Intestinal microbiota transplantation, a simple and effective treatment for severe and refractory Clostridium difficile infection.

Abstract:

BACKGROUND:Restoring normal fecal flora through intestinal microbiota transplantation (IMT) was successful in curing recurrent Clostridium difficile infection (CDI). However, only a few cases have been reported of IMT being utilized for the treatment of severe or fulminant CDI. AIM:Is IMT a simple and effective treatment for severe and recurrent CDI? METHODS:In this retrospective study, we report 14 patients with severe CDI refractory to conventional medical therapy, who underwent IMT. Fresh donor stool specimen was manually homogenized with warm tap water, filtered through gauze and then instilled through nasogastric tube (NGT). The primary outcome was clinical cure, defined as less than 3 loose bowel movements a day on day 7 after IMT and no need for further CDI therapy. The secondary outcomes were recurrence of CDI within 100 days of IMT and 30-day mortality after IMT. Descriptive statistics were done. RESULTS:Fourteen patients with severe and refractory CDI received IMT. Mean age was 73.4 ± 11.9 years (range 52-92). IMT was given via NGT in 13 of the 14 patients. Eleven patients (79 %) achieved cure after IMT. No recurrence was seen in the patients who responded to IMT and were alive within the 100 day follow-up period. IMT was well tolerated. The 30-day all-cause mortality was 29 %, all 4 patients died as a result of their underlying cancer. No patients died as a result of CDI or IMT. CONCLUSIONS:IMT performed at the bedside via NGT is effective and safe for the treatment of severe and refractory CDI, and prevents recurrence.

journal_name

Dig Dis Sci

authors

Zainah H,Hassan M,Shiekh-Sroujieh L,Hassan S,Alangaden G,Ramesh M

doi

10.1007/s10620-014-3296-y

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

181-5

issue

1

eissn

0163-2116

issn

1573-2568

journal_volume

60

pub_type

杂志文章
  • Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects.

    abstract::There is a growing body of experimental and clinical evidence to suggest that oral or rectal administration of 5-ASA or 5-ASA conjugates is associated with significant adverse side effects including pancreatitis, hepatitis, and renal toxicity. The objective of this study was to assess the ability of 5-ASA to interact ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296008

    authors: Grisham MB,Ware K,Marshall S,Yamada T,Sandhu IS

    更新日期:1992-09-01 00:00:00

  • Nicotine and smoking do not decrease basal gastric mucosal blood flow in anesthetized rats.

    abstract::The literature regarding the effect of nicotine and cigarette smoke on gastric blood flow is conflicting. The hydrogen gas clearance technique was used to measure the effects of nicotine and cigarette smoke on basal gastric mucosal blood flow in anesthetized rats. Blood flow was measured before, during, and after trea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01320320

    authors: Robert ME,Leung FW,Guth PH

    更新日期:1986-05-01 00:00:00

  • Hepatitis A, hepatitis B, and combination hepatitis vaccines for immunoprophylaxis: an update.

    abstract::Since the publication of the last extensive review of hepatitis vaccines, use of inactivated hepatitis A vaccines has been extended to high-risk regions of the United States and specific patient groups, such as those with chronic liver disease, and use of the recombinant hepatitis B vaccines has been recommended for o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1023/a:1015397807278

    authors: Koff RS

    更新日期:2002-06-01 00:00:00

  • Immunolocalization and expression of kallistatin and tissue kallikrein in human inflammatory bowel disease.

    abstract::The distribution of tissue kallikrein (TK) and its plasma inhibitor, kallistatin in plasma and intestinal tissue, was studied in patients with active ulcerative colitis (UC) and Crohn's disease (CD). TK was localized to goblet cells and kallistatin to epithelial cells of normal human intestine. Both proteins are visua...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1022569623350

    authors: Stadnicki A,Mazurek U,Gonciarz M,Plewka D,Nowaczyk G,Orchel J,Pastucha E,Plewka A,Wilczok T,Colman RW

    更新日期:2003-03-01 00:00:00

  • Two-color immunofluorescence and flow cytometric analysis of lamina propria lymphocyte subsets in ulcerative colitis and Crohn's disease.

    abstract::By using two-color immunofluorescence with fluorescein isothiocyanate (FITC) and phycoerythrin (PE)-labelled monoclonal antibodies and multiparameter flow cytometry, we investigated lamina propria lymphocyte subsets of patients with ulcerative colitis (UC) and Crohn's disease (CD). Leu-3/Leu-2 (CD4/CD8) ratio of lamin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296815

    authors: Senju M,Wu KC,Mahida YR,Jewell DP

    更新日期:1991-10-01 00:00:00

  • Pathophysiology, Aetiology and Treatment of Gastroparesis.

