当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > The Incidence, Predictors and Outcomes of Gastrointestinal Bleeding in Patients with Left Ventricular Assist Device (LVAD).

The Incidence, Predictors and Outcomes of Gastrointestinal Bleeding in Patients with Left Ventricular Assist Device (LVAD).

Abstract：

OBJECTIVES:To evaluate rate, recurrence, and predictors of gastrointestinal bleeding (GIB) and impact of endoscopy in left ventricular assist device (LVAD) patients. METHODS:This is a cohort study of all patients who received the current-generation continuous-flow HeartMate II LVAD from 2005 to 2013 at our institution. Patients were followed up, and GIB events recorded until death, time of heart transplantation, or end of observation. RESULTS:LVAD was implanted in 112 patients (median age 67 years, 88% male). A total of 44 patients (39%) had 74 GIB events occurring at a rate of 42.9 per 100 p-y. Endoscopy was performed in 77% of patients, and GIB source was identified in 57% with upper GIB found in almost two-third of cases. Right ventricular dysfunction and post-LVAD ejection fraction >30% were associated with higher GIB rates. Higher pulsatility index was associated with lower GIB rates. Re-bleeding occurred in 19 (43%) patients at a rate of 62.5 per 100 p-y and was not affected by endoscopic therapy at the index endoscopy. CONCLUSIONS:GIB in LVAD patients is common, occurring primarily in the upper GI tract. Upper endoscopy is the preferred strategy though lower endoscopy is also recommended for a full workup. Endoscopy can identify GIB lesions in about 50% of patients, but re-bleeding is common. Right ventricular dysfunction and post-LVAD ejection fraction >30% are associated with higher GIB rates. Higher pulsatility index is associated with lower GIB rates. Reduction in pump speed is a potential strategy for managing and preventing GIB.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

Jabbar HR,Abbas A,Ahmed M,Klodell CT Jr,Chang M,Dai Y,Draganov PV

doi

10.1007/s10620-015-3743-4

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

3697-706

issue

12

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-015-3743-4

journal_volume

60

pub_type

杂志文章

相关文献

DIGESTIVE DISEASES AND SCIENCES文献大全
  • Production of a polar metabolite of 1,25-dihydroxyvitamin D3 in a rat liver perfusion system.

    abstract：:When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results i...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01391637

    authors： Kumar R,Nagubandi S,Londowski JM

    更新日期：1981-03-01 00:00:00

  • Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model.

    abstract：:Alkaline sphingomyelinase (Alk-SMase) is a key enzyme in the intestinal tract for digestion of dietary sphingomyelin (SM), which generates lipid messengers with cell-cycle regulating effects. The enzyme is significantly decreased in ulcerative colitis and colon cancer. Based on this information, we wanted to investiga...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-008-0509-2

    authors： Andersson D,Kotarsky K,Wu J,Agace W,Duan RD

    更新日期：2009-07-01 00:00:00

  • Central nervous system lymphoma presenting as dysphagia.

    abstract：:Two patients are presented having lymphomatous involvement of the central nervous system in whom dysphagia was the predominant symptom. All indicated studies failed to reveal evidence of direct esophageal involvement, and the dysphagia improved during treatment of the neural component. Esophageal manometric studies re...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01311710

    authors： Benjamin SB,Eisold J,Gerhardt DC,Castell DO

    更新日期：1982-02-01 00:00:00

  • Clinical experience of hepatic hemangioma undergoing hepatic resection.

    abstract：:The indications for surgery on cavernous hemangiomas, the most common benign tumors of the liver, remain unclear. This study reviewed 43 patients with cavernous hemangioma of the liver who underwent hepatic resection from 1984 to 2000. Patients were divided into three groups based on the reasons for surgery. Group I c...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1023099529229

    authors： Tsai HP,Jeng LB,Lee WC,Chen MF

    更新日期：2003-05-01 00:00:00

  • Bronchial hyperresponsiveness in irritable bowel syndrome.

    abstract：:Extraintestinal symptoms are often found in patients with irritable bowel syndrome (IBS). Recent studies suggest that IBS is associated with bronchial hyperresponsiveness. But it is still arguable that the bronchial hyperresponsiveness is associated with IBS patients. The purpose of this study is to investigate the po...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-005-2916-y

    authors： Jun DW,Lee OY,Yoon HJ,Lee HL,Yoon BC,Choi HS,Lee MH,Lee DH,Kee CS

    更新日期：2005-09-01 00:00:00

  • Antibiotic properties of bovine lactoferrin on Helicobacter pylori.

