was undertaken to examine the validity of this hypothesis. Accordingly, the effects of intraluminal ethanol perfusion (3.0 a...

journal_title：Digestive diseases and sciences

authors： Buell MG,Dinda PK,Beck IT

更新日期：1983-11-01 00:00:00

abstract：:Although the pathogenic mechanisms of inflammatory bowel diseases are not fully understood, colonic microbiota may affect the induction of colonic inflammation, and some probiotics and prebiotics have been reported to suppress colitis. The inhibitory effects of brown rice fermented by Aspergillus oryzae (FBRA), a fibe...

journal_title：Digestive diseases and sciences

authors： Kataoka K,Ogasa S,Kuwahara T,Bando Y,Hagiwara M,Arimochi H,Nakanishi S,Iwasaki T,Ohnishi Y

更新日期：2008-06-01 00:00:00

abstract：:Cyclin D1 plays an important role in the multi-step process of gastrointestinal tumorigenesis. We hypothesize that normal enterocytes over-expressing cyclin D1 will demonstrate a transformed phenotype. The nontumorigenic intestinal epithelial cell line, IEC-18, was transfected with the vector pMV7-CCND1, encoding cycl...

journal_title：Digestive diseases and sciences

authors： Kazanov D,Shapira I,Pick M,Kolker O,Liberman E,Deutsch V,Strier L,Dvory-Sobol H,Kunik T,Arber N

更新日期：2003-07-01 00:00:00

abstract：:Ten patients were prospectively studied using 99mTc-PIPIDA imaging to evaluate the effects of fasting and parenteral alimentation on gallbladder function. Three of ten patients had initial nonvisualization of the gallbladder for up to 2 hr, yet had normal visualization on repeat imaging performed after resumption of o...

journal_title：Digestive diseases and sciences

authors： Potter T,McClain CJ,Shafer RB

更新日期：1983-08-01 00:00:00

abstract：:Little information on functional status and well-being is available in patients with functional gastrointestinal disease. We aimed to evaluate whether quality of life is poorer in patients with functional dyspepsia. A consecutive sample of 73 patients with functional dyspepsia completed a validated questionnaire prior...

journal_title：Digestive diseases and sciences

authors： Talley NJ,Weaver AL,Zinsmeister AR

更新日期：1995-03-01 00:00:00

abstract：:It is known that the muscularis mucosae and mucosa are not pharmacologically homogeneous throughout the rat colon. The aim of this study was to simultaneously characterize all three neurokinin (NK) receptors in the muscularis mucosae and mucosa along the length of the rat colon. Strips of proximal, mid, and distal col...

journal_title：Digestive diseases and sciences

authors： Appleyard CB,Morales M,Percy WH

更新日期：2006-03-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disea...

journal_title：Digestive diseases and sciences

authors： Simon TG,Corey KE,Chung RT,Giugliano R

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The Gastroenterology Core Curriculum requires training in women's digestive disorders; however, requirements do not necessarily produce knowledge and competence. Our study goals were: (1) to compare perceptions of education, fellow-reported levels of competence, and attitudes towards training in wom...

journal_title：Digestive diseases and sciences

authors： Saha S,Roberson E,Richie K,Lindstrom MJ,Esposti SD,Wald A

更新日期：2011-03-01 00:00:00

abstract：:In previous studies, the majority of patients with the cholestatic liver diseases, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), had increased hepatic copper (Cu) levels even in early stages of disease. We prospectively measured hepatic copper content by atomic absorption spectrophotometry ...

journal_title：Digestive diseases and sciences

authors： Kowdley KV,Knox TA,Kaplan MM

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Postmenopausal women have a higher risk of nonalcoholic steatohepatitis (NASH) along with an increase in age, and vitamin D deficiency occurs in some patients with NASH. AIM:We performed ovariectomy (OVX) surgery on female mice to mimic menopause, fed them a choline-deficient high-fat (CDHF) diet to induce ...

journal_title：Digestive diseases and sciences

authors： Ma L,Ishigami M,Honda T,Yokoyama S,Yamamoto K,Ishizu Y,Kuzuya T,Hayashi K,Hirooka Y,Goto H

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) screening is cost-effective and prevents death from CRC if used appropriately. Physicians do not recommend CRC screening according to guidelines. Physician-related factors associated with CRC screening knowledge are unknown. AIMS:We tested the accuracy of CRC screening knowledge in a...

journal_title：Digestive diseases and sciences

authors： Patell R,Karwa A,Lopez R,Burke CA

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Birth characteristics, including weight and gestational age, may be associated with risk of Barrett's esophagus (BE), the only known precursor for esophageal adenocarcinoma; however, data are limited. AIMS:To examine associations between various birth characteristics and BE, and whether these associations a...

journal_title：Digestive diseases and sciences

authors： Shiota S,El-Serag HB,Thrift AP

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Ectopic expression of gastric intrinsic factor (IF) has been described in rodent models of chronic gastritis. AIMS:The current study undertook to determine if ectopic IF was also present in chronic gastritis in humans and might identify the process of ectopic protein expression as part of the response to ch...

