Mechanisms of Probiotic VSL#3 in a Rat Model of Visceral Hypersensitivity Involves the Mast Cell-PAR2-TRPV1 Pathway.

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in affluent countries. Recent studies have reported that circular RNAs (circRNAs) are important regulators of hepatic steatosis. However, the role and mechanism of circRNA in NAFLD are poorly understood. AIMS:This study is to ...

journal_title：Digestive diseases and sciences

authors： Li P,Shan K,Liu Y,Zhang Y,Xu L,Xu L

更新日期：2019-01-01 00:00:00

abstract：:A case of heterotopic bone formation in a primary rectal adenocarcinoma was recently observed in a 54-year-old woman. This unusual finding was present both in the diagnostic biopsy and in the subsequently resected bowel. Pertinent gross and microscopic features are presented. This report represents the twelfth case in...

journal_title：Digestive diseases and sciences

authors： Ansari MQ,Sachs IL,Max E,Alpert LC

更新日期：1992-10-01 00:00:00

abstract：INTRODUCTION:Increased nonacid reflux is diagnosed in a subgroup of patients with gastroesophageal reflux disease who often present with reflux symptoms refractory to proton-pump inhibitor therapy. Despite the prevalence of this condition, the management approach for patients with increased nonacid reflux can often be ...

journal_title：Digestive diseases and sciences

authors： Reddy CA,Watts L,Baker JR,Chen JW

更新日期：2020-05-23 00:00:00

abstract：:Lichen planus is a common mucocutaneus disorder that rarely involves the esophagus. We report two challenging cases presenting with recurrent dysphagia originally suspected due to gastroesophageal reflux. Subsequent evaluation revealed peculiar endoscopic findings of desquamative esophagitis leading to the diagnosis o...

journal_title：Digestive diseases and sciences

authors： Ukleja A,DeVault KR,Stark ME,Achem SR

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Notoginsenoside R1 (NG-R1) is the predominant active ingredient and a novel triterpene saponin compound extracted from the roots of Panax notoginseng. To date, to the best of our knowledge, there are no previous studies concerning the effect of NG-R1 on hepatocellular carcinoma (HCC). AIMS:To investigate th...

journal_title：Digestive diseases and sciences

authors： Li Y,Li Z,Jia Y,Ding B,Yu J

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Hypoxia is an important factor in malignant tumors, and glycolysis is a major metabolic contributor in their development. Glycolytic enzymes have gained increasing attention as potential therapeutic targets because they are associated with cancer-specific metabolism. Fructose-bisphosphate aldolase A (ALDOA),...

journal_title：Digestive diseases and sciences

authors： Li X,Jiang F,Ge Z,Chen B,Yu J,Xin M,Wang J,An L,Wei J,Wu L

更新日期：2019-11-01 00:00:00

abstract：:Using conventional statistical analysis and multiple regression analysis, we investigated the viral and host factors that influence the response to recombinant interferon-alpha 2a therapy in patients with chronic hepatitis C. A total of 36 patients was randomly assigned to three administration schedules, 12 patients i...

journal_title：Digestive diseases and sciences

authors： Matsumoto A,Tanaka E,Suzuki T,Ogata H,Kiyosawa K

更新日期：1994-06-01 00:00:00

abstract：:With the growing popularity of propofol mediated deep sedation for upper gastrointestinal (GI) endoscopic procedures, challenges are being felt and appreciated. Research suggests that management of the airway is anything but routine in this setting. Although many studies and meta-analyses have demonstrated the safety ...

journal_title：Digestive diseases and sciences

authors： Goudra B,Singh PM

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Numerous experiments have shown that alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are present in cells of various cancer and can play role in carcinogenesis. In previous investigations we have found elevated levels of alcohol dehydrogenase class III activity in pancreatic cancer cells. It ca...

journal_title：Digestive diseases and sciences

authors： Jelski W,Zalewski B,Szmitkowski M

更新日期：2008-08-01 00:00:00

abstract：:Our purpose is to develop a standard method for preparing the bile for beta-glucuronidase determination by removal of bile acids and conjugated bilirubin which interfere with its activity. The bile acids and conjugated bilirubin in their purified solutions and in the diluted gallbladder biles could be extracted comple...

journal_title：Digestive diseases and sciences

authors： Ho YC,Ho KJ

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that healing in intestinal wounds is proportionally faster than skin. Cytokines and growth factors play a major role in these coordinated wound-healing events. We hypothesized that this more rapid intestinal healing is due to an early upregulation of proinflammatory cytokines (IL-...

