Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis.

abstract：BACKGROUND:Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the ...

journal_title：Digestive diseases and sciences

authors： Merino J,Aller MA,Rubio S,Arias N,Nava MP,Loscertales M,Arias J,Arias JL

更新日期：2011-08-01 00:00:00

abstract：:The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be "bad" (proinflammatory) or "good" (anti-inflammatory). Mouse models of colitis show an increase in conjugated B...

journal_title：Digestive diseases and sciences

authors： Sitkin S,Pokrotnieks J

更新日期：2020-10-16 00:00:00

abstract：:This study was done to examine the role of cyclooxygenase (COX) in lipopolysaccharide (LPS)-induced gastroprotection and gastric stasis. In conscious rats, LPS dose and time dependently increased gastric luminal fluid accumulation. LPS decreased blood flow (laser Doppler) and prevented gastric injury from acidified et...

journal_title：Digestive diseases and sciences

authors： West SD,Suliburk JW,Smith GS,Mercer DW

更新日期：2006-04-01 00:00:00

abstract：:We examined the influences of aging on gastric damage and gastric mucosal blood flow (GMBF) responses induced by acid back-diffusion, following the barrier disruption, and investigated the relation of capsaicin-sensitive sensory nerves to these changes. Male Fischer rats 3, 13, and 24 months old were used. Under ureth...

journal_title：Digestive diseases and sciences

authors： Miyake H,Inaba N,Kato S,Takeuchi K

更新日期：1996-02-01 00:00:00

abstract：:Hilar cancers carry a dismal prognosis. Palliation of obstructive jaundice in patients with hilar cancer can be achieved by either surgical or nonsurgical means. Selection of the appropriate palliative measures is a challenging problem. Segmental bilioenteric anastomosis procedures were performed on 19 patients with h...

journal_title：Digestive diseases and sciences

authors： Yilmaz S,Kirimlioglu V,Katz DA,Caglikulekci M,Yilmaz M

更新日期：2000-08-01 00:00:00

abstract：:Rectally administered suspensions of 5-aminosalicylic acid (5-ASA) are topically effective in treating left-sided ulcerative colitis. The extent to which the contents of these enemas are distributed to inflamed mucosal linings has not previously been determined. This study was undertaken to validate a technique for la...

journal_title：Digestive diseases and sciences

authors： Vitti RA,Meyers F,Knight LC,Siegel JA,Malmud LS,Fisher RS

更新日期：1989-11-01 00:00:00

abstract：:We evaluated the sequence diversity of the hypervariable region 1 (HVR1) of hepatitis C virus (HCV) in HCV-infected patients in whom the mode of transmission is unknown. The sequence diversity of HVR1 in 26 Japanese patients with chronic HCV infection of unknown mode of transmission (UT) was compared with 17 patients ...

journal_title：Digestive diseases and sciences

authors： Toyoda H,Fukuda Y,Hayakawa T,Kumada T,Nakano S,Takamatsu J,Saito H

更新日期：1999-10-01 00:00:00

abstract：:Our purpose was to observe the effects of sodium phosphate (NaP) colonoscopy preparation on serum electrolytes, phosphate, and calcium and to identify factors associated with any adverse effects. In an unselected group of 100 consecutive patients attending for out patient colonoscopy, 45% of patients had raised serum ...

journal_title：Digestive diseases and sciences

authors： Ainley EJ,Winwood PJ,Begley JP

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:An imbalance in gut microbiota seems to contribute to the development of chronic inflammatory disorders of the gastrointestinal tract, such as ulcerative colitis (UC). Although it has been suggested that probiotic supplementation is an effective approach to colitis, its effects on intestinal flora and on muc...

journal_title：Digestive diseases and sciences

authors： D'Incà R,Barollo M,Scarpa M,Grillo AR,Brun P,Vettorato MG,Castagliuolo I,Sturniolo GC

更新日期：2011-04-01 00:00:00

abstract：:The study was undertaken to examine regional differences in the concentrations of five regulatory peptides in the human colonic mucosa. Biopsies were obtained during routine colonoscopy from 33 patients whose colonic mucosa was macroscopically and histologically normal. Regulatory peptides were extracted, and measured...

journal_title：Digestive diseases and sciences

authors： Calam J,Ghatei MA,Domin J,Adrian TE,Myszor M,Gupta S,Tait C,Bloom SR

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The timing of menarche in Crohn's disease (CD) is poorly described. Our objectives were to study age at menarche onset in CD, and factors associated with this. METHODS:We compared the age at menarche of 34 CD patients with that for 545 controls, using data in the National Health and Nutrition Exami...

