The association between the survivin C-31G polymorphism and gastric cancer risk in a Chinese population.

Abstract:

INTRODUCTION:The C-31G polymorphism in the survivin promoter could de-repress the cell-cycle-dependent transcription of the human survivin gene, resulting in overexpression of survivin. This survivin mutation has only been studied on cervical carcinoma. However, no study has ever been conducted to evaluate the effect of the polymorphism on other cancers, including gastric cancer. METHODS:In this hospital-based, case-control study, we investigated the association between the survivin C-31G polymorphism and risk of gastric cancer in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocols. RESULTS:No statistically significant association was observed between gastric cancer risk and the variant genotype (GG + GC). However, the variant genotype (GG + GC) was either associated with risk of distal gastric cancer (odds ratios=0.50, 95% confidence interval=0.30-0.83) or with risk of well-differentiated tumor (odds ratios=0.46, 95% confidence interval=0.22-0.97). CONCLUSION:Our results demonstrate that the survivin C-31G polymorphism may be involved in distal gastric carcinogenesis and tumor differentiation in a Chinese population.

journal_name

Dig Dis Sci

authors

Yang L,Zhu H,Zhou B,Gu H,Yan H,Tang N,Dong H,Sun Q,Cong R,Chen G,Wang B

doi

10.1007/s10620-008-0441-5

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

1021-8

issue

5

eissn

0163-2116

issn

1573-2568

journal_volume

54

pub_type

杂志文章
  • Role of osteopontin in calcification in autoimmune pancreatitis.

    abstract:OBJECTIVES:The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression. METHODS:Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specime...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0418-4

    authors: Takada H,Nakazawa T,Ohara H,Ando T,Hayashi K,Naito I,Okumura F,Tanaka H,Yamada T,Takahashi S,Joh T

    更新日期:2009-04-01 00:00:00

  • Gallbladder mucosal protein secretion during development of experimental cholecystitis.

    abstract::The development of experimental cholecystitis produced by lysophosphatidylcholine is associated with reversal of the normal absorptive characteristics of gallbladder mucosa, resulting in the intraluminal accumulation of water, glycoprotein, and protein. The purpose of the present study was to attempt to ascertain if t...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02064215

    authors: Kaminski DL,Deshpande YG,Li A,Dysart F,Nag M

    更新日期:1995-05-01 00:00:00

  • Zinc and the liver: an active interaction.

    abstract::Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-006-9462-0

    authors: Stamoulis I,Kouraklis G,Theocharis S

    更新日期:2007-07-01 00:00:00

  • Measurement of bile acid half-life using [75Se]HCAT in health and intestinal diseases. Comparison with [75Se]HCAT abdominal retention methods.

    abstract::The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predic...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308176

    authors: Ferraris R,Galatola G,Barlotta A,Pellerito R,Fracchia M,Cottino F,de la Pierre M

    更新日期:1992-02-01 00:00:00

  • Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis.

    abstract::We postulated that coadministration of cholylsarcosine with ursodeoxycholic acid might provide additional benefit to primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid. Our aim was to test the tolerability and the effect of adjuvant cholylsarcosine on liver tests and plasma choleste...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018868126743

    authors: Ricci P,Hofmann AF,Hagey LR,Jorgensen RA,Rolland Dickson E,Lindor KD

    更新日期:1998-06-01 00:00:00

  • Increased Prevalence of Obesity and Metabolic Syndrome in Patients with Alcoholic Fatty Liver Disease.

    abstract:BACKGROUND AND AIMS:Obesity and diabetes are risk factors for advanced alcoholic liver disease, and both are components of the metabolic syndrome. We aimed to assess the prevalence of metabolic syndrome and its components in a contemporary US cohort of adults with alcoholic liver disease and compare it to a historic co...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06056-1

    authors: Singh A,Amin H,Garg R,Gupta M,Lopez R,Alkhouri N,MCCullough A

    更新日期:2020-11-01 00:00:00

  • Autophagy Genes of Host Responds to Disruption of Gut Microbial Community by Antibiotics.