    abstract：:To investigate a potential new treatment for gastric Helicobacter pylori infection, we have examined the use of the natural antibiotic lactoferrin, found in bovine milk, for activity against Helicobacter species both in vitro and in vivo. Lactoferrin was bacteriostatic to H. pylori when cultured at concentrations > or...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1026675916421

    authors： Dial EJ,Hall LR,Serna H,Romero JJ,Fox JG,Lichtenberger LM

    更新日期：1998-12-01 00:00:00

  • Gastric acid secretion in cold urticaria.

    abstract：:Four patients with cold urticaria and six control subjects were studied. Gastric acid output was measured for 1 hr before and 1 hr after the immersion of both hands in ice cold water. The mean acid output fell in the control group by 16.3%. Acid output in the cold urticaria patients rose in each case following the col...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01315214

    authors： Lass N,Doron O,Gilat T

    更新日期：1980-07-01 00:00:00

  • Direct-Acting Antiviral Therapy for Chronic HCV Infection Results in Liver Stiffness Regression Over 12 Months Post-treatment.

    abstract：BACKGROUND:Liver fibrosis stage determines risk of morbidity and mortality from chronic hepatitis C virus (HCV) infection. Prior data have shown long-term reversal of liver fibrosis, measured by vibration-controlled transient elastography (VCTE), in patients successfully treated with interferon-based therapies. AIM:Ou...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-017-4749-x

    authors： Chan J,Gogela N,Zheng H,Lammert S,Ajayi T,Fricker Z,Kim AY,Robbins GK,Chung RT

    更新日期：2018-02-01 00:00:00

  • Glucagon-like peptide-2 induces a specific pattern of adaptation in remnant jejunum.

    abstract：:Glucagon-like peptide-2 (GLP-2) is an enteroendocrine hormone which is uniquely trophic for the intestine; a physiological role in regulating nutrient absorptive capacity is becoming apparent. GLP-2, independent of enteral feeding, stimulates a classical pattern of intestinal adaptation in terminal ileum following res...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-006-9077-5

    authors： Sigalet DL,Bawazir O,Martin GR,Wallace LE,Zaharko G,Miller A,Zubaidi A

    更新日期：2006-09-01 00:00:00

  • Helicobacter pylori seroconversion in asymptomatic blood donors: a five-year follow-up.

    abstract：:Several techniques have been developed to diagnose Helicobacter pylori infection and two noninvasive methods are available: carbon 13-urea breath test (UBT) and serology. Measurement of IgG serum antibodies by enzyme-linked immunosorbent assay (ELISA) is a reliable and inexpensive method for detection of infection. Th...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1005589700652

    authors： Menegatti M,Figura N,Farinelli S,Landi F,Acciardi C,Ricci C,Holton J,Gatta L,Crosatti M,Polacci R,Miglioli M,Vaira D

    更新日期：2000-08-01 00:00:00

  • Action of ethanol on gastrin release in the dog.

    abstract：:In conscious dogs with gastric and duodenal Thomas fistulas, we studied the effect of ethanol on plasma concentrations of gastrin. Ethanol was given either as an infusion into a peripheral vein (1.95 M, 200 ml/hr) or into the duodenum (0.95 M, 400 ml/hr) or as an intragastric bolus injection. The effect of the intraga...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296856

    authors： Eysselein VE,Singer MV,Wentz H,Goebell H

    更新日期：1984-01-01 00:00:00

  • Double-duct sign in the era of endoscopic ultrasound: the prevalence of occult pancreaticobiliary malignancy.

    abstract：BACKGROUND AND AIM:Simultaneous dilatation of the common bile duct and pancreatic duct, "double-duct sign" (DDS), is an ominous finding concerning for pancreaticobiliary malignancy. Little evidence exists to guide the initial evaluation and subsequent follow-up for patients with DDS in the absence of jaundice or focal ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-014-3133-3

    authors： Cohen J,Sawhney MS,Pleskow DK,Chuttani R,Patel NJ,Sheridan J,Berzin TM

    更新日期：2014-09-01 00:00:00

  • Effect of aspirin on gallbladder motility in patients with gallstone disease. A randomized, double-blind, placebo-controlled trial of two dosage schedules.

    abstract：:Patients with gallstone disease have impaired gallbladder motility. Prostaglandins are thought to be important mediators of gallbladder hypomotility. We assessed the effect of aspirin, a prostaglandin inhibitor on gallbladder resting volume and ejection fraction according to a double-blind study protocol in 20 healthy...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF02212702

    authors： Das A,Baijal SS,Saraswat VA

    更新日期：1995-08-01 00:00:00

  • Impaired interdigestive pancreatic polypeptide release. Early hormonal disorder in chronic pancreatitis?