journal_title：Digestive diseases and sciences

authors： Shao JS,Carmel R,Alpers DH

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Trinitrobenzenesulfonic acid (TNBS)-induced colitis is one of the most widely used experimental colitis models. However, there is no standard procedure for inducing colitis by TNBS because it is difficult to achieve a uniform distribution of colitis. We have developed a modified method of murine TNBS-induced...

journal_title：Digestive diseases and sciences

authors： Terai T,Osawa S,Tani S,Oishi S,Arai Y,Yamada T,Sugimoto M,Furuta T,Kanaoka S,Miyajima H,Sugimoto K

更新日期：2014-07-01 00:00:00

abstract：:Slow transit constipation (STC) is a severe motility disorder, which in the majority of cases is of unknown etiology. In some, symptoms arise de novo in childhood, but a proportion of patients present in later life, including after pelvic surgery or childbirth. Our aims were: (1) to describe our current knowledge of t...

journal_title：Digestive diseases and sciences

authors： Knowles CH,Scott SM,Lunniss PJ

更新日期：2001-02-01 00:00:00

abstract：:Patients with long-standing ulcerative colitis (UC) or Crohn's colitis are at increased risk of developing colorectal cancer (CRC). Given that most cases of CRC are thought to arise from dysplasia, previous guidelines have recommended endoscopic surveillance with random biopsies obtained from all segments of the colon...

journal_title：Digestive diseases and sciences

authors： Sengupta N,Yee E,Feuerstein JD

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Intestinal Behcet's disease (BD) is a specific subtype of BD. Effective drug therapy for intestinal BD remains elusive. AIMS:To investigate long-term outcomes and identify predictors of sustained response in intestinal BD patients receiving infliximab (IFX) treatment. METHODS:The medical records were revie...

journal_title：Digestive diseases and sciences

authors： Zou J,Ji DN,Cai JF,Guan JL,Bao ZJ

更新日期：2017-02-01 00:00:00

abstract：:Positive findings on capsule endoscopy (CE) often prompt a follow-up procedure with therapeutic intent. Our purpose was to review the therapeutic yield of subsequent procedural interventions based on positive CE findings. The medical records of all patients who underwent CE between June 2002 and February 2005 for obsc...

journal_title：Digestive diseases and sciences

authors： Baichi MM,Arifuddin RM,Mantry PS

更新日期：2007-05-01 00:00:00

abstract：:We evaluated the alveolar-arterial oxygen difference (deltaA-a) and the ratio between PaO2 and the fractional concentration of inspired oxygen (P/F) in acute pancreatitis. Eleven patients had mild uncomplicated disease, six showed acute abdominal fluid collections, six had acute abdominal collections and asymptomatic ...

journal_title：Digestive diseases and sciences

authors： Salomone T,Tosi P,Di Battista N,Binetti N,Raiti C,Tomassetti P,Migliori M,Gullo L

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:ESD allows higher rates of en-bloc and R0 resections, but has occasionally complications such as aspiration pneumonia. Factors associated with aspiration pneumonia are not completely understood. AIMS:To analyze the relationship between aspiration pneumonia and preoperative factors including pulmonary functi...

journal_title：Digestive diseases and sciences

authors： Matsumi A,Takenaka R,Ando C,Sato Y,Takei K,Yasutomi E,Okanoue S,Oka S,Kawai D,Kataoka J,Takemoto K,Tsugeno H,Fujiki S,Kawahara Y

更新日期：2017-11-01 00:00:00

abstract：:The aim of our prospective randomized study involving 100 patients was to investigate whether Doppler ultrasound can be used to select patients at risk for ulcer rebleeding. Ulcers in the Forrest group classified as having a visible vessel or a clot were treated prophylactically by injection with epinephrine solution....

journal_title：Digestive diseases and sciences

authors： Kohler B,Maier M,Benz C,Riemann JF

更新日期：1997-07-01 00:00:00

abstract：:The aim of the study was to assess the value of quantitative attenuation values (Hounsfield units) and of gallstone pattern by computerized tomography in predicting response to bile acid therapy. We carried out a prospective study in a multicenter setting on 90 consecutive outpatients with radiolucent gallstones. All ...

journal_title：Digestive diseases and sciences

authors： Petroni ML,Jazrawi RP,Grundy A,Lanzini A,Pigozzi MG,Biasio A,Heaton KW,Virjee J,Northfield TC

更新日期：1995-09-01 00:00:00

abstract：:The aim of this study was to assess the potential of leflunomide, an immunosuppressant in rheumatoid arthritis, as a second-line immunosuppression treatment of patients with Crohn's disease refractory or intolerant to azathioprine. The study cohort consisted of 24 patients. The primary end point was steroid-free remis...

journal_title：Digestive diseases and sciences

authors： Holtmann MH,Gerts AL,Weinman A,Galle PR,Neurath MF

更新日期：2008-04-01 00:00:00