Fecal clearance of alpha1-antitrypsin with lansoprazole can detect protein-losing gastropathy.

Abstract:

:Detecting plasma protein loss from the stomach is quite difficult by measuring fecal alpha1-AT clearance because alpha1-AT is rapidly destroyed in the gastric juice at values below pH 3. We examined protein loss from the stomach using fecal alpha1-AT clearance with lansoprazole, a proton pump inhibitor. A 38-year-old Japanese male presented with hypoproteinemia (total serum protein: 4.4 g/dl). Abdominal scintigraphy using technetium-99m-labeled albumin revealed distinct radioactivity accumulation in the small intestine. It strongly suggested excessive protein loss to the gastrointestinal tract. Although, regular fecal alpha1-AT clearance was within the normal range (<13 ml/day), the fecal alpha1-AT clearance with the administration of lansoprazole was 80.5 ml/day. The results indicated that this method using lansoprazole is simple and useful for detecting protein-losing gastropathy.

journal_name

Dig Dis Sci

authors

Takeda H,Nishise S,Furukawa M,Nagashima R,Shinzawa H,Takahashi T

doi

10.1023/a:1026625308572

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

2313-8

issue

11

eissn

0163-2116

issn

1573-2568

journal_volume

44

pub_type

杂志文章
  • Periampullary Diverticula and ERCP Outcomes: A Systematic Review and Meta-Analysis.

    abstract:INTRODUCTION:Periampullary diverticulum (PAD) is most often asymptomatically found in elderly population. ERCP in the presence of PAD is technically challenging since the location and orientation of the ampulla could be altered. Various studies have reported differing results on the technical success and safety outcome...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10620-018-5314-y

    authors: Jayaraj M,Mohan BP,Dhindsa BS,Mashiana HS,Radhakrishnan G,Dhir V,Trindade AJ,Adler DG

    更新日期:2019-05-01 00:00:00

  • Salivary growth factors and cytokines are not deficient in patients with gastroesophageal reflux disease or Barrett's esophagus.

    abstract::Growth factors, such as epidermal growth factor (EGF), are known to protect upper gut mucosa against irritants and to enhance healing of ulcerative lesions in animal models. A number of salivary growth factors are found in human saliva. The aim of this study was to determine if salivary growth factors and cytokines ar...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005615703009

    authors: Kongara K,Varilek G,Soffer EE

    更新日期:2001-03-01 00:00:00

  • Mechanisms of bombesin on growth of gastrinoma (PT) in vivo.

    abstract::The growth of the human gastrinoma model (PT) in athymic nude mice is stimulated by bombesin (BBS), an amphibian peptide homologous to both human gastrin-releasing peptide (GRP) and neuromedin B (NMB). The mechanism is not known, and a potent and specific GRP-R antagonist BIM26226, which has low affinity for NMB-R, wa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02071398

    authors: Chu KU,Ishizuka J,Battey JF,Uchida T,Beauchamp RD,Townsend CM Jr,Thompson JC

    更新日期:1996-11-01 00:00:00

  • Death due to acute pancreatitis. A retrospective analysis of 405 autopsy cases.

    abstract::A large retrospective autopsy study of patients was analyzed to evaluate the major etiologic and pathologic factors contributing to fatal acute pancreatitis (AP). From an autopsy population of 50,227 patients, 405 cases were identified where AP was defined as the official primary cause of death. AP was classified acco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/BF01308298

    authors: Renner IG,Savage WT 3rd,Pantoja JL,Renner VJ

    更新日期:1985-10-01 00:00:00

  • Hemodynamic effects of rapid injection into the canine superior mesenteric artery.

    abstract::We explored the hemodynamic effects of rapid injection of 0.9% saline and arterial blood into the canine superior mesenteric artery in anesthetized animals. Mesenteric artery blood flow and pressure were measured in the vessel distal to the site of injection. Injection rates were at or below the rate of blood flow in ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01309495

    authors: Jacobson ED,Eldon C,Fondacaro JD

    更新日期:1981-10-01 00:00:00

  • Regional differences in concentrations of regulatory peptides in human colon mucosal biopsy.

    abstract::The study was undertaken to examine regional differences in the concentrations of five regulatory peptides in the human colonic mucosa. Biopsies were obtained during routine colonoscopy from 33 patients whose colonic mucosa was macroscopically and histologically normal. Regulatory peptides were extracted, and measured...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01537267

    authors: Calam J,Ghatei MA,Domin J,Adrian TE,Myszor M,Gupta S,Tait C,Bloom SR

    更新日期:1989-08-01 00:00:00

  • Intraperitoneal administration of fetuin-A attenuates D-galactosamine/lipopolysaccharide-induced liver failure in mouse.

