Abstract:
:The aim of the present study was to investigate the antioxidative effects of water-soluble vitamin E derivative, 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol (TMG), on ischemia-reperfusion (I/R) -induced gastric mucosal injury in rats. Gastric ischemia was induced by applying a small clamp to the celiac artery and reoxygenation was produced by removal of the clamp. The area of gastric mucosal erosion, the concentration of thiobarbituric acid-reactive substances, and the myeloperoxidase activity in gastric mucosa significantly increased in I/R groups compared with those of sham-operated groups. These increases were significantly inhibited by pretreatment with TMG. The contents of both mucosal TNF-alpha and CINC-2beta in I/R groups were also increased compared with the levels of those in sham-operated groups. These increases of the inflammatory cytokines were significantly inhibited by the treatment with TMG. It is concluded that TMG inhibited lipid peroxidation and reduced development of the gastric mucosal inflammation induced by I/R in rats.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Ichikawa H,Yoshida N,Takano H,Ishikawa T,Handa O,Takagi T,Naito Y,Murase H,Yoshikawa Tdoi
10.1023/a:1021778229997subject
Has Abstractpub_date
2003-01-01 00:00:00pages
54-8issue
1eissn
0163-2116issn
1573-2568journal_volume
48pub_type
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