Abstract:
:Alcoholic liver disease (ALD) is characterized by elevated serum IgA concentrations, the presence of circulating immune complexes containing IgA, and IgA deposits along sinusoids in the liver. When combined with the presupposed IgA-clearance function of the liver, a causal association between IgA abnormalities and the liver disease in ALD can be suggested. This prompted us to study the presence and concentration of circulating IgA-containing immune complexes (IgA-CIC) in 41 patients with ALD and 41 patients with other nonalcoholic liver diseases having comparable serum IgA levels. We searched for relationships among IgA-CIC and history of alcohol abuse, liver histopathology, and IgA deposits in the liver. Using an anti-IgA inhibition binding assay, 56% of the patients exhibited IgA-CIC in polyethylene glycol precipitate of serum and 38% showed IgA-CIC in whole serum. The prevalence and concentration of IgA-CIC was lowest in cases with nonspecific changes or steatosis in the liver biopsy and highest in cases with hepatitis or cirrhosis (P less than 0.01). The occurrence of IgA-CIC was not related to a history of alcohol abuse or to the presence of IgA deposits along hepatic sinusoids (which occurred in 78% of ALD and 20% of non-ALD cases). A skin biopsy was available from 34 patients (19 with ALD and 15 with non-ALD). In 68% of these biopsies, IgA deposits were observed in superficial blood capillaries.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
van de Wiel A,Valentijn RM,Schuurman HJ,Daha MR,Hené RJ,Kater Ldoi
10.1007/BF01540430subject
Has Abstractpub_date
1988-06-01 00:00:00pages
679-84issue
6eissn
0163-2116issn
1573-2568journal_volume
33pub_type
杂志文章abstract:BACKGROUND:Obesity is considered a risk factor for other chronic diseases, and diets rich in lipids can cause alterations in the intestinal functions. AIM:The aim of this study was to investigate the effects of a high-fat diet (HFD) on the myenteric plexus of the large intestine in mice. METHODS:Swiss mice were distr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3402-1
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Corticotropin-releasing factor (CRF) peptides exert profound effects on the secretomotor function of the gastrointestinal tract. Nevertheless, despite the presence of CRF peptides and receptors in colonic tissue, their influence on colonic blood flow (CBF) is unknown. AIM:To determine the effect and mechani...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3579-y
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Diarrhea, a major pathological hallmark of inflammatory bowel disease, is characterized by a significant reduction in the expression and function of key intestinal ion transporters. The adoptive naïve CD4+ T cell transfer colitis is an immune-based, chronic colitis mouse model which resembles human Crohn's d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05945-4
更新日期:2020-06-01 00:00:00
abstract:INTRODUCTION:Crohn's disease (CD) and ulcerative colitis (UC) are associated with considerable direct healthcare costs. There have been few comprehensive analyses of all IBD- and non-IBD comorbidities that determine direct costs in this population. METHODS:We used data from a validated cohort of patients with inflamma...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06329-9
更新日期:2020-05-20 00:00:00
abstract::Recording of evoked potential responses represents an objective and quantifiable method to study visceral afferent sensory pathways in humans. We examined the evoked responses to mechanical distension (balloon) and electrical stimulation of the proximal and distal esophagus. A standard manometric catheter with a latex...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026667123187
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Intraductal ultrasonography (IDUS) is a useful procedure for diagnosing microlithiasis in the bile duct but it is not easy to differentiate between tiny echogenicity and real microlithiasis. We compared the echogenicity seen on IDUS and the findings of bile microscopy (BM) of bile that was collected in the c...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0770-z
更新日期:2010-03-01 00:00:00
abstract::In cases of difficult biliary cannulation, transpancreatic sphincterotomy (TPS) can be an alternative approach of biliary access. However, its success and safety profile have not been studied in detail. A systematic review and meta-analysis were performed to study the overall cannulation success and adverse events of ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析
doi:10.1007/s10620-019-05640-4
更新日期:2019-09-01 00:00:00
abstract::Significant species differences have been demonstrated in gastric physiology, a factor that limits extrapolation of animal data to man. Primate physiology is thought to be similar to that of man; however, gastric function has not been adequately documented in the primate. In the present study six baboons (body weight ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295997
更新日期:1992-09-01 00:00:00
abstract::This study was undertaken to investigate the effect of ingestion of 80 g Vivonex on gallbladder volume, plasma cholecystokinin (CCK), and pancreatic polypeptide (PP) in eight healthy volunteers and to compare the results with those obtained after ingestion of 60 ml corn oil. Gallbladder volumes were measured by ultras...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296686
更新日期:1987-01-01 00:00:00
abstract::Duodenal resistance to gastric outflow is known to participate in the regulation of gastric emptying of liquids in animals, but the role of this mechanism in humans has not been extensively investigated. In this work we studied the gastric emptying of liquids in patients with megaduodenum, who putatively have increase...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026684418333
更新日期:2000-11-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9272-4
更新日期:2007-04-01 00:00:00
abstract::Several techniques have been developed to diagnose Helicobacter pylori infection and two noninvasive methods are available: carbon 13-urea breath test (UBT) and serology. Measurement of IgG serum antibodies by enzyme-linked immunosorbent assay (ELISA) is a reliable and inexpensive method for detection of infection. Th...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005589700652
更新日期:2000-08-01 00:00:00
abstract::Longitudinal shortening of the esophagus during peristaltic contraction has been previously analyzed globally using spaced mucosal clips. This method gives a relatively crude measurement. In this study, local longitudinal shortening (LLS) was evaluated using simultaneous high-resolution endoluminal ultrasound (HREUS) ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-3092-4
