Abstract:
:The gut smooth muscle in the intact conscious state exhibits three distinct types of contractions: rhythmic phasic contractions, tone, and ultrapropulsive contractions. The motility functions of these contractions differ markedly. The phasic contractions mix and propel the ingested food in an orderly fashion so that the nutrients can be absorbed. The ultrapropulsive contractions are of two types, giant migrating contractions (GMCs) and retrograde giant contractions (RGCs). GMCs produce mass movements in the caudal direction and RGCs in the oral direction. GMCs are associated with the symptoms of diarrhea, abdominal cramping, tenesmus, and urgency of defecation. The RGCs regurgitate the contents of the upper small intestine into the stomach in preparation of their expulsion by the somatomotor response. Tachykinins and their receptors are strategically located on the enteric neurons and smooth muscle cells to regulate the above contractions. Recent findings show that NK-1 receptors located on colonic circular smooth muscle cells may mediate colonic GMCs, whereas NK-3 receptors located on presynaptic neurons may mediate the small intestinal GMCs. The molecular and cellular mechanisms of stimulation of RGCs are not known. NK-1 receptor antagonists have shown potential therapeutic effects on vomiting induced by a variety of stimuli in experimental animals.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Sarna SKsubject
Has Abstractpub_date
1999-08-01 00:00:00pages
114S-118Sissue
8 Suppleissn
0163-2116issn
1573-2568journal_volume
44pub_type
杂志文章,评审abstract::The association of chronic intestinal pseudoobstruction with ophthalmoplegia has been reported previously in visceral myopathies. We report a case of this association in which muscle mitochondria had a crystalline appearance, a dense core, and decreased cytochrome c oxidase and succinate cytochrome c reductase activit...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01307743
更新日期:1992-03-01 00:00:00
abstract::To examine the differentiating parameters between cholesterol and pigment gallstones, we compared the nucleation times, concentrations of biliary lipid and protein, and the distribution of vesicular cholesterol in gallbladder bile of 16 patients with cholesterol, eight patients with black pigment gallstones, and nine ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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doi:10.1007/BF01296532
更新日期:1986-11-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296453
更新日期:1986-07-01 00:00:00
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05962-3
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06178-6
更新日期:2021-01-01 00:00:00
abstract::We measured the effects of cimetidine on antibiotic concentrations in the luminal portion of gastric mucosa. Guinea pigs were premedicated with cimetidine 4 mg/kg intramuscularly. Clindamycin, an antibiotic previously characterized under physiologic pH conditions, was administered intramuscularly and levels measured i...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01300082
更新日期:1991-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1021069508731
更新日期:2002-12-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2074-y
更新日期:2012-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318118
更新日期:1986-03-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1024131814888
更新日期:2003-07-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01320320
更新日期:1986-05-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01333703
更新日期:1979-08-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-005-2482-3
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
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更新日期:2015-01-01 00:00:00
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journal_title:Digestive diseases and sciences
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更新日期:2018-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005697422454
更新日期:2001-01-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308166
更新日期:1992-02-01 00:00:00
abstract::The effects on the sphincter of Oddi of intravenous administration of dipyrone, 2.5 g; tramadol, 50 mg; indomethacin, 75 mg; N-butylscopolamine, 20 mg; and nitroglycerin, 1 mg, in comparison to physiological saline were assessed in a single-blind study in 36 patients hospitalized with upper abdominal pain. Basal sphin...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF02088751
更新日期:1996-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s10620-018-5217-y
更新日期:2019-01-01 00:00:00
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doi:10.1007/s10620-015-3967-3
更新日期:2016-04-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-9700-5
更新日期:2007-10-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-018-5378-8
更新日期:2019-03-01 00:00:00
abstract::We previously reported that various gastric irritants induced both apoptosis and necrosis in cultured gastric mucosal cells. In a continuation of this work, the present study has examined the effects of prostaglandin E2 (PGE2), a cytoprotective factor for gastric mucosa in vivo, on gastric irritant-induced apoptosis a...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1020164000898
更新日期:2002-10-01 00:00:00