    abstract:BACKGROUND:Fulminant hepatic failure (FHF) is a devastating syndrome, which sometimes results in death or liver transplantation, in which inflammation would aggravate the development of fetuin-A which would act as an anti-inflammatory factor and may be an available approach to attenuate FHF. AIMS:The purpose of this s...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3071-0

    authors: Zhang P,Shen H,Huang J,Wang H,Zhang B,Zhou R,Zhong B,Fan X

    更新日期:2014-08-01 00:00:00

  • The human intestinal microflora.

    abstract::The major host defense mechanisms against bacterial overgrowth in the small bowel are the normal propulsive activity of the bowel itself and gastric acid secretion. Microbial interactions are a major factor in regulating the indigenous bacterial flora. Studies of the bacterial enzymes of the gut suggest that changes i...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01295996

    authors: Simon GL,Gorbach SL

    更新日期:1986-09-01 00:00:00

  • Liver histology changes in nonalcoholic steatohepatitis after one year of treatment with probucol.

    abstract:BACKGROUND:Probucol, a lipid-lowering agent with antioxidant effects, is effective in normalizing liver enzymes in patients with nonalcoholic steatohepatitis (NASH). We studied changes in the liver histology of patients with NASH after use of probucol for one year. METHODS:Ten patients with biopsy-proven NASH were inc...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10620-007-0109-6

    authors: Merat S,Aduli M,Kazemi R,Sotoudeh M,Sedighi N,Sohrabi M,Malekzadeh R

    更新日期:2008-08-01 00:00:00

  • Effect of opiates on gastroduodenal motility following surgical operation.

    abstract::Following surgical operations, opiate analgesics are widely used to control pain. This situation was used to investigate patterns of human gastroduodenal motility and the effect of opiate analgesics on this motility during the early postoperative period. Gastric contractions were absent for 6--12 hr following surgery ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01314760

    authors: Ingram DM,Catchpole BN

    更新日期:1981-11-01 00:00:00

  • Impaired Quality of Life, Work, and Activities Among Adults with Clostridium difficile Infection: A Multinational Survey.

    abstract:BACKGROUND:Evidence of humanistic detriments of Clostridium difficile infection (CDI) remains limited. AIMS:To assess humanistic burden associated with CDI. METHODS:Self-reported National Health and Wellness Survey data between 2013 and 2016 were analyzed for the USA, five European countries, China, and Brazil. Outco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-018-5222-1

    authors: Heinrich K,Harnett J,Vietri J,Chambers R,Yu H,Zilberberg M

    更新日期:2018-11-01 00:00:00

  • Failure of inhibitor assay to determine isoamylase distribution.

    abstract::Isoamylase distribution in the urine of normal individuals and patients admitted to the hospital with hyperamylasemia was determined by a wheat inhibitor mmethod and compared to results obtained by cellulose-acetate electrophoresis. We report two cases where the inhibitor ethod failed to give accurate results in urine...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01311727

    authors: Gersten M,Bank S,Lendvai S

    更新日期:1983-11-01 00:00:00

  • Measurement of small intestinal permeability markers, lactulose, and mannitol in serum: results in celiac disease.

    abstract::To date, tests of small intestinal passive permeability have involved the ingestion of test molecules whose permeation is assessed indirectly by measuring their urinary recovery. Excretion ratios of marker molecules (eg, lactulose-to-mannitol excretion ratio, LMER) are useful clinically. Measurement of permeability ma...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026679123148

    authors: Cox MA,Lewis KO,Cooper BT

    更新日期:1999-02-01 00:00:00

  • Apoptosis induced by ischemia-reperfusion and fasting in gastric mucosa compared to small intestinal mucosa in rats.

    abstract::The effect of ischemia-reperfusion and 48-hr fasting on apoptosis was characterized in rat gastric mucosa and compared to small intestinal mucosa. Under halothane anesthesia, the celiac artery or superior mesenteric artery in the rat was occluded for 60 min followed by reperfusion. Occlusion of the celiac artery reduc...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005695031233

    authors: Fukuyama K,Iwakiri R,Noda T,Kojima M,Utsumi H,Tsunada S,Sakata H,Ootani A,Fujimoto K

    更新日期:2001-03-01 00:00:00

  • Reevaluation of manometric criteria for vigorous achalasia. Is this a distinct clinical disorder?

