Abstract：
BACKGROUND AND AIM:Although the serum sodium level has been reported to be a prognostic and predictive marker for the therapeutic effects of lung cancer and renal cell carcinoma treated with molecular targeted therapy, the serum sodium level has not been investigated in hepatocellular carcinoma (HCC) patients treated with sorafenib. The aim of our analysis was to assess the prognostic role of serum sodium levels in these patients. METHODS:We retrospectively analyzed 341 HCC patients treated with sorafenib between 2009 and 2012 in our hospital and other related institutions. RESULTS:A total of 178 patients were enrolled in this study. The median age was 72 years (44-88), and 148 patients (83%) were male. The median overall survival (OS) was 12.9 months, and the median time to progression (TTP) was 3.1 months. Hyponatremia (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.26-2.52), a lower sodium level (HR 1.57, 95% CI 1.07-2.80), and a high level of α-fetoprotein (AFP) (≥ 200 ng/mL) (HR 1.78, 95% CI 1.26-2.52) were independent prognostic factors for TTP. We also categorized the patients into three groups according to serum sodium and AFP levels: Group A (n = 39) (serum sodium > 140 mEq/L, AFP < 200 ng/mL), Group C (n = 58) (serum sodium ≤ 140 mEq/L, AFP ≥ 200 ng/mL), and Group B (n = 81) (other patients). Significantly longer TTP and OS were observed in the following order: Groups A, C, and B. CONCLUSION:Serum sodium levels are associated with the effectiveness of sorafenib. The serum sodium level can predict the therapeutic effect of sorafenib in advanced HCC patients.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Kegasawa T,Sakamori R,Maesaka K,Yamada R,Tahata Y,Urabe A,Kodama T,Hikita H,Imanaka K,Ohkawa K,Hiramatsu N,Oshita M,Yamada Y,Inada M,Yakushijin T,Imai Y,Tatsumi T,Takehara Tdoi
10.1007/s10620-020-06380-6subject
Has Abstractpub_date
2020-06-17 00:00:00eissn
0163-2116issn
1573-2568pii
10.1007/s10620-020-06380-6pub_type
杂志文章abstract：PURPOSE:Hepatocyte expression of HBV surface, core, and x antigens (HBsAg, HBcAg and HBxAg), semi-quantitated by immunopathology, were correlated with clinical and virological data in 80 patients with chronic hepatitis B. RESULTS:Seventy patients were HBsAg positive in cytoplasm, 61 were HBcAg positive, including 45 i...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0895-0
更新日期：2010-02-01 00:00:00
abstract：:Congenital gastric outlet anomalies are rarely seen defects resulting from early embryologic development of foregut. We report a case of congenital pyloric outlet anomaly in a 60-year-old man with mild postprandial epigastric discomfort of approximately 3 months' duration. Endoscopic examination of the stomach showed ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-9228-8
更新日期：2007-04-01 00:00:00
abstract：:During topical dissolution of gallstones, solvent can escape to the duodenum causing toxic effects that have not yet been adequately quantified. We compared the local intestinal cytotoxic and systemic hepatotoxic effects of two gallstone solvents, methyl tert-butyl ether and ethyl propionate, on the rabbit's duodenum....