journal_title：Digestive diseases and sciences

authors： Zubaidi A,Buie WD,Hart DA,Sigalet D

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:There is a large Barrett's esophagus patient population undergoing endoscopic surveillance. Methods to stratify patients into higher and lower risk groups may enable more varied surveillance intervals for patients with non-dysplastic Barrett's esophagus that could optimize use of endoscopy resources. OBJECT...

journal_title：Digestive diseases and sciences

authors： Kunzmann AT,Coleman HG,Johnston BT,Turkington RC,McManus D,Anderson LA,Thrift AP

更新日期：2020-07-20 00:00:00

abstract：:Detecting plasma protein loss from the stomach is quite difficult by measuring fecal alpha1-AT clearance because alpha1-AT is rapidly destroyed in the gastric juice at values below pH 3. We examined protein loss from the stomach using fecal alpha1-AT clearance with lansoprazole, a proton pump inhibitor. A 38-year-old ...

journal_title：Digestive diseases and sciences

authors： Takeda H,Nishise S,Furukawa M,Nagashima R,Shinzawa H,Takahashi T

更新日期：1999-11-01 00:00:00

abstract：:Vitamin D deficiency is frequently observed in patients with Crohn's disease and may be associated with an increased risk of development of metabolic bone disease. To estimate the incidence of metabolic bone disease by noninvasive methods, 31 patients (17-75 years old) with Crohn's disease and low 25-hydroxyvitamin D ...

journal_title：Digestive diseases and sciences

authors： Vogelsang H,Ferenci P,Woloszczuk W,Resch H,Herold C,Frotz S,Gangl A

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND AND AIM:Aberrant methylation of specific genes is frequent event in hepatocellular carcinoma (HCC). Our present study aims to explore the methylation levels of acid phosphatase locus 1 (ACP1), bone morphogenetic protein 4 (BMP4), and testis-specific protein, Y-encoded-like 5 (TSPYL5) and their potential clin...

journal_title：Digestive diseases and sciences

authors： Qiu X,Hu B,Huang Y,Deng Y,Wang X,Zheng F

更新日期：2016-01-01 00:00:00

abstract：:Fractional systemic bioavailability of orally administered drugs was found to be unexpectedly low in liver cirrhosis, even after surgical portal-systemic shunting. Fecal loss or intestinal first-pass elimination were assumed to explain the finding. In this paper we evaluated alternative pathophysiological interpretati...

journal_title：Digestive diseases and sciences

authors： Molino G,Avagnina P,Garrone C,Sansoè G,Degerfeld MM,Peretti P,Tinivella M,Bianco S

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:An increasing number of studies have found that long non-coding RNAs (lncRNAs) play an important role in carcinogenesis and tumor progression, whereas their molecular mechanisms of function remain largely unknown. AIMS:This study was aimed to explore the biological function and underlying mechanism of a new...

journal_title：Digestive diseases and sciences

authors： He W,Zhang D,Li D,Zhu D,Geng Y,Wang Q,He J,Wu J

更新日期：2020-11-03 00:00:00

abstract：:In this study, two antiallergic compounds, betamethasone and disodium cromoglycate were tested in an animal model of intestinal anaphylaxis. Rats, immunized with Nippostrongylus brasiliensis, were challenged intravenously with whole worm antigen or saline. Antigen challenge resulted in significant abnormalities: epith...

journal_title：Digestive diseases and sciences

authors： D'Incà R,Hunt RH,Perdue MH

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Acute variceal bleeding (AVB) in patients with cirrhosis is associated with high mortality, ranging from 12 to 20% at 6 weeks. The existing prognostic models for AVB lack precision and require further validation. AIM:In this prospective study, we aimed to develop and validate a new prognostic model for AVB,...

journal_title：Digestive diseases and sciences

authors： Rout G,Sharma S,Gunjan D,Kedia S,Saraya A,Nayak B,Singh V,Kumar R,Shalimar

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori vacuolating cytotoxin, VacA, stimulates apoptosis via a mitochondria-dependent pathway. VacA induces apoptosis via activation of the pro-apoptotic B-cell lymphoma (Bcl)-2 family proteins, Bcl-2-associated X protein (Bax) and Bcl-2 homologous antagonist/killer (Bak), while the implication ...

journal_title：Digestive diseases and sciences

authors： Matsumoto A,Isomoto H,Nakayama M,Hisatsune J,Nishi Y,Nakashima Y,Matsushima K,Kurazono H,Nakao K,Hirayama T,Kohno S

更新日期：2011-04-01 00:00:00

abstract：:The ascitic fluid concentrations of cholesterol and fibronectin and the serum-ascites albumin difference were compared with two conventional tests of ascitic fluid, total protein and LDH, in their diagnostic ability for detection of malignancy in ascitic samples from 69 patients with ascites: 54 with ascites due to li...

