Abstract：
:Campylobacter pyloridis has been associated with antral gastritis and duodenal ulcer. To study the pathogenetic role of these organisms in duodenal ulcer, endoscopic biopsies, two from the first part of duodenum, four from antrum, and four from body and fundus, were taken before and after four weeks of cimetidine treatment (1.2 g/day) from 67 patients with active duodenal ulcer. The biopsies were examined for the presence and severity of any inflammation by two independent pathologists in the absence of any clinical information and for the occurrence and density of Campylobacter pyloridis by culture and Warthin-Starry stain. Before treatment, inflammation was present in 71.1, 100, and 25.8%, while the organisms were present in 34.3, 91.0, and 79.1% of the duodenal, antral, and fundal biopsies, respectively. With complete healing of duodenal ulcer, inflammation was present in 48.9, 98.2, and 30.2%, while the organisms were present in 25, 76.7, and 63.3% of the respective mucosae. With ulcer healing, duodenitis became significantly milder (P less than 0.05). With improvement of gastritis and duodenitis, there was no significant change in the occurrence and density of Campylobacter pyloridis. These findings indicate that healing of duodenal ulcer is not influenced by the presence of Campylobacter pyloridis, which is frequently found in the gastroduodenal mucosa of patients with duodenal ulcer, but does not appear to be associated with mucosal inflammation except in the antrum.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Hui WM,Lam SK,Chau PY,Ho J,Lui I,Lai CL,Lok AS,Ng MMdoi
10.1007/BF01296375subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1255-60issue
11eissn
0163-2116issn
1573-2568journal_volume
32pub_type
杂志文章abstract：BACKGROUND AND AIMS:Hepatoportal sclerosis (HPS) is a clinicopathologic condition that is clinically characterized by portal hypertension (varices and portosystemic collateral vessels), splenomegaly and pancytopenia, in the absence of cirrhosis. Although the etiology is obscure, a number of theories such as immunologic...
journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章,meta分析,评审
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journal_title：Digestive diseases and sciences
pub_type： 杂志文章
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更新日期：1993-08-01 00:00:00
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更新日期：2004-10-01 00:00:00
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更新日期：1982-05-01 00:00:00
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pub_type： 临床试验,杂志文章
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journal_title：Digestive diseases and sciences
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journal_title：Digestive diseases and sciences
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更新日期：1998-09-01 00:00:00
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更新日期：1995-05-01 00:00:00
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journal_title：Digestive diseases and sciences
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