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018830622508
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND:Helminth infection has been proven to reduce the severity of experimental inflammatory bowel disease (IBD). The excretory-secretory proteins of helminths play an important role in the process of immunomodulation. AIMS:In the present study, we aimed to investigate the protective potential of recombinant Tric...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1689-8
更新日期：2011-10-01 00:00:00
abstract：:Rabeprazole is the only proton pump inhibitor that enhances the content of gastric mucin in experimental animals. We have studied, therefore, the effect of rabeprazole on the content of gastric mucin, mucus, and its viscosity in 21 asymptomatic volunteers in a double-blind study. The mucus content during rabeprazole a...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1021983611768
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:The early diagnosis of pancreas allograft dysfunction is crucial for the management and long-term survival of transplanted pancreases. We investigated whether intercellular adhesion molecular-1 (ICAM-1), Fas, and Fas ligand (FasL) can be used as novel biomarkers of acute pancreaticoduodenal allograft dysfunc...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-013-2904-6
更新日期：2014-04-01 00:00:00
abstract：:We present the case of a 60-year-old male patient, who had several episodes of melena during the last years. One month ago he had a new episode of digestive bleeding, and an endoscopic study was performed that showed at 35 cm from the dental arcade a polypoid, pedunculated lesion, with a diameter of 5 cm and a submuco...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087691
更新日期：1994-12-01 00:00:00
abstract：:Peutz-Jeghers syndrome (PJS) is an autosomal-dominant inherited disorder characterized by mucocutaneous pigmentation, hamartomatous polyposis of the gastrointestinal tract, and an increased risk for the development of both gastrointestinal and extraintestinal malignancies. Germline mutation of the STK11 gene, which en...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0837-x
更新日期：2010-04-01 00:00:00
abstract：:Many physiological factors can alter gastric emptying, and the role of gastric emptying in functional dyspepsia is controversial. The aim of this study was to assess the effects of different factors (age, sex, the degree of dyspeptic and irritable bowel symptoms, lactase deficiency, smoking habits, the use of antiinfl...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018826917657
更新日期：1998-06-01 00:00:00
abstract：:Two new preparations are under clinical trial for use in the treatment of ulcerative proctitis and left-sided colitis. One is 5-aminosalicylate, a component of sulfasalazine. This substance has virtually no immunomodulating capabilities. Evidence for efficacy equal to that of sulfasalazine in acute colitis has been ob...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/BF01538136
更新日期：1988-03-01 00:00:00
abstract：:Pulmonary injury with leukocyte infiltration is a frequent occurrence in obstructive cholangitis patients. We wished to evaluate the roles of reactive oxygen species and vascular cell adhesion molecule-1 (VCAM-1) in this distant organ failure. Wild type (WT) and transgenic (SODtg) mice overexpressing superoxide dismut...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1017980406036
更新日期：2002-03-01 00:00:00
abstract：:Gallbladder dynamics, cholecystokinin (CCK), and pancreatic polypeptide (PP) release were studied in 14 patients with chronic pancreatitis (CP) (2 females, 12 males; age range 24-56 years) and 12 control subjects (4 females, 8 males, 21-50 years). On day 1, gallbladder contractility was investigated after ceruletide i...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01316503
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND AND AIMS:The present study aimed to identify the differential expressed genes that are related to acute pancreatitis. METHODS:Microarray datasets GSE109227 and GSE3644 were downloaded from the public database and analyzed to screen the genes. Afterward, integrated analysis of these genes were performed, inc...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-019-05928-5
更新日期：2020-06-01 00:00:00
abstract：:Gastritis caused by Helicobacter pylori (HP) is common in patients with nonulcer dyspepsia (NUD), but an etiologic relationship between the histologic lesion and clinical symptoms is unproven. HP is inhibited by bismuth subsalicylate (BSS), a traditional remedy for dyspeptic complaints. The aim of this study was to as...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01303177
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:A possible association between nonalcoholic fatty liver disease (NAFLD) and hypothyroidism has been suggested. The recognized link between hypothyroidism and elements of the metabolic syndrome may explain this association. AIM:The purpose of this study was to determine the prevalence of hypothyroidism in a ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-2006-2
更新日期：2012-02-01 00:00:00
abstract：:Bicyclol is a synthetic antihepatitis drug with antioxidative property. The present study was performed to investigate the effect of bicyclol on liver regeneration after partial hepatectomy in rats. Bicyclol (300 mg/kg) was given to rats subjected to 70% hepatectomy three times before operation. At 6, 24, and 48 h aft...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0715-6
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:The majority of ghrelin producing cells (GPC) are present in the fundic gland of the stomach and recognized as X/A like cells. The detailed distribution of GPC in the stomach is still unknown in healthy and pathological subjects. METHODS:We investigated the detailed distribution of GPC in the stomach, especi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1986-2
更新日期：2012-05-01 00:00:00
abstract：:Sumatriptan, a 5-HT1-receptor agonist has been shown to delay gastric emptying of liquids and solids in humans. However, no data are available of the effect of sumatriptan on gastric adaptation after distension with liquids and on symptoms induced by gastric distension. In 23 normal subjects and 30 dyspeptic patients ...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1023/a:1020588832411
更新日期：2002-11-01 00:00:00
abstract：:The presence in the esophagus of three distinct entities--Barrett's mucosa, Crohn's disease, and adenocarcinoma--is a very rare finding. In a 60-year-old man with a long history of heartburn and recently developed dysphagia, narrowing of the distal esophagus was found to be related to the presence of Barrett's mucosa....