    abstract：:The purpose of this study was to investigate interdigestive cycling and postprandial release of pancreatic polypeptide (PP) in relation to exocrine pancreatic function in chronic pancreatitis (CP). We investigated nine patients with mild-moderate CP (MCP), eight patients with severe CP and steathorrea (SCP), and 17 he...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02090063

    authors： Pieramico O,Nelson DK,Glasbrenner B,Malfertheiner P

    更新日期：1994-01-01 00:00:00

  • A Prospective Study on Contrast-Enhanced Endoscopic Ultrasound for Differential Diagnosis of Pancreatic Cystic Neoplasms.

    abstract：BACKGROUND AND AIMS:To determine the value of contrast-enhanced endoscopic ultrasound (CE-EUS) for differentiation of pancreatic cystic neoplasms (PCNs). METHODS:From April 2015 to December 2017, 82 patients were enrolled in this study. All patients were confirmed to have PCNs by surgical pathology. Prior to surgery, ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-019-05718-z

    authors： Zhong L,Chai N,Linghu E,Li H,Yang J,Tang P

    更新日期：2019-12-01 00:00:00

  • Immunohistochemical Assessment of CD30+ Lymphocytes in the Intestinal Mucosa Facilitates Diagnosis of Pediatric Ulcerative Colitis.

    abstract：BACKGROUND:Diagnosis of pediatric inflammatory bowel diseases (IBD) remains challenging. We aimed at the value of immunohistochemical assessment of CD30+ lymphocytes in the intestinal mucosa in differential diagnosis between pediatric Crohn's disease (CD) and ulcerative colitis (UC) and its utility as a predictor of fu...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-5018-3

    authors： Fabian O,Hradsky O,Drskova T,Mikus F,Zamecnik J,Bronsky J

    更新日期：2018-07-01 00:00:00

  • Different profile of peripheral antioxidant enzymes and lipid peroxidation in active and non-active inflammatory bowel disease patients.

    abstract：BACKGROUND:The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and t...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-012-2510-z

    authors： Achitei D,Ciobica A,Balan G,Gologan E,Stanciu C,Stefanescu G

    更新日期：2013-05-01 00:00:00

  • Longer-term outcomes of nutritional management of Crohn's disease in children.

    abstract：BACKGROUND:While the short-term benefits of exclusive enteral nutrition (EEN) for induction of remission in children with Crohn's disease (CD) are well documented, the longer-term outcomes are less clear. AIM:This retrospective study aimed to ascertain the outcomes for up to 24 months following EEN in a group of child...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-012-2232-2

    authors： Lambert B,Lemberg DA,Leach ST,Day AS

    更新日期：2012-08-01 00:00:00

  • The changing faces of eosinophilic esophagitis: the impact of consensus guidelines at the University of South Florida.

    abstract：BACKGROUND AND AIMS:Prior to the consensus guideline conference in 2007, eosinophilic esophagitis (EoE) was uncommon dominated by the fibrostenotic phenotype, but over the past decade has become a common cause of dysphagia with more inflammatory phenotypes diagnosed. We assessed the impact of guideline definitions on t...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-014-3517-4

    authors： Lipka S,Boyce HW,Kumar A,Richter JE

    更新日期：2015-06-01 00:00:00

  • A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome.

    abstract：PURPOSE:The objectives of this study were, firstly, to determine the diversity of the host's gut microbiota in irritable bowel syndrome (IBS) using a culture-independent method (DGGE of the 16S rRNA gene) and, secondly, to examine mucosal biopsies of IBS patients and compare them to their own fecal microbiota. METHODS...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-009-0934-x

    authors： Codling C,O'Mahony L,Shanahan F,Quigley EM,Marchesi JR

    更新日期：2010-02-01 00:00:00

  • Intercellular adhesion molecular-1, Fas, and Fas ligand as diagnostic biomarkers for acute allograft rejection of pancreaticoduodenal transplantation in pigs.

    abstract：BACKGROUND:The early diagnosis of pancreas allograft dysfunction is crucial for the management and long-term survival of transplanted pancreases. We investigated whether intercellular adhesion molecular-1 (ICAM-1), Fas, and Fas ligand (FasL) can be used as novel biomarkers of acute pancreaticoduodenal allograft dysfunc...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-013-2904-6

    authors： Dong GH,Li XF,Li JZ,Zhang ZD,Hu WM,Luo YH,Li ZD,Tian BL,He MX,Zhu XW

    更新日期：2014-04-01 00:00:00

  • Mechanism of intragastric tetramethylammonium protection against 40% ethanol injury in rat stomach.

    abstract：:The effect of tetramethylammonium (TMA), a ganglionic stimulant, on gastric mucosal injury induced by 40% ethanol was examined. In studies I-III, rats were treated with intragastric vehicle or TMA (1 or 10 mg/kg). In study I, 1 hr after the treatment, 40% ethanol was given intragastrically. The length of the linear co...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01316804

    authors： Endoh K,Kao J,Baker M,Scremin OU,Leung FW

    更新日期：1993-04-01 00:00:00

  • Nucleotide sequence analysis of the precore region in patients with spontaneous reactivation of chronic hepatitis B.

