Abstract:
:The aim of this study was to assess the potential of leflunomide, an immunosuppressant in rheumatoid arthritis, as a second-line immunosuppression treatment of patients with Crohn's disease refractory or intolerant to azathioprine. The study cohort consisted of 24 patients. The primary end point was steroid-free remission, and secondary end points were changes in the Crohn's disease activity index (CDAI) and steroid intake, responsiveness of arthralgias and adverse events. Results were expressed in medians (quartiles). The remission rate increased from 21 to 42% by week 16 (P < 0.05). In the intention-to-treat analysis, the CDAI decreased from 219 to 87 (P = 0.018) and the steroid intake from 25 to 3 mg/day (P = 0.033). In the per-protocol analysis, the CDAI decreased from 182 to 87 (P = 0.0183) and the steroid intake from 45 to 4 mg/day (P = 0.0778). Patients with arthralgias improved significantly. However, adverse side effects were frequent. Leflunomide may improve disease activity, especially in terms of arthralgias, and reduce steroid intake. Adverse events were more frequent in our patients than has been reported in controlled studies for rheumatoid arthritis but corresponded to those found in post-marketing studies.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Holtmann MH,Gerts AL,Weinman A,Galle PR,Neurath MFdoi
10.1007/s10620-007-9953-7subject
Has Abstractpub_date
2008-04-01 00:00:00pages
1025-32issue
4eissn
0163-2116issn
1573-2568journal_volume
53pub_type
临床试验,杂志文章abstract::Three cases of gastritis glandularis et cystica profunda are presented, two associated with severe chronic gastritis and the other with invasive gastric carcinoma and chronic gastritis. This poorly known entity consists of benign downgrowths of deep gastric glands through the muscularis mucosae into the submucosa. The...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297238
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients. METHODS:A total of 163 patients were randomized into two groups: Group A to consume...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-019-05695-3
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Partially covered metal stents (PCMS) have been increasingly used for both malignant and benign biliary indications. This study reports their complications and subsequent management. METHODS:Over 5 years, all patients receiving biliary PCMS were followed prospectively until stent-related dysfunction or deat...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0756-x
更新日期:2010-02-01 00:00:00
abstract::Recent evidence suggests a role of reactive oxygen intermediates (ROI) in intracellular signaling and regulation of gene expression. We examined whether expression of interleukin-8 (IL-8), a key cytokine in the inflammatory responses of gastric epithelial cells, is sensitive to antioxidants and oxidative stress. IL-8 ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026638014062
更新日期:1999-02-01 00:00:00
abstract::We studied the effects of the calcium-channel blocker, nifedipine, on solid and liquid phases of gastric emptying in 10 healthy male volunteers. Each subject underwent a dual-isotope radionuclide gastric emptying determination with and without the preadministration of nifedipine, 30 mg orally, given 20 min prior to in...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01320483
更新日期:1985-08-01 00:00:00
abstract::This review article deals with the clinical value of capsule endoscopy for visualization of the colon. Since its introduction in 2006, the colon capsule endoscopy underwent major technological improvements. The improved performance of colon capsule endoscopy is reviewed based on three multicenter prospective studies. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3534-y
更新日期:2015-03-01 00:00:00
abstract::A novel probe was developed from genomic DNA of Helicobacter pylori ATCC type strain 43629. It hybridized with all 73 H. pylori clinical isolates tested but not with any of 183 non-H. pylori DNAs in dot blot hybridization. Typing tests revealed 41 different HaeIII-digestion patterns from 57 H. pylori strains tested. B...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018847522200
更新日期:1998-06-01 00:00:00
abstract::The mechanism by which alcohol causes pancreatic damage is still largely unknown. One important contributory factor may be the endothelins, potent vasoconstricting endothelial-derived peptides. The aim of this study was to examine in vivo endothelin release from the pancreatic vascular endothelium after alcohol ingest...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018845710446
更新日期:1998-05-01 00:00:00
abstract::Barrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC). Both are important health issues as they have rising incidences in the Western world. Improving the management of BE relies on understanding the underlying biology of this disease, but t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-016-4109-2
更新日期:2016-07-01 00:00:00
abstract::To evaluate the frequency and significance of alpha1-antitrypsin deficiency in type 1 autoimmune hepatitis, 181 Caucasian patients were assessed for variant phenotypes. Three hundred three Caucasian patients with various other chronic liver diseases were similarly evaluated. Twenty-one of the 181 patients (12%) had he...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018875401612
更新日期:1998-08-01 00:00:00
abstract::The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01550972
更新日期:1988-07-01 00:00:00
abstract::A retrospective multicenter analysis of 652 patients with chronic hepatitis C who have been treated with interferon (IFN) was performed to assess the effects of IFN on the clinical course and development of HCC. During a mean follow-up of 54.8 months, hepatocellular carcinoma (HCC) developed in 7.0% of the patients. T...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
doi:10.1023/a:1013244326874
更新日期:2002-01-01 00:00:00
abstract::We describe a case with prolonged survival of 2 years in a female patient with pancreatic ductal adenocarcinoma who, at diagnosis, already had liver spread and eventually succumbed to brain metastases which scanned positive with [(111)In-DTPA] octreotide scintiscan (OctreoScan). Subsequently, the patient underwent a c...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0531-4
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Mucosal addressin cell adhesion molecule-1 (MAdCAM-1), a member of the immunoglobulin superfamily, is essential for gut-specific homing of leukocytes; however, it has not been well characterized in rhesus macaques. AIMS:To obtain the complete nucleotide sequence of rhesus macaque MAdCAM-1 cDNA and determine...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3209-0