    abstract::Clinical and manometric data from 97 consecutive patients with idiopathic achalasia were analyzed to see if a distinct subset with vigorous achalasia could be identified. Statistical analyses failed to detect a unique group of subjects based on the distribution of contraction wave amplitudes alone. Because of this, pa...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01318195

    authors: Todorczuk JR,Aliperti G,Staiano A,Clouse RE

    更新日期:1991-03-01 00:00:00

  • Malignant lymphoma of the liver. Report of five cases and review of the literature.

    abstract::Primary hepatic lymphoma is a rare disease. We report five cases here and summarize clinical and pathologic features of our own and reported cases from Western countries and Japan. The total number of cases was 68. The age of patients ranged from 7 to 87 years (median 55) with a male-to-female ratio of 3.1:1. Chronic ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/BF01300294

    authors: Ohsawa M,Aozasa K,Horiuchi K,Kataoka M,Hida J,Shimada H,Oka K,Wakata Y

    更新日期:1992-07-01 00:00:00

  • Enteral access by double-balloon enteroscopy: an alternative method of direct percutaneous endoscopic jejunostomy placement.

    abstract:BACKGROUND:Although direct percutaneous endoscopic jejunal feeding tube placement is an increasingly accepted method of providing small-bowel access for long-term enteral nutrition, it is reliant on push enteroscopy and remains a technically challenging procedure with significant failure rates. Double-balloon enterosco...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1306-2

    authors: Despott EJ,Gabe S,Tripoli E,Konieczko K,Fraser C

    更新日期:2011-02-01 00:00:00

  • Prealbumin and D-dimer as Prognostic Indicators for Rebleeding in Patients with Nonvariceal Upper Gastrointestinal Bleeding.

    abstract:BACKGROUND:Determining the risk stratification of nonvariceal upper gastrointestinal bleeding (NVUGIB) plays a vital role in treating upper gastrointestinal bleeding (UGIB). Traditional scores like Glasgow-Blatchford score (GBS), Rockall score (RS), and AIMS65 score have been widely utilized in UGIB practice, however e...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06420-1

    authors: Yue W,Liu Y,Jiang W,Huang J,Liu J

    更新日期:2020-06-24 00:00:00

  • Women's health training in gastroenterology fellowship: a national survey of fellows and program directors.

    abstract:BACKGROUND AND AIMS:The Gastroenterology Core Curriculum requires training in women's digestive disorders; however, requirements do not necessarily produce knowledge and competence. Our study goals were: (1) to compare perceptions of education, fellow-reported levels of competence, and attitudes towards training in wom...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-010-1532-7

    authors: Saha S,Roberson E,Richie K,Lindstrom MJ,Esposti SD,Wald A

    更新日期:2011-03-01 00:00:00

  • Gallbladder ejection fraction and its relationship to sphincter of Oddi dysfunction.

    abstract::Theoretically, relative distal common bile duct obstruction due to sphincter of Oddi dysfunction may be a cause of poor gallbladder evacuation observed on quantitative cholescintigraphy. In this study, the relationship of sphincter of Oddi dysfunction to the gallbladder ejection fraction by quantitative cholescintigra...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02090199

    authors: Ruffolo TA,Sherman S,Lehman GA,Hawes RH

    更新日期:1994-02-01 00:00:00

  • The Great View Forward: The Use of a Colonoscope for Distal Duodenal Stent Placement.

    abstract:INTRODUCTION:Stent placement in the distal duodenum can be difficult. We describe a case report of a 94-year-old man with metastatic pancreatic head cancer compressing the third and fourth portions of the duodenum, treated by endoscopic stent placement using a colonoscope. AREAS COVERED:A literature review highlighted...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-019-05768-3

    authors: Minervini A,Lauro A,Pagano N,Vaccari S,D'Andrea V,Marino IR,Cervellera M,Tonini V

    更新日期:2019-09-01 00:00:00

  • Spontaneous swallowing rate and emotional state. Possible mechanism for stress-related gastrointestinal disorders.

    abstract::Excessive spontaneous swallowing has been associated with a variety of common gastrointestinal symptoms including abdominal pain, heartburn, and bloating and may contribute to disorders such as hiatus hernia, duodenal ulcer, and irritable bowel syndrome. The present study investigated the hypothesis that changes in em...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02065410

    authors: Cuevas JL,Cook EW 3rd,Richter JE,McCutcheon M,Taub E

    更新日期:1995-02-01 00:00:00

  • Medium- and high-dose omeprazole plus amoxicillin for eradication of Helicobacter pylori in duodenal ulcer disease.

    abstract::The purpose of the present study was to investigate the Helicobacter pylori eradication potency of combined amoxicillin-omeprazole treatment in patients with duodenal ulcer disease and to compare the efficacy of two omeprazole and amoxicillin doses concerning H. pylori eradication, ulcer healing, pain relief, and safe...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02088052

    authors: Labenz J,Rühl GH,Bertrams J,Börsch G

    更新日期:1994-07-01 00:00:00

  • Influence of Severe Vitamin D Deficiency on the Clinical Course of Inflammatory Bowel Disease.

    abstract:BACKGROUND:Previous studies have shown vitamin D status to be associated with disease activity in patients with inflammatory bowel disease (IBD), but its influence on the clinical course of IBD has not been established. AIMS:We aimed to analyze whether the serum 25-hydroxyvitamin D3 [25(OH)D] status is associated with...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06207-4

    authors: Ham NS,Hwang SW,Oh EH,Kim J,Lee HS,Park SH,Yang DH,Ye BD,Byeon JS,Myung SJ,Yang SK

    更新日期:2020-03-26 00:00:00

  • Lactulose/mannitol test and specificity, sensitivity, and area under curve of intestinal permeability parameters in patients with liver cirrhosis and Crohn's disease.

    abstract:UNLABELLED:The purpose of this study was to investigate and compare the specificity, sensitivity, and area under curve (AUC) of the lactulose/mannitol ratio, lactulose/creatinine ratio, and lactulose recovery and their diagnostic value for intestinal permeability assessment within the absorption lactulose/mannitol (L/M...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-0184-8

    authors: Dastych M,Dastych M Jr,Novotná H,Cíhalová J

    更新日期:2008-10-01 00:00:00

  • Effects of several denervation procedures on distribution of calcitonin gene-related peptide and substance P immunoreactive in rat stomach.

    abstract::The effect of chemical deafferentation, vagotomy (VGX), and gangliosympathectomy (GSX) on the density of fibers containing calcitonin gene-related peptide (CGRP) and substance P (Sub.P) in the rat gastric wall was studied. Chemical deafferentation by capsaicin abolished the density of CGRP-immunoreactive (IR) fibers, ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018858208532

    authors: Suzuki T,Kagoshima M,Shibata M,Inaba N,Onodera S,Yamaura T,Shimada H

    更新日期:1997-06-01 00:00:00

  • Role of carbonic anhydrase in basal and stimulated bicarbonate secretion by the guinea pig duodenum.

    abstract::The role of carbonic anhydrase in the process of proximal duodenal mucosal bicarbonate secretion was investigated in the guinea pig. In a series of experiments in vivo, the duodenum was perfused with 24 mmol/liter NaHCO3 solution (+ NaCl for isotonicity) to ensure that active duodenal HCO3- secretion against a concent...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02087561

    authors: Muallem R,Reimer R,Odes HS,Schwenk M,Beil W,Sewing KF

    更新日期:1994-05-01 00:00:00

  • Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome.

    abstract::We describe a 36-year-old man with advanced multiple myeloma (Salmon and Durie stage III) who developed jaundice and severe cholestasis after a first cure with systemic chemotherapy of vincristine, doxorubicin, and oral dexamethasone (VAD). Serology for hepatitis A, B, and C and for CMV was negative. A liver ultrasoun...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1014773512707

    authors: Michopoulos S,Petraki K,Petraki C,Dimopoulos MA

    更新日期:2002-04-01 00:00:00

  • Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle.

    abstract::Glutamine synthetase is responsible for the ATP-dependent amidation of glutamate to glutamine. In liver the enzyme is highly localized in perivenous hepatocytes; in brain the enzyme is localized in astrocytes. Portacaval anastomosis resulted in liver atrophy, hyperammonemia, and up to 90% loss of glutamine synthetase ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01300297

    authors: Girard G,Butterworth RF

    更新日期:1992-07-01 00:00:00

  • Glucagon-like peptide-2 induces a specific pattern of adaptation in remnant jejunum.

    abstract::Glucagon-like peptide-2 (GLP-2) is an enteroendocrine hormone which is uniquely trophic for the intestine; a physiological role in regulating nutrient absorptive capacity is becoming apparent. GLP-2, independent of enteral feeding, stimulates a classical pattern of intestinal adaptation in terminal ileum following res...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-9077-5

    authors: Sigalet DL,Bawazir O,Martin GR,Wallace LE,Zaharko G,Miller A,Zubaidi A

    更新日期:2006-09-01 00:00:00