Anomalous plasma cyclic AMP responses to glucagon in patients with liver disease.

Abstract:

:The purpose of the present study is to show anomalies of the plasma cAMP response of patients with hepatic disorders to a single injection of a low dose of glucagon (1 microgram/kg body wt). The response was markedly blunted in patients with liver cirrhosis and potentiated in patients with acute or chronic hepatitis. This glucagon test is, therefore, promising for development as a simple diagnostic means without undertaking liver biopsy to distinguish cirrhosis from chronic hepatitis.

journal_name

Dig Dis Sci

authors

Maekubo H,Matsushima T,Okada F,Honma M,Ui M

doi

10.1007/BF01308330

subject

Has Abstract

pub_date

1980-09-01 00:00:00

pages

700-4

issue

9

eissn

0163-2116

issn

1573-2568

journal_volume

25

pub_type

杂志文章
  • Comparison of three types of precut technique to achieve common bile duct cannulation: a retrospective analysis of 274 cases.

    abstract:BACKGROUND:The aim of this retrospective study was to evaluate the success rate and complications of three precut techniques of sphincterotomy after failure of conventional techniques of cannulation of common bile duct (CBD). PATIENTS AND METHODS:Between January 2003 and October 2011, 2,903 consecutive ERCPs were perf...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2271-8

    authors: Katsinelos P,Gkagkalis S,Chatzimavroudis G,Beltsis A,Terzoudis S,Zavos C,Gatopoulou A,Lazaraki G,Vasiliadis T,Kountouras J

    更新日期:2012-12-01 00:00:00

  • Type 1 autoimmune hepatitis in Taiwan: diagnosis using the revised criteria of the International Autoimmune Hepatitis Group.

    abstract::Autoimmune hepatitis (AIH) is rare in Asian countries compared to the West, and an exceptionally low prevalence was noted previously in Taiwan. Using the revised criteria of the IAIHG, 48 cases of AIH patients were diagnosed. All patients were consecutively diagnosed over a period of 5 years. Detailed medical historie...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-005-9068-y

    authors: Koay LB,Lin CY,Tsai SL,Lee C,Lin CN,Sheu MJ,Kuo HT,Sun CS

    更新日期:2006-11-01 00:00:00

  • Role of calcium in thromboxane B2-mediated injury to rabbit gastric mucosal cells.

    abstract::A sustained increase in cytosolic Ca2+ can damage gastric mucosal cells. The present study has examined the role of Ca2+ in thromboxane B2 (TXB2)-mediated damage of rabbit isolated gastric mucosal cells. Cells were isolated from rabbit oxyntic mucosa by collagenase-EDTA digestion. Cell metabolic activity and cell dama...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02208674

    authors: Wong HM,Soper BD,Tepperman BL

    更新日期:1995-09-01 00:00:00

  • Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer.

    abstract::The aim of this study was to compare alcohol and smoking as risk factors in the development of chronic pancreatitis and pancreatic cancer. We considered only male subjects: (1) 630 patients with chronic pancreatitis who developed 12 pancreatic and 47 extrapancreatic cancers; (2) 69 patients with histologically well do...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026670911955

    authors: Talamini G,Bassi C,Falconi M,Sartori N,Salvia R,Rigo L,Castagnini A,Di Francesco V,Frulloni L,Bovo P,Vaona B,Angelini G,Vantini I,Cavallini G,Pederzoli P

    更新日期:1999-07-01 00:00:00

  • Diclofenac delays healing of gastroduodenal mucosal lesions. Double-blind, placebo-controlled endoscopic study in healthy volunteers.

    abstract::The effects of the water-soluble and delayed-release formulations of a nonsteroidal antiinflammatory drug, diclofenac, on the healing of gastroduodenal mucosal lesions were compared in a double-blind, double cross-over, placebo-controlled endoscopic study conducted in 14 healthy volunteers. Severe endoscopic lesions (...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF01297025

    authors: Stadler P,Armstrong D,Margalith D,Saraga E,Stolte M,Lualdi P,Mautone G,Blum AL

    更新日期:1991-05-01 00:00:00

  • Increased susceptibility to severe chronic liver damage in CXCR4 conditional knock-out mice.

