Regional variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon.

Abstract:

:It is known that the muscularis mucosae and mucosa are not pharmacologically homogeneous throughout the rat colon. The aim of this study was to simultaneously characterize all three neurokinin (NK) receptors in the muscularis mucosae and mucosa along the length of the rat colon. Strips of proximal, mid, and distal colonic muscularis mucosae were prepared for isometric recording or sheets of muscle-free mucosa were mounted in Ussing chambers for measurement of short-circuit current. In both muscularis mucosae and mucosa the greatest responses to substance P were found in the proximal region. Use of selective agonists revealed the presence of all three NK receptors in both structures, however, selective antagonism suggests that only NK2 receptors in the muscularis mucosae and NK1 receptors in the mucosa are physiologically relevant. In conclusion, substance P-induced responses in the rat colon are region-specific and not mediated by a single NK receptor subtype common to both structures.

journal_name

Dig Dis Sci

authors

Appleyard CB,Morales M,Percy WH

doi

10.1007/s10620-006-3163-6

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

506-16

issue

3

eissn

0163-2116

issn

1573-2568

journal_volume

51

pub_type

杂志文章
  • Comparison of Immune Microenvironment Between Colon and Liver Metastatic Tissue in Colon Cancer Patients with Liver Metastasis.

    abstract:BACKGROUND:Liver metastasis is an indicator of unfavorable responses to immunotherapy in colorectal cancer patients. However, the difference of immune microenvironment between primary tumors and liver metastases has not been well understood. PATIENTS AND METHODS:Fifty-four colon cancer with liver metastasis patients w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06203-8

    authors: Zhou SN,Pan WT,Pan MX,Luo QY,Zhang L,Lin JZ,Zhao YJ,Yan XL,Yuan LP,Zhang YX,Yang DJ,Qiu MZ

    更新日期:2020-03-19 00:00:00

  • Screening Women Aged 50-59 for CRC Using Fecal Occult Blood Test Produces Outcomes Similar to Men Undergoing Screening Colonoscopy.

    abstract:BACKGROUND:Average-risk women aged 50-59 years have a lower incidence and mortality of colorectal cancer relative to age-matched men, calling into question the benefit of screening colonoscopy in this age group. AIMS:We aimed to determine whether FOBT is an effective initial screening test in 50-59-year-old women. ME...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-018-5156-7

    authors: Mooers HM,Holub JL,Lieberman DA

    更新日期:2018-10-01 00:00:00

  • Esophagitis impairs esophageal smooth muscle reactivity in the rat model: an in vitro study.

    abstract::The present study investigated how reflux-induced esophagitis affects the smooth muscle reactivity of the esophageal body. Two different esophagitis models were used: acid gastric and mixed duodenogastric reflux. All test animals apart from the controls developed gross and histologic evidence of esophagitis. Contracti...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000004518.98825.6c

    authors: Tugay M,Yildiz F,Utkan T,Müezzinoğlu B,Erden F,Gacar N,Ulak G

    更新日期:2003-11-01 00:00:00

  • Endoscopy, gastric ulcer, and gastric cancer. Follow-up endoscopy for all gastric ulcers?

    abstract::The practice of following benign-appearing gastric ulcers until healing was critically evaluated in a retrospective manner by reviewing all gastric ulcers that were followed with serial endoscopy and all gastric cancers diagnosed at the University of Alabama at Birmingham. The stated purpose of following ulcers to hea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01307545

    authors: Pruitt RE,Truss CD

    更新日期:1993-02-01 00:00:00

  • IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen.

    abstract::We have previously shown that methane on lactulose breath test (LBT) is highly associated with constipation in IBS and that methane gas itself slows small bowel transit in dogs. Previous studies suggest that serotonin may have a role in the control of transit in IBS. In this study, we aim to evaluate the role of serot...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000011607.24171.c0

    authors: Pimentel M,Kong Y,Park S

    更新日期:2004-01-01 00:00:00

  • Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.

    abstract::Rebamipide, a gastroprotective drug, is a compound selected from over 500 amino acid analogs of 2(1H)-quinolinone tested for gastroprotective action and for efficacy to heal experimental gastric ulcers. This drug stimulates prostaglandin generation in gastric mucosa and improves not only the speed but also the quality...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Arakawa T,Kobayashi K,Yoshikawa T,Tarnawski A

    更新日期:1998-09-01 00:00:00

  • Hepatitis B virus markers and antibodies to hepatitis C virus in Japanese patients with hepatocellular carcinoma.

