Polymorphism of IL-8 in 251 allele and gastric cancer susceptibility: a meta-analysis.

Abstract:

BACKGROUND:The relationship of gastric cancer to the presence of interleukin-8 (IL-8) 251 T/A has been reported with conflicting results. AIM:To further explore the association of IL-8 251 allele polymorphism with gastric cancer susceptibility. METHODS:We performed an extensive search of relevant studies and carried out a meta-analysis, including ten studies with 2,195 gastric cancer cases and 3,505 controls, to obtain a more precise estimate. RESULTS:The combined results based on all studies showed that the IL-8 251 allele AA genotype was a risk factor for gastric cancer [AA versus TT: odds ratio (OR) = 1.363, 95% confidence interval (CI): 1.199-1.527]. In subgroup analysis, a clear effect of AA in IL-8 251 allele was shown in Asians (AA versus TT: OR = 1.593, 95% CI: 1.013-2.173) but not in Caucasians or Mexicans. When stratified by Lauren classification, we found that the IL-8 251 allele TA and AA polymorphism was significantly associated with the diffuse type of gastric cancer (TA versus TT: OR = 1.448, 95% CI: 1.177-1.720; AA versus TT: OR = 1.586, 95% CI: 1.128-2.044). The IL-8 251 AA genotype was found to be a risk factor for cardiac gastric cancer (AA versus TT: OR = 1.840, 95% CI: 1.112-2.568) but not for noncardiac gastric cancer. CONCLUSIONS:This meta-analysis suggested that IL-8 251 allele A>T polymorphism might be a risk factor for gastric cancer.

journal_name

Dig Dis Sci

authors

Wang J,Pan HF,Hu YT,Zhu Y,He Q

doi

10.1007/s10620-009-0978-y

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

1818-23

issue

7

eissn

0163-2116

issn

1573-2568

journal_volume

55

pub_type

杂志文章,meta分析,评审
  • Statins in primary biliary cirrhosis: are they safe?

    abstract:BACKGROUND AND AIM:Although cholesterol levels are elevated in patients with primary biliary cirrhosis (PBC), most PBC patients are not at increased risk of dying from atherosclerotic heart disease. There is, however, a subgroup, approximately 10%, who have additional disorders of lipid metabolism. They might benefit f...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0988-9

    authors: Abu Rajab M,Kaplan MM

    更新日期:2010-07-01 00:00:00

  • Nucleotide sequence analysis of the precore region in patients with spontaneous reactivation of chronic hepatitis B.

    abstract::The role of HBV precore mutations in the spontaneous reactivation of chronic hepatitis B (CHB) is currently unknown. We studied 10 patients with CHB; five were HBeAg+ (group I) and five were anti-HBe+ (group II). All 10 had spontaneous reactivation of CHB as defined by the appearance of clinical symptoms along with an...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02088138

    authors: Laskus T,Rakela J,Tong MJ,Persing DH

    更新日期:1994-09-01 00:00:00

  • Comparative effectiveness research of chronic hepatitis B and C cohort study (CHeCS): improving data collection and cohort identification.

    abstract:BACKGROUND AND AIMS:The Chronic Hepatitis Cohort Study (CHeCS) is a longitudinal observational study of risks and benefits of treatments and care in patients with chronic hepatitis B (HBV) and C (HCV) infection from four US health systems. We hypothesized that comparative effectiveness methods-including a centralized d...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3272-6

    authors: Lu M,Rupp LB,Moorman AC,Li J,Zhang T,Lamerato LE,Holmberg SD,Spradling PR,Teshale EH,Vijayadeva V,Boscarino JA,Schmidt MA,Nerenz DR,Gordon SC

    更新日期:2014-12-01 00:00:00

  • Central nervous system lymphoma presenting as dysphagia.

    abstract::Two patients are presented having lymphomatous involvement of the central nervous system in whom dysphagia was the predominant symptom. All indicated studies failed to reveal evidence of direct esophageal involvement, and the dysphagia improved during treatment of the neural component. Esophageal manometric studies re...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01311710

    authors: Benjamin SB,Eisold J,Gerhardt DC,Castell DO

    更新日期:1982-02-01 00:00:00

  • Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle.

    abstract::Glutamine synthetase is responsible for the ATP-dependent amidation of glutamate to glutamine. In liver the enzyme is highly localized in perivenous hepatocytes; in brain the enzyme is localized in astrocytes. Portacaval anastomosis resulted in liver atrophy, hyperammonemia, and up to 90% loss of glutamine synthetase ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01300297

    authors: Girard G,Butterworth RF

    更新日期:1992-07-01 00:00:00

  • Development of an Algorithm to Identify Cases of Nonalcoholic Steatohepatitis Cirrhosis in the Electronic Health Record.

