Transgenic Expression of Vitamin D Receptor in Gut Epithelial Cells Ameliorates Spontaneous Colitis Caused by Interleukin-10 Deficiency.

abstract：BACKGROUND:Patients with irritable bowel syndrome (IBS) frequently have meal-related symptoms and can recognize specific trigger foods. Lactose intolerance is a well-established carbohydrate malabsorption syndrome that causes symptoms similar to IBS such as bloating, abdominal pain, and diarrhea. However, the prevalenc...

journal_title：Digestive diseases and sciences

authors： Kim SB,Calmet FH,Garrido J,Garcia-Buitrago MT,Moshiree B

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Computed tomography (CT) and magnetic resonance (MR) enterography are now widely used to diagnose and monitor Crohn's disease. AIM:We sought to assess the use of enterography for management of inflammatory bowel disease (IBD) in our medical center. METHODS:We performed a retrospective review of all patient...

journal_title：Digestive diseases and sciences

authors： Patel NS,Pola S,Muralimohan R,Zou GY,Santillan C,Patel D,Levesque BG,Sandborn WJ

更新日期：2014-04-01 00:00:00

abstract：:Lansoprazole, a proton pump inhibitor, exerts prominent antiulcer activity via both antisecretory and mucosal protective actions. Although the antisecretory action has been explained by inactivation of (H+, K+)-ATPase in parietal cells, the mode of mucosal protective action remains to be elucidated. In the present stu...

journal_title：Digestive diseases and sciences

authors： Inada I,Satoh H

更新日期：1996-04-01 00:00:00

abstract：:The role of HBV precore mutations in the spontaneous reactivation of chronic hepatitis B (CHB) is currently unknown. We studied 10 patients with CHB; five were HBeAg+ (group I) and five were anti-HBe+ (group II). All 10 had spontaneous reactivation of CHB as defined by the appearance of clinical symptoms along with an...

journal_title：Digestive diseases and sciences

authors： Laskus T,Rakela J,Tong MJ,Persing DH

更新日期：1994-09-01 00:00:00

abstract：:An intravenous injection of diphenylthiocarbazone (dithizone), a zinc chelator, induces selective killing and rapid regeneration of Paneth cells, which have a large amount of zinc in their cytoplasmic granules. We examined the expression pattern of transforming growth factor (TGF) -alpha and TGF-beta1 in this regenera...

journal_title：Digestive diseases and sciences

authors： Seno H,Sawada M,Fukuzawa H,Morita Y,Takaishi S,Hiai H,Chiba T

更新日期：2001-05-01 00:00:00

abstract：:Barrett's esophagus (BE) is a well-known premalignant condition that can be associated with the development of dysplasia and adenocarcinoma. In the past, esophagectomy was the standard treatment for patients with BE with high grade dysplasia (HGD) and early cancer (EC). However, esophagectomy is not necessarily the on...

journal_title：Digestive diseases and sciences

authors： Azarm A,Lukolic I,Shukla M,Concha-Parra R,Gress F

更新日期：2012-12-01 00:00:00

abstract：:Pancreatic polypeptide (PP) has been shown to be released postprandially in several species. In this study we tested the efficacy of an amino acid solution (905 mOsM), 0.1 N HCl (300 mOsM), 905 mOsM NaCl, 300 mOsM glucose, corn oil, and balloon distention within the stomach, duodenum, or ileum in stimulating release o...

journal_title：Digestive diseases and sciences

authors： Duke GE,Kimmel JR,Durham K,Pollock HG,Bertoy R,Rains-Epstein D

更新日期：1982-09-01 00:00:00

abstract：:Lafutidine, a histamine H2-receptor antagonist, exhibits gastric mucosal protective action mediated by capsaicin-sensitive afferent neurons, in addition to a potent antisecretory effect. In this study we examined the effect of lafutidine on dextran sulfate Na (DSS)-induced ulcerative colitis in rats, in relation to ca...

journal_title：Digestive diseases and sciences

authors： Okayama M,Tsubouchi R,Kato S,Takeuchi K

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model. METHODS:The rats underwent ...

journal_title：Digestive diseases and sciences

authors： Feng Y,Han Z,Gu B,Li X,Wang B,Guo F,Praseedom RK,Wang F,Cheng H,Lucas A,Li Y,Chen H

更新日期：2020-09-01 00:00:00

abstract：:Patients with chronic epigastric to right upper quadrant pain are often considered to have gallbladder of sphincter of Oddi dysfunction, but standard tests are nondiagnostic. In 62 consecutive patients with this compliant undergoing antroduodenal manometry, we correlated a change on duodenal motility with spasm of the...

