Abstract:
OBJECTIVES:The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression. METHODS:Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specimens of 42 patients. Pancreatic tissues from male Wistar Bonn/Kobori rats were also used as an animal autoimmune pancreatitis model. RESULTS:The incidences of osteopontin expression in centroacinar cells in chronic pancreatitis with calcification and in autoimmune pancreatitis were significantly greater than that in normal pancreas (P < 0.05). Some cases of chronic pancreatitis and autoimmune pancreatitis expressed CD44 in centroacinar cells and ductal cells. In male Wistar Bonn/Kobori rats, the inflammatory area and percentage of osteopontin-CD44-positive cells increased with advancing age (P < 0.01 or 0.05). CONCLUSIONS:These results suggest that autoimmune pancreatitis has the potential for pancreatic calcification over a long-term clinical course.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Takada H,Nakazawa T,Ohara H,Ando T,Hayashi K,Naito I,Okumura F,Tanaka H,Yamada T,Takahashi S,Joh Tdoi
10.1007/s10620-008-0418-4subject
Has Abstractpub_date
2009-04-01 00:00:00pages
793-801issue
4eissn
0163-2116issn
1573-2568journal_volume
54pub_type
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