Abstract:
:Continuous noninvasive measurement of local blood flow at one or more chosen sites will be useful during experiments on the liver, during liver surgery, or after hepatic transplantation. We have compared a Clark-type flow-dependent oxygen electrode having a 3-mm-diameter cathode applied to the surface of rabbit liver to an electromagnetic flowmeter (EMF) on the portal vein. Reduction in portal flow (ranging from 4 to 100% and maintained over 2 min), correlated with reduction in electrode output (r = 0.944, P less than 0.001). Electrode output was independent of systemic arterial PO2 (ranging from 85 to 340 mm Hg) (P greater than 0.99) and thus of oxygen in inspired gases. These results indicate that this electrode gives a continuous indication of portal venous inflow when hepatic central inflow is undisturbed and may thus prove to be a useful tool in the clinical assessment of liver perfusion.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Piasecki C,Seifalian AMdoi
10.1007/BF01537421subject
Has Abstractpub_date
1990-03-01 00:00:00pages
399-405issue
3eissn
0163-2116issn
1573-2568journal_volume
35pub_type
杂志文章abstract::Recombinant fibroblast growth factors (FGFs) maintain the integrity of the gut epithelium and reduce mucosal injury in experimental inflammatory bowel disease (IBD). Chemically synthesized FGF mimetics could potentially extend the utility of FGFs by tailoring them for optimal bioactivity and oral administration, for e...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9641-z
更新日期:2007-09-01 00:00:00
abstract::We investigated whether S-adenosyl-L-methionine (SAMe) influences the inhibitory effect of ethanol on bile secretion and ethanol hepatotoxicity in the isolated perfused rat liver. SAMe (25 mg/kg intramuscularly three times a day) was administered for three days consecutively. Liver was then isolated and perfused with ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02285216
更新日期:1995-07-01 00:00:00
abstract:UNLABELLED:The lactulose breath test (LBT) and gastroenterocolonic scintigraphy (GECS) can both be used to measure orocecal transit time (OCTT). The aims of this study were (1) to measure OCTT by LBT and GECS and (2) to determine whether lactulose alters orocecal transit. METHODS:Eight normal subjects underwent simult...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1023/a:1018864400566
更新日期:1997-01-01 00:00:00
abstract::The use of total parenteral nutrition and enteral nutrition in inflammatory bowel disease has become commonplace. Except for well-documented improvements in nutritional parameters, the efficacy of these treatments for primary therapy or for complications remains largely unproven. ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,评审
doi:10.1007/BF01312471
更新日期:1987-12-01 00:00:00
abstract::The hepatic stimulatory substance (HSS) extracted from weanling rat livers was purified 381,000-fold using chromatographic techniques including nondissociating polyacrylamide gel electrophoresis (nondenaturing PAGE). The activity of this highly purified HSS, named Acr-F4, was assessed in two in vivo models. In 40% hep...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297037
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) is the number one cause of liver disease in the United States. The prevalence rates in African Americans (AA), while significantly lower than other ethnic groups with similar known risk factors, have been quoted as high as 24 %. We aim to determine if the pre...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2652-7
更新日期:2013-08-01 00:00:00
abstract::Consumption of high-fiber diets has been recommended prior to fecal blood testing to increase bleeding from polyps, cancer, and other lesions associated with mucosal erosion in the gastrointestinal tract. The effect of a high-fiber diet on fecal hemoglobin loss was examined in 17 healthy subjects during two dietary pe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297143
更新日期:1991-07-01 00:00:00
abstract::Inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer (CRC). The risk of CRC begins to increase 8 or 10 years after the diagnosis of IBD. This type of cancer is called colitis-associated CRC (CA-CRC). The molecular pathogenesis of inflammatory epithelium might play a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3646-4
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:A significant proportion of patients with Crohn's disease (CD) lose response to antibodies directed against tumor necrosis factor α (TNF). Prior TNF-antagonist failure is associated with lower rates of response to subsequent TNF-antagonist therapy. In patients failing two anti-TNF agents, a choice exists b...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1896-3
更新日期:2012-02-01 00:00:00
abstract::All cases of hepatolithiasis showed features of chronic proliferative cholangitis, and it has been speculated that the atypical glandular proliferation might be a precursor to overt cholangiocarcinoma. Proliferative cell nuclear antigen (PCNA) is a nuclear protein synthesized in the G1/S phase of the cell cycle and th...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026604704029
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Split dose bowel preparations (SDP) have superior outcomes for colonoscopy as compared to evening before regimens. However, the association of the actual volume of the SDP to colonoscopy outcome measures has not been well studied. AIMS:Compare adenoma detection rate (ADR), sessile serrated polyp detection r...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5102-8
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Individuals with inflammatory bowel disease (IBD) are at increased risk of developing colorectal cancer (CRC) compared with the general population. Previous studies show this risk is strongly associated with dysplasia, extent of disease, duration of disease, and degree of inflammation, while chemoprevention ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0942-x
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) pathophysiology has not been fully understood. Abnormalities of serine proteases have been identified in IBS patients. In addition, protease-activated receptors (PAR) activation interferes with several components of the pathogenesis of IBS, so, evaluating the PAR expression in ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1827-3
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND AIM:Diabetes is the main cause of gastroparesis accompanying decreased neuronal nitric oxide synthase (nNOS) in myenteric ganglia of the stomach. Decreased nNOS expression in the stomach also results from defects in apolipoprotein E (ApoE), which is secreted by astrocytes and has neuroprotective effects ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4820-7