    abstract::Sera from Japanese patients with chronic liver disease were tested for hepatitis B virus (HBV) markers and antibodies to hepatitis C virus (anti-HCV), and the results were correlated to the presence of hepatocellular carcinoma. In chronic non-A, non-B liver disease, anti-HCV prevalence was high both in patients with h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308344

    authors: Yuki N,Hayashi N,Kasahara A,Hagiwara H,Katayama K,Fusamoto H,Kamada T

    更新日期:1992-01-01 00:00:00

  • The serotonin transporter polymorphism rs25531 is associated with irritable bowel syndrome.

    abstract::Irritable bowel syndrome is a frequent gastrointestinal disorder of unknown etiology. The serotonin transporter regulates the intensity and duration of serotonin signaling in the gut and is, therefore, an attractive candidate gene for irritable bowel syndrome. Previous studies investigating the 5-HTTLPR and Stin2 VNTR...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0666-3

    authors: Kohen R,Jarrett ME,Cain KC,Jun SE,Navaja GP,Symonds S,Heitkemper MM

    更新日期:2009-12-01 00:00:00

  • Paradoxical relationship between substrates and agonist-induced contractions of opossum esophageal body and sphincter in vitro.

    abstract::Possible differences in the abilities of esophageal body and lower esophageal sphincter muscles to utilize substrates to support agonist-induced contractions were studied. Strips of longitudinal, circular, and lower esophageal sphincter muscle from the opossum esophagus were first contracted to approximately 70% of th...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297447

    authors: Percy WH,Sutherland J,Christensen J

    更新日期:1991-08-01 00:00:00

  • Differential distribution of human epidermal growth factor receptor family in acute pancreatitis.

    abstract::Using northern blot analysis and immunohistochemistry, we assessed the expression and distribution of human epidermal growth factor receptor-1 (HER-1), HER-2, and HER-3 in pancreatic tissues obtained from patients with acute pancreatitis (AP). Overall, HER-1, HER-2, and HER-3 mRNA levels were similar in the normal pan...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02208997

    authors: Ebert M,Friess H,Büchler MW,Korc M

    更新日期:1995-10-01 00:00:00

  • Comparison of three types of precut technique to achieve common bile duct cannulation: a retrospective analysis of 274 cases.

    abstract:BACKGROUND:The aim of this retrospective study was to evaluate the success rate and complications of three precut techniques of sphincterotomy after failure of conventional techniques of cannulation of common bile duct (CBD). PATIENTS AND METHODS:Between January 2003 and October 2011, 2,903 consecutive ERCPs were perf...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2271-8

    authors: Katsinelos P,Gkagkalis S,Chatzimavroudis G,Beltsis A,Terzoudis S,Zavos C,Gatopoulou A,Lazaraki G,Vasiliadis T,Kountouras J

    更新日期:2012-12-01 00:00:00

  • Diagnosis of malignant ascites. Comparison of ascitic fibronectin, cholesterol, and serum-ascites albumin difference.

    abstract::The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01550972

    authors: Prieto M,Gómez-Lechón MJ,Hoyos M,Castell JV,Carrasco D,Berenguer J

    更新日期:1988-07-01 00:00:00

  • Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole.

    abstract:OBJECTIVE:This study focused on unhealed gastrocutaneous fistulas to resolve whether standard drugs that promote healing of gastric ulcers may simultaneously have the same effect on cutaneous wounds, and corticosteroid aggravation, and to demonstrate why peptides such as BPC 157 exhibit a greater healing effect. Theref...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0332-9

    authors: Skorjanec S,Dolovski Z,Kocman I,Brcic L,Blagaic Boban A,Batelja L,Coric M,Sever M,Klicek R,Berkopic L,Radic B,Drmic D,Kolenc D,Ilic S,Cesarec V,Tonkic A,Zoricic I,Mise S,Staresinic M,Ivica M,Lovric Bencic M,Anic

    更新日期:2009-01-01 00:00:00

  • Experience with the new 4-way, 5.5-mm ultrathin endoscope: a case series.

    abstract:BACKGROUND AND STUDY AIMS:Use of ultrathin (ut) endoscopes is sometimes limited by their design (outer diameter, tip angulation and image quality). New ut-endoscopes are being designed to address these limitations. A new ut-endoscope, XGIF-PV70N5 (Olympus America Inc.), with an outer diameter of 5.5 mm, 4-way angulatio...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1344-9

    authors: Agrawal D,Wong RC,Isenberg G,Faulx A,Chak A

    更新日期:2011-03-01 00:00:00

  • MR enteroclysis: imaging technique of choice in diagnosis of small bowel diseases.