journal_title：Digestive diseases and sciences

authors： Koussayer T,Ducker TE,Clench MH,Mathias JR

更新日期：1995-08-01 00:00:00

abstract：:We measured the effects of cimetidine on antibiotic concentrations in the luminal portion of gastric mucosa. Guinea pigs were premedicated with cimetidine 4 mg/kg intramuscularly. Clindamycin, an antibiotic previously characterized under physiologic pH conditions, was administered intramuscularly and levels measured i...

journal_title：Digestive diseases and sciences

authors： Westblom TU,Duriex DE

更新日期：1991-01-01 00:00:00

abstract：:Chronic abdominal wall pain (CAWP) is common and frequently mistaken for visceral pain. We determined the stability of this diagnosis with Main Outcome Measures of: (a) change of pain intensity after local anesthetic-corticosteroid injection, (b) pain relief after three or more months follow-up, and (c) costs of diagn...

journal_title：Digestive diseases and sciences

authors： Greenbaum DS,Greenbaum RB,Joseph JG,Natale JE

更新日期：1994-09-01 00:00:00

abstract：:We examined the influences of aging on gastric damage and gastric mucosal blood flow (GMBF) responses induced by acid back-diffusion, following the barrier disruption, and investigated the relation of capsaicin-sensitive sensory nerves to these changes. Male Fischer rats 3, 13, and 24 months old were used. Under ureth...

journal_title：Digestive diseases and sciences

authors： Miyake H,Inaba N,Kato S,Takeuchi K

更新日期：1996-02-01 00:00:00

abstract：:Dermatitis herpetiformis (DH) and isolated gluten-sensitive enteropathy (GSE) are gluten-sensitive diseases in which ingestion of dietary gluten results in the development of clinical disease. Patients with DH develop cutaneous IgA deposits and a severe skin disease, but rarely develop gastrointestinal symptoms. Patie...

journal_title：Digestive diseases and sciences

authors： Hall RP 3rd,Smith AD,Streilein RD

更新日期：2000-10-01 00:00:00

abstract：:In vitro and in vivo experiments were carried out with medium-chain glycerides. In vitro, cholesterol gallstones were rapidly dissolved by medium-chain glycerides; control experiments with saline solution failed to modify the size of the stones. In vivo, medium-chain glycerides were instilled through an intraductal tu...

journal_title：Digestive diseases and sciences

authors： Uribe M,Uscanga L,Farca S,Sanjurjo JL,LaGarriga J,Ortíz JH

更新日期：1981-07-01 00:00:00

abstract：:Our purpose is to develop a standard method for preparing the bile for beta-glucuronidase determination by removal of bile acids and conjugated bilirubin which interfere with its activity. The bile acids and conjugated bilirubin in their purified solutions and in the diluted gallbladder biles could be extracted comple...

journal_title：Digestive diseases and sciences

authors： Ho YC,Ho KJ

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVES:Pancreas divisum (PD) as a cause of pancreatitis has been debated. In this study, we report the association of multiple gene polymorphisms on the risk of RAP in the presence of PD. DESIGN:We enrolled 687 individuals (167 IRAP, 276 ICP, and 244 unrelated healthy controls) from May 2015 to September 2016. Pat...

journal_title：Digestive diseases and sciences

authors： Talukdar R,Aslam M,Reddy DN,Nabi Z,Shava U,Ravikanth VV,Avanthi S,Govardhan B

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND:Hospital-acquired pneumonia after an endoscopic submucosal dissection (ESD) can prolong the patient's stay in the hospital, leading to greater healthcare costs. However, little is known of the characteristics and risk factors associated with this complication. AIMS:To analyze the clinical features of pneumo...

journal_title：Digestive diseases and sciences

authors： Park CH,Kim H,Kang YA,Cho IR,Kim B,Heo SJ,Shin S,Lee H,Park JC,Shin SK,Lee YC,Lee SK

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The present study aimed to identify the differential expressed genes that are related to acute pancreatitis. METHODS:Microarray datasets GSE109227 and GSE3644 were downloaded from the public database and analyzed to screen the genes. Afterward, integrated analysis of these genes were performed, inc...

journal_title：Digestive diseases and sciences

authors： Fan L,Hui X,Mao Y,Zhou J

更新日期：2020-06-01 00:00:00

abstract：:Squamous cell carcinoma represents the most common primary malignant lesion of the esophagus (1). The initial manifestation of lymphosarcoma infrequently occurs in the gastrointestinal tract, and in one large series, there were no lymphosarcomas presenting in the esophagus (2). In the case described below, a primary h...

journal_title：Digestive diseases and sciences

authors： Berman MD,Falchuk KR,Trey C,Gramm HF

更新日期：1979-11-01 00:00:00

abstract：:Gastrin-secreting tumors have been identified in ectopic locations including the ovary; the mechanisms regulating gastrin gene expression, its distribution, and signaling pathways in these ectopic tissues are not known. The purpose of our present study was to determine: (1) whether the gastrin gene and peptide could b...