    abstract:BACKGROUND:Defective autophagic machinery, such as that in Crohn's disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities. However, whether or not host autophagy responds to changes in the resident gut microbial community is not known. Here, we investiga...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-017-4589-8

    authors: Singh SB,Wilson M,Ritz N,Lin HC

    更新日期:2017-06-01 00:00:00

  • Octreotide uptake in intracranial metastasis of pancreatic ductal adenocarcinoma origin in a patient with a prolonged clinical course.

    abstract::We describe a case with prolonged survival of 2 years in a female patient with pancreatic ductal adenocarcinoma who, at diagnosis, already had liver spread and eventually succumbed to brain metastases which scanned positive with [(111)In-DTPA] octreotide scintiscan (OctreoScan). Subsequently, the patient underwent a c...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-008-0531-4

    authors: Marepaily R,Micheals D,Sloan A,Hatfield J,Adsay V,Joyrich R,Ullah N,Tobi M

    更新日期:2009-01-01 00:00:00

  • Transenteral bowel preparation for colonoscopy is more comfortable than the traditional method with no inferiority in efficacy.

    abstract:BACKGROUND:Transenteral (TE) administration of a bowel cleanser prior to colonoscopy avoids the discomfort associated with drinking a large volume of unpalatable cleanser. AIM:To explore patient comfort, preference for future colonoscopy, the efficacy and adverse events associated with TE bowel preparation. METHODS:B...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10620-014-3344-7

    authors: Jung SW,Jung DH,Shin YC,Moh IH,Yoo H,Jang SI,Shin SR,Kim JB,Park SH,Lee MS

    更新日期:2015-01-01 00:00:00

  • Psychological comparison of patients with nutcracker esophagus and irritable bowel syndrome.

    abstract:UNLABELLED:Recent evidence suggests that psychological factors may affect esophageal as well as intestinal motility. To study this further, we compared the psychological profiles of 20 irritable bowel patients and 20 patients with recurrent noncardiac chest pain associated with high-amplitude peristaltic contractions i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01300697

    authors: Richter JE,Obrecht WF,Bradley LA,Young LD,Anderson KO

    更新日期:1986-02-01 00:00:00

  • Recalibrating the Child-Turcotte-Pugh Score to Improve Prediction of Transplant-Free Survival in Patients with Cirrhosis.

    abstract:BACKGROUND:The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE:The objective of this study was to identify evidence-based cutpoints for the CTP laboratory...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-016-4239-6

    authors: Kaplan DE,Dai F,Skanderson M,Aytaman A,Baytarian M,D'Addeo K,Fox R,Hunt K,Knott A,Mehta R,Pedrosa M,Pocha C,Valderrama A,Taddei T,VOCAL Study Group.

    更新日期:2016-11-01 00:00:00

  • Early increase of bone resorption in patients with liver cirrhosis secondary to viral hepatitis.

    abstract::Bone loss is an established complication of cholestatic liver cirrhosis, while little is known about bone mass and metabolism in noncholestatic liver cirrhosis. The aim of the present study is, therefore, to evaluate bone mass and mineral metabolism in patients with liver cirrhosis secondary to viral hepatitis. Bone m...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005568406664

    authors: Corazza GR,Trevisani F,Di Stefano M,De Notariis S,Veneto G,Cecchetti L,Minguzzi L,Gasbarrini G,Bernardi M

    更新日期:2000-07-01 00:00:00

  • Short-term effects of bile diversion on postgastrectomy gastric histology.

    abstract::Twelve partially gastrectomized subjects who have consecutively undergone total biliary diversion for severe bilious vomiting were studied before and after operation in order to assess the effects of surgery on gastric histology and enterogastric reflux. Before and six months after operation, the following protocol wa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536682

    authors: Bechi P,Amorosi A,Mazzanti R,Buccarelli A,Pantalone D,Cortesini C

    更新日期:1988-10-01 00:00:00

  • Malignant lymphoma of the liver. Report of five cases and review of the literature.

