Abstract:
INTRODUCTION:The C-31G polymorphism in the survivin promoter could de-repress the cell-cycle-dependent transcription of the human survivin gene, resulting in overexpression of survivin. This survivin mutation has only been studied on cervical carcinoma. However, no study has ever been conducted to evaluate the effect of the polymorphism on other cancers, including gastric cancer. METHODS:In this hospital-based, case-control study, we investigated the association between the survivin C-31G polymorphism and risk of gastric cancer in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocols. RESULTS:No statistically significant association was observed between gastric cancer risk and the variant genotype (GG + GC). However, the variant genotype (GG + GC) was either associated with risk of distal gastric cancer (odds ratios=0.50, 95% confidence interval=0.30-0.83) or with risk of well-differentiated tumor (odds ratios=0.46, 95% confidence interval=0.22-0.97). CONCLUSION:Our results demonstrate that the survivin C-31G polymorphism may be involved in distal gastric carcinogenesis and tumor differentiation in a Chinese population.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Yang L,Zhu H,Zhou B,Gu H,Yan H,Tang N,Dong H,Sun Q,Cong R,Chen G,Wang Bdoi
10.1007/s10620-008-0441-5subject
Has Abstractpub_date
2009-05-01 00:00:00pages
1021-8issue
5eissn
0163-2116issn
1573-2568journal_volume
54pub_type
杂志文章abstract:OBJECTIVES:The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression. METHODS:Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specime...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0418-4
更新日期:2009-04-01 00:00:00
abstract::The development of experimental cholecystitis produced by lysophosphatidylcholine is associated with reversal of the normal absorptive characteristics of gallbladder mucosa, resulting in the intraluminal accumulation of water, glycoprotein, and protein. The purpose of the present study was to attempt to ascertain if t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02064215
更新日期:1995-05-01 00:00:00
abstract::Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver f...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-006-9462-0
更新日期:2007-07-01 00:00:00
abstract::The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predic...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308176
更新日期:1992-02-01 00:00:00
abstract::We postulated that coadministration of cholylsarcosine with ursodeoxycholic acid might provide additional benefit to primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid. Our aim was to test the tolerability and the effect of adjuvant cholylsarcosine on liver tests and plasma choleste...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018868126743
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Obesity and diabetes are risk factors for advanced alcoholic liver disease, and both are components of the metabolic syndrome. We aimed to assess the prevalence of metabolic syndrome and its components in a contemporary US cohort of adults with alcoholic liver disease and compare it to a historic co...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06056-1
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Defective autophagic machinery, such as that in Crohn's disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities. However, whether or not host autophagy responds to changes in the resident gut microbial community is not known. Here, we investiga...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4589-8
更新日期:2017-06-01 00:00:00
abstract::We describe a case with prolonged survival of 2 years in a female patient with pancreatic ductal adenocarcinoma who, at diagnosis, already had liver spread and eventually succumbed to brain metastases which scanned positive with [(111)In-DTPA] octreotide scintiscan (OctreoScan). Subsequently, the patient underwent a c...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0531-4
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Transenteral (TE) administration of a bowel cleanser prior to colonoscopy avoids the discomfort associated with drinking a large volume of unpalatable cleanser. AIM:To explore patient comfort, preference for future colonoscopy, the efficacy and adverse events associated with TE bowel preparation. METHODS:B...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-014-3344-7
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:Recent evidence suggests that psychological factors may affect esophageal as well as intestinal motility. To study this further, we compared the psychological profiles of 20 irritable bowel patients and 20 patients with recurrent noncardiac chest pain associated with high-amplitude peristaltic contractions i...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01300697
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE:The objective of this study was to identify evidence-based cutpoints for the CTP laboratory...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4239-6
更新日期:2016-11-01 00:00:00
abstract::Bone loss is an established complication of cholestatic liver cirrhosis, while little is known about bone mass and metabolism in noncholestatic liver cirrhosis. The aim of the present study is, therefore, to evaluate bone mass and mineral metabolism in patients with liver cirrhosis secondary to viral hepatitis. Bone m...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005568406664
更新日期:2000-07-01 00:00:00
abstract::Twelve partially gastrectomized subjects who have consecutively undergone total biliary diversion for severe bilious vomiting were studied before and after operation in order to assess the effects of surgery on gastric histology and enterogastric reflux. Before and six months after operation, the following protocol wa...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536682
更新日期:1988-10-01 00:00:00
abstract::Primary hepatic lymphoma is a rare disease. We report five cases here and summarize clinical and pathologic features of our own and reported cases from Western countries and Japan. The total number of cases was 68. The age of patients ranged from 7 to 87 years (median 55) with a male-to-female ratio of 3.1:1. Chronic ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/BF01300294
