Abstract:
:Concentration and voltage dependence of Mg transport across the rat duodenum was measured in an Ussing chamber. Mucosa (m) to serosa (s) Mg flux exhibits a cellular fraction comparable to that found for Ca. Mg sm flux is purely diffusive and probably restricted to the paracellular pathway. At all concentrations between 0.5 and 5 mmol/liter, Mg is secreted. Diffuse sm Mg flux is 3.5 times higher than the diffusive component of ms Mg transport. This prevalence of diffusive sm Mg flux over that from mucosa to serosa, which may be explained by an "anomalous solvent drag effect," is responsible for the Mg secretion observed. Mg 5 mmol/liter decreases ms Ca flux and abolishes Ca absorption. The voltage clamp experiments reveal that Mg has no effect on the cellular transport but only decreases diffusive ms Ca flux. 1 alpha,25-dihydroxyvitamin D3 has only a small effect on cellular Mg transport but remarkably stimulates ms Ca flux and increases Ca absorption by about 85%. Dexamethasone increases ms Mg flux but decreases ms Ca transport and hereby abolished Mg secretion or Ca absorption. In conclusion, Mg is secreted across the short-circuited duodenum whereas Ca is absorbed. There is evidence that both earth alkalines are transported by distinct cellular mechanisms. The data also demonstrate that diffusive movement across the paracellular pathway plays an important role on net Mg transport.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Karbach U,Schmitt A,Saner FHdoi
10.1007/BF01296406subject
Has Abstractpub_date
1991-11-01 00:00:00pages
1611-8issue
11eissn
0163-2116issn
1573-2568journal_volume
36pub_type
杂志文章abstract:BACKGROUND:Small bowel mass lesions (SBML) are a relatively common cause of obscure gastrointestinal bleeding (OGIB). Their detection has been limited by the inability to endoscopically examine the entire small intestine. This has changed with the introduction of capsule endoscopy (CE) and double balloon enteroscopy (D...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
doi:10.1007/s10620-007-0110-0
更新日期:2008-08-01 00:00:00
abstract:INTRODUCTION:Voluntary muscle activity, including swallowing, decreases during the night. The association between nocturnal awakenings and swallowing activity is under-researched with limited information on the frequency of swallows during awake and asleep periods. AIM:The aim of this study was to assess nocturnal swa...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-012-2474-z
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abstract::Food allergy, a commonly increasing problem worldwide, defined as an adverse immune response to food. A variety of immune-related effector cells such as mast cells, eosinophils, neutrophils, and T cells are involved in food-related allergic responses categorized as IgE mediated, non-IgE mediated, and mixed (IgE and no...
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journal_title:Digestive diseases and sciences
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更新日期:1991-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
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journal_title:Digestive diseases and sciences
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更新日期:1991-12-01 00:00:00
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pub_type: 杂志文章,多中心研究,评审
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journal_title:Digestive diseases and sciences
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更新日期:2021-01-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:2015-07-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5416-6
更新日期:2019-05-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:1996-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10620-010-1249-7
更新日期:2010-08-01 00:00:00
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journal_title:Digestive diseases and sciences
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doi:10.1007/s10620-007-0063-3
更新日期:2008-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005541305255
更新日期:2001-02-01 00:00:00
abstract::The objective of this study was to determine if HCV can be transmitted from patient to patient in psychiatric institutions and to determine possible routes of infection. We did a cross-sectional survey of 196 Japanese psychiatric patients tested for HCV and HBV markers and 400 age- and sex-matched controls. Anti-HCV w...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Lymphocytic esophagitis is a rare esophageal condition. Our knowledge of potential risk factors and treatment outcomes of lymphocytic esophagitis is limited. AIM:To investigate potential risk factors associated with the development of lymphocytic esophagitis and compare clinical characteristics and treatmen...
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pub_type: 杂志文章
doi:10.1007/s10620-012-2239-8
更新日期:2012-11-01 00:00:00
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doi:10.1007/s10620-010-1142-4
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:1997-05-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3046-1
更新日期:2014-07-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:1987-11-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01540562
更新日期:1990-12-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:1982-05-01 00:00:00