Electrogastrography in patients with gastroparesis and effect of long-term cisapride.

Abstract:

:Abnormalities in the gastric pacemaker potentials occur in patients with impaired gastric emptying. It is unclear if treatment effects the underlying rhythm or if normalization of dysrhythmias is important. We examined the effect of cisapride using surface electrogastrograms and radionuclide gastric emptying studies of patients with idiopathic and diabetic gastroparesis. Twelve of 14 patients had abnormal baseline electrogastrograms. After six months of cisapride, four patients had normalization of their electrical activity and six had improvement. Patients with idiopathic gastroparesis had an increase in gastric emptying at 120 min from 48.9 +/- 3.8% (baseline) to 70.9 +/- 6.0% (six months), P = 0.009. Patients with diabetes mellitus had a similar improvement. Patients who had normalization of the electrogastrogram had a greater gastric emptying rate than patients with continued dysrhythmias. Thus, dysrhythmias are important in the etiology for gastroparesis, but other factors need to be examined.

journal_name

Dig Dis Sci

authors

Rothstein RD,Alavi A,Reynolds JC

doi

10.1007/BF01308614

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

1518-24

issue

8

eissn

0163-2116

issn

1573-2568

journal_volume

38

pub_type

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