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Impaired alveolar gas exchange in acute pancreatitis.

Abstract：

:We evaluated the alveolar-arterial oxygen difference (deltaA-a) and the ratio between PaO2 and the fractional concentration of inspired oxygen (P/F) in acute pancreatitis. Eleven patients had mild uncomplicated disease, six showed acute abdominal fluid collections, six had acute abdominal collections and asymptomatic x-ray lung involvement, three presented transient dyspneic episodes, and four had severe acute pancreatitis requiring prolonged oxygen therapy. In the uncomplicated disease, respiratory function was normal; in the six patients with abdominal collections only, deltaA-a increased by 50% and P/F decreased by 20-30%; in the six patients with abdominal collections and asymptomatic x-ray lung involvement, deltaA-a increased by 50-70% and P/F decreased by 40%; the three patients with dyspneic episodes showed a twofold increase in deltaA-a and a 40% decrease in P/F; the four patients with severe pancreatitis had a two- to threefold increase in deltaA-a and a 40-50% decrease in P/F. Hence respiratory function is normal only in uncomplicated pancreatitis; in the presence of complications, disturbance of gas exchange always occurs, requiring careful control and treatment.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Salomone T,Tosi P,Di Battista N,Binetti N,Raiti C,Tomassetti P,Migliori M,Gullo L

doi

10.1023/a:1019668728058

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

2025-8

issue

9

eissn

0163-2116

issn

1573-2568

journal_volume

47

pub_type

杂志文章

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