Abstract:
:We describe the first reported case of generalized tonic-clonic seizures induced by meperidine premedication for a colonoscopy procedure in a 63-year-old woman with Alzheimer's disease. The active metabolite of meperidine, normeperidine, is postulated to be the precipitating cause of the seizures, although a cholinesterase inhibitor and an N-methyl-D: -aspartate receptor antagonist, both routinely used for treatment of Alzheimer's disease, may have contributed by reducing the seizure threshold. The neuronal changes which occur in Alzheimer's disease can themselves also predispose to seizures. We recommend avoidance of meperidine for all flexible endoscopic procedures on patients with Alzheimer's disease and in any patient with a condition that predisposes to seizures, and suggest the use of alternative opioids.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Nagler J,Hammarth PM,Poppers DMdoi
10.1007/s10620-007-9822-4subject
Has Abstractpub_date
2008-01-01 00:00:00pages
62-4issue
1eissn
0163-2116issn
1573-2568journal_volume
53pub_type
杂志文章abstract:BACKGROUND:Gut inflammation is prevalent in chronic kidney disease (CKD) and likely contributes to systemic inflammation via disruption of the epithelial tight junction with subsequent endotoxin and bacterial translocation. AIMS:To study the expression profile of inflammatory and tight junction proteins in the colon f...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3428-4
更新日期:2015-05-01 00:00:00
abstract::There continues to be disagreement regarding the effects of ethanol on gastric emptying. This study was designed to assess different degrees of ethanol exposure on gastric emptying. Scintigraphic gastric emptying studies were performed in healthy adult cats and the half time (t1/2) of gastric emptying was obtained fro...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536917
更新日期:1990-04-01 00:00:00
abstract::Ten patients were prospectively studied using 99mTc-PIPIDA imaging to evaluate the effects of fasting and parenteral alimentation on gallbladder function. Three of ten patients had initial nonvisualization of the gallbladder for up to 2 hr, yet had normal visualization on repeat imaging performed after resumption of o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01312557
更新日期:1983-08-01 00:00:00
abstract::Pancreaticopleural fistulas are a rare complication of pancreatitis. We report two cases from our institution and review 37 cases of pancreaticopleural fistulas identified in the literature. Endoscopic retrograde cholangiopancreatography was more sensitive compared to computed tomography in demonstrating pancreaticopl...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-3073-7
更新日期:2006-01-01 00:00:00
abstract::A randomized controlled clinical study was conducted to determine (a) whether basic aluminum sucrose sulfate (sucralfate) is effective in preventing or reducing gastric ulcer recurrence, and (b) the clinical parameters contributing to ulcer recurrence after endoscopically proved healing has been effected. A total of 1...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01312725
更新日期:1980-01-01 00:00:00
abstract::The diagnostic accuracy of two different methods of sectioning rectal biopsies was evaluated prospectively. The frequency of focal and diffuse findings in more than 80 serial sections from a limited portion of the well-oriented areas of 74 biopsies was compared with that found in three or more step sections distribute...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295652
更新日期:1982-05-01 00:00:00
abstract:INTRODUCTION:Interpretation of video capsule data is time-consuming. Olympus capsule endoscopy (CE) software systems are equipped with auto-speed-adjusted and express-selected playback modes and overview function in an effort to reduce reading times. The clinical efficacy of these new playback features is unknown. Our ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-012-2074-y
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Subjects with fatty liver disease (FLD) can show increased hepatic 2-deoxy-2-((18)F)fluoro-D-glucose (FDG) uptake, but the role of hepatic inflammation has not been explored. AIMS:We investigated whether hepatic inflammatory response, as implicated by elevated serum markers, is associated with increased liv...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2957-6
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:SEL1L gene product is implicated in the endoplasmic reticulum (ER)-associated protein degradation and Unfolded Protein Response pathways. This gene and associated miRNAs have been indicated as predictive and prognostic markers of pancreatic cancer. AIM:Explore the role of SEL1L in colorectal cancer (CRC) pr...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-011-2026-y
更新日期:2012-04-01 00:00:00
abstract::Turmeric is widely used in Indian cuisine. The main constituents of turmeric are curcumin and its analogues, which are well-known antioxidant compounds. In the present study, we hypothesized that turmeric in curry might increase bowel motility and activate hydrogen-producing bacterial flora in the colon, thereby incre...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-008-0550-1
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The underlying mechanisms of nonalcoholic steatohepatitis (NASH) are poorly understood, and little is known about hepatocellular apoptosis in NASH. Cyclooxygenase (COX)-2, the key enzyme in eicosanoid metabolism, is highly expressed in NASH. COX-2 can also regulate the release of mediators of inf...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-013-2823-6
更新日期:2013-10-01 00:00:00
abstract::Ornithine decarboxylase (ODC) activity has been associated with mucosal growth and injury, yet, little information is available on ODC activity during gastric ulcer healing. We measured ODC activity in the ulcer base submucosa and the surrounding mucosa at 1 cm and 2 cm and assessed ulcer surface healing and a histolo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01300280
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Transenteral (TE) administration of a bowel cleanser prior to colonoscopy avoids the discomfort associated with drinking a large volume of unpalatable cleanser. AIM:To explore patient comfort, preference for future colonoscopy, the efficacy and adverse events associated with TE bowel preparation. METHODS:B...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-014-3344-7
更新日期:2015-01-01 00:00:00