    abstract:BACKGROUND:The chemokine SDF-1 and its receptor CXCR4 are essential for the proper functioning of multiple organs. In the liver, cholangiocytes and hepatic progenitor cells (HPCs) are the main cells that produce SDF-1, and SDF-1 is thought to be essential for HPC-stimulated liver regeneration. AIMS:In this study, CXCR...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2239-8

    authors: Tsuchiya A,Imai M,Kamimura H,Takamura M,Yamagiwa S,Sugiyama T,Nomoto M,Heike T,Nagasawa T,Nakahata T,Aoyagi Y

    更新日期:2012-11-01 00:00:00

  • Comparative effects of adjuvant cimetidine and omeprazole during pancreatic enzyme replacement therapy.

    abstract::In a double-blind, randomized crossover study, the hypotheses were tested that more powerful inhibition of gastric acid secretion by adjuvant omeprazole further improves the efficacy of pancreatic enzyme replacement therapy compared to adjuvant cimetidine and that excluding the influence of pH-related factors, by virt...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02087549

    authors: Bruno MJ,Rauws EA,Hoek FJ,Tytgat GN

    更新日期:1994-05-01 00:00:00

  • The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.

    abstract::This study investigates the varied expression of DNA methyltransferase (DNMT) proteins in gastric cancer (GC) and their relationship with the biological behavior of the tissues. Immunohistochemistry was used to detect the expression of the 3 DNMTs in gastric tissues. We discovered that the positive rates of DNMT1, DNM...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-0145-2

    authors: Ding WJ,Fang JY,Chen XY,Peng YS

    更新日期:2008-08-01 00:00:00

  • Longer-term outcomes of nutritional management of Crohn's disease in children.

    abstract:BACKGROUND:While the short-term benefits of exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) are well documented, the longer-term outcomes are less clear. AIM:This retrospective study aimed to ascertain the outcomes for up to 24 months following EEN in a group of child...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-012-2232-2

    authors: Lambert B,Lemberg DA,Leach ST,Day AS

    更新日期:2012-08-01 00:00:00

  • Human beta-glucuronidase. Measurement of its activity in gallbladder bile devoid of intrinsic interference.

    abstract::Our purpose is to develop a standard method for preparing the bile for beta-glucuronidase determination by removal of bile acids and conjugated bilirubin which interfere with its activity. The bile acids and conjugated bilirubin in their purified solutions and in the diluted gallbladder biles could be extracted comple...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536028

    authors: Ho YC,Ho KJ

    更新日期:1988-04-01 00:00:00

  • In vitro recovery of canine gastric mucosal surface hydrophobicity and potential difference after aspirin damage.

    abstract::This study determined how the luminal surface hydrophobicity and transmucosal potential difference (PD) of canine gastric mucosa changed during the recovery period after the tissue was challenged with acidified aspirin. Luminal aspirin reduced both the contact angle and PD of mucosae incubated in Ussing chambers. Afte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02065551

    authors: Goddard PJ,Lichtenberger LM

    更新日期:1995-06-01 00:00:00

  • Purified micronized flavonoid fraction ameliorates the injury of spleen and ileum secondary to hepatic ischemia-reperfusion in rats.

    abstract:BACKGROUND:Flavonoids have been subjected to considerable investigations due to their antioxidant and anti-inflammatory properties. Yet the effects of flavonoids on the ileum and spleen against hepatic ischemia-reperfusion injury have so far not been addressed. AIMS:We aimed to investigate whether micronized purified ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-1018-7

    authors: Yildiz F,Terzi A,Coban S,Bitiren M,Celik H,Aksoy N,Ozdogan MK,Cakir H

    更新日期:2010-08-01 00:00:00

  • Attenuated GABAergic Signaling in Intestinal Epithelium Contributes to Pathogenesis of Ulcerative Colitis.

    abstract:BACKGROUND:Neuromediators produced by enteric nervous system regulate inflammatory processes via interacting with enteric immune system. Role of γ-aminobutyric acid (GABA), which is also a neuromediator, has been implicated in autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, where...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-017-4662-3

    authors: Aggarwal S,Ahuja V,Paul J

    更新日期:2017-10-01 00:00:00

  • Effect of cholestyramine and cholecystokinin receptor antagonist CR1505 (loxiglumide) on lower esophageal sphincter pressure in man.

    abstract::Cholecystokinin (CCK) decreases lower esophageal sphincter pressure (LESP) in man. Cholestyramine, a nonabsorbable bile salt binding resin, stimulates endogenous CCK secretion. We have investigated the effect of oral ingestion of 16 g cholestyramine without and with infusion of the CCK receptor antagonist CR1505 (loxi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296114

    authors: Masclee AA,Jansen JB,Rovati LC,Lamers CB

    更新日期:1993-10-01 00:00:00

  • Small intestinal permeability to mannitol, lactulose, and polyethylene glycol 400 in celiac disease.

