Abstract:
:Trichinella spiralis infection in rodents is a well-known model of intestinal inflammation associated with hypermotility and hypersecretion. Our aim was to use this experimental model to elucidate if iNOS was involved in the development of gastrointestinal hypermotility. Rats infected with Trichinella spiralis were treated for 4 days with the nitric oxide synthase inhibitors L-NAME or L-NIL. Treatment began either simultaneously with the infection or 3 days after infection when inflammation was already fully developed. In all cases, at day 10-12 after infection, anesthetized rats were prepared with strain gauges and electrodes in the small intestine to evaluate motor activity of the small intestine. In addition, histology and iNOS immunohistochemistry studies were performed. The results showed that both NOS inhibitors blocked iNOS expression in the intestine. None of the NOS inhibitors attenuated the inflammatory process. However, the preventive treatment with L-NIL reversed hypermotility. In contrast, the treatment with NOS inhibitors 3 days after infection was not so effective in reversing motor alterations. L-NAME, but not L-NIL, caused alterations on spontaneous motility. In conclusion, these results indicate that iNOS participates in the development of motor hypermotility in the gut.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Torrents D,Prats N,Vergara Pdoi
10.1023/a:1023796108391subject
Has Abstractpub_date
2003-06-01 00:00:00pages
1035-49issue
6eissn
0163-2116issn
1573-2568journal_volume
48pub_type
杂志文章abstract:BACKGROUND:We have reported previously that Candida albicans is involved in the pathogenesis of peptic ulcer perforation; it was shown that C. albicans aggravated the severity of duodenal ulceration and increased the rate of perforation. We considered it incumbent upon us to ascertain whether C. albicans is a virulence...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-0159-9
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journal_title:Digestive diseases and sciences
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1984-04-01 00:00:00
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journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
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