Abstract:
:If an effective hepatic assist system existed, it could serve as a bridge to transplantation. Most of the patients waiting for liver transplantation have chronic liver insufficiency but are not in hepatic coma. Various hepatic assist systems have been used to salvage patients with acute liver insufficiency. Most attempts have been disappointing. The methods used have included plasma exchange, plasma adsorption, double filtration, cryofiltration, thermofiltration, the combination of plasma exchange and amino acid hemodialysis, and others. For patients with chronic liver disease with moderate liver function impairment and limited to one or only a few areas of metabolic abnormality, a hepatic assist might allow the life of the patient to be maintained temporarily. The application of hepatic assist methods for chronic liver disease patients treated at the Cleveland Clinic has been encouraging. One of the patients who suffered from sclerosing cholangitis has maintained a near-normal life for almost five years by 170 plasma treatments. This is in spite of the fact that, at the onset of treatment, the patient was nearly comatose. Unfortunately, this patient did not wish to receive a liver transplantation. Based upon this experience, the concept of a bridge to transplantation approach to hepatic assist devices appears feasible. In addition, it is speculated that hepatic assistance during the early recovery stage of liver transplantation and during mild episodes of rejection may be useful.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Takahashi T,Malchesky PS,Nosé Ydoi
10.1007/BF01307531subject
Has Abstractpub_date
1991-09-01 00:00:00pages
1327-40issue
9eissn
0163-2116issn
1573-2568journal_volume
36pub_type
历史文章,杂志文章,评审abstract::Duodenal resistance to gastric outflow is known to participate in the regulation of gastric emptying of liquids in animals, but the role of this mechanism in humans has not been extensively investigated. In this work we studied the gastric emptying of liquids in patients with megaduodenum, who putatively have increase...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026684418333
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:The arrival of tacrolimus has drastically improved AALDLT recipients' survival. However, little data of tacrolimus have been reported concerning its effects on lipid metabolism for AALDLT recipients. AIM:Out aim was to investigate the relationship between tacrolimus blood concentration and lipid metabolism ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1817-5
更新日期:2012-01-01 00:00:00
abstract::This study investigated the effects of portal hypertension on gastric motor and secretory functions and the role of endothelin in rats. Control; sham-operated; endothelin-A receptor blocker, BQ 485 (1 microgram/kg)-treated; portal hypertensive; and portal hypertension +, endothelin-A receptor blocker-treated rats were...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02282345
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Data on real-life patterns of biologic use for inflammatory bowel disease (IBD) are scarce. AIMS:We aimed to examine the patterns of biologic use and the factors associated with non-persistence and switching of biologics in Korean IBD patients. METHODS:Using National Health Insurance claims, we collected d...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05867-1
更新日期:2020-05-01 00:00:00
abstract::Somatostatin inhibits colonic ion secretion in animal models and cultured intestinal cell lines via somatostatin receptor subtype 2 and subtype 1, respectively. In a recent in vitro ion transport study of the human colon, somatostatin was shown to stimulate short-circuit current, a measure of electrogenic ion transpor...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1012392307462
更新日期:2001-11-01 00:00:00
abstract::The evaluation of a group of polyamine analogs as agents to ameliorate diarrhea-predominant irritable bowel syndrome is described. Each compound was assessed when administered subcutaneously in a psychological stress-induced model of irritable bowel syndrome in rodents for its ability to reduce stool output in a dose-...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1012750723644
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Primary liver cancer constitutes an increasingly malignancy in the Western world and one of the leading causes of cancer-related deaths worldwide. The purpose of this study was to evaluate and compare long-term outcomes after R0 resections in noncirrhotic livers for hepatocellular carcinoma (HCC) and intrahe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0408-6
更新日期:2009-04-01 00:00:00
abstract::The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01550972
更新日期:1988-07-01 00:00:00
abstract::Despite progress in therapeutic approaches for the elimination of hepatitis C, chronic hepatitis C virus infection remains an important cause of liver disease. Therapeutic intervention with the currently available interferon-based treatment regimens is quite successful, but treatment is difficult to tolerate and is co...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/s10620-006-9484-7
更新日期:2007-04-01 00:00:00
abstract::The aim of this study was to clarify the pathogenesis of Helicobacter pylori-negative duodenal ulcer (DU) by investigating the meal-stimulated serum gastrin (SG) response. The subjects were 9 patients with H. pylori-negative DU, 28 H. pylori-positive DU, 11 H. pylori-positive volunteers, and 30 H. pylori-negative volu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1022808003014
更新日期:2003-04-01 00:00:00
abstract::NSAID use and Helicobacter pylori both cause damage to the gastric mucosa and can cause peptic ulcers. Our aim was to test the relationship between gastric mucosal polymorphonuclear leukocyte (PMN) infiltration and the severity of NSAID-induced gastric injury. H. pylori density, mucosal interleukin-8 (IL-8), and nitri...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1013251100950
更新日期:2002-01-01 00:00:00
abstract::Fourteen patients with duodenal ulcers and eight healthy volunteers were examined to measure interdigestive gastroduodenal motility and plasma motilin. In order to study the effects of gastric acid on the gastroduodenal motility, 20 mg of famotidine was administered intravenously. The motility index of the gastric ant...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295907
更新日期:1993-05-01 00:00:00
abstract::Our objective was to investigate the expression of HMGA1 mRNA and protein in hepatocellular carcinoma (HCC) and the correlation between its expression and clinical pathological characteristics and prognosis. HMGA1 expression was determined at both the mRNA level and the protein level in 30 HCC tissues and their corres...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2934-9
更新日期:2005-10-01 00:00:00