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536067
更新日期：1989-02-01 00:00:00
abstract：:Over the past two decades, evidence has accumulated to challenge the traditional view that cardiac mucosa, which is comprised exclusively of mucus glands, is the normal lining of the most proximal portion of the stomach (the gastric cardia). There is now considerable evidence to suggest that cardiac mucosa develops as...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-018-5063-y
更新日期：2018-08-01 00:00:00
abstract：:The molecular mechanisms of Helicobacter pylori associated tumor development are poorly understood. The spectra of genetic alterations in neoplasms may provide clues to the molecular carcinogenesis of a tumor and may be relevant for the prognosis of the patients. We investigated the p53 mutation pattern and the protei...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1013275706401
更新日期：2002-01-01 00:00:00
abstract：:This study was undertaken to compare the effects of subtotal Billroth II gastrectomy on gastric emptying and gastrointestinal motility with previously published results in intact dogs and in dogs with subtotal Roux-Y gastrectomy. Extraluminal strain gauge transducers were used to study gastrointestinal motility after ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537268
更新日期：1989-08-01 00:00:00
abstract：:We conducted a randomized prospective study with extended intraesophageal pH monitoring on two consecutive nights to test the hypothesis that a waterbed (WB) might increase recumbent acid exposure compared to a regular bed (RB). We studied 10 controls (mean age 29 years; five males, five females) with no history of re...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01537115
更新日期：1989-10-01 00:00:00
abstract：:The distribution of tissue kallikrein (TK) and its plasma inhibitor, kallistatin in plasma and intestinal tissue, was studied in patients with active ulcerative colitis (UC) and Crohn's disease (CD). TK was localized to goblet cells and kallistatin to epithelial cells of normal human intestine. Both proteins are visua...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1022569623350
更新日期：2003-03-01 00:00:00
abstract：:Duodenal resistance to gastric outflow is known to participate in the regulation of gastric emptying of liquids in animals, but the role of this mechanism in humans has not been extensively investigated. In this work we studied the gastric emptying of liquids in patients with megaduodenum, who putatively have increase...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026684418333
更新日期：2000-11-01 00:00:00
abstract：:Autoimmune hepatitis has a variable clinical phenotype, and the absence of conventional autoantibodies does not preclude its diagnosis or need for treatment. The goals of this review are to describe the frequency and nature of autoantibody-negative autoimmune hepatitis, indicate its outcome after corticosteroid treatm...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-011-2017-z
更新日期：2012-03-01 00:00:00
abstract：:The clonality of gastric glands remains a controversial topic. Chimeric mouse studies suggested that all gastric glands were monoclonal. However, using the X-linked transgenic mouse model, we have suggested that most glands are polyclonal during development and that the fraction of monoclonal glands increases after bi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/b:ddas.0000017441.06479.c8
更新日期：2004-02-01 00:00:00
abstract：:On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of lif...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1023/b:ddas.0000034551.39324.c3
更新日期：2004-06-01 00:00:00
abstract：AIM:To investigate whether a diagnostic delay is associated with a poor outcome in Crohn's disease (CD). METHODS:Medical and socioeconomic characteristics as well as medications and need for surgery of consecutive CD adults patients followed in three referral centers were prospectively recorded using an electronic dat...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-016-4189-z
更新日期：2016-11-01 00:00:00
abstract：:The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be "bad" (proinflammatory) or "good" (anti-inflammatory). Mouse models of colitis show an increase in conjugated B...
journal_title：Digestive diseases and sciences
pub_type： 信件
doi：10.1007/s10620-020-06650-3
更新日期：2020-10-16 00:00:00