    abstract::Primary hepatic lymphoma is a rare disease. We report five cases here and summarize clinical and pathologic features of our own and reported cases from Western countries and Japan. The total number of cases was 68. The age of patients ranged from 7 to 87 years (median 55) with a male-to-female ratio of 3.1:1. Chronic ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/BF01300294

    authors: Ohsawa M,Aozasa K,Horiuchi K,Kataoka M,Hida J,Shimada H,Oka K,Wakata Y

    更新日期:1992-07-01 00:00:00

  • Electrogastrography in patients with gastroparesis and effect of long-term cisapride.

    abstract::Abnormalities in the gastric pacemaker potentials occur in patients with impaired gastric emptying. It is unclear if treatment effects the underlying rhythm or if normalization of dysrhythmias is important. We examined the effect of cisapride using surface electrogastrograms and radionuclide gastric emptying studies o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308614

    authors: Rothstein RD,Alavi A,Reynolds JC

    更新日期:1993-08-01 00:00:00

  • IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen.

    abstract::We have previously shown that methane on lactulose breath test (LBT) is highly associated with constipation in IBS and that methane gas itself slows small bowel transit in dogs. Previous studies suggest that serotonin may have a role in the control of transit in IBS. In this study, we aim to evaluate the role of serot...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/b:ddas.0000011607.24171.c0

    authors: Pimentel M,Kong Y,Park S

    更新日期:2004-01-01 00:00:00

  • Clinical patterns, natural history, and progression of ulcerative colitis. A long-term follow-up of 1116 patients.

    abstract::We studied the natural history of ulcerative colitis (UC) by following 1116 patients in whom UC had been diagnosed or confirmed at The Cleveland Clinic Foundation between 1960 and 1983. Data before 1973 were obtained retrospectively. Criteria for inclusion in the study were: a diagnosis of UC confirmed by clinical, ra...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01295733

    authors: Farmer RG,Easley KA,Rankin GB

    更新日期:1993-06-01 00:00:00

  • Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle.

    abstract::Glutamine synthetase is responsible for the ATP-dependent amidation of glutamate to glutamine. In liver the enzyme is highly localized in perivenous hepatocytes; in brain the enzyme is localized in astrocytes. Portacaval anastomosis resulted in liver atrophy, hyperammonemia, and up to 90% loss of glutamine synthetase ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01300297

    authors: Girard G,Butterworth RF

    更新日期:1992-07-01 00:00:00

  • Peritoneal sarcoidosis. An unrecognized cause of sclerosing peritonitis.

    abstract::In a Caucasian woman with a history of ocular and pulmonary sarcoidosis, the occurrence of sclerosing peritonitis with exudative ascites but without any of the well-known causes of this syndrome prompts us to consider that sclerosing peritonitis is a manifestation of sarcoidosis. The dramatic improvement that occurred...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01299875

    authors: Ngô Y,Messing B,Marteau P,Nouël O,Pasquiou A,Lavergne A,Rambaud JC

    更新日期:1992-11-01 00:00:00

  • Cardiac Metaplasia: Follow, Treat, or Ignore?

    abstract::Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-018-5063-y

    authors: Spechler SJ

    更新日期:2018-08-01 00:00:00

  • Serum levels of soluble immune factors and pathogenesis of chronic hepatitis C, and their relation to therapeutic response to interferon-alpha.

    abstract::To test the role of immune reactivity in the pathogenesis of hepatitis C, serum soluble immune factors were measured in a cohort of 57 patients with chronic hepatitis C, and in 20 healthy subjects. Levels of interleukin-1 beta, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and interleu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02087671

    authors: Quiroga JA,Martin J,Pardo M,Carreño V

    更新日期:1994-11-01 00:00:00

  • Enhanced absorption of macromolecules. A secondary factor in Crohn's disease.

    abstract::We explored the function of the intestine's mucosal barrier to foreign antigen entry in Crohn's disease. Macroscopically and microscopically uninvolved areas of the small intestines of patients with Crohn's disease were examined. We studied 27 endoscopic biopsy samples from 17 patients with Crohn's disease and 14 samp...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02088568

    authors: Malin M,Isolauri E,Pikkarainen P,Karikoski R,Isolauri J

    更新日期:1996-07-01 00:00:00

  • Measurement of small intestinal permeability markers, lactulose, and mannitol in serum: results in celiac disease.

