Fatal progressive hepatic necrosis associated with lamotrigine treatment: a case report and literature review.

Abstract:

:We present a case of fatal, progressive hepatotoxicity in a patient treated with lamotrigine. After presenting with a rash and fever, she developed elevated liver function tests and clinical sequelae of hepatic failure. The subacute course of her progressive liver damage is documented in serial liver biopsies. While her initial biopsy showed approximately 50% hepatocyte necrosis, her post mortem examination performed three weeks later displayed massive hepatic necrosis with extensive bile duct proliferation. Although she was taking other antipsychotics at the time, her clinical course best parallels other reports of lamotrigine-associated hepatotoxicity. Here we discuss not only the clinicopathologic findings of this case but also review the pertinent literature.

journal_name

Dig Dis Sci

authors

Overstreet K,Costanza C,Behling C,Hassanin T,Masliah E

doi

10.1023/a:1019627618972

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

1921-5

issue

9

eissn

0163-2116

issn

1573-2568

journal_volume

47

pub_type

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