Dopamine-induced migrating myoelectrical complex-like activity in human duodenum.

Abstract:

:The effect of dopamine on human gastric and small intestinal interdigestive motility was investigated in 12 subjects. Intestinal motility was recorded by means of a four-lumen polyvinyl probe with four open tips located 15 cm apart, continuously perfused with distilled water. In each subject during the same study, after recording two consecutive spontaneous phase III of migrating myoelectrical complexes and when a phase II appeared, dopamine was infused intravenously twice in a dose of 5 micrograms/kg/min for 15 min with an interval of 20 min between each infusion. In six subjects, the second dopamine infusion was preceded by a treatment with sulpiride (10 mg, intravenously, as bolus) or domperidone (10 mg, intravenously, as bolus), each considered a highly selective dopamine antagonist. The results show that dopamine stimulates duodenal motility producing a pattern similar to that observed in phase III of spontaneously occurring migrating myoelectrical complexes. The second dopamine infusion reproduced in all cases the same pattern of motility as observed during the first infusion. Sulpiride and domperidone prevented the effect of dopamine in all cases. It is therefore suggested that dopamine-induced duodenal motility may involve specific dopaminergic receptors.

journal_name

Dig Dis Sci

authors

Marzio L,Neri M,Di Giammarco AM,Cuccurullo F,Lanfranchi GA

doi

10.1007/BF01311668

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

349-54

issue

4

eissn

0163-2116

issn

1573-2568

journal_volume

31

pub_type

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