    abstract::MR enteroclysis is becoming a very important imaging modality in the workup and follow-up of small bowel diseases. The technique has many advantages, including the absence of ionizing radiation, ability to control luminal distension, superior tissue characterization, multiplanar capabilities, and mural and extramural ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-2700-z

    authors: Wiarda BM,Kuipers EJ,Houdijk LP,Tuynman HA

    更新日期:2005-06-01 00:00:00

  • High-fat diet promotes neuronal loss in the myenteric plexus of the large intestine in mice.

    abstract:BACKGROUND:Obesity is considered a risk factor for other chronic diseases, and diets rich in lipids can cause alterations in the intestinal functions. AIM:The aim of this study was to investigate the effects of a high-fat diet (HFD) on the myenteric plexus of the large intestine in mice. METHODS:Swiss mice were distr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3402-1

    authors: Beraldi EJ,Soares A,Borges SC,de Souza AC,Natali MR,Bazotte RB,Buttow NC

    更新日期:2015-04-01 00:00:00

  • Gastric functions in portal hypertension. Role of endothelin.

    abstract::This study investigated the effects of portal hypertension on gastric motor and secretory functions and the role of endothelin in rats. Control; sham-operated; endothelin-A receptor blocker, BQ 485 (1 microgram/kg)-treated; portal hypertensive; and portal hypertension +, endothelin-A receptor blocker-treated rats were...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02282345

    authors: Günal O,Yeğen C,Aktan AO,Yalin R,Yeğen BC

    更新日期:1996-03-01 00:00:00

  • Different mechanism of magnesium and calcium transport across rat duodenum.

    abstract::Concentration and voltage dependence of Mg transport across the rat duodenum was measured in an Ussing chamber. Mucosa (m) to serosa (s) Mg flux exhibits a cellular fraction comparable to that found for Ca. Mg sm flux is purely diffusive and probably restricted to the paracellular pathway. At all concentrations betwee...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296406

    authors: Karbach U,Schmitt A,Saner FH

    更新日期:1991-11-01 00:00:00

  • Magnesium transport across colon ascendens of the rat.

    abstract::Concentration and voltage dependence of unidirectional Mg fluxes across the rat colon ascendens were measured in a modified Ussing chamber. Mucosa (M) to serosa (S) Mg flux exhibits a cellular component, whereas SM flux is totally diffusive. At all the concentrations between 0.125 and 8 mmol/liter MS Mg transport is h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536699

    authors: Karbach U

    更新日期:1989-12-01 00:00:00

  • Serum antibodies against Helicobacter pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma.

    abstract::Infection with Helicobacter pylori is associated with the development of gastric cancer. To study whether the infection with H. pylori strains expressing the vacuolating cytotoxin (VacA) and/or the cytotoxin-associated protein (CagA) is associated with an increased risk of developing gastric adenocarcinoma, sera of 90...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018849112533

    authors: Rudi J,Kolb C,Maiwald M,Zuna I,von Herbay A,Galle PR,Stremmel W

    更新日期:1997-08-01 00:00:00

  • Effectiveness of leukocyte interferon-alpha treatment in patients with chronic hepatitis C not responsive to recombinant interferon.

    abstract::Twenty-four patients with chronic active HCV infection, nonresponders to a previous treatment cycle with recombinant interferon-alpha (r-IFNA), underwent retreatment with leukocyte (LE-) IFN-alpha. This was administered at the dose of 3 MU three times a week, for either six months (group A) or 12 months (group B). All...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1023/a:1026693901012

    authors: Scotto G,Grimaldi M

    更新日期:1998-10-01 00:00:00

  • Asymptomatic Helicobacter pylori gastritis is associated with increased sucrose permeability.

    abstract::Our aim was to investigate whether there are changes in permeability to sucrose in asymptomatic Helicobacter pylori gastritis. Nineteen asymptomatic subjects with Helicobacter pylori-associated gastritis with no or mild mucosal atrophy and 19 age- and sex-matched normal controls were studied by peroral load of sucrose...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018809913230

    authors: Borch K,Sjöstedt C,Hannestad U,Söderholm JD,Franzén L,Mårdh S

    更新日期:1998-04-01 00:00:00

  • Changes in plasma and duodenal cholecystokinin concentrations after pancreatic duct occlusion in rats.