    abstract::Mannitol (molecular weight 182), lactulose (342), and polyethylene glycol 400 (range 242-550) absorption was studied in 25 controls, 22 untreated celiacs, and 13 treated celiacs. Untreated celiacs absorbed less mannitol and more lactulose than controls. Absorption of higher as well as lower molecular-weight polyethyle...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01318423

    authors: Ukabam SO,Cooper BT

    更新日期:1984-09-01 00:00:00

  • Selection of HCV NS5A quasispecies during IFN therapy in patients with chronic HCV.

    abstract::Interferon treatment of chronic hepatitis C virus infection is successful in a minority of patients. The sequence of the interferon sensitivity determining region (ISDR) of the NS5A protein may determine the outcome of therapy in patients infected with HCV genotype 1. To determine whether IFN treatment caused selectio...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1010623417345

    authors: Paterson M,Laxton C,Goldin RD,Ackrill AM,Foster GR

    更新日期:2001-07-01 00:00:00

  • Intravenous cyclosporine in attacks of ulcerative colitis: short-term and long-term responses.

    abstract::The present study reports the results of intravenous cyclosporine in 32 patients with refractory and/or severe attacks of ulcerative colitis (UC). Twenty of 32 patients responded to intravenous cyclosporine; cyclosporine was clinically effective and improved colonic lesions. However, one colonic perforation and one po...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02100145

    authors: Carbonnel F,Boruchowicz A,Duclos B,Soulé JC,Lerebours E,Lémann M,Belaïche J,Colombel JF,Cosnes J,Gendre JP

    更新日期:1996-12-01 00:00:00

  • Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver.

    abstract:BACKGROUND AND AIMS:Minimal hepatic encephalopathy is the mildest form of the spectrum of hepatic encephalopathy (HE) that impairs health-related quality of life. We assessed (1) the usefulness of psychometric hepatic encephalopathy score and critical flicker frequency for the diagnosis of minimal hepatic encephalopath...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1249-7

    authors: Dhiman RK,Kurmi R,Thumburu KK,Venkataramarao SH,Agarwal R,Duseja A,Chawla Y

    更新日期:2010-08-01 00:00:00

  • Flexible sigmoidoscopy for colorectal cancer screening in the elderly.

    abstract::Data on performance characteristics of flexible sigmoidoscopy (FS) between age groups are limited. This study evaluates screening FS in subjects > or = 75 years of age (elderly) compared with ages 50-74 years (general screening population). Data were collected on patient characteristics, insertion depth, procedural di...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10620-005-3022-x

    authors: Pabby A,Suneja A,Heeren T,Farraye FA

    更新日期:2005-11-01 00:00:00

  • Effects of stimulation and inhibition of acid secretion on gastric damage induced by platelet-activating factor.

    abstract::Intravenous administration of platelet-activating factor (PAF) induces extensive damage in rat gastric mucosa. The aim of the present study was to examine whether the presence or absence of acid in the gastric lumen could modify the PAF-induced gastric damage. The effects of inhibition of basal and pentagastrin-stimul...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296615

    authors: Piqué JM,Pérez Ayuso RM,Bilbao J,Terés J

    更新日期:1991-12-01 00:00:00

  • The role of N-acetyltransferase 2 polymorphism in the etiopathogenesis of inflammatory bowel disease.

    abstract:BACKGROUND AND PURPOSE:Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn's disease (CD), which are complex genetic disorders resulting from the interplay between several genetic and environmental risk factors. The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of n...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1527-4

    authors: Baranska M,Trzcinski R,Dziki A,Rychlik-Sych M,Dudarewicz M,Skretkowicz J

    更新日期:2011-07-01 00:00:00

  • Bacterial Infection in Patients with Cirrhosis: Don't Get Bugged to Death.

    abstract::Bacterial infection remains a leading cause of mortality and morbidity for patients with cirrhosis, with hospitalization, alterations in the intestinal microbiota, and therapeutic drugs all implicated in its development. Bacterial infections also remain the most common precipitant of acute-on-chronic liver failure, wi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/s10620-019-05943-6

    authors: Cannon MD,Martin P,Carrion AF

    更新日期:2020-01-01 00:00:00

  • Protection against gastric ischemia-reperfusion injury by nitric oxide generators.

