Abstract：
:The prevalence of the recently described deamidated gliadin peptide antibodies was compared with that of the routinely used antigliadin, antiendomysial, and tissue transglutaminase antibodies in the sera of 128 untreated celiac patients and 134 controls. Sensitivity and specificity for celiac disease were 83.6 and 90.3% for IgA and 84.4 and 98.5% for IgG antibodies to deamidated gliadin peptides. The new test displayed higher diagnostic accuracy than antigliadin antibodies and, although less sensitive than antiendomysial and tissue transglutaminase antibodies, showed significantly higher specificity than tissue transglutaminase antibodies (P < 0.001). Persistence of peptide antibodies after gluten withdrawal was an expression of low compliance with the diet and of the lack of improvement of the intestinal mucosa. The combined use of tissue transglutaminase and deamidated gliadin peptide antibodies seems to be a very useful tool for celiac disease diagnosis. Moreover, antibodies to deamidated gliadin peptides can be helpful in disease follow-up.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Volta U,Granito A,Fiorini E,Parisi C,Piscaglia M,Pappas G,Muratori P,Bianchi FBdoi
10.1007/s10620-007-0058-0subject
Has Abstractpub_date
2008-06-01 00:00:00pages
1582-8issue
6eissn
0163-2116issn
1573-2568journal_volume
53pub_type
杂志文章abstract：BACKGROUND:Liver metastasis is an indicator of unfavorable responses to immunotherapy in colorectal cancer patients. However, the difference of immune microenvironment between primary tumors and liver metastases has not been well understood. PATIENTS AND METHODS:Fifty-four colon cancer with liver metastasis patients w...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06203-8
更新日期：2020-03-19 00:00:00
abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is now recognized as a leading cause of liver dysfunction. Gastroesophageal reflux disease (GERD) is a common disorder causing symptoms that often impair patients' quality of life. In recent years, the prevalence of both these diseases has increased, partially overlap...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3113-7
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-012-2510-z
更新日期：2013-05-01 00:00:00
abstract：:The efficacy of short-course (three months), low-dose (3 million units three times a week) interferon as treatment for acute hepatitis C was evaluated in a meta-analysis of controlled trials. Nine studies (five randomized and four nonrandomized) found by MEDLINE search were eligible for analysis. The outcomes assessed...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,meta分析
doi：10.1007/BF02088245
更新日期：1996-06-01 00:00:00
abstract：:Our aim was to determine the effect of intestinal transection and resection on the prevalence of enteric flora and evaluate whether any such changes alter luminal SCFA and lactic acid content. Dogs underwent either 50% proximal (PR, N = 6) or distal (DR, N = 7) resection, distal resection with bypass of the ileocecal ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018831728734
更新日期：1998-03-01 00:00:00
abstract：:Glycoprotein and glycolipid constituents were examined in purified microvillus and basolateral membranes isolated from rat small intestinal epithelial cells. SDS-polyacrylamide gel electrophoresis showed that the molecular weights of most of the major proteins from microvillus membranes were over 100 kD, whereas the m...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536338
更新日期：1989-04-01 00:00:00
abstract：:The preoperative determination of the localization of a small insulinoma is sometimes difficult using routine imaging techniques. We have used the selective arterial calcium injection (SACI) test to determine the location of the tumor preoperatively. The pathophysiologic basis of the SACI test is based on the responsi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026626014100
更新日期：1998-11-01 00:00:00
abstract：:Antagonists of nitric oxide synthesis inhibit nerve-induced hyperpolarization and relaxation of muscle from the opossum lower esophageal sphincter. These studies test the hypothesis that nitric oxide is released during stimulation of intrinsic esophageal nerves. The intrinsic nerves were stimulated with an electrical ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02088117
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:MELD attempts to objectively predict the risk of mortality of patients with liver cirrhosis and is commonly used to prioritize organ allocation. Despite the usefulness of the MELD, updated metrics could further improve the accuracy of estimates of survival. AIMS:To assess and compare the prognostic ability ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5360-5
更新日期：2019-02-01 00:00:00
abstract：:Free radical damage in reflux esophagitis of rats induced by 24-hr duodenojejunal ligation was studied. Oxygen free radicals were selectively blocked. Groups were: sham operation, reflux, reflux + superoxide dismutase (SOD), catalase, dimethylthiourea, allopurinol, and inactivated SOD or inactivated catalase alone or ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02065541
更新日期：1995-06-01 00:00:00
abstract：:Clinical and manometric data from 97 consecutive patients with idiopathic achalasia were analyzed to see if a distinct subset with vigorous achalasia could be identified. Statistical analyses failed to detect a unique group of subjects based on the distribution of contraction wave amplitudes alone. Because of this, pa...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318195
更新日期：1991-03-01 00:00:00
abstract：:Hepatitis B virus (HBV) DNA integrates into the host DNA and shows a series of potentially oncogenetic properties, but HBV is not an acutely transforming virus, because HCC develops decades after infection. Other factors, namely cirrhosis, inflammation, alcohol intake, and viral superinfections, could promote the onco...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297460
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND AND AIM:The liver has a high capacity of its regeneration. Most hepatic cells are quiescent unless otherwise stimulated such as their injury or ablation. A previous study suggest that pre-activated hepatic cells have a positive effect on their regeneration. In this study, we examined whether the pre-activate...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3536-9
更新日期：2015-06-01 00:00:00
abstract：:Our purpose was to determine if the presence of duodenal diverticula predisposes to the development of pancreaticobiliary disease. Between May 1999 and February 2001, 381 patients were examined by endoscopic retrograde cholangiopancreaticography. Of these patients, 51 had periampullary diverticula. In 27 patients the ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-004-9597-9