更新日期:2017-12-01 00:00:00
abstract::Gastritis, an inflammatory state in gastric mucosa, can be induced experimentally in various ways. The present study considered the iodoacetamide model (Iodo). Omega-3 fatty acids (fish oil), black seed oil, and curcuminoids (natural products) in addition to omeprazole (synthetic proton-pump inhibitor) were tested. Su...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0246-6
更新日期:2008-07-01 00:00:00
abstract::This study aimed at establishment of adequate evaluation of intestinal viability before release of the strangulated intestine by measuring electrical properties. In rats a 20-cm segment of the distal ileum and mesentery was strangulated. The intestine was strangulated for 0, 2, 15, 45, 90, and 120 min. The conductance...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/b:ddas.0000026310.71607.4c
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. METHODS:We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3102-x
更新日期:2014-08-01 00:00:00
abstract::One hundred nineteen children, either French or from the Ivory Coast, aged 1-8 years, were submitted to pancreatic function testing by duodenal aspiration. Trypsin, chymotrypsin, lipase, phospholipase, amylase, volume, bicarbonate, chloride, and calcium were estimated before and after an intravenous injection of 1 CU ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01320311
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:There is increased awareness about risks and benefits of using domperidone to treat gastroparesis. AIM:To describe the outcome of treating patients with refractory gastroparesis symptoms with domperidone. METHODS:Domperidone 10 mg QID or TID was prescribed to patients with refractory gastroparesis symptoms...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4272-5
更新日期:2016-12-01 00:00:00
abstract::Colorectal cancer results in significant morbidity and mortality in the United States. Screening is a critical component of cancer prevention. However, research has suggested that physicians may inconsistently adhere to surveillance guidelines. Since residency training can significantly impact upon future practice pat...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018837603989
更新日期:1997-06-01 00:00:00
abstract::Bleeding from esophagogastric varices is a potentially deadly complication in patients with hepatosplenic schistosomiasis. The aim of this study is to establish indicators of variceal bleeding. We studied 40 patients with compensated hepatosplenic schistosomiasis and varices, analyzing four endoscopic (variceal size, ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005501930808
更新日期:2000-05-01 00:00:00
abstract::Among 56 cases who presented to Kanto-Teishin Hospital complaining of bloody diarrhea or considerable hematochezia of acute onset, 8 cases (14.3%) were considered due to colitis associated with oral ampicillin therapy. The bloody diarrhea, often with abdominal cramps, began 2-7 days after starting the treatment. The d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01311944
更新日期:1979-12-01 00:00:00
abstract::The purpose of this study was to investigate the potential of a computerized auscultation method for providing an objective, quantitative measure characteristic of irritable bowel syndrome. Bowel sounds from irritable bowel patients and normal controls were digitized using an electronic stethoscope. Computerized analy...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1023/a:1018859110022
更新日期:1999-09-01 00:00:00
abstract::A 68-year-old man developed hepatic injury with no hypersensitivity reaction after three years of hydralazine therapy. The liver injury histologically showed centrilobular zonal necrosis. Clinical, biochemical, and histological recovery followed discontinuation of the drug. Challenge tests and serial liver biopsies re...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01338533
更新日期:1980-11-01 00:00:00
abstract:INTRODUCTION:The C-31G polymorphism in the survivin promoter could de-repress the cell-cycle-dependent transcription of the human survivin gene, resulting in overexpression of survivin. This survivin mutation has only been studied on cervical carcinoma. However, no study has ever been conducted to evaluate the effect o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0441-5
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Computed tomography (CT) and magnetic resonance (MR) enterography are now widely used to diagnose and monitor Crohn's disease. AIM:We sought to assess the use of enterography for management of inflammatory bowel disease (IBD) in our medical center. METHODS:We performed a retrospective review of all patient...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2964-7
更新日期:2014-04-01 00:00:00
abstract::To study the efficacy of standard blood tests of liver function (LFTs) and technetium-99m liver scan followed by laparoscopy in the diagnosis of solid malignant tumors of the liver, 100 consecutive patients were evaluated who had these tests because of clinical suspicion of liver neoplasm. Malignant liver tumors were ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01333702
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:The role of 5-aminosalicylic acid (5-ASA or mesalamine) in the prevention of colorectal cancer in ulcerative colitis (UC) patients was reported, but the effect on molecular targets in UC colon mucosa is unknown. AIM:This observational study evaluates gene expression levels of 5-ASA targets using serial colo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5378-8
更新日期:2019-03-01 00:00:00
abstract::A pathogenic role of nitric oxide has been suggested in acute and chronic intestinal inflammation. We took the opportunity offered by studies in patients with excluded colon, which represents a model of chronic intestinal inflammation with no exogenous nitrite or nitrate supply, to evaluate the quantity and the qualit...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018885217154
更新日期:1997-12-01 00:00:00
abstract::The bile acids in brown pigment stones and gallbladder bile were fractionated into free acids, glycine and taurine conjugates, and sulfates using diethylaminohydroxypropyl Sephadex LH-20 (DEAP-LH-20) column chromatography and were quantitated by gas chromatography. Twenty-eight cases of brown pigment stones were studi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01537218
更新日期:1990-01-01 00:00:00