    abstract::Nitric oxide appears to play an important role in maintaining gastric mucosal integrity. This study aimed to investigate whether a nitric oxide donor (sodium nitroprusside) or stimulation of endogenous nitric oxide synthesis (with acetylcholine) protects against gastric ischemia-reperfusion injury. Rats were subjected...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02090210

    authors: Andrews FJ,Malcontenti-Wilson C,O'Brien PE

    更新日期:1994-02-01 00:00:00

  • Changes in Serum Myostatin Levels in Alcoholic Hepatitis Correlate with Improvement in MELD.

    abstract:BACKGROUND:Alcoholic hepatitis (AH) is a serious clinical syndrome often associated with muscle wasting. Myostatin, a member of the transforming growth factor-β superfamily, has been studied in diseases with muscle wasting; however, the role of myostatin in AH is unknown. AIMS:To investigate the association between my...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06632-5

    authors: Shamseddeen H,Madathanapalli A,Are VS,Shah VH,Sanyal AJ,Tang Q,Liang T,Gelow K,Zimmers TA,Chalasani N,Desai AP

    更新日期:2020-10-19 00:00:00

  • Carcinoid tumor of the biliary system. Case report and literature review.

    abstract::Work-up of a 62-year-old black male, with a complaint of low back pain for three months, revealed a mass in the porta hepatis, narrowing of the common hepatic duct, and dilated intrahepatic bile ducts. A 3 X 4-cm tumor in the common hepatic duct was excised and biliary continuity restored by hepaticojejunostomy. The e...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296145

    authors: Jutte DL,Bell RH Jr,Penn I,Powers J,Kolinjivadi J

    更新日期:1987-07-01 00:00:00

  • Hydralazine-induced liver injury.

    abstract::A 68-year-old man developed hepatic injury with no hypersensitivity reaction after three years of hydralazine therapy. The liver injury histologically showed centrilobular zonal necrosis. Clinical, biochemical, and histological recovery followed discontinuation of the drug. Challenge tests and serial liver biopsies re...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01338533

    authors: Itoh S,Yamaba Y,Ichinoe A,Tsukada Y

    更新日期:1980-11-01 00:00:00

  • Predicting short-term mortality and long-term survival for hospitalized US patients with alcoholic hepatitis.

    abstract:BACKGROUND:No study has evaluated current scoring systems for their accuracy in predicting short and long-term outcome of alcoholic hepatitis in a US population. METHODS:We reviewed electronic records for patients with alcoholic liver disease (ALD) admitted to Parkland Memorial Hospital between January 2002 and August...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-013-3020-3

    authors: Cuthbert JA,Arslanlar S,Yepuri J,Montrose M,Ahn CW,Shah JP

    更新日期:2014-07-01 00:00:00

  • Enzymatic determination of serum 3 alpha-sulfated bile acids concentration with bile acid 3 alpha-sulfate sulfohydrolase.

    abstract::A newly developed enzymatic method for determining urinary 3 alpha-sulfated bile acids was used to measure serum 3 alpha-sulfated bile acid levels in 114 patients with hepatobiliary diseases and 56 healthy subjects. The lowest measurable amount of the 3 alpha-sulfated bile acids was 0.5 mumol/liter. The standard curve...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02087901

    authors: Kato T,Yoneda M,Nakamura K,Makino I

    更新日期:1996-08-01 00:00:00

  • Correction to: Antenatal Management for Women with Inflammatory Bowel Disease: Experience from Our 'IBD MOM' Clinic.

    abstract::The original version of the article unfortunately contained tagging error in first and family name of authors Ariella Bar-Gil Shitrit and Ami Ben Ya'acov. This has been corrected with this erratum. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s10620-018-5084-6

    authors: Bar-Gil Shitrit A,Cohen Y,Hassin O,Ben Ya'acov A,Farkash R,Koslowsky B,Milgrom Y,Livovsky DM,Samueloff A,Goldin E,Grisaru-Granovsky S

    更新日期:2018-09-01 00:00:00

  • Intraluminal release of serotonin, substance P, and gastrin in the canine small intestine.

    abstract::Several gastrointestinal hormones have been found in the intestinal lumen, but as yet their physiologic role is not yet clear. We have previously shown in anesthesized animals that electrical vagal stimulation provokes simultaneous intraluminal release of serotonin (5-HT) and substance P (SP). The aim of this study wa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297056

    authors: Ferrara A,Zinner MJ,Jaffe BM

    更新日期:1987-03-01 00:00:00