更新日期:2014-10-01 00:00:00
abstract::With the growing popularity of propofol mediated deep sedation for upper gastrointestinal (GI) endoscopic procedures, challenges are being felt and appreciated. Research suggests that management of the airway is anything but routine in this setting. Although many studies and meta-analyses have demonstrated the safety ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-016-4375-z
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Although the use of cold snare polypectomy (CSP) has spread rapidly, its safety for pedunculated (Ip) polyps remains controversial. In particular, the outcomes of hot snare polypectomy (HSP) and CSP for Ip polyps have not been previously compared. AIMS:This study evaluated whether the rate of delayed postpo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06436-7
更新日期:2020-07-04 00:00:00
abstract::The main pancreatic duct epithelium acts as a barrier to the diffusion of molecules from the duct lumen into pancreatic acinar and interstitial tissue. We studied sequential ultrastructural characteristics of the loss of epithelial barrier function in the cat using lanthanum, an electron-opaque tracer, following perfu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01300091
更新日期:1991-01-01 00:00:00
abstract::We conducted this study to evaluate the impact of the expression of peroxisome proliferator-activated receptor delta on angiogenesis in tissue samples of colorectal cancer. We examined 52 samples of primary human colorectal carcinomas and matched normal adjacent tissues to evaluate the expression of peroxisome prolife...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0465-x
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Hypoxia is an important factor in malignant tumors, and glycolysis is a major metabolic contributor in their development. Glycolytic enzymes have gained increasing attention as potential therapeutic targets because they are associated with cancer-specific metabolism. Fructose-bisphosphate aldolase A (ALDOA),...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05642-2
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND AND AIM:Although cholesterol levels are elevated in patients with primary biliary cirrhosis (PBC), most PBC patients are not at increased risk of dying from atherosclerotic heart disease. There is, however, a subgroup, approximately 10%, who have additional disorders of lipid metabolism. They might benefit f...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0988-9
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) pathophysiology has not been fully understood. Abnormalities of serine proteases have been identified in IBS patients. In addition, protease-activated receptors (PAR) activation interferes with several components of the pathogenesis of IBS, so, evaluating the PAR expression in ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1827-3
更新日期:2012-01-01 00:00:00
abstract::A patient with congenital asucrasia was investigated using in vivo differential urinary disaccharide excretion. Impaired hydrolysis of sucrose and isomaltose, but normal lactase activity, were demonstrated and confirmed by in vitro estimation. The technique of differential disaccharide excretion can now be used to ass...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536167
更新日期:1989-01-01 00:00:00
abstract::To evaluate pancreatic exocrine function in uremia, 25 patients undergoing regular hemodialysis without clinical evidence of pancreatic disease and 25 healthy control subjects were studied by fecal elastase 1 and chymotrypsin. Abdominal ultrasonography and measurement of serum lipase, calcium, phosphate, and parathorm...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026487807555
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Oxaliplatin is one of the most effective chemotherapeutic drugs used for the treatment of colorectal cancer (CRC). However, intervention that attenuates the resistance of oxaliplatin is still required in the treatment of CRC. AIMS:To investigate the role of miR-325 in changing the oxaliplatin sensitivity to...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06579-7
更新日期:2020-09-10 00:00:00
abstract::The evaluation of a group of polyamine analogs as agents to ameliorate diarrhea-predominant irritable bowel syndrome is described. Each compound was assessed when administered subcutaneously in a psychological stress-induced model of irritable bowel syndrome in rodents for its ability to reduce stool output in a dose-...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1012750723644
更新日期:2001-12-01 00:00:00
abstract::This study was designed to assess the central nervous system actions of human calcitonin (hCalc) and human calcitonin gene-related peptide (hCGRP) on meal-stimulated gastric acid secretion in awake beagle dogs. hCalc (0.1-1.0 nmol/kg) and hCGRP (0.01-1.0 nmol/kg) injected into the third cerebral ventricle significantl...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296295
更新日期:1987-04-01 00:00:00
abstract::The preoperative determination of the localization of a small insulinoma is sometimes difficult using routine imaging techniques. We have used the selective arterial calcium injection (SACI) test to determine the location of the tumor preoperatively. The pathophysiologic basis of the SACI test is based on the responsi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026626014100
更新日期:1998-11-01 00:00:00
abstract:UNLABELLED:The purpose of this study was to investigate and compare the specificity, sensitivity, and area under curve (AUC) of the lactulose/mannitol ratio, lactulose/creatinine ratio, and lactulose recovery and their diagnostic value for intestinal permeability assessment within the absorption lactulose/mannitol (L/M...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-0184-8
更新日期:2008-10-01 00:00:00
abstract::The effect of various prokinetic drugs was assessed in animals with Roux-en-Y gastrojejunostomy. The agents tested were (1) bethanechol 2.5 mg subcutaneously at 0 min and 30 min postprandially (pp); (2) metoclopramide 20 mg intravenous bolus at 0 min pp; (3) a combination of 1 and 2; (4) oxytocin 5 mg intramuscularly ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536681
更新日期:1988-10-01 00:00:00
abstract::Endoscopic injection sclerotherapy is known to cause a variety of motility abnormalities, but the correlation between these changes and symptomatology has not been clearly defined. To assess the effects of endoscopic sclerosis of varices on esophageal function and symptoms, we prospectively studied esophageal motility...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318367
更新日期:1985-01-01 00:00:00