更新日期:2006-01-01 00:00:00
abstract::Five healthy young adults developed an acute self-limiting ulcerative esophagitis. Two had definite evidence of herpes virus being present and a third one had appropriate changes in herpes simplex viral titer. All cases followed a characteristic and similar course consisting of sudden onset of odynophagia, multiple di...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01489322
更新日期:1979-07-01 00:00:00
abstract::Expressive loss of the tumor suppressor deleted in colon cancer (DCC) may be superior to lymph node status in predicting patient survival for intermediate stage colon cancer. A polymerase chain reaction (PCR)-based method for detecting DCC would be ideal as a prognostic indicator. DCC is an alternatively spliced molec...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010626929411
更新日期:2001-09-01 00:00:00
abstract::The role of mucosal T-cell activation in HIV-associated enteropathy is uncertain. Twenty Zambian patients with AIDS and chronic diarrhea were studied, as were nine controls. Distal duodenal biopsies were taken at endoscopy. Morphometric analysis and dual color immunofluorescence staining were performed. Villous height...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010738818127
更新日期:2001-05-01 00:00:00
abstract::The techniques commonly used to evaluate the transit of contents through the gut feature some limitations for being either inaccurate, invasive, inconvenient, or potentially dangerous for the subjects. Aim of this study was to establish a safe, noninvasive and accurate technique for the measurement of segmental oroana...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296499
更新日期:1992-10-01 00:00:00
abstract::Viral dynamic studies in chronic hepatitis C virus (HCV) infection indicate a significantly shortened survival of virus-infected cells. Since at the steady state of chronic viral infection, the rate of infected cell elimination equals new cell regeneration, this would imply a high rate of hepatocyte turnover in chroni...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1015800126283
更新日期:2002-07-01 00:00:00
abstract::We examined the effect of cyclooxygenase (COX) inhibitors on dextran sulfate sodium (DSS)-induced ulcerative colitis in rats and investigated the role of COX isozymes in the pathogenesis of this model. Experimental colitis was induced by treatment with 2.5% DSS in drinking water for 6 days. Indomethacin (a nonselectiv...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9597-z
更新日期:2007-09-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4610-2
更新日期:2017-08-01 00:00:00
abstract::We compared changes in gastric mucosal blood flow (GMBF) and left gastric artery blood flow (LGABF) in response to pharmacological, physiological, and pathological stimuli. GMBF and LGABF were measured by the hydrogen gas clearance and perivascular ultrasonic transit time techniques, respectively, under baseline condi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018807009266
更新日期:1997-09-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3296-y
更新日期:2015-01-01 00:00:00
abstract::Patients with symptomatic cholelithiasis who represent higher than normal surgical risks may be the most suitable candidates for medical dissolution of gallstones. Chenodeoxycholic acid was given to 97 patients in a dosage of 15 mg/kg of body weight per day for a period of two years. Complete gallstone dissolution occ...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01308157
更新日期:1983-06-01 00:00:00
abstract::Canine and human exocrine pancreatic secretion into the duodenum during fasting is cyclical and related to intestinal motility. To characterize the composition of pure pancreatic juice during the cyclically recurring sequence of propagated motor events (interdigestive motor complex) and to establish whether pancreatic...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01367667
更新日期:1981-07-01 00:00:00
abstract::The protective effect of a human strain of Bifidobacterium bifidum (B. bifidum) against murine group A rotavirus (MRV) was examined in the intestines of BALB/c infected mice. In experiments designed to determine whether B. bifidum mediated MRV shedding during diarrheal disease, pregnant dams (and their expected litter...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02087647
更新日期:1994-11-01 00:00:00
abstract::Concentration and voltage dependence of Mg transport across the rat duodenum was measured in an Ussing chamber. Mucosa (m) to serosa (s) Mg flux exhibits a cellular fraction comparable to that found for Ca. Mg sm flux is purely diffusive and probably restricted to the paracellular pathway. At all concentrations betwee...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296406
更新日期:1991-11-01 00:00:00
abstract::Basal gastric acid output was analyzed prospectively in 110 patients with endoscopically documented duodenal ulcer disease to determine the frequency of gastric acid hypersecretion in patients with bleeding versus nonbleeding ulcers. Thirty-eight patients with stigmata of an actively or recently bleeding duodenal ulce...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01307543
更新日期:1993-02-01 00:00:00
abstract::Biliary mucin was isolated from human hepatic bile, and its induced effects on the appearance time of cholesterol monohydrate crystals (nucleation time) and on the precipitation of calcium carbonate were studied in vitro to examine the possible significance of mucin for ductular gallstone formation. Mucin was isolated...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295919
更新日期:1993-05-01 00:00:00
abstract::Concentration and voltage dependence of unidirectional Mg fluxes across the rat colon ascendens were measured in a modified Ussing chamber. Mucosa (M) to serosa (S) Mg flux exhibits a cellular component, whereas SM flux is totally diffusive. At all the concentrations between 0.125 and 8 mmol/liter MS Mg transport is h...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536699
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Assessment and quantification of actual liver function is crucial in patients with chronic liver disease to monitor disease progression and predict individual prognosis. Mathematical models, such as model for end-stage liver disease, are used for risk stratification of patients with chronic liver disease but...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3250-z
更新日期:2014-12-01 00:00:00