journal_title：Digestive diseases and sciences

authors： Kim HJ,Evers BM,Banker NA,Greeley GH Jr,Hellmich MR,Thompson JC,Townsend CM Jr

更新日期：1998-07-01 00:00:00

abstract：:One hundred sixty-two patients chronically ingesting ibuprofen, piroxicam, or naproxen for osteoarthritis, who had abdominal pain and an endoscopically proven gastric ulcer were evaluated for eight weeks in a randomized, double-blind trial comparing misoprostol (200 micrograms four times daily with meals and at bedtim...

journal_title：Digestive diseases and sciences

authors： Jaszewski R,Graham DY,Stromatt SC

更新日期：1992-12-01 00:00:00

abstract：:The development of experimental cholecystitis produced by lysophosphatidylcholine is associated with reversal of the normal absorptive characteristics of gallbladder mucosa, resulting in the intraluminal accumulation of water, glycoprotein, and protein. The purpose of the present study was to attempt to ascertain if t...

journal_title：Digestive diseases and sciences

authors： Kaminski DL,Deshpande YG,Li A,Dysart F,Nag M

更新日期：1995-05-01 00:00:00

abstract：:Several techniques have been developed to diagnose Helicobacter pylori infection and two noninvasive methods are available: carbon 13-urea breath test (UBT) and serology. Measurement of IgG serum antibodies by enzyme-linked immunosorbent assay (ELISA) is a reliable and inexpensive method for detection of infection. Th...

journal_title：Digestive diseases and sciences

authors： Menegatti M,Figura N,Farinelli S,Landi F,Acciardi C,Ricci C,Holton J,Gatta L,Crosatti M,Polacci R,Miglioli M,Vaira D

更新日期：2000-08-01 00:00:00

abstract：INTRODUCTION:Stent placement in the distal duodenum can be difficult. We describe a case report of a 94-year-old man with metastatic pancreatic head cancer compressing the third and fourth portions of the duodenum, treated by endoscopic stent placement using a colonoscope. AREAS COVERED:A literature review highlighted...

journal_title：Digestive diseases and sciences

authors： Minervini A,Lauro A,Pagano N,Vaccari S,D'Andrea V,Marino IR,Cervellera M,Tonini V

更新日期：2019-09-01 00:00:00

abstract：:In previous studies, the majority of patients with the cholestatic liver diseases, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), had increased hepatic copper (Cu) levels even in early stages of disease. We prospectively measured hepatic copper content by atomic absorption spectrophotometry ...

journal_title：Digestive diseases and sciences

authors： Kowdley KV,Knox TA,Kaplan MM

更新日期：1994-11-01 00:00:00

abstract：:Radionuclide gastric solid-phase emptying was studied in 10 subjects with diabetic gastroparesis comparing the acute intravenous administration of cisapride (2.5, 5, 10 mg), placebo, and metoclopramide (10 mg). No hemodynamic or electrocardiographic changes were noted. While both cisapride and metoclopramide normalize...

journal_title：Digestive diseases and sciences

authors： McHugh S,Lico S,Diamant NE

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The expanded polytetrafluoroethylene (ePTFE)-covered stent has been widely used in the transjugular intrahepatic portosystemic shunt (TIPS) procedure. However, the epidemiologic data of acute TIPS occlusion (ATO) and the underlying mechanisms are scarce. AIMS:The purpose of this study was to evaluate the in...

journal_title：Digestive diseases and sciences

authors： Wang X,Luo X,Zhao M,Song J,Li X,Yang L

更新日期：2020-10-01 00:00:00

abstract：:Crohn's disease (CD) is a heterogeneous disorder. A genetic linkage to chromosome 16 (IBD1) has been previously observed and replicated in unrelated populations. Recently, in this region, NOD2/CARD15 has been identified as a susceptibility gene. The aim of this report is to determine whether this gene is implicated in...

journal_title：Digestive diseases and sciences

authors： Zouiten-Mekki L,Zaouali H,Boubaker J,Karoui S,Fekih M,Matri S,Hamzaoui S,Filali A,Chaabouni H,Hugot JP

更新日期：2005-01-01 00:00:00

abstract：:To date few therapies have been shown to reliably prevent the evolution of Crohn's disease (CD). The traditional Chinese medicine, Tripterygium wilfordii Hook F (TWHF), has both immunomodulatory and anti-inflammatory activities. Our aim was to investigate the potential efficacy of T2, the major constituent of extracts...

journal_title：Digestive diseases and sciences

authors： Ren J,Tao Q,Wang X,Wang Z,Li J

更新日期：2007-08-01 00:00:00