Abstract:
:Longitudinal shortening of the esophagus during peristaltic contraction has been previously analyzed globally using spaced mucosal clips. This method gives a relatively crude measurement. In this study, local longitudinal shortening (LLS) was evaluated using simultaneous high-resolution endoluminal ultrasound (HREUS) and manometry based on basic principles of muscle mechanics. We sought to determine if there are regional differences in LLS of the esophageal muscle during swallow-induced peristaltic contraction and evaluate shortening of the circular smooth muscle (CSM) and longitudinal smooth muscle (LSM) of the esophagus. Twenty normal subjects underwent simultaneous HREUS/manometry at 4 levels (5, 10, 15, and 20 cm above the upper border of the lower esophageal sphincter [LES] high-pressure zone) in the esophagus with 5-mL swallows of water. Ultrasound images were recorded with synchronized manometric pressure data. The images were digitized and the cross-sectional surface area (CSA) of the LSM, CSM, and total muscle (TM) were measured at baseline (at rest) and at peak intraluminal pressure (implying peak CSM contraction) during swallowing. LLS was calculated for the CSM and LSM using the principle of mass conservation, whereby the change in CSA relative to the resting CSA is quantitatively equal to the relative change in length of a local longitudinal muscle segment.CSM, LSM, and TM all shortened longitudinally, with the circular muscle shortening more than the longitudinal muscle, LLS of the CSM and TM layers at 5 cm above the LES was significantly greater than at 20 cm (CSM: 30% difference, P < .001; TM: 18% difference, P < .05). The greater shortening of LSM at 5 versus 20 cm was found not to be statistically significant (11% difference, P > .05). Peak intraluminal pressure strongly correlated with peak muscle thickness of all layers at all levels (r = 0.96-0.98).LLS increases from the proximal to the distal esophagus during bolus transport. CSM and LSM both shorten longitudinally, with CSM shortening more than LSM. The increase in LLS increases the efficiency of peristaltic contraction and likely contributes to the axial displacement of the LES preceding hiatal opening and esophageal emptying.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Dai Q,Korimilli A,Thangada VK,Chung CY,Parkman H,Brasseur J,Miller LSdoi
10.1007/s10620-006-3092-4subject
Has Abstractpub_date
2006-01-01 00:00:00pages
105-9issue
1eissn
0163-2116issn
1573-2568journal_volume
51pub_type
杂志文章abstract:INTRODUCTION:Liver transplant recipients often perform liver biopsy (LB), specially in the context of potentially recurring diseases, such as hepatitis C infection. However, the LB has risks of complications, despite being the gold standard. Transient elastography (TE) is a noninvasive method comparable to the LB to ev...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4349-1
更新日期:2017-01-01 00:00:00
abstract::The significance of hyperplastic polyps of the gastric antrum in anemic patients with suspected gastrointestinal bleeding has not been determined. The aim of this study is to evaluate the prevalence and prognosis of such polyps in this patient group. Clinical records of patients referred to our endoscopy lab from Nove...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9182-5
更新日期:2007-01-01 00:00:00
abstract::As infection influences the pathogenesis and presentation of celiac disease, we investigated the expression of natural antibiotics in this condition. Twenty-three adults were prospectively studied: 10 controls and 13 subjects with untreated celiac disease. Distal duodenal biopsies were taken at baseline and after 6 mo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2575-z
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results. AIM:To further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility. METHODS:We performed an extensive search of relevant studies and carried ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10620-009-0978-y
更新日期:2010-07-01 00:00:00
abstract::Previous studies have shown that duodenal motility patterns differ in preterm and term infants, but antral motor activities were not compared. Using a validated, low-compliance, continuous-perfusion, neonatal manometric system, antral and duodenal motility was studied in 19 preterm and nine term infants. Antral motili...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308336
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:COVID-19 has caused a backlog of endoscopic procedures; colonoscopy must now be prioritized to those who would benefit most. We determined the proportion of screening and surveillance colonoscopies appropriate for rescheduling to a future year through strict adoption of US Multi-Society Task Force (USMSTF) g...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06539-1
更新日期:2020-08-16 00:00:00
abstract:BACKGROUND:Hepatitis C (HCV) knowledge is limited in injection drug users (IDU). Vulnerable populations including IDUs are disproportionally affected by HCV. Effective HCV education can potentially reduce disparity in HCV prevalence and its outcome in this population. AIM:This study aimed to assess the impact of forma...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1455-3
更新日期:2011-01-01 00:00:00
abstract::We have developed an improved semiconductor recording probe for monitoring motility of the upper small intestine in humans. The probe consists of six ultraminiature silicon pressure sensors spaced 10 cm apart and encased in a flexible polyurethane sheath. The probe is small [2.67 mm (8F) diameter], is easily passed tr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308196
更新日期:1985-02-01 00:00:00
abstract::To examine the differentiating parameters between cholesterol and pigment gallstones, we compared the nucleation times, concentrations of biliary lipid and protein, and the distribution of vesicular cholesterol in gallbladder bile of 16 patients with cholesterol, eight patients with black pigment gallstones, and nine ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296790
更新日期:1993-01-01 00:00:00
abstract::This study investigated the effects of intravenous morphine on gastric antral and duodenal motility in healthy volunteers. Intravenous morphine (both infusion and bolus) increased duodenal motility, typically as bursts of contractions similar to phase III of the migrating motor complex. Intravenous infusion of morphin...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026684132254
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Wnt-β-catenin signaling is essential for homeostasis of intestinal stem cells in mice and is thought to promote intestinal crypt fission. AIMS:The aim of this study was to investigate Wnt-β-catenin signaling in intestinal crypts of human infants. METHODS:Duodenal biopsies from nine infants (mean, range 0.9...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5286-y