    abstract:BACKGROUND AND AIMS:Current genetic research of nonalcoholic steatohepatitis (NASH) cirrhosis is limited by our ability to accurately identify cases on a large scale. Our objective was to develop and validate an electronic health record (EHR) algorithm to accurately identify cases of NASH cirrhosis in the EHR. METHODS...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06388-y

    authors: Danford CJ,Lee JY,Strohbehn IA,Corey KE,Lai M

    更新日期:2020-06-13 00:00:00

  • Bile acid composition in brown pigment stones.

    abstract::The bile acids in brown pigment stones and gallbladder bile were fractionated into free acids, glycine and taurine conjugates, and sulfates using diethylaminohydroxypropyl Sephadex LH-20 (DEAP-LH-20) column chromatography and were quantitated by gas chromatography. Twenty-eight cases of brown pigment stones were studi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01537218

    authors: Akiyoshi T,Nakayama F

    更新日期:1990-01-01 00:00:00

  • Different mechanism of magnesium and calcium transport across rat duodenum.

    abstract::Concentration and voltage dependence of Mg transport across the rat duodenum was measured in an Ussing chamber. Mucosa (m) to serosa (s) Mg flux exhibits a cellular fraction comparable to that found for Ca. Mg sm flux is purely diffusive and probably restricted to the paracellular pathway. At all concentrations betwee...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296406

    authors: Karbach U,Schmitt A,Saner FH

    更新日期:1991-11-01 00:00:00

  • Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy.

    abstract:BACKGROUND:Small bowel mass lesions (SBML) are a relatively common cause of obscure gastrointestinal bleeding (OGIB). Their detection has been limited by the inability to endoscopically examine the entire small intestine. This has changed with the introduction of capsule endoscopy (CE) and double balloon enteroscopy (D...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-007-0110-0

    authors: Ross A,Mehdizadeh S,Tokar J,Leighton JA,Kamal A,Chen A,Schembre D,Chen G,Binmoeller K,Kozarek R,Waxman I,Dye C,Gerson L,Harrison ME,Haluszka O,Lo S,Semrad C

    更新日期:2008-08-01 00:00:00

  • Involvement of Transient Receptor Potential Vanilloid Receptor 1, (TRPV1)-Expressing Vagal Nerve in the Inhibitory Effect of Gastric Acidification on Exogenous Motilin-Induced Gastric Phase III Contractions in Suncus murinus.

    abstract:BACKGROUND:Gastric acidification inhibits motilin-induced gastric phase III contractions. However, the underlying mechanism has not been thoroughly investigated. Here, we studied the inhibitory mechanism by gastric acidification on motilin-induced contraction in Suncus murinus (S. murinus). METHODS:We measured interdi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-015-4023-z

    authors: Yoshimura M,Mikami T,Kuroda K,Nishida M,Ito K,Mondal A,Koyama K,Jogahara T,Sakata I,Sakai T

    更新日期:2016-06-01 00:00:00

  • Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder.

    abstract::Biliary mucin was regarded as a major contributing factor in formation of pigment stones as well as cholesterol ones. The aim of this study was to elucidate the mechanism of biliary mucin secretion in canine gallbladder epithelial (CGBE) cells treated by lipopolysaccharides (LPS) with special reference to cyclooxygena...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1022832608466

    authors: Kim HJ,Lee SK,Kim MH,Seo DW,Min YI

    更新日期:2003-04-01 00:00:00

  • Anatomical Location of Pathology Is Predictive of Prolonged Fluoroscopy Time During ERCP: A Multicenter American Study.

    abstract:BACKGROUND:Different factors have been associated with prolonged fluoroscopy time (FT) during endoscopic retrograde cholangiopancreatography (ERCP). AIM:We hypothesize that FT depends on both the anatomical location of the pathology managed during ERCP and the complexity of the ERCP. METHODS:Three centers participate...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-014-3508-5

    authors: Alkhatib AA,Abdel Jalil AA,Faigel DO,Pannala R,Crowell M,Harrison ME

    更新日期:2015-06-01 00:00:00

  • Sulfamethoxazole-induced hepatic injury.

    abstract::A patient with several episodes of jaundice associated with sulfamethoxazole therapy is described. In contrast to the histologic picture of hepatocellular necrosis with or without cholestasis that is generally associated with sulfonamide hepatotoxicity, in the present case a relatively pure cholestatic pattern was fou...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01316868

    authors: Steinbrecher UP,Mishkin S

    更新日期:1981-08-01 00:00:00

  • Mantle zone lymphoma of the colon simulating diffuse inflammatory bowel disease. Role of immunohistochemistry in establishing the diagnosis.

