Nonalcoholic steatohepatitis and cirrhosis with Mallory's hyalin with ultrastructural study of one case.

Abstract:

:Clinical features and liver biopsy findings were studied in six patients with nonalcoholic steatohepatitis associated with hyalin. A comparative study was made on the ultrastructure of the hyalin in one patient with nonalcoholic steatohepatitis and in one patient with alcoholic hepatitis. The patients, all over 50 years old, comprised two females and one male with steatohepatitis and three females with micronodular cirrhosis. They showed obesity, hepatomegaly, and mild abnormalities on laboratory tests. Three of them showed maturity-onset diabetes. The hyalin was found in the cytoplasm of swollen hepatocytes of the centrilobular or in the peripheral region of nodules and was accompanied by necrosis. Ultrastructurally, the hyalin comprised filamentous structures and vesicular or angular structures resembling disorganized circular or branched rough endoplasmic reticulum. It resembled that found in the liver of patients with alcoholic hepatitis.

journal_name

Dig Dis Sci

authors

Itoh S,Matsuo S,Ichinoe A,Yamaba Y,Miyazawa M

doi

10.1007/BF01296754

subject

Has Abstract

pub_date

1982-04-01 00:00:00

pages

341-6

issue

4

eissn

0163-2116

issn

1573-2568

journal_volume

27

pub_type

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