journal_title：Digestive diseases and sciences

authors： Gupta N,Lustig RH,Kohn MA,Vittinghoff E

更新日期：2012-11-01 00:00:00

abstract：:Simultaneous recordings of gastric manometry and myoelectrical activity were made in 10 patients with gastroparesis. Intravenous erythromycin (100 mg) was administered in the fasting state for a period of 30 min. Subcutaneous injection of octreotide (100 microg) was administered before one of the four identical test m...

journal_title：Digestive diseases and sciences

authors： Chen JD,Lin ZY,Edmunds MC 3rd,McCallum RW

更新日期：1998-01-01 00:00:00

abstract：:The headword "overlap syndromes" of liver diseases includes the coexistence of autoimmune hepatitis, primary biliary cirrhosis, and primary sclerosing cholangitis. These syndromes often represent a diagnostic and therapeutic challenge for hepatologists; it remains unclear whether these overlap syndromes form distinct ...

journal_title：Digestive diseases and sciences

authors： Durazzo M,Premoli A,Paschetta E,Belci P,Spandre M,Bo S

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Obesity is associated with a proinflammatory state. AIM:To determine whether obesity at diagnosis is a risk factor for Crohn's disease vs. ulcerative colitis and also vs. community controls and whether there is a U-shaped relationship between body mass index at diagnosis and risk of Crohn's disease versus u...

journal_title：Digestive diseases and sciences

authors： Mendall MA,Gunasekera AV,John BJ,Kumar D

更新日期：2011-03-01 00:00:00

abstract：:Pulmonary injury with leukocyte infiltration is a frequent occurrence in obstructive cholangitis patients. We wished to evaluate the roles of reactive oxygen species and vascular cell adhesion molecule-1 (VCAM-1) in this distant organ failure. Wild type (WT) and transgenic (SODtg) mice overexpressing superoxide dismut...

journal_title：Digestive diseases and sciences

authors： Morise Z,Ueda M,Kitajima M,Epstein CJ,Granger DN,Grisham MB

更新日期：2002-03-01 00:00:00

abstract：:Short chain fatty acids may protect colonic mucosa against neoplastic transformation by modulating colonocyte phenotype, DNA synthesis, and c-myc levels. To test this hypothesis, nonmalignant and malignant human colonocytes were isolated from surgical specimens and treated with 10 mM acetate, propionate, or butyrate. ...

journal_title：Digestive diseases and sciences

authors： Emenaker NJ,Basson MD

更新日期：2001-01-01 00:00:00

abstract：:Lansoprazole, a proton pump inhibitor, exerts prominent antiulcer activity via both antisecretory and mucosal protective actions. Although the antisecretory action has been explained by inactivation of (H+, K+)-ATPase in parietal cells, the mode of mucosal protective action remains to be elucidated. In the present stu...

journal_title：Digestive diseases and sciences

authors： Inada I,Satoh H

更新日期：1996-04-01 00:00:00

abstract：:The effects of somatostatin on diarrhea and on small intestinal flow of water and electrolytes (slow-marker perfusion technique) in a patient with pancreatic cholera are reported. Continuous intravenous infusion of somatostatin (8 micrograms/kg/hr) suppressed the diarrhea, but a rebound was observed after somatostatin...

journal_title：Digestive diseases and sciences

authors： Ruskoné A,René E,Chayvialle JA,Bonin N,Pignal F,Kremer M,Bonfils S,Rambaud JC

更新日期：1982-05-01 00:00:00

abstract：:Previous studies have shown that duodenal motility patterns differ in preterm and term infants, but antral motor activities were not compared. Using a validated, low-compliance, continuous-perfusion, neonatal manometric system, antral and duodenal motility was studied in 19 preterm and nine term infants. Antral motili...

journal_title：Digestive diseases and sciences

authors： Ittmann PI,Amarnath R,Berseth CL

更新日期：1992-01-01 00:00:00

abstract：:Minimal hepatic encephalopathy (MHE) describes patients with chronic liver disease or cirrhosis who have no clinical symptoms of brain dysfunction but perform worse on psychometric tests compared with healthy subjects. The pathogenesis of hepatic encephalopathy is controversial although ammonia has been found to induc...

journal_title：Digestive diseases and sciences

authors： Malaguarnera M,Greco F,Barone G,Gargante MP,Malaguarnera M,Toscano MA

更新日期：2007-11-01 00:00:00

abstract：:Patients with Zollinger-Ellison syndrome whose gastric acid secretion or symptoms were not controlled by cimetidine in conventional dosage were selected for studies of responsiveness of their acid secretion to increasing doses of cimetidine, used either alone or in combination with a long-acting anticholinergic agent,...