    abstract::Gastroparesis is characterized by delayed gastric emptying, with symptoms such as nausea, vomiting and abdominal pain, in the absence of mechanical obstruction. In most cases, it is idiopathic although diabetes mellitus is another leading cause. The physiology of gastric emptying is a complex process which is influenc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-020-06287-2

    authors: Sullivan A,Temperley L,Ruban A

    更新日期:2020-06-01 00:00:00

  • Mechanical strain stress suppresses expression of HSP70 and wound restoration in gastric mucosal cells.

    abstract::The major heat shock protein, HSP70, is known to be involved in cytoprotection against environmental stresses mediated by their function as a "molecular chaperone." However, the influence of HSP70 on gastric mucosal healing under physical stimulation or stress is not completely understood. Rat gastric mucosal cells (R...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9795-3

    authors: Odashima M,Otaka M,Matsuhashi T,Jin M,Horikawa Y,Ohba R,Itoh H,Watanabe S

    更新日期:2007-11-01 00:00:00

  • Evaluation of elevation of the head of the bed, bethanechol, and antacid form tablets on gastroesophageal reflux.

    abstract::To ascertain how elevation of the head of the bed, bethanechol, and antacid foam tablets affect gastroesophageal reflux, we used prolonged intraesophageal pH monitoring in 55 symptomatic patients. Acid exposure was separated into reflux frequency and esophageal acid clearance time and recorded during the day in the up...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01316854

    authors: Johnson LF,DeMeester TR

    更新日期:1981-08-01 00:00:00

  • Risk of Early Colorectal Cancers Needs to Be Considered in Inflammatory Bowel Disease Care.

    abstract:BACKGROUND:Current guidelines recommend starting colorectal cancer (CRC) surveillance 8-10 years after inflammatory bowel disease (IBD) onset. Recent studies report that the incidence of CRC within 8-10 years of IBD onset (i.e., early CRC) ranges from 12 to 42%. AIMS:To describe the current prevalence of early CRC in ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-05554-1

    authors: Cohen-Mekelburg S,Schneider Y,Gold S,Ghosh G,Rosenblatt R,Hajifathalian K,Scherl E,Schnoll-Sussman F,Katz P,Steinlauf A

    更新日期:2019-08-01 00:00:00

  • Gut bacterial translocation contributes to microinflammation in experimental uremia.

    abstract:BACKGROUND:Microinflammation frequently develops in chronic uremia with pathological intestinal changes. However, the relationship between gut bacterial translocation and microinflammation in uremia has not been widely investigated. AIM:This study aimed to investigate whether gut microbiome dysbiosis and translocation...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2242-0

    authors: Wang F,Zhang P,Jiang H,Cheng S

    更新日期:2012-11-01 00:00:00

  • Toxocariasis masquerading as liver and lung metastatic nodules in patents with gastrointestinal cancer: clinicopathologic study of five cases.

    abstract:BACKGROUND:There are sporadic reports in the literature in which radiologic liver and lung lesions found incidentally during follow-up metastatic surveillance were shown to be caused by toxocariasis. AIMS:The objective of the work discussed in this report was to identify common clinical and histopathological features ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1833-5

    authors: Park S,Kim YS,Kim YJ,Kyung SY,Park JW,Jeong SH,Lee SP

    更新日期:2012-01-01 00:00:00

  • Intracerebroventricular administration of human calcitonin and human calcitonin gene-related peptide inhibits meal-stimulated gastric acid secretion in the dog.

    abstract::This study was designed to assess the central nervous system actions of human calcitonin (hCalc) and human calcitonin gene-related peptide (hCGRP) on meal-stimulated gastric acid secretion in awake beagle dogs. hCalc (0.1-1.0 nmol/kg) and hCGRP (0.01-1.0 nmol/kg) injected into the third cerebral ventricle significantl...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296295

    authors: Lenz HJ,Brown MR

    更新日期:1987-04-01 00:00:00

  • Colonoscopy: the current king of the hill in the USA.

    abstract::Colonoscopy is the dominant colorectal cancer screening strategy in the USA. There are no randomized controlled trials completed of screening colonoscopy, but multiple lines of evidence establish that colonoscopy reduces colorectal cancer incidence in both the proximal and distal colon. Colonoscopy is highly operator ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-014-3448-0

    authors: Rex DK

    更新日期:2015-03-01 00:00:00

  • Balance of CD8+ CD28+ / CD8+ CD28- T lymphocytes is vital for patients with ulcerative colitis.