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Although a genetic component has been identified as a risk factor for developing inflammatory bowel disease, there is evidence that dietary factors also play a role in the development of this disease. AIMS:The aim of this study was to determine the effects of feeding a red meat diet with and without resista...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2844-1
更新日期:2013-12-01 00:00:00
abstract::To examine the relationship between peptic ulcer and gastric cancer, we investigated 2529 patients with peptic ulcer diagnosed from 1963 to 1975. During the follow-up period of 9-23 years, we found 38 in whom gastric cancer developed or who died of gastric cancer. Included were nine in whom gastric cancer was detected...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01540181
更新日期:1990-06-01 00:00:00
abstract::Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02100135
更新日期:1996-12-01 00:00:00
abstract::The neutralizing capacity of two antacids (Alucol = A, Syntrogel = S), differing both in their composition and theoretical neutralizing capacity, was evaluated in vitro and in vivo. In vitro at pH 3.5, 1 ml of A or S neutralizes 3.9 and 1.6 meq of acid, respectively, in an aqueous solution. When tested in vivo in the ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01320257
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND AND AIM:Previous studies evaluating the safety of endoscopic retrograde cholangiopancreatography (ERCP) in patients with end-stage renal disease (ESRD) undergoing hemodialysis reported an increased risk of post-procedural bleeding. We investigated the safety and efficacy of ERCP for the treatment of choledoc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5112-6
更新日期:2018-11-01 00:00:00
abstract::Choledochoduodenostomy may be followed by the "sump syndrome." This previously required surgical intervention. We describe the successful application of endoscopic therapy in two patients with this syndrome. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318873
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND AND AIM:Although cholesterol levels are elevated in patients with primary biliary cirrhosis (PBC), most PBC patients are not at increased risk of dying from atherosclerotic heart disease. There is, however, a subgroup, approximately 10%, who have additional disorders of lipid metabolism. They might benefit f...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0988-9
更新日期:2010-07-01 00:00:00
abstract::Minimal hepatic encephalopathy (MHE) describes patients with chronic liver disease or cirrhosis who have no clinical symptoms of brain dysfunction but perform worse on psychometric tests compared with healthy subjects. The pathogenesis of hepatic encephalopathy is controversial although ammonia has been found to induc...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-006-9687-y
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Despite national campaigns and other efforts to improve colorectal cancer (CRC) screening, participation rates remain below targets set by expert panels. We hypothesized that availability and practice patterns of healthcare providers may contribute to this gap. METHOD:Using data of the Medical Expenditure P...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06541-7
更新日期:2021-01-01 00:00:00
abstract::To study the clinicopathologic features of hepatitis C viremic patients negative for hepatitis C antibodies (anti-HCV) by current second-generation assay, we categorized 139 consecutive histologically verified patients with chronic non-A, non-B hepatitis into three groups: 121 (87%) were positive for second-generation...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02208599
更新日期:1996-01-01 00:00:00
abstract::An intravenous injection of diphenylthiocarbazone (dithizone), a zinc chelator, induces selective killing and rapid regeneration of Paneth cells, which have a large amount of zinc in their cytoplasmic granules. We examined the expression pattern of transforming growth factor (TGF) -alpha and TGF-beta1 in this regenera...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1010797609041
更新日期:2001-05-01 00:00:00
abstract::Inflammatory bowel disease (IBD) is an important etiologic factor in the development of colorectal cancer (CRC). The risk of CRC begins to increase 8 or 10 years after the diagnosis of IBD. This type of cancer is called colitis-associated CRC (CA-CRC). The molecular pathogenesis of inflammatory epithelium might play a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-015-3646-4
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND/AIMS:There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, popul...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5073-9
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE:The objective of this study was to identify evidence-based cutpoints for the CTP laboratory...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4239-6
更新日期:2016-11-01 00:00:00
abstract::All cases of hepatolithiasis showed features of chronic proliferative cholangitis, and it has been speculated that the atypical glandular proliferation might be a precursor to overt cholangiocarcinoma. Proliferative cell nuclear antigen (PCNA) is a nuclear protein synthesized in the G1/S phase of the cell cycle and th...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026604704029
更新日期:1999-11-01 00:00:00
abstract::Since granulocyte elastase has been shown to be involved in the pathogenesis of gastric mucosal lesion formation induced by nonsteroidal antiinflammatory drugs, inhibition of granulocyte elastase release from neutrophils may be useful in the prevention of these lesions. The objective of this study was to determine whe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::Biomagnetic measurements are based on the noninvasive recording of magnetic signals produced by biological sources such as nervous system and muscle. The aim of this study was to obtain multichannel magnetic field recordings from the human gastrointestinal tract and to localize the sources of these signals three-dimen...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018852208687
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Inflammatory bowel disease (IBD) is a chronic, debilitating condition with high emergency department (ED) utilization. We aimed to investigate the utilization patterns of ED by IBD patients and measure hospitalization and surgical rates following ED visits. METHODS:We conducted a cross-sectional study of ad...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3895-2
更新日期:2016-02-01 00:00:00
abstract::The aim of the present study was to investigate the antioxidative effects of water-soluble vitamin E derivative, 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol (TMG), on ischemia-reperfusion (I/R) -induced gastric mucosal injury in rats. Gastric ischemia was induced by applying a small clamp to the c...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1021778229997
更新日期:2003-01-01 00:00:00