    abstract::We describe the first reported case of mantle zone lymphoma of the colon presenting as diffuse ileocolitis simulating severe inflammatory bowel disease. This case serves to illustrate the importance of immunohistochemistry in establishing the diagnosis of lymphoma in extranodal sites. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01300394

    authors: McCullough JE,Kim CH,Banks PM

    更新日期:1992-06-01 00:00:00

  • Transpapillary Biliary Cannulation is Difficult in Cases with Large Oral Protrusion of the Duodenal Papilla.

    abstract:BACKGROUND:Biliary cannulation failure is a major problem during endoscopic retrograde cholangiopancreatography. It remains unclear how duodenal papilla morphology affects biliary cannulation. Therefore, we proposed a new classification system for the duodenal papilla based on oral protrusion pattern (ratio of the leng...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-019-05510-z

    authors: Watanabe M,Okuwaki K,Kida M,Imaizumi H,Yamauchi H,Kaneko T,Iwai T,Hasegawa R,Miyata E,Masutani H,Tadehara M,Adachi K,Koizumi W

    更新日期:2019-08-01 00:00:00

  • Effects of high-fiber diet on fecal blood content (HemoQuant assay) in healthy subjects.

    abstract::Consumption of high-fiber diets has been recommended prior to fecal blood testing to increase bleeding from polyps, cancer, and other lesions associated with mucosal erosion in the gastrointestinal tract. The effect of a high-fiber diet on fecal hemoglobin loss was examined in 17 healthy subjects during two dietary pe...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01297143

    authors: Slavin JL,Melcher EA,Sundeen M,Schwartz S

    更新日期:1991-07-01 00:00:00

  • Efficacy of 5-aminosalicylic acid enemas versus hydrocortisone enemas in ulcerative colitis.

    abstract::A controlled trial has been carried out in order to compare the efficacy of enemas containing a high dosage of 5-ASA (4 g) versus enemas containing hydrocortisone 100 mg. The trial was conducted on 86 patients, 44 of whom received 5-ASA and 42 received hydrocortisone. The results were favorable in terms of clinical, s...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01312467

    authors: Campieri M,Gionchetti P,Belluzzi A,Brignola C,Migaldi M,Tabanelli GM,Bazzocchi G,Miglioli M,Barbara L

    更新日期:1987-12-01 00:00:00

  • Bortezomib synergizes TRAIL-induced apoptosis in gastric cancer cells.

    abstract::Background/Aims Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as a newly identified biological agent has shown promising antitumor effects in a wide range of cancers. However, gastric cancer cells are less sensitive than other cancer cells to TRAIL-induced apoptosis.Here, we combined TRAIL with borte...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1191-8

    authors: Liu J,Qu XJ,Xu L,Zang Y,Qu JL,Hou KZ,Liu YP

    更新日期:2010-12-01 00:00:00

  • Palliative decompression of obstructive hilar malignancies utilizing an extrahilar biliary approach.

    abstract::Hilar cancers carry a dismal prognosis. Palliation of obstructive jaundice in patients with hilar cancer can be achieved by either surgical or nonsurgical means. Selection of the appropriate palliative measures is a challenging problem. Segmental bilioenteric anastomosis procedures were performed on 19 patients with h...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005569128877

    authors: Yilmaz S,Kirimlioglu V,Katz DA,Caglikulekci M,Yilmaz M

    更新日期:2000-08-01 00:00:00

  • Mapping analysis of ghrelin producing cells in the human stomach associated with chronic gastritis and early cancers.

    abstract:OBJECTIVE:The majority of ghrelin producing cells (GPC) are present in the fundic gland of the stomach and recognized as X/A like cells. The detailed distribution of GPC in the stomach is still unknown in healthy and pathological subjects. METHODS:We investigated the detailed distribution of GPC in the stomach, especi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1986-2

    authors: Takiguchi S,Adachi S,Yamamoto K,Morii E,Miyata H,Nakajima K,Yamasaki M,Kangawa K,Mori M,Doki Y

    更新日期:2012-05-01 00:00:00

  • Characterization of early developmental pattern of expression of neurotensin/neuromedin N gene in foregut and midgut.

    abstract::The gut endocrine gene, neurotensin (NT/N), is expressed in a strict temporally and spatially specific pattern. Utilizing a sensitive reverse transcription-polymerase chain reaction procedure, we analyzed foregut and midgut organs for NT/N expression, determined the earliest apparent time point that NT/N is expressed ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026637730050

    authors: Wang XM,Evers BM

    更新日期:1999-01-01 00:00:00

  • Canine small bowel motor activity in response to intraduodenal infusion of nutrient mixtures of increasing caloric load in dogs.

    abstract::The effect of nutrients on small intestinal motility is controversial. Our aim was to analyze the effect of intraduodenal infusion of mixtures of nutrients of increasing caloric load, on intestinal motility. Studies were performed in dogs with a duodenal cannula. Isosmolar infusions of saline, 0.5, 2, and 4 kcal/min w...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1024799303676

    authors: Defilippi C

    更新日期:2003-08-01 00:00:00

  • Pancreatitis as initial presentation of cystic fibrosis in young adults. A report of two cases.