    abstract：:The role of HBV precore mutations in the spontaneous reactivation of chronic hepatitis B (CHB) is currently unknown. We studied 10 patients with CHB; five were HBeAg+ (group I) and five were anti-HBe+ (group II). All 10 had spontaneous reactivation of CHB as defined by the appearance of clinical symptoms along with an...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02088138

    authors： Laskus T,Rakela J,Tong MJ,Persing DH

    更新日期：1994-09-01 00:00:00

  • Cumulative Inflammation Could Be a Risk Factor for Intestinal Failure in Crohn's Disease.

    abstract：BACKGROUND:Intestinal failure is the most critical complication of Crohn's disease. Intestinal failure requires home parenteral nutrition, which worsens the quality of life of the patients and sometimes causes life-threatening complications. AIMS:The purpose of this study was to investigate the incidence and risk fact...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-019-05553-2

    authors： Watanabe Y,Miyoshi N,Fujino S,Takahashi H,Haraguchi N,Hata T,Matsuda C,Yamamoto H,Doki Y,Mori M,Mizushima T

    更新日期：2019-08-01 00:00:00

  • Expression of gastric antisecretory and prostaglandin E receptor binding activity of misoprostol by misoprostol free acid.

    abstract：:In enriched canine parietal cell preparations, misoprostol, an analog of prostaglandin E1 methyl ester, was rapidly deesterified to misoprostol free acid. Under this circumstance, misoprostol and misoprostol free acid exhibited equal antisecretory potency against histamine-stimulated acid secretion and bound equally w...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01297024

    authors： Tsai BS,Kessler LK,Stolzenbach J,Schoenhard G,Bauer RF

    更新日期：1991-05-01 00:00:00

  • Infectious esophagitis following liver and renal transplantation.

    abstract：:Upper gastrointestinal endoscopy was performed for the evaluation of infectious esophagitis in 19 consecutive subjects evaluated prospectively before orthotopic liver transplantation (OLTx), in a separate group of 27 subjects post-OLTx, and in 21 subjects following orthotopic renal transplantation (ORTx). None of the ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01535788

    authors： Alexander JA,Brouillette DE,Chien MC,Yoo YK,Tarter RE,Gavaler JS,Van Thiel DH

    更新日期：1988-09-01 00:00:00

  • Alcohol and smoking as risk factors in chronic pancreatitis and pancreatic cancer.

    abstract：:The aim of this study was to compare alcohol and smoking as risk factors in the development of chronic pancreatitis and pancreatic cancer. We considered only male subjects: (1) 630 patients with chronic pancreatitis who developed 12 pancreatic and 47 extrapancreatic cancers; (2) 69 patients with histologically well do...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1026670911955

    authors： Talamini G,Bassi C,Falconi M,Sartori N,Salvia R,Rigo L,Castagnini A,Di Francesco V,Frulloni L,Bovo P,Vaona B,Angelini G,Vantini I,Cavallini G,Pederzoli P

    更新日期：1999-07-01 00:00:00

  • Intragastric alcohol causes endothelin release from feline pancreas.

    abstract：:The mechanism by which alcohol causes pancreatic damage is still largely unknown. One important contributory factor may be the endothelins, potent vasoconstricting endothelial-derived peptides. The aim of this study was to examine in vivo endothelin release from the pancreatic vascular endothelium after alcohol ingest...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1018845710446

    authors： Lewis MP,Reber PU,Kusske AM,Toyama MT,Todd KE,Ashley SW,Reber HA

    更新日期：1998-05-01 00:00:00

  • Fibrin ring granulomas in hepatitis A.

    abstract：:Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus, Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypers...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01308088

    authors： Ruel M,Sevestre H,Henry-Biabaud E,Courouce AM,Capron JP,Erlinger S

    更新日期：1992-12-01 00:00:00

  • Hepatopulmonary syndrome in noncirrhotic portal hypertensive patients.

    abstract：:Hepatopulmonary syndrome has yet not been sufficiently assessed in noncirrhotic portal hypertension. The prevalence of hepatopulmonary syndrome was determined in 31 consecutive patients with noncirrhotic portal hypertension (19 idiopathic portal hypertension, 7 portal vein thrombosis, 5 congenital hepatic fibrosis) an...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1022549018807

    authors： Kaymakoglu S,Kahraman T,Kudat H,Demir K,Cakaloglu Y,Adalet I,Dincer D,Besisik F,Boztas G,Sözen AB,Mungan Z,Okten A

    更新日期：2003-03-01 00:00:00