Abstract:
:We present a case of fatal, progressive hepatotoxicity in a patient treated with lamotrigine. After presenting with a rash and fever, she developed elevated liver function tests and clinical sequelae of hepatic failure. The subacute course of her progressive liver damage is documented in serial liver biopsies. While her initial biopsy showed approximately 50% hepatocyte necrosis, her post mortem examination performed three weeks later displayed massive hepatic necrosis with extensive bile duct proliferation. Although she was taking other antipsychotics at the time, her clinical course best parallels other reports of lamotrigine-associated hepatotoxicity. Here we discuss not only the clinicopathologic findings of this case but also review the pertinent literature.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Overstreet K,Costanza C,Behling C,Hassanin T,Masliah Edoi
10.1023/a:1019627618972subject
Has Abstractpub_date
2002-09-01 00:00:00pages
1921-5issue
9eissn
0163-2116issn
1573-2568journal_volume
47pub_type
杂志文章,评审abstract::A gangliocytic paraganglioma (GP) is an extremely rare neurogenic tumor nearly located in the second portion of the duodenum and has been regarded as benign. We report a case of duodenal GP in a 53-year-old man. The GP arose in the second portion of the duodenum and was shown by histological examination to consist of ...
journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-006-9370-3
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abstract::A new extracorporeal piezoelectric lithotripter was tested for its gallstone disintegration capability. A total of 177 surgically removed gallbladder stones were submitted to piezoelectric shock-wave treatment. Prior to shock-wave application, the diameter, weight, and volume of all the stones and CT density and MR si...
journal_title:Digestive diseases and sciences
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doi:10.1007/BF01536364
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abstract::Theoretically, relative distal common bile duct obstruction due to sphincter of Oddi dysfunction may be a cause of poor gallbladder evacuation observed on quantitative cholescintigraphy. In this study, the relationship of sphincter of Oddi dysfunction to the gallbladder ejection fraction by quantitative cholescintigra...
journal_title:Digestive diseases and sciences
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doi:10.1007/BF02090199
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abstract::Segments of rat ileum and colon were infused in vivo to test if 0.1 M lactate, 10(-4) M H+, or both altered mucosal structure and function. In the first series of experiments, lactate concentration was kept at 0.1 M while H+ was varied from 10(-4) to 10(-7) M. Lactate and 10(-4) M H+ in the colon, and lactate and 10(-...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308119
更新日期:1982-01-01 00:00:00
abstract::Nitric oxide appears to play an important role in maintaining gastric mucosal integrity. This study aimed to investigate whether a nitric oxide donor (sodium nitroprusside) or stimulation of endogenous nitric oxide synthesis (with acetylcholine) protects against gastric ischemia-reperfusion injury. Rats were subjected...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02090210
更新日期:1994-02-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-020-06388-y
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abstract::Papillary stenosis is an imprecisely defined clinical syndrome which eludes definitive diagnosis. In this study we evaluated 26 patients with suspected papillary stenosis by manometric examination of the sphincter of Oddi done during ERCP examination. Basal pressure in the sphincter of Oddi was elevated in 14 of the p...
journal_title:Digestive diseases and sciences
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doi:10.1007/BF01308431
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-009-0870-9
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journal_title:Digestive diseases and sciences
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doi:10.1023/a:1018856112765
更新日期:1997-05-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/BF01347905
更新日期:1986-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01297052
更新日期:1987-03-01 00:00:00
abstract::Cholecystectomy is one of the commonest surgical procedures in the Western world, with more than half a million procedures performed annually in the United States alone. In recent years, studies of gallstone pathogenesis and gallbladder disease have increasingly focused on abnormal gallbladder motility in the pathogen...
journal_title:Digestive diseases and sciences
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doi:10.1007/BF02063233
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1226-1
更新日期:2010-08-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-020-06517-7
更新日期:2020-08-04 00:00:00
abstract::The effect of nutrients on small intestinal motility is controversial. Our aim was to analyze the effect of intraduodenal infusion of mixtures of nutrients of increasing caloric load, on intestinal motility. Studies were performed in dogs with a duodenal cannula. Isosmolar infusions of saline, 0.5, 2, and 4 kcal/min w...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1024799303676
更新日期:2003-08-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02090220
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01299827
更新日期:1979-06-01 00:00:00
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journal_title:Digestive diseases and sciences
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abstract::Squamous cell carcinoma represents the most common primary malignant lesion of the esophagus (1). The initial manifestation of lymphosarcoma infrequently occurs in the gastrointestinal tract, and in one large series, there were no lymphosarcomas presenting in the esophagus (2). In the case described below, a primary h...
journal_title:Digestive diseases and sciences
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doi:10.1007/BF01324907
更新日期:1979-11-01 00:00:00
abstract::A case of heterotopic bone formation in a primary rectal adenocarcinoma was recently observed in a 54-year-old woman. This unusual finding was present both in the diagnostic biopsy and in the subsequently resected bowel. Pertinent gross and microscopic features are presented. This report represents the twelfth case in...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1017959801493
更新日期:2002-03-01 00:00:00
abstract::Psychological distress is often observed in patients with gastrointestinal illness. To date, there has been limited research conducted to assess the prevalence and impact of post-traumatic stress disorder (PTSD) in gastrointestinal cohorts. The aim of this systematic review is to review the evidence for the prevalence...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-020-06798-y
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journal_title:Digestive diseases and sciences
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更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Polymerase chain reaction (PCR) assays are the standard for detecting hepatitis C virus viremia. The transcription-mediated amplification (TMA)-based assay is more sensitive. METHODS:We retrospectively reviewed the charts of patients with a post-end of treatment (EOT) PCR-/TMA+ result to assess the clinical...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1820-x
更新日期:2012-01-01 00:00:00