    abstract:BACKGROUND:Immune balances are important for many diseases including ulcerative colitis (UC). This study aimed to explore the role of the balance between CD8+ CD28+ and CD8+ CD28- T lymphocytes for the immunological pathogenesis of UC. METHODS:Sixteen patients with UC, 16 patients with irritable bowel syndrome (IBS) a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2327-9

    authors: Dai SX,Wu G,Zou Y,Feng YL,Liu HB,Feng JS,Chi HG,Lv RX,Zheng XB

    更新日期:2013-01-01 00:00:00

  • Clinical patterns, natural history, and progression of ulcerative colitis. A long-term follow-up of 1116 patients.

    abstract::We studied the natural history of ulcerative colitis (UC) by following 1116 patients in whom UC had been diagnosed or confirmed at The Cleveland Clinic Foundation between 1960 and 1983. Data before 1973 were obtained retrospectively. Criteria for inclusion in the study were: a diagnosis of UC confirmed by clinical, ra...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01295733

    authors: Farmer RG,Easley KA,Rankin GB

    更新日期:1993-06-01 00:00:00

  • Resource utilization and survival among Medicare patients with advanced liver disease.

    abstract:BACKGROUND:The prevalence of advanced liver disease and its complications may be on the rise within the Medicare population. The study aim was trend assessment for prevalence, mortality and resource utilization of patients with advanced liver disease. METHODS:A retrospective, cross-sectional design was used to analyze...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3318-9

    authors: Otgonsuren M,Henry L,Hunt S,Venkatesan C,Mishra A,Younossi ZM

    更新日期:2015-02-01 00:00:00

  • [35S]methionine interaction with rat liver tRNA and effect of chemical carcinogens.

    abstract::The interaction of [35S]methionine with hepatic tRNA in normal, carcinogen-treated, and partially hepatectomized rats was studied. tRNA was preferentially labeled following [35S]methionine (1.6 mCi, 25 mg/kg body wt) administration by intraperitoneal injection. The extent of [35S]methionine-tRNA interaction was impair...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297152

    authors: Kanduc D,Quagliariello E

    更新日期:1991-07-01 00:00:00

  • Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing.

    abstract::Rebamipide, a gastroprotective drug, is a compound selected from over 500 amino acid analogs of 2(1H)-quinolinone tested for gastroprotective action and for efficacy to heal experimental gastric ulcers. This drug stimulates prostaglandin generation in gastric mucosa and improves not only the speed but also the quality...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:

    authors: Arakawa T,Kobayashi K,Yoshikawa T,Tarnawski A

    更新日期:1998-09-01 00:00:00

  • Reactive oxygen species and vascular cell adhesion molecule-1 in distant organ failure following bile duct obstruction in mice.

    abstract::Pulmonary injury with leukocyte infiltration is a frequent occurrence in obstructive cholangitis patients. We wished to evaluate the roles of reactive oxygen species and vascular cell adhesion molecule-1 (VCAM-1) in this distant organ failure. Wild type (WT) and transgenic (SODtg) mice overexpressing superoxide dismut...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1017980406036

    authors: Morise Z,Ueda M,Kitajima M,Epstein CJ,Granger DN,Grisham MB

    更新日期:2002-03-01 00:00:00

  • Peroral Endoscopic Myotomy Is a Safe and Feasible Option in Management of Esophageal Diverticula: Systematic Review and Meta-Analysis.

    abstract::Esophageal diverticula can cause significant symptoms and affect the quality of life. There has been recent interest in the use of peroral endoscopic myotomy in the management of esophageal diverticula (D-POEM). In this meta-analysis, we have evaluated the efficacy and safety of D-POEM in the management of esophageal ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-020-06678-5

    authors: Kamal F,Khan MA,Lee-Smith W,Sharma S,Marella HK,Iqbal U,Mcdonough S,Aslam A,Ismail MK,Tombazzi C,Adler DG

    更新日期:2020-10-29 00:00:00

  • Hemodynamic characterization in experimental liver cirrhosis induced by thioacetamide administration.

    abstract::Systemic and splanchnic hemodynamics in experimental liver cirrhosis in rats induced by thioacetamide were evaluated by the radioactive microsphere method. Cardiac output and regional blood flow were measured in conscious and anesthetized control and cirrhotic rats. The conscious thioacetamide-treated rats had hyperdy...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01299895

    authors: Hori N,Okanoue T,Sawa Y,Mori T,Kashima K

    更新日期:1993-12-01 00:00:00

  • Interactions of Hepatitis B Virus Infection with Nonalcoholic Fatty Liver Disease: Possible Mechanisms and Clinical Impact.

    abstract::Hepatitis B virus (HBV) infection is a major etiology of chronic liver disease worldwide. In the past decade, nonalcoholic fatty liver disease (NAFLD) has emerged as a common liver disorder in general population. Accordingly, the patient number of chronic hepatitis B (CHB) concomitant with NAFLD grows rapidly. The pre...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-015-3772-z

    authors: Lin CW,Huang XL,Liu HL,Wang Y

    更新日期:2015-12-01 00:00:00

  • Manometric diagnosis of diffuse esophageal spasm.