journal_title：Digestive diseases and sciences

authors： Prieto M,Gómez-Lechón MJ,Hoyos M,Castell JV,Carrasco D,Berenguer J

更新日期：1988-07-01 00:00:00

abstract：:A case of small bowel ulceration and perforation possibly due to therapy with Klotrix in a patient with Crohn's disease is presented. Following emergent surgery with creation of a diverting loop jejunostomy, subsequent reestablishment of intestinal continuity was carried out with excellent clinical results. Gastrointe...

journal_title：Digestive diseases and sciences

authors： Brower RA

更新日期：1986-12-01 00:00:00

abstract：:Although systemic steroids remain as the gold standard for the treatment of acute moderate to severe active ulcerative colitis (UC), 15-57% of patients do not achieve clinical remission. We sought to identify clinical, biological, or radiologic predictive factors of response to steroid treatment in acute UC attacks. T...

journal_title：Digestive diseases and sciences

authors： Bernal I,Mañosa M,Domènech E,Garcia-Planella E,Navarro M,Lorenzo-Zúñiga V,Cabré E,Gassull MA

更新日期：2006-08-01 00:00:00

abstract：:Previous studies have demonstrated alterations in brain response to rectal distension in patients with irritable bowel syndrome (IBS) compared to controls. Our aim was to compare regional brain activity in response to rectal balloon distension in patients with IBS and healthy controls. We studied six patients with IBS...

journal_title：Digestive diseases and sciences

authors： Ringel Y,Drossman DA,Turkington TG,Bradshaw B,Hawk TC,Bangdiwala S,Coleman RE,Whitehead WE

更新日期：2003-09-01 00:00:00

abstract：:Over a one-year period, 95 children and adolescents presenting with epigastric pain and/or vomiting, and without associated risk factors for development of peptide disease, underwent endoscopic antral biopsies for pathologic diagnosis and to detect presence of Campylobacter ss. pylori (C. pylori). Additional biopsies ...

journal_title：Digestive diseases and sciences

authors： Glassman MS,Schwarz SM,Medow MS,Beneck D,Halata M,Berezin S,Newman LJ

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:The risk of pancreatic cancer is elevated among people with new-onset diabetes (NOD). Based on Rochester Epidemiology Project Data, the Enriching New-Onset Diabetes for Pancreatic Cancer (END-PAC) model was developed and validated. AIMS:We validated the END-PAC model in a cohort of patients with NOD using r...

journal_title：Digestive diseases and sciences

authors： Chen W,Butler RK,Lustigova E,Chari ST,Wu BU

更新日期：2021-01-01 00:00:00

abstract：:Upper gastrointestinal endoscopy was performed for the evaluation of infectious esophagitis in 19 consecutive subjects evaluated prospectively before orthotopic liver transplantation (OLTx), in a separate group of 27 subjects post-OLTx, and in 21 subjects following orthotopic renal transplantation (ORTx). None of the ...

journal_title：Digestive diseases and sciences

authors： Alexander JA,Brouillette DE,Chien MC,Yoo YK,Tarter RE,Gavaler JS,Van Thiel DH

更新日期：1988-09-01 00:00:00

abstract：:Studies have shown a promoting effect of food on small intestinal absorption. Casein hydrolysate seems be more effective in increasing of D-xylose absorption in dogs than the whole protein and lactulose. The purpose this study was to analyze the effect of groups of peptides derived from casein hydrolysate on the absor...

journal_title：Digestive diseases and sciences

authors： Defilippi C,Madrid AM,Salas K,Michea L,Lagos N

更新日期：2000-04-01 00:00:00

abstract：:Various reports on the prevalence of gastroesophageal reflux disease (GERD) and uninvestigated dyspepsia have been conducted in Western countries. We sought to determine the frequency of GERD symptoms and uninvestigated dyspepsia in Korea. Telephone interviews were conducted with 1,044 individuals. Of all subjects, 7....

journal_title：Digestive diseases and sciences

authors： Yang SY,Lee OY,Bak YT,Jun DW,Lee SP,Lee SH,Park GT,Yoon BC,Choi HS,Hahm JS,Lee MH,Lee DH

更新日期：2008-01-01 00:00:00

abstract：:Growth factors, such as epidermal growth factor (EGF), are known to protect upper gut mucosa against irritants and to enhance healing of ulcerative lesions in animal models. A number of salivary growth factors are found in human saliva. The aim of this study was to determine if salivary growth factors and cytokines ar...

journal_title：Digestive diseases and sciences

authors： Kongara K,Varilek G,Soffer EE

更新日期：2001-03-01 00:00:00