    abstract::Because of marked improvement in diagnosis and management, cystic fibrosis is now more frequently noted in young adults, many of whom have only mild clinical forms. Pancreatitis is a known complication of cystic fibrosis and may occur at any time in the course of the disease; in rare instances, pancreatitis is the fir...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01317036

    authors: Masaryk TJ,Achkar E

    更新日期:1983-10-01 00:00:00

  • Preventive effect of zaprinast and 3-isobutyl, 1-methylxanthine (phosphodiesterase inhibitors) on gastric injury induced by nonsteroidal antiinflammatory drugs in rats.

    abstract::Cyclic GMP plays an important role in maintaining homeostasis in the gastric mucosa. NSAIDs damage the mucosa by mechanisms that may be mediated by alterations in the intragastric concentration of cyclic GMP. To test this hypothesis we studied the effects of the oral administration of acetylsalicylic acid (100, 300, a...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1023020201005

    authors: Herrerías JM,Esteban JM,Caballero-Plasencia AM,Valenzuela-Barranco M,Motilva V,Alarcón C,Martín J,Herrerías JM Jr,Esteban P

    更新日期:2003-05-01 00:00:00

  • Specific metabolic effect of sodium nitrite on fat metabolism by mucosal cells of the colon.

    abstract::The effect on the mucosa of sodium nitrite that enters the colon from the ileum or transmucosally from the circulation is unknown. Isolated colonic mucosal cells and Roux-en-Y colostomies were used to test whether high doses of sodium nitrite (5-40 mM) had any harmful histological or inhibitory metabolic actions on th...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01320321

    authors: Roediger WE,Radcliffe BC,Deakin EJ,Nance SH

    更新日期:1986-05-01 00:00:00

  • PRKCSH genetic mutation was not found in Taiwanese patients with polycystic liver disease.

    abstract::Polycystic liver disease (PCLD) without polycystic kidney is infrequent in clinical setting. Family clustering is found in patients with PCLD, and it is inherited in an autosomal dominant fashion. Through positional cloning in North America and Europe (mostly in Dutch and Finnish descents), mutations in PRKCSH gene on...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0776-6

    authors: Yang AM,Shih SC,Chu CH,Wang TE,Yang WS

    更新日期:2010-03-01 00:00:00

  • The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice.

    abstract:BACKGROUND:Helminth infection has been proven to reduce the severity of experimental inflammatory bowel disease (IBD). The excretory-secretory proteins of helminths play an important role in the process of immunomodulation. AIMS:In the present study, we aimed to investigate the protective potential of recombinant Tric...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-011-1689-8

    authors: Du L,Tang H,Ma Z,Xu J,Gao W,Chen J,Gan W,Zhang Z,Yu X,Zhou X,Hu X

    更新日期:2011-10-01 00:00:00

  • Improved prognosis of cirrhosis patients with esophageal varices and thrombocytopenia treated by endoscopic variceal ligation plus partial splenic embolization.

    abstract::The aim of this study was to assess the efficacy of the combination of endoscopic variceal ligation (EVL) and partial splenic embolization (PSE) compared with EVL alone in cirrhosis patients with thrombocytopenia. In a prospective study, 84 cirrhosis patients with esophageal varices and thrombocytopenia (platelet coun...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s10620-006-3137-8

    authors: Ohmoto K,Yoshioka N,Tomiyama Y,Shibata N,Takesue M,Yoshida K,Kuboki M,Yamamoto S

    更新日期:2006-02-01 00:00:00

  • MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor.

    abstract:BACKGROUND:miR-30a expression is down-regulated and regulates tumor suppressors in various cancers. AIM:We investigated the mechanisms underlying the biological role of miR-30a in CRC. METHODS:MicroRNA, mRNA, and protein expression were analyzed by quantitative real-time PCR and Western blot. The migration and invasi...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-017-4763-z

    authors: Liu YC,Park YR,Kim SL,Lee ST,Kim SW

    更新日期:2017-11-01 00:00:00

  • Hyperphosphorylation of retinoblastoma protein and stimulation of growth by okadaic acid in human pancreatic cancer.

    abstract::Phosphorylation/dephosphorylation of intracellular proteins are important steps in the regulation of cell growth. Okadaic acid, an inhibitor of the serine/threonine protein phosphatases 1 and 2A, is a potent tumor promoter. This effect may be through the inhibition of dephosphorylation (termed "hyperphosphorylation") ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02093599

    authors: Hirai A,Bold RJ,Ishizuka J,Hirai M,Townsend CM Jr,Thompson JC

    更新日期:1996-10-01 00:00:00