Antibiotic properties of bovine lactoferrin on Helicobacter pylori.

Abstract:

:To investigate a potential new treatment for gastric Helicobacter pylori infection, we have examined the use of the natural antibiotic lactoferrin, found in bovine milk, for activity against Helicobacter species both in vitro and in vivo. Lactoferrin was bacteriostatic to H. pylori when cultured at concentrations > or =0.5 mg/ml. Growth of H. pylori was not inhibited by another milk constituent, lysozyme, or by a metabolite of lactoferrin, lactoferricin B, but growth was inhibited by the iron chelator deferoxamine mesylate. Lactoferrin inhibition of growth could be reversed by addition of excess iron to the medium. Lactoferrin in retail dairy milk was found to be more stable intragastrically than unbuffered, purified lactoferrin. Treatment of H. felis-infected mice with lactoferrin partially reversed mucosal disease manifestations. It is concluded that bovine lactoferrin has significant antimicrobial activity against Helicobacter species in vitro and in vivo. Bovine lactoferrin should be further investigated for possible use in H. pylori infections in man.

journal_name

Dig Dis Sci

authors

Dial EJ,Hall LR,Serna H,Romero JJ,Fox JG,Lichtenberger LM

doi

10.1023/a:1026675916421

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

2750-6

issue

12

eissn

0163-2116

issn

1573-2568

journal_volume

43

pub_type

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