journal_title：Digestive diseases and sciences

authors： McCarthy DM,Hyman PE

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Gastroparesis is a heterogeneous disorder. Patient characteristics and treatment responsiveness may differ based on the extent of delay in gastric emptying. AIMS:Characterize gastroparesis patients based on the degree of delay in gastric emptying, and assess the relationship of patient demographics, symptom...

journal_title：Digestive diseases and sciences

authors： Navas CM,Wadas ED,Zbib NH,Crowell MD,Lacy BE

更新日期：2020-04-18 00:00:00

abstract：:The effects of nonsteroidal antiinflammatory drugs on ulcerogenesis and gastric secretion were evaluated in a pylorus-ligated rat model. Oral administration of salicylate (50 mg/kg), aspirin (50 mg/kg), and indomethacin (3.5 mg/kg) significantly increased ulcerogenesis over the basal value by six- to sevenfold, but ib...

journal_title：Digestive diseases and sciences

authors： Wagner KA,Nandi J,King RL,Levine RA

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND/AIM:Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal recessive inherited disease that predominantly affects eastern Mediterranean populations. Fetuin-A is a well known negative acute-phase protein. Studies of this glycoprotein as a marker of inflammation in FMF a...

journal_title：Digestive diseases and sciences

authors： Oncu K,Yazgan Y,Tanoglu A,Kaplan M,Ermis F,Ipcioglu OM,Kara M,Kucuk I,Ozari HO

更新日期：2013-11-01 00:00:00

abstract：:Small bowel tumors are rare, accounting for 1-2% of all gastrointestinal neoplasms. We sought to determine the diagnostic and therapeutic impact of double-balloon enteroscopy (DBE) in patients with small bowel tumors. Between January 2005 and March 2008, 78 patients underwent 96 DBE. All nine patients (seven males; me...

journal_title：Digestive diseases and sciences

authors： Almeida N,Figueiredo P,Lopes S,Gouveia H,Leitão MC

更新日期：2009-07-01 00:00:00

abstract：AIM:To identify the clinical and biochemical predictors of histologic disease severity in patients with non-alcoholic steatohepatitis (NASH). METHOD:Clinical, anthropometric and biochemical data of 71 consecutive patients with a histological diagnosis of NASH were retrieved from the medical database. The histologic cr...

journal_title：Digestive diseases and sciences

authors： Singh DK,Sakhuja P,Malhotra V,Gondal R,Sarin SK

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The role of 5-aminosalicylic acid (5-ASA or mesalamine) in the prevention of colorectal cancer in ulcerative colitis (UC) patients was reported, but the effect on molecular targets in UC colon mucosa is unknown. AIM:This observational study evaluates gene expression levels of 5-ASA targets using serial colo...

journal_title：Digestive diseases and sciences

authors： Bajpai M,Seril DN,Van Gurp J,Geng X,Alvarez J,Minacapelli CD,Gorin S,Das KK,Poplin E,Cheng J,Amenta PS,Das KM

更新日期：2019-03-01 00:00:00

abstract：:Local or national policy, patients' preferences, safety and/or economic concerns, or reimbursement issues may dictate stopping drug in inflammatory bowel diseases (IBD) patients. Sustained deep remission is an important predictor of a better outcome after anti-tumor necrosis (TNF) factor therapy discontinuation, inclu...

journal_title：Digestive diseases and sciences

authors： Williet N,Paul S,Peyrin-Biroulet L,Roblin X

更新日期：2016-04-01 00:00:00

abstract：:The aim of this study was to assess the efficacy of the combination of endoscopic variceal ligation (EVL) and partial splenic embolization (PSE) compared with EVL alone in cirrhosis patients with thrombocytopenia. In a prospective study, 84 cirrhosis patients with esophageal varices and thrombocytopenia (platelet coun...

journal_title：Digestive diseases and sciences

authors： Ohmoto K,Yoshioka N,Tomiyama Y,Shibata N,Takesue M,Yoshida K,Kuboki M,Yamamoto S

更新日期：2006-02-01 00:00:00

abstract：:If an effective hepatic assist system existed, it could serve as a bridge to transplantation. Most of the patients waiting for liver transplantation have chronic liver insufficiency but are not in hepatic coma. Various hepatic assist systems have been used to salvage patients with acute liver insufficiency. Most attem...

journal_title：Digestive diseases and sciences

authors： Takahashi T,Malchesky PS,Nosé Y

更新日期：1991-09-01 00:00:00