abstract::The current cost of endoscopically screening patients with gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) is considerable. A nonendoscopic device that allows for screening of these patients would offer significant cost savings. This pilot study evaluates the utility of cytologically diagnosing BE ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1012771328187
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Regenerating islet-derived 3 (Reg3) is abnormally expressed in several human digestive system diseases, including chronic pancreatitis (CP) and pancreatic cancer (PC). AIM:The purpose of this study was to clarify the mechanism of the enhanced expression of Reg3 in inflammation-induced PC. METHODS:C57BL/6 m...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3787-5
更新日期:2015-12-01 00:00:00
abstract::We previously demonstrated that false-positive findings for tumor markers are frequently observed, and that the sensitivity of marker monitoring for early detection of the recurrence is low after curative resection of gastric cancer. The aim of this study was to investigate whether such characters are specific to gast...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-0046-4
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Corticotropin-releasing factor (CRF) peptides exert profound effects on the secretomotor function of the gastrointestinal tract. Nevertheless, despite the presence of CRF peptides and receptors in colonic tissue, their influence on colonic blood flow (CBF) is unknown. AIM:To determine the effect and mechani...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-3579-y
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE:The objective of this study was to identify evidence-based cutpoints for the CTP laboratory...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-016-4239-6
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:MicroRNA is essential for the malignant progression of human gastric cancer (GC), which is a leading cause of cancer deaths. However, the mechanism is still not so clear. AIMS:In our present research, we investigated the effect of miR-9-5p in GC. METHODS:We detected miR-9-5p expression in human gastric epi...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05626-2
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:There have been conflicting reports comparing the prevalence of large polyps (>9 mm) between Hispanics and non-Hispanic whites (NHW). Differences between Hispanic subpopulations may account for these variations. AIMS:We aimed to assess the prevalence of large polyps (>9 mm) in Hispanics from Mexican- and no...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5304-0
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Liver stiffness measurement (LSM) by transient elastography is a popular noninvasive test of fibrosis. Traditional LSM cutoffs dichotomize patients and do not clearly indicate the confidence of diagnosis. AIM:We derived and validated probability functions of fibrosis and cirrhosis based on LSM and determine...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
doi:10.1007/s10620-014-3488-5
更新日期:2015-05-01 00:00:00
abstract::A case of small bowel ulceration and perforation possibly due to therapy with Klotrix in a patient with Crohn's disease is presented. Following emergent surgery with creation of a diverting loop jejunostomy, subsequent reestablishment of intestinal continuity was carried out with excellent clinical results. Gastrointe...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01299819
更新日期:1986-12-01 00:00:00
abstract::New studies monitoring ambulatory esophageal pressures during food ingestion often compare results to normal values obtained from supine liquid swallows. We compared distal esophageal peristaltic and lower esophageal sphincter (LES) pressures in 15 normal subjects during six liquid swallows in the upright and supine p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536799
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Little is known on practice patterns of endoscopists for the management of Barrett's esophagus (BE) over the last decade. AIMS:Our aim was to assess practice patterns of endoscopists for the diagnosis, surveillance and treatment of BE. METHODS:All members of the Italian Society of Digestive Endoscopy (SIED...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06615-6
更新日期:2020-09-28 00:00:00
abstract:BACKGROUND:Polymerase chain reaction (PCR) assays are the standard for detecting hepatitis C virus viremia. The transcription-mediated amplification (TMA)-based assay is more sensitive. METHODS:We retrospectively reviewed the charts of patients with a post-end of treatment (EOT) PCR-/TMA+ result to assess the clinical...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-1820-x
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Thymoquinone (TQ) is the major constituent of Nigella sativa seed and has shown biological activity in various human carcinomas. However, few studies have reported its effect on esophageal carcinoma (EC). AIMS:To explore the chemosensitive effect and mechanism of TQ in augmentation of cisplatin (DDP)-induce...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4856-8
更新日期:2018-01-01 00:00:00
abstract::This study was undertaken to determine whether the synthetic prostaglandin E2 analog enprostil is able to inhibit basal and postprandial hypergastrinemia induced by omeprazole. We also studied the effect of omeprazole, enprostil, and the combination of both drugs on serum pepsinogen A and C levels. Eight normal subjec...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02088350
更新日期:1994-03-01 00:00:00
abstract::The effect of ursodeoxycholic acid (UDCA) on bile lipid composition and bile acid kinetics was evaluated in seven cholesterol gallstone patients following one month of UDCA administration (12 mg/kg/day). UDCA administration induces a significant reduction in the cholesterol saturation index (SI). After UDCA treatment,...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01324739
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:The gut is an important target organ of injury during critically ill conditions. Although Gram staining is a common and quick method for identifying bacteria, its clinical application has not been fully evaluated in critically ill conditions. AIMS:This study's aims were to identify patterns of Gram-stained ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-010-1486-9
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Relative adrenal insufficiency (RAI) is frequently observed in patients with cirrhosis. We sought to identify evidence in the literature regarding the impact of RAI on clinical outcomes in cirrhotic patients. METHODS:We conducted a systematic review (SR) and meta-analysis (MA) using the Ovid-MEDLINE, EMBASE...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10620-017-4471-8
更新日期:2017-04-01 00:00:00