    abstract::To date, tests of small intestinal passive permeability have involved the ingestion of test molecules whose permeation is assessed indirectly by measuring their urinary recovery. Excretion ratios of marker molecules (eg, lactulose-to-mannitol excretion ratio, LMER) are useful clinically. Measurement of permeability ma...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026679123148

    authors: Cox MA,Lewis KO,Cooper BT

    更新日期:1999-02-01 00:00:00

  • Portal hemodynamics by duplex Doppler sonography in different grades of cirrhosis.

    abstract::Not much is known about the relationship between portal hemodynamics and the grades of cirrhosis. Using pulsed Doppler ultrasonography, we studied portal vein diameter, portal flow velocity, and portal blood flow rate in 37 patients with liver cirrhosis (11 Child's A, 13 Child's B, and 13 Child's C) and 10 healthy con...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018814624307

    authors: Chawla Y,Santa N,Dhiman RK,Dilawari JB

    更新日期:1998-02-01 00:00:00

  • Intraluminal release of serotonin, substance P, and gastrin in the canine small intestine.

    abstract::Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297056

    authors: Ferrara A,Zinner MJ,Jaffe BM

    更新日期:1987-03-01 00:00:00

  • Effects of ursodeoxycholate and other bile salts on levels of rat intestinal alkaline sphingomyelinase: a potential implication in tumorigenesis.

    abstract::Previous studies showed that bile salts had a promoting effect on colon cancer development and this effect was inhibited by ursodeoxycholate (UDC). We recently found that both human colorectal adenomas and carcinomas were associated with a specific decrease in alkaline sphingomyelinase activity. In this work, we compa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018807600683

    authors: Duan RD,Cheng Y,Tauschel HD,Nilsson A

    更新日期:1998-01-01 00:00:00

  • Influences of the Gut Microbiota on DNA Methylation and Histone Modification.

    abstract::The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian gastrointestinal tract that can impact physiologic and pathologic processes. However, our understanding of the underlying mechanism for the dynamic interaction between host and gut microbiota is still in its infancy. The highly evolved ep...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-017-4538-6

    authors: Ye J,Wu W,Li Y,Li L

    更新日期:2017-05-01 00:00:00

  • Children with cystic fibrosis have prolonged chemical clearance of acid reflux compared to symptomatic children without cystic fibrosis.

    abstract:OBJECTIVES:Few studies compare gastroesophageal reflux (GER) parameters of cystic fibrosis (CF) children and symptomatic non-CF children. We aimed to compare the impedance-pH (IMP-pH) parameters for these two groups and to test the hypothesis that prolonged acid exposure in CF patients is due to delayed chemical cleara...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-2950-0

    authors: Woodley FW,Machado RS,Hayes D Jr,Di Lorenzo C,Kaul A,Skaggs B,McCoy K,Patel A,Mousa H

    更新日期:2014-03-01 00:00:00

  • Hemodynamic effects of rapid injection into the canine superior mesenteric artery.

    abstract::We explored the hemodynamic effects of rapid injection of 0.9% saline and arterial blood into the canine superior mesenteric artery in anesthetized animals. Mesenteric artery blood flow and pressure were measured in the vessel distal to the site of injection. Injection rates were at or below the rate of blood flow in ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01309495

    authors: Jacobson ED,Eldon C,Fondacaro JD

    更新日期:1981-10-01 00:00:00

  • More than Just a Hole in the Wall: Evolving Management and Treatment Paradigms of Suppurative Gastritis.

    abstract::Suppurative gastritis is an uncommon lesion and often an occult cause of upper abdominal pain without florid signs of a septic focus. There are two main phenotypic forms: (1) localized, also referred to as gastric abscess; and (2) diffuse, in which the differential diagnosis includes a more diverse range of benign and...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-020-06356-6

    authors: Coles M,Madray V,Cox K,Uy P,Sharma A

    更新日期:2020-08-01 00:00:00