Yoghurts containing probiotics reduce disruption of the small intestinal barrier in methotrexate-treated rats.

Abstract:

:Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow's milk yoghurt (CY; fermented with Lactobacillus johnsonii), MTX + sheep's milk yoghurt (SY; containing Lactobacillus bulgaricus and Streptococcus thermophilus), and saline. Treatment gavage occurred twice daily for 7 days pre-MTX and 5 days post-MTX. Intestinal permeability was assessed on days -7, -1, 2, and 5 of the trial. Intestinal sections were collected at sacrifice for histological and biochemical analyses. Histology revealed that rats receiving CY and SY did not have a significantly damaged duodenum compared to controls. However, an improved small intestinal barrier function was evident, determined by a decreased lactulose/mannitol ratio. Probiotics containing SY and CY may be useful in preventing disruption to intestinal barrier function in MTX-induced mucositis.

journal_name

Dig Dis Sci

authors

Southcott E,Tooley KL,Howarth GS,Davidson GP,Butler RN

doi

10.1007/s10620-008-0275-1

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

1837-41

issue

7

eissn

0163-2116

issn

1573-2568

journal_volume

53

pub_type

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