Abstract:
BACKGROUND:The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results. AIM:To further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility. METHODS:We performed an extensive search of relevant studies and carried out a meta-analysis, including ten studies with 2,195 gastric cancer cases and 3,505 controls, to obtain a more precise estimate. RESULTS:The combined results based on all studies showed that the IL-8 251 allele AA genotype was a risk factor for gastric cancer [AA versus TT: odds ratio (OR) = 1.363, 95% confidence interval (CI): 1.199-1.527]. In subgroup analysis, a clear effect of AA in IL-8 251 allele was shown in Asians (AA versus TT: OR = 1.593, 95% CI: 1.013-2.173) but not in Caucasians or Mexicans. When stratified by Lauren classification, we found that the IL-8 251 allele TA and AA polymorphism was significantly associated with the diffuse type of gastric cancer (TA versus TT: OR = 1.448, 95% CI: 1.177-1.720; AA versus TT: OR = 1.586, 95% CI: 1.128-2.044). The IL-8 251 AA genotype was found to be a risk factor for cardiac gastric cancer (AA versus TT: OR = 1.840, 95% CI: 1.112-2.568) but not for noncardiac gastric cancer. CONCLUSIONS:This meta-analysis suggested that IL-8 251 allele A>T polymorphism might be a risk factor for gastric cancer.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Wang J,Pan HF,Hu YT,Zhu Y,He Qdoi
10.1007/s10620-009-0978-ysubject
Has Abstractpub_date
2010-07-01 00:00:00pages
1818-23issue
7eissn
0163-2116issn
1573-2568journal_volume
55pub_type
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
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journal_title:Digestive diseases and sciences
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pub_type: 杂志文章,多中心研究
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journal_title:Digestive diseases and sciences
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pub_type: 临床试验,杂志文章
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更新日期:2006-02-01 00:00:00
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