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Gastroparesis is a heterogeneous disorder. Patient characteristics and treatment responsiveness may differ based on the extent of delay in gastric emptying. AIMS:Characterize gastroparesis patients based on the degree of delay in gastric emptying, and assess the relationship of patient demographics, symptom...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06258-7
更新日期：2020-04-18 00:00:00
abstract：:Lafutidine, a histamine H2-receptor antagonist, exhibits gastric mucosal protective action mediated by capsaicin-sensitive afferent neurons, in addition to a potent antisecretory effect. In this study we examined the effect of lafutidine on dextran sulfate Na (DSS)-induced ulcerative colitis in rats, in relation to ca...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000043389.96490.76
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND AND AIMS:The nature and outcomes of infection among patients with cirrhosis in safety-net hospitals are not well described. We aimed to characterize the rate of and risk factors for infection, both present on admission and nosocomial, in this unique population. We hypothesized that infections would be associ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06164-y
更新日期：2021-01-01 00:00:00
abstract：:Dientamoeba fragilis is an intestinal protozoan parasite associated with gastrointestinal symptoms. This study was undertaken in a semicommunal group reported to have a high prevalence of this parasite. Stools were collected from 81 adult group members. Intestinal parasites were observed in stool specimens of 45 (56%)...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01324950
更新日期：1983-04-01 00:00:00
abstract：:Immune (gamma) interferon is a substance produced by immunologically activated mononuclear cells. Besides its antiviral activity, interferon gamma has a crucial role in immunoregulation, by acting directly upon lymphocytes and monocytes, and interacting with other soluble mediators of the immune response. Studies of t...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536683
更新日期：1988-10-01 00:00:00
abstract：:Hepatolithiasis is a major disease in Asia but differences in operative incidence between countries have not been examined. A retrospective study was conducted in Taiwan, Hong Kong, and Singapore, and the results were compared with those in Japan with the aim of defining factors involved in the etiology of the conditi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01347905
更新日期：1986-01-01 00:00:00
abstract：:A patient with congenital asucrasia was investigated using in vivo differential urinary disaccharide excretion. Impaired hydrolysis of sucrose and isomaltose, but normal lactase activity, were demonstrated and confirmed by in vitro estimation. The technique of differential disaccharide excretion can now be used to ass...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536167
更新日期：1989-01-01 00:00:00
abstract：:Studies have shown a promoting effect of food on small intestinal absorption. Casein hydrolysate seems be more effective in increasing of D-xylose absorption in dogs than the whole protein and lactulose. The purpose this study was to analyze the effect of groups of peptides derived from casein hydrolysate on the absor...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005439525762
更新日期：2000-04-01 00:00:00
abstract：:Telomerase acitivity can be induced in human B lymphocytes by in vitro stimulation of their antigen receptors. To determine whether telomerase activity is induced in vivo, we analyzed telomerase activity in B lymphocytes from the mesenteric lymph nodes of patients with inflammatory bowel disease (IBD), whose lymph nod...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026107429546
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency is common in patients with inflammatory bowel diseases. The vitamin D receptor (VDR) is a nuclear hormone receptor mediating the activity of vitamin D hormone. Our previous studies showed that intestinal epithelial VDR signaling inhibits colitis by protecting the mucosal epithelial barri...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3634-8
更新日期：2015-07-01 00:00:00
abstract：:Dysmotility and delayed emptying of the stomach have been reported in patients with chronic renal failure (CRF). The aim of this study was to investigate whether gastric myoelectrical activity was impaired in patients with CRF using electrogastrography. The electrogastrogram (EGG) was recorded in 24 symptomatic patien...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018856112765
更新日期：1997-05-01 00:00:00
abstract：:The effect of insulin on the myoelectric activity of the small intestine was determined in conscious pigs. Animals were implanted with electrodes along the small intestine, a strain gage on the stomach and catheters in both saphenous arteries. Feeding modified the migrating myoelectric complex (MMC), a cyclic pattern ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01307973
更新日期：1981-01-01 00:00:00
abstract：:Resistant starch is by definition that part of starch that escapes digestion in the small bowel. Cecal fermentation of resistant starch into short-chain fatty acids will result subsequently in a decrease in pH. Thus, resistant starch may have the same effect on colonic luminal contents and mucosa as some fiber compone...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087431
更新日期：1994-04-01 00:00:00
abstract：:We studied intraesophageal pressure changes in patients with symptoms of gastroesophageal reflux and an abnormal 24-hr pH monitoring record (N = 52). Our method was simultaneous esophageal manometry and pH monitoring. We observed a three-component esophageal manometric sequence (EMS). When this sequence recurred over ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01538066
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND AND AIMS:Researchers have not clearly described the clinical and pathogenetic features of hypoganglionosis and adult-onset Hirschsprung's disease, which cause pseudo-obstruction or intractable constipation. We conducted this study to explore these features of hypoganglionosis and adult-onset Hirschsprung's d...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1522-9
更新日期：2011-06-01 00:00:00
abstract：:Gastrin-secreting tumors have been identified in ectopic locations including the ovary; the mechanisms regulating gastrin gene expression, its distribution, and signaling pathways in these ectopic tissues are not known. The purpose of our present study was to determine: (1) whether the gastrin gene and peptide could b...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018846311239
更新日期：1998-07-01 00:00:00
