Abstract:
:The gut endocrine gene, neurotensin (NT/N), is expressed in a strict temporally and spatially specific pattern. Utilizing a sensitive reverse transcription-polymerase chain reaction procedure, we analyzed foregut and midgut organs for NT/N expression, determined the earliest apparent time point that NT/N is expressed in the gastrointestinal tract and compared the temporal relationship of NT/N with other genes. NT/N expression was detected in the fetal and early postnatal stomach. In the small bowel, NT/N was expressed at the earliest fetal time (14 days) that the small bowel could be reliably delineated from other gut organs; in contrast, expression of sucrase-isomaltase was only apparent at 28 days after birth. NT/N was expressed in the fetal (12, 14 and 16 days) liver and then again on days 3 and 7 after birth; however, NT/N was detected only in the fetal (14 and 16 days) pancreas. Finally, NT/N expression was first detected at approximately 12 days gestation in the primitive foregut and midgut, thus occurring significantly earlier than actual intestinal cytodifferentiation. NT/N is widely expressed in the gastrointestinal tract during fetal development, suggesting the presence of a shared ancestral stem cell; NT/N expression is then restricted to the small bowel of the adult. The determination of the cellular factors regulating the expression of NT/N will provide a better understanding of the mechanisms responsible for the strict patterning of gene expression in the gastrointestinal tract and possibly gut differentiation.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Wang XM,Evers BMdoi
10.1023/a:1026637730050subject
Has Abstractpub_date
1999-01-01 00:00:00pages
33-40issue
1eissn
0163-2116issn
1573-2568journal_volume
44pub_type
杂志文章abstract::It has not been fully understood how intact protein antigens escape digestion in the course of absorption. The present study was designed to investigate the mechanism that heat stress induced an increase in intact protein antigen absorption. Human colonic cell line Caco-2 cells were treated with high temperature (37 t...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-9003-2
更新日期:2006-05-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:1986-08-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:1988-05-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3186-3
更新日期:2014-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1012771328187
更新日期:2001-12-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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更新日期:2005-11-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
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journal_title:Digestive diseases and sciences
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更新日期:1993-11-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 信件
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01393761
更新日期:1982-08-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,评审
doi:10.1007/BF01312471
更新日期:1987-12-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0942-x
更新日期:2010-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01324957
更新日期:1983-04-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-009-0723-6
更新日期:2009-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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