Abstract:
:Small intestinal permeability was employed to assess the efficacy of commercially available yoghurts containing probiotics in a rat model of methotrexate (MTX)-induced mucositis. Male Sprague-Dawley rats were allocated to four groups (n = 8): MTX + water, MTX + cow's milk yoghurt (CY; fermented with Lactobacillus johnsonii), MTX + sheep's milk yoghurt (SY; containing Lactobacillus bulgaricus and Streptococcus thermophilus), and saline. Treatment gavage occurred twice daily for 7 days pre-MTX and 5 days post-MTX. Intestinal permeability was assessed on days -7, -1, 2, and 5 of the trial. Intestinal sections were collected at sacrifice for histological and biochemical analyses. Histology revealed that rats receiving CY and SY did not have a significantly damaged duodenum compared to controls. However, an improved small intestinal barrier function was evident, determined by a decreased lactulose/mannitol ratio. Probiotics containing SY and CY may be useful in preventing disruption to intestinal barrier function in MTX-induced mucositis.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Southcott E,Tooley KL,Howarth GS,Davidson GP,Butler RNdoi
10.1007/s10620-008-0275-1subject
Has Abstractpub_date
2008-07-01 00:00:00pages
1837-41issue
7eissn
0163-2116issn
1573-2568journal_volume
53pub_type
杂志文章abstract::Survivin is known to be overexpressed in various human malignancies, including pancreatic cancer, and to cause resistance to radiation and chemotherapy, so the regulation of this molecule could be a new strategy for treating pancreatic cancer. In our study, a short interfering RNA (siRNA) plasmid expression vector aga...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:1993-07-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:1990-02-01 00:00:00
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更新日期:1999-12-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
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更新日期:2013-04-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:2000-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Digestive diseases and sciences
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更新日期:2003-04-01 00:00:00
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更新日期:2021-01-03 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2016-11-01 00:00:00