Abstract：
:The purpose of this study was to examine the effect of perfusion of the colon with a fatty acid (oleic acid) on peptone-stimulated gastric acid secretion and release of gastrin in conscious dogs. Gastric acid secretion was monitored by continuous intragastric titration. Perfusion of the colon with sodium oleate (24 mmol/hr) inhibited gastric acid secretion (14.2 +/- 2.6 meq/hr) stimulated by a peptone meal (1%) significantly (P less than 0.05) when compared to perfusion of the colon with saline alone (20.1 +/- 1.6 meq/hr). The serum elevation in gastrin in response to intragastric instillation of the peptone meal was not affected by the colonic perfusion of oleic acid. Plasma concentrations of peptide YY (PYY) increased significantly in response to perfusion of the colon with saline or sodium oleate, and the integrated release of PYY in response to sodium oleate [6.9 +/- 2.8 ng (60-120) min/ml] was significantly greater than the response to saline [3.1 +/- 0.7 ng (60-120) min/ml]. The results of this study indicate that inhibition of gastric acid secretion by perfusion of the colon with fat is not due to an inhibition of gastrin release. In addition, because PYY is an inhibitor of gastric acid secretion, it is possible that PYY participates as an inhibitor of gastric acid secretion by the colon.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Hashimoto T,Lluis F,Gomez G,Hill FL,Greeley GH Jr,Thompson JCdoi
10.1007/BF01297136subject
Has Abstractpub_date
1991-07-01 00:00:00pages
888-92issue
7eissn
0163-2116issn
1573-2568journal_volume
36pub_type
杂志文章abstract：:The aim of this study was to examine the seroprevalence of antibody to CagA antigen, as well as other major H. pylori antigens by Western blot in H. pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51). The role of the host and environmental factors was also evaluated. There ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1026634721351
更新日期：1999-10-01 00:00:00
abstract：:A 36-year-old female with a six-year history of Crohn's disease of the anus and colon was found to have in situ cloacogenic carcinoma of the anus after having undergone total proctocolectomy for massive bleeding. This case further supports the association between Crohn's disease of the gastrointestinal tract and its p...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01395512
更新日期：1980-06-01 00:00:00
abstract：BACKGROUND AND AIMS:Accumulating evidence has indicated that variations of mitochondrial DNA (mtDNA) content may affect the susceptibility to hepatocellular carcinoma (HCC). However, no study has been conducted to evaluate the association of circulating mtDNA content and the risk of liver cirrhosis, a leading cause of ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-015-3523-1
更新日期：2015-06-01 00:00:00
abstract：:Achalasia has been described following fundoplication and is attributed to vagal nerve damage during surgery. Similarly, other traumatic events to the distal esophagus may be linked to the development of achalasia. Operative and nonoperative trauma as a possible factor in the development of achalasia was studied. A re...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-004-9577-0
更新日期：2004-11-01 00:00:00
abstract：:In a double-blind study on 19 patients with the diagnosis of chronic pancreatitis, the effects of treatment with a granulated pancreatic enzyme preparation (Pankreon) were compared with those of placebo administration. One week of treatment with each preparation was preceded by one week without any medication. The pat...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01315137
更新日期：1983-02-01 00:00:00
abstract：:Dysmotility and delayed emptying of the stomach have been reