Abstract：
:Orocecal transit time was determined by the lactulose hydrogen breath test in nine healthy volunteers after administration of placebo, loperamide (16 mg per os), and loperamide (16 mg per os) followed by oral naloxone at doses of 16 and 32 mg. The four tests were performed in double-blind conditions and in random sequences. Transit time (mean, SD) after loperamide (128.8 min, 32.9) was significantly increased (P less than 0.05) compared with placebo (85.5 min, 35.7), loperamide followed by naloxone 16 mg (88.8 min, 46.2), and loperamide followed by naloxone 32 mg (84.4 min, 40.6). These results show that the peripheral opioid agonist loperamide delays orocecal transit in healthy subjects and that naloxone per os at adequate doses antagonizes this effect.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Basilisco G,Camboni G,Bozzani A,Paravicini M,Bianchi PAdoi
10.1007/BF01296704subject
Has Abstractpub_date
1987-08-01 00:00:00pages
829-32issue
8eissn
0163-2116issn
1573-2568journal_volume
32pub_type
临床试验,杂志文章,随机对照试验abstract：UNLABELLED:The lactulose breath test (LBT) and gastroenterocolonic scintigraphy (GECS) can both be used to measure orocecal transit time (OCTT). The aims of this study were (1) to measure OCTT by LBT and GECS and (2) to determine whether lactulose alters orocecal transit. METHODS:Eight normal subjects underwent simult...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1023/a:1018864400566
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Diagnosis of eosinophilic esophagitis (EoE) requires quantification of esophageal eosinophilia. AIMS:The aims of this study were to assess inter- and intraobserver reliability for measuring esophageal eosinophil counts and to validate a novel method of determining tissue eosinophil density using digitized h...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-1005-z
更新日期：2010-07-01 00:00:00
abstract：:Clostridium difficile (CD) is one of the most common causes of diarrhea in solid organ transplantation (SOT). Between 1996 and 2005, a total of 2474 solid organ transplants were performed at our institution, of which 43 patients developed CD-associated diarrhea. There were 3 lung, 3 heart, 20 liver, 8 kidney-pancreas,...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-007-9770-z
更新日期：2007-11-01 00:00:00
abstract：:We examined the effect of sildenafil, an inhibitor of phosphodiesterase subtype 5, that catalyzes hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP), on indomethacin-induced small-intestinal ulceration in rats and investigated the mechanism of this action, especially in relation to endogenous nitric oxide (NO)....
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0646-7
更新日期：2009-11-01 00:00:00
abstract：:Cytomegalovirus (CMV) inclusions were found at colonic perforation sites in three patients with clinical settings suggesting a compromised immunologic status. This could be interpreted as: (1) CMV was an etiologic agent in these perforations; or (2) CMV was an opportunistic superinfection in areas of preexisting infla...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01297124
更新日期：1979-05-01 00:00:00
abstract：:Trichinella spiralis infection in rodents is a well-known model of intestinal inflammation associated with hypermotility and hypersecretion. Our aim was to use this experimental model to elucidate if iNOS was involved in the development of gastrointestinal hypermotility. Rats infected with Trichinella spiralis were tr...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1023796108391
更新日期：2003-06-01 00:00:00
abstract：:Ehlers-Danlos syndrome (EDS) type IV is an autosomal dominant connective tissue disease caused by mutations in the type III collagen gene resulting in extreme tissue fragility. Affected individuals are at risk of dramatic and often fatal complications, mostly spontaneous arterial, uterine, or colonic ruptures. Phenoty...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018869617076
更新日期：1997-08-01 00:00:00
abstract：:Glutamine synthetase is responsible for the ATP-dependent amidation of glutamate to glutamine. In liver the enzyme is highly localized in perivenous hepatocytes; in brain the enzyme is localized in astrocytes. Portacaval anastomosis resulted in liver atrophy, hyperammonemia, and up to 90% loss of glutamine synthetase ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300297
更新日期：1992-07-01 00:00:00
abstract：:A method for isolating and characterizing intestinal lymphoid cells from colonoscopic biopsies is presented. Intraepithelial lymphocytes were separated from the lamina propria by incubation in edetic acid (EDTA) and lamina propria lymphoid cells isolated by incubation in collagenase followed by Ficoll-Hypaque density ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01300700
更新日期：1986-02-01 00:00:00
abstract：:The effects of 10-day bilateral adrenalectomy on morphometry, proliferation, and apoptosis were determined in the small intestine of 3-month-old Sprague-Dawley rats. The activities of sucrase, lactase, and its respective mRNA, aminopeptidase N, and intestinal alkaline phosphatase were also evaluated. Adrenalectomy lea...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1010611228730
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:DNA methylation mainly affects tumor suppressor genes in the development of hepatocellular carcinoma (HCC). However, sera methylation of specific genes in hepatitis B virus (HBV)-related HCC remains unknown. AIMS:The purpose of this study was to identify methylation frequencies of sera E-cadherin (CDH1), DN...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章
doi：10.1007/s10620-015-3975-3
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Obesity and metabolic syndrome are risk factors for colorectal neoplasia (CRN). However, the association between metabolically healthy obese (MHO) or metabolically unhealthy non-obese (MUNO) status and the risk of CRN remains unclear. AIMS:We aimed to elucidate the association between MHO or MUNO status and...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5239-5
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) is the number one cause of liver disease in the United States. The prevalence rates in African Americans (AA), while significantly lower than other ethnic groups with similar known risk factors, have been quoted as high as 24 %. We aim to determine if the pre...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-013-2652-7
更新日期：2013-08-01 00:00:00
abstract：:We report a case of localized jejunal amyloidosis occurring in a 74-year-old man who experienced an episode of digestive bleeding while he was receiving oral anticoagulation. It illustrates a rare entity, characterized by an endoscopic aspect of polypoid, pseudotumoral formations. Histologically, submucosal connective...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005536901678
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:While gastroesophageal reflux disease (GERD) is common in Middle Eastern countries, little data exists on the epidemiology of Barrett's esophagus (BE). AIMS:We aimed to determine the prevalence of BE among patients undergoing esophagogastroduodenoscopy (EGD) in a cohort of Saudi patients. METHODS:We retros...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-020-06503-z
更新日期：2020-08-04 00:00:00
abstract：:This study was undertaken to investigate the effect of ingestion of 80 g Vivonex on gallbladder volume, plasma cholecystokinin (CCK), and pancreatic polypeptide (PP) in eight healthy volunteers and to compare the results with those obtained after ingestion of 60 ml corn oil. Gallbladder volumes were measured by ultras...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296686
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:There have been conflicting reports comparing the prevalence of large polyps (>9 mm) between Hispanics and non-Hispanic whites (NHW). Differences between Hispanic subpopulations may account for these variations. AIMS:We aimed to assess the prevalence of large polyps (>9 mm) in Hispanics from Mexican- and no...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-018-5304-0
更新日期：2019-01-01 00:00:00
abstract：:The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtim...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s10620-006-9111-7
更新日期：2006-12-01 00:00:00
abstract：:Bone loss is an established complication of cholestatic liver cirrhosis, while little is known about bone mass and metabolism in noncholestatic liver cirrhosis. The aim of the present study is, therefore, to evaluate bone mass and mineral metabolism in patients with liver cirrhosis secondary to viral hepatitis. Bone m...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005568406664
更新日期：2000-07-01 00:00:00
abstract：PURPOSE:In previous studies the NFKBIA 3'UTR (untranslated region) AA genotype was associated with Crohn's disease (CD), while the NFKB1-94ins/delATTG mutation increased the risk for ulcerative colitis (UC). The aim of our study was to investigate these two polymorphisms and patients' response to medical therapy and/or...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0351-6
更新日期：2009-02-01 00:00:00
abstract：:Peutz-Jeghers syndrome (PJS) is an autosomal-dominant inherited disorder characterized by mucocutaneous pigmentation, hamartomatous polyposis of the gastrointestinal tract, and an increased risk for the development of both gastrointestinal and extraintestinal malignancies. Germline mutation of the STK11 gene, which en...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0837-x
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Acid reflux has been associated with poor outcomes following lung transplantation. Unlike surgical fundoplication, the role of noninvasive, pharmacologic acid suppression remains uncertain. AIMS:To assess the relationship between post-transplant acid suppression with proton pump inhibitors (PPI) or histamin...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-017-4827-0
更新日期：2018-02-01 00:00:00
abstract：:Concentration and voltage dependence of Mg transport across the rat duodenum was measured in an Ussing chamber. Mucosa (m) to serosa (s) Mg flux exhibits a cellular fraction comparable to that found for Ca. Mg sm flux is purely diffusive and probably restricted to the paracellular pathway. At all concentrations betwee...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296406
更新日期：1991-11-01 00:00:00
abstract：:We postulated that coadministration of cholylsarcosine with ursodeoxycholic acid might provide additional benefit to primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid. Our aim was to test the tolerability and the effect of adjuvant cholylsarcosine on liver tests and plasma choleste...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018868126743
更新日期：1998-06-01 00:00:00
abstract：:Pancreaticopleural fistulas are a rare complication of pancreatitis. We report two cases from our institution and review 37 cases of pancreaticopleural fistulas identified in the literature. Endoscopic retrograde cholangiopancreatography was more sensitive compared to computed tomography in demonstrating pancreaticopl...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-006-3073-7
更新日期：2006-01-01 00:00:00
abstract：AIM:Several models of experimental ulcerative colitis have been previously reported. To date, only one model of Crohn's colitis that was induced by trinitrobenzene sulfonic acid has been described. MATERIALS AND METHODS:Twenty-one male albino rats were divided into three groups: group I: sham control group (n = 7), gr...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1697-8
更新日期：2011-10-01 00:00:00
abstract：:Antimony electrodes are clinically useful because of their low cost and simple construction; they have no glass to break. There is only a few hundred ohms resistance between an antimony pH electrode and the reference electrode so that the voltage generated can be recorded with simple low-impedance recorders linked to ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01537242
更新日期：1990-08-01 00:00:00
abstract：:Development of type 1 insulin-dependent diabetes mellitus has been recently reported in patients who underwent interferon-alpha (IFN-alpha) therapy because of chronic viral hepatitis. Furthermore IFN-alpha seems to be involved in the immunological events that lead to beta-cell destruction and development of type 1 dia...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF02087923
更新日期：1996-08-01 00:00:00
abstract：:Microvesicular steatosis is a potentially severe manifestation of valproic acid hepatotoxicity due to an acquired impairment of mitochondrial function. Tests currently used to investigate mitochondrial fonction are cumbersome and cannot be used routinely. We report on a noninvasive breath test using [13C]methionine fo...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1012791832730
更新日期：2001-12-01 00:00:00
abstract：:Orlistat (tetrahydrolipstatin) is a potent inhibitor of gastric and pancreatic lipase activity causing a diminution of free fatty acids in the intestinal lumen. The release of cholecystokinin (CCK) critically depends on the presence of free fatty acids in the small intestine. Postprandial CCK release and gallbladder c...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02100135
更新日期：1996-12-01 00:00:00
