Seizures in an Alzheimer's disease patient as a complication of colonoscopy premedication with meperidine.

Abstract:

:We describe the first reported case of generalized tonic-clonic seizures induced by meperidine premedication for a colonoscopy procedure in a 63-year-old woman with Alzheimer's disease. The active metabolite of meperidine, normeperidine, is postulated to be the precipitating cause of the seizures, although a cholinesterase inhibitor and an N-methyl-D: -aspartate receptor antagonist, both routinely used for treatment of Alzheimer's disease, may have contributed by reducing the seizure threshold. The neuronal changes which occur in Alzheimer's disease can themselves also predispose to seizures. We recommend avoidance of meperidine for all flexible endoscopic procedures on patients with Alzheimer's disease and in any patient with a condition that predisposes to seizures, and suggest the use of alternative opioids.

journal_name

Dig Dis Sci

authors

Nagler J,Hammarth PM,Poppers DM

doi

10.1007/s10620-007-9822-4

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

62-4

issue

1

eissn

0163-2116

issn

1573-2568

journal_volume

53

pub_type

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