    abstract::There are no requirements concerning the amplitude of simultaneous contractions among the present criteria for the manometric diagnosis of diffuse esophageal spasm. The purpose of this investigation was to determine whether the current criteria effectively identify an appropriately homogenous patient population. Sixty...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02088558

    authors: Allen ML,DiMarino AJ Jr

    更新日期:1996-07-01 00:00:00

  • Artificial liver. State of the art.

    abstract::If an effective hepatic assist system existed, it could serve as a bridge to transplantation. Most of the patients waiting for liver transplantation have chronic liver insufficiency but are not in hepatic coma. Various hepatic assist systems have been used to salvage patients with acute liver insufficiency. Most attem...

    journal_title:Digestive diseases and sciences

    pub_type: 历史文章,杂志文章,评审

    doi:10.1007/BF01307531

    authors: Takahashi T,Malchesky PS,Nosé Y

    更新日期:1991-09-01 00:00:00

  • Surface structure of single-gland adenoma in familial adenomatous polyposis.

    abstract::Magnifying videoendoscopic observation of a minute lesion with a single IIIL type cryptal orifice was reported. This minute lesion was a single-gland adenoma accompanied histopathologically by a bud of adenomatous gland and was located in the upper part of the mucosa. This finding regarding a pit pattern should make p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1020143529123

    authors: Tamura S,Nakajo K,Kitamura M,Kamiji I,Onishi S

    更新日期:2002-10-01 00:00:00

  • Unusual Sites of Necrotic Collections in Acute Necrotizing Pancreatitis: Association with Parenchymal Necrosis and Clinical Outcomes.

    abstract:BACKGROUND:The presence of necrotic collection in acute necrotizing pancreatitis (ANP) at intra-abdominal sites other than the retroperitoneum has not been systematically studied. AIM:To investigate unusual sites of necrotic collections at computed tomography (CT) and to evaluate association with pancreatic necrosis a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06526-6

    authors: Gupta P,Virk M,Gulati A,Muktesh G,Shah J,Samanta J,Mandavdhare H,Sharma V,Dutta U,Kochhar R

    更新日期:2020-08-10 00:00:00

  • Cost-effectiveness and diagnostic effectiveness analyses of multiple algorithms for the diagnosis of Lynch syndrome.

    abstract:BACKGROUND AND AIMS:The optimal algorithm to identify Lynch syndrome (LS) among patients with colorectal cancer (CRC) is unclear. The definitive test for LS, germline testing, is too expensive to be applied in all cases. Initial screening with the revised Bethesda Guidelines (RBG) cannot be applied in a considerable nu...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3248-6

    authors: Gould-Suarez M,El-Serag HB,Musher B,Franco LM,Chen GJ

    更新日期:2014-12-01 00:00:00

  • Validation of the Enriching New-Onset Diabetes for Pancreatic Cancer Model in a Diverse and Integrated Healthcare Setting.

    abstract:BACKGROUND:The risk of pancreatic cancer is elevated among people with new-onset diabetes (NOD). Based on Rochester Epidemiology Project Data, the Enriching New-Onset Diabetes for Pancreatic Cancer (END-PAC) model was developed and validated. AIMS:We validated the END-PAC model in a cohort of patients with NOD using r...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06139-z

    authors: Chen W,Butler RK,Lustigova E,Chari ST,Wu BU

    更新日期:2021-01-01 00:00:00

  • Oral specific desensitization in food-allergic children.

    abstract::The possibility of obtaining oral desensitization in patients with food allergy is still a matter of debate. We decided to evaluate the safety and efficacy of standardized protocols for oral desensitization with the most common food allergens. Forty-two children (ages up to 16 years) diagnosed as affected by food alle...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10620-006-9245-7

    authors: Patriarca G,Nucera E,Pollastrini E,Roncallo C,De Pasquale T,Lombardo C,Pedone C,Gasbarrini G,Buonomo A,Schiavino D

    更新日期:2007-07-01 00:00:00

  • Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma.

    abstract::Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD+)-dependent type III histone deacetylases, are produced by cells to support in the defense against chronic stress conditions such as metabolic syndromes, neurodegeneration, and cancer. SIRT-3 is one of the most studied members of the mitochondr...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-017-4615-x

    authors: De Matteis S,Granato AM,Napolitano R,Molinari C,Valgiusti M,Santini D,Foschi FG,Ercolani G,Vespasiani Gentilucci U,Faloppi L,Scartozzi M,Frassineti GL,Casadei Gardini A

    更新日期:2017-08-01 00:00:00