    abstract::The changes in plasma and duodenal cholecystokinin (CCK) concentrations after pancreatic duct occlusion were examined in rats. The rats were sacrificed 1, 3, 7, 10, 14, and 30 days after occlusion of the duct. Histological examination showed acute inflammation on days 1 and 3 after duct occlusion, interstitial fibrosi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01307730

    authors: Miyasaka K,Funakoshi A,Jimi A,Nakamura R,Matsumoto M,Kitani K

    更新日期:1992-03-01 00:00:00

  • Exposure to Ambient Air Pollution and the Risk of Inflammatory Bowel Disease: A European Nested Case-Control Study.

    abstract:BACKGROUND:Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). AIM:We investigated the association between air pollution exposure and IBD. METHODS:The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn's disease (CD) (n = 38) an...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4249-4

    authors: Opstelten JL,Beelen RMJ,Leenders M,Hoek G,Brunekreef B,van Schaik FDM,Siersema PD,Eriksen KT,Raaschou-Nielsen O,Tjønneland A,Overvad K,Boutron-Ruault MC,Carbonnel F,de Hoogh K,Key TJ,Luben R,Chan SSM,Hart AR,Bueno-de-

    更新日期:2016-10-01 00:00:00

  • Protective effect of morin on dimethylnitrosamine-induced hepatic fibrosis in rats.

    abstract::Morin, a plant-derived flavonoid, has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the protective effect of morin on hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Oral administration of morin remarkably prevented weight loss in the body and liver ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0404-x

    authors: Lee HS,Jung KH,Park IS,Kwon SW,Lee DH,Hong SS

    更新日期:2009-04-01 00:00:00

  • Minidose aspirin and gastrointestinal bleeding--a retrospective, case-control study in hospitalized patients.

    abstract::Low or minimal doses of aspirin are widely used for prevention of cardiovascular diseases. Aspirin is known to produce severe adverse gastrointestinal effects, such as bleeding and perforation. Less is known about the risk associated with minidose aspirin. Our aim was to assess the possible association of upper gastro...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-2906-0

    authors: Sapoznikov B,Vilkin A,Hershkovici M,Fishman M,Eliakim R,Niv Y

    更新日期:2005-09-01 00:00:00

  • Tiotidine, a new H2-receptor antagonist, is a potent inhibitor of nocturnal acid secretion in duodenal ulcer patients.

    abstract::The efficacy of tiotidine, a new H2-receptor antagonist, in reducing nocturnal acid secretion of duodenal ulcer patients (N = 12, ages 21-60 years) was investigated. Different doses of tiotidine, 25, 50, 100, and 150 mg or placebo, were given as a single oral dose and acid secretion collected overnight. Tiotidine prod...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01313586

    authors: Valenzuela JE,Strecker RB,Douglas AP

    更新日期:1981-05-01 00:00:00

  • Gastroparesis and Severity of Delayed Gastric Emptying: Comparison of Patient Characteristics, Treatments and Medication Adverse Events.

    abstract:BACKGROUND:Gastroparesis is a heterogeneous disorder. Patient characteristics and treatment responsiveness may differ based on the extent of delay in gastric emptying. AIMS:Characterize gastroparesis patients based on the degree of delay in gastric emptying, and assess the relationship of patient demographics, symptom...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06258-7

    authors: Navas CM,Wadas ED,Zbib NH,Crowell MD,Lacy BE

    更新日期:2020-04-18 00:00:00

  • Enteral access by double-balloon enteroscopy: an alternative method of direct percutaneous endoscopic jejunostomy placement.

    abstract:BACKGROUND:Although direct percutaneous endoscopic jejunal feeding tube placement is an increasingly accepted method of providing small-bowel access for long-term enteral nutrition, it is reliant on push enteroscopy and remains a technically challenging procedure with significant failure rates. Double-balloon enterosco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1306-2

    authors: Despott EJ,Gabe S,Tripoli E,Konieczko K,Fraser C

    更新日期:2011-02-01 00:00:00

  • Adoption of Multi-society Guidelines Facilitates Value-Based Reduction in Screening and Surveillance Colonoscopy Volume During COVID-19 Pandemic.

    abstract:BACKGROUND:COVID-19 has caused a backlog of endoscopic procedures; colonoscopy must now be prioritized to those who would benefit most. We determined the proportion of screening and surveillance colonoscopies appropriate for rescheduling to a future year through strict adoption of US Multi-Society Task Force (USMSTF) g...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06539-1

    authors: Xiao AH,Chang SY,Stevoff CG,Komanduri S,Pandolfino JE,Keswani RN

    更新日期:2020-08-16 00:00:00