更新日期:1992-07-01 00:00:00
abstract::Abnormalities in the gastric pacemaker potentials occur in patients with impaired gastric emptying. It is unclear if treatment effects the underlying rhythm or if normalization of dysrhythmias is important. We examined the effect of cisapride using surface electrogastrograms and radionuclide gastric emptying studies o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308614
更新日期:1993-08-01 00:00:00
abstract::We have previously shown that methane on lactulose breath test (LBT) is highly associated with constipation in IBS and that methane gas itself slows small bowel transit in dogs. Previous studies suggest that serotonin may have a role in the control of transit in IBS. In this study, we aim to evaluate the role of serot...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/b:ddas.0000011607.24171.c0
更新日期:2004-01-01 00:00:00
abstract::We studied the natural history of ulcerative colitis (UC) by following 1116 patients in whom UC had been diagnosed or confirmed at The Cleveland Clinic Foundation between 1960 and 1983. Data before 1973 were obtained retrospectively. Criteria for inclusion in the study were: a diagnosis of UC confirmed by clinical, ra...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295733
更新日期:1993-06-01 00:00:00
abstract::Glutamine synthetase is responsible for the ATP-dependent amidation of glutamate to glutamine. In liver the enzyme is highly localized in perivenous hepatocytes; in brain the enzyme is localized in astrocytes. Portacaval anastomosis resulted in liver atrophy, hyperammonemia, and up to 90% loss of glutamine synthetase ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01300297
更新日期:1992-07-01 00:00:00
abstract::In a Caucasian woman with a history of ocular and pulmonary sarcoidosis, the occurrence of sclerosing peritonitis with exudative ascites but without any of the well-known causes of this syndrome prompts us to consider that sclerosing peritonitis is a manifestation of sarcoidosis. The dramatic improvement that occurred...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01299875
更新日期:1992-11-01 00:00:00
abstract::Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-018-5063-y
更新日期:2018-08-01 00:00:00
abstract::To test the role of immune reactivity in the pathogenesis of hepatitis C, serum soluble immune factors were measured in a cohort of 57 patients with chronic hepatitis C, and in 20 healthy subjects. Levels of interleukin-1 beta, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and interleu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087671
更新日期:1994-11-01 00:00:00
abstract::We explored the function of the intestine's mucosal barrier to foreign antigen entry in Crohn's disease. Macroscopically and microscopically uninvolved areas of the small intestines of patients with Crohn's disease were examined. We studied 27 endoscopic biopsy samples from 17 patients with Crohn's disease and 14 samp...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02088568
更新日期:1996-07-01 00:00:00
abstract::To date, tests of small intestinal passive permeability have involved the ingestion of test molecules whose permeation is assessed indirectly by measuring their urinary recovery. Excretion ratios of marker molecules (eg, lactulose-to-mannitol excretion ratio, LMER) are useful clinically. Measurement of permeability ma...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026679123148
更新日期:1999-02-01 00:00:00
abstract::Not much is known about the relationship between portal hemodynamics and the grades of cirrhosis. Using pulsed Doppler ultrasonography, we studied portal vein diameter, portal flow velocity, and portal blood flow rate in 37 patients with liver cirrhosis (11 Child's A, 13 Child's B, and 13 Child's C) and 10 healthy con...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018814624307
更新日期:1998-02-01 00:00:00
abstract::Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297056
更新日期:1987-03-01 00:00:00
abstract::Previous studies showed that bile salts had a promoting effect on colon cancer development and this effect was inhibited by ursodeoxycholate (UDC). We recently found that both human colorectal adenomas and carcinomas were associated with a specific decrease in alkaline sphingomyelinase activity. In this work, we compa...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018807600683
更新日期:1998-01-01 00:00:00
abstract::The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian gastrointestinal tract that can impact physiologic and pathologic processes. However, our understanding of the underlying mechanism for the dynamic interaction between host and gut microbiota is still in its infancy. The highly evolved ep...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-017-4538-6
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:Few studies compare gastroesophageal reflux (GER) parameters of cystic fibrosis (CF) children and symptomatic non-CF children. We aimed to compare the impedance-pH (IMP-pH) parameters for these two groups and to test the hypothesis that prolonged acid exposure in CF patients is due to delayed chemical cleara...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2950-0
更新日期:2014-03-01 00:00:00
abstract::We explored the hemodynamic effects of rapid injection of 0.9% saline and arterial blood into the canine superior mesenteric artery in anesthetized animals. Mesenteric artery blood flow and pressure were measured in the vessel distal to the site of injection. Injection rates were at or below the rate of blood flow in ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01309495
更新日期:1981-10-01 00:00:00
abstract::Suppurative gastritis is an uncommon lesion and often an occult cause of upper abdominal pain without florid signs of a septic focus. There are two main phenotypic forms: (1) localized, also referred to as gastric abscess; and (2) diffuse, in which the differential diagnosis includes a more diverse range of benign and...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-020-06356-6
更新日期:2020-08-01 00:00:00