abstract::The literature regarding the effect of nicotine and cigarette smoke on gastric blood flow is conflicting. The hydrogen gas clearance technique was used to measure the effects of nicotine and cigarette smoke on basal gastric mucosal blood flow in anesthetized rats. Blood flow was measured before, during, and after trea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01320320
更新日期:1986-05-01 00:00:00
abstract::The morphine-Prostigmin test (MPT) has been advocated as a diagnostic test for identifying patients with papillary stenosis. We studied 14 patients referred for possible papillary stenosis with the MPT and ERCP sphincter of Oddi manometry. The response to the MPT (symptoms, serum amylase/lipase values) was evaluated b...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01299827
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND AND AIMS:The impact of obesity on survival following liver transplantation is unclear, and existing studies report conflicting results. Our current study aims to further delineate the impact of obesity using population-based registry data from the USA. METHODS:All US adult liver transplant recipients from 2...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3469-8
更新日期:2015-04-01 00:00:00
abstract::Metoclopramide tablets have been approved for use in the acute and chronic management of diabetic gastroparesis. Its efficacy as an antiemetic has been well documented. We measured the acute and chronic effects of oral metoclopramide on gastric liquid emptying in 12 diabetic patients with symptoms of stasis using scin...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01318364
更新日期:1985-01-01 00:00:00
abstract::Many physiological factors can alter gastric emptying, and the role of gastric emptying in functional dyspepsia is controversial. The aim of this study was to assess the effects of different factors (age, sex, the degree of dyspeptic and irritable bowel symptoms, lactase deficiency, smoking habits, the use of antiinfl...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018826917657
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Gastrointestinal motility disorder is an important pathological basis for functional dyspepsia (FD). Epigastric ache and discomfort are the main symptoms of FD, and ghrelin deficiency is closely related to the occurrence and development of FD. While electroacupuncture (EA) alleviated the symptoms of FD patie...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05960-5
更新日期:2020-06-01 00:00:00
abstract::In Japanese healthy CYP2C19 extensive metabolizers, rabeprazole 10 mg shows a faster onset of action and stronger inhibition of acid secretion than does omeprazole 20 mg on the first 3 days of administration. We evaluated gastric ulcer improvement after 1 week's treatment with rabeprazole or omeprazole in relation to ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10620-007-9965-3
更新日期:2008-04-01 00:00:00
abstract::Many studies have indicated changes in neuropeptides in inflammatory bowel disease (IBD), but with contradictory results. Nerve growth factor also has a potential role in the maintenance of enteric nerves and may be associated with IBD. A quantitative immunohistochemical method was used to measure area density of immu...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1017943430627
更新日期:2002-03-01 00:00:00
abstract:AIM:Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. METHODS:In this prospective study, consecutive CHB patients on co...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-019-05717-0
更新日期:2019-12-01 00:00:00
abstract::Previous studies have shown that duodenal motility patterns differ in preterm and term infants, but antral motor activities were not compared. Using a validated, low-compliance, continuous-perfusion, neonatal manometric system, antral and duodenal motility was studied in 19 preterm and nine term infants. Antral motili...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308336
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression. METHODS:Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specime...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-008-0418-4
更新日期:2009-04-01 00:00:00
abstract::To study the efficacy of standard blood tests of liver function (LFTs) and technetium-99m liver scan followed by laparoscopy in the diagnosis of solid malignant tumors of the liver, 100 consecutive patients were evaluated who had these tests because of clinical suspicion of liver neoplasm. Malignant liver tumors were ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01333702
更新日期:1979-08-01 00:00:00
abstract::In this study, we examined the effect of rebamipide, a mucoprotective drug, on gastric ulcer healing in Mongolian gerbils infected with H. pylori. Male Mongolian gerbils were inoculated with H. pylori or vehicle alone 12 hr after the production of an acetic acid-induced gastric ulcer. On day 5, the gerbils inoculated ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1015879421739
更新日期:2002-07-01 00:00:00
abstract::Telomerase acitivity can be induced in human B lymphocytes by in vitro stimulation of their antigen receptors. To determine whether telomerase activity is induced in vivo, we analyzed telomerase activity in B lymphocytes from the mesenteric lymph nodes of patients with inflammatory bowel disease (IBD), whose lymph nod...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026107429546
更新日期:2003-10-01 00:00:00
abstract::Rebamipide, a gastroprotective drug, is a compound selected from over 500 amino acid analogs of 2(1H)-quinolinone tested for gastroprotective action and for efficacy to heal experimental gastric ulcers. This drug stimulates prostaglandin generation in gastric mucosa and improves not only the speed but also the quality...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:
更新日期:1998-09-01 00:00:00
abstract::We have used double-contrast radiographic techniques to clarify what changes in the configuration and movements of the gastroduodenal junction result when peptic lesions involve the distal gastric segment between the proximal (PPL) and the distal pyloric muscle loop (DPL). Among 50 cases of pyloric ulceration diagnose...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01540562
更新日期:1990-12-01 00:00:00
abstract::The current cost of endoscopically screening patients with gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) is considerable. A nonendoscopic device that allows for screening of these patients would offer significant cost savings. This pilot study evaluates the utility of cytologically diagnosing BE ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1012771328187
更新日期:2001-12-01 00:00:00