Production of a polar metabolite of 1,25-dihydroxyvitamin D3 in a rat liver perfusion system.

Abstract:

:When radiolabeled 1,25-dihydroxyvitamin D3 is added to the perfusion medium of a rat liver perfusion system, a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver and excreted in the bile. Addition of radiolabeled 1,25-dihydroxyvitamin D3 to the perfusion medium without a liver in the circuit results in no formation of the polar metabolite. These data suggest that a polar metabolite of 1,25-dihydroxyvitamin D3 is formed in the liver prior to being excreted in bile. Moreover, it is likely that polar metabolites of 1,25-dihydroxyvitamin D3 present in the bile of rats in vivo are formed in the liver.

journal_name

Dig Dis Sci

authors

Kumar R,Nagubandi S,Londowski JM

doi

10.1007/BF01391637

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

242-6

issue

3

eissn

0163-2116

issn

1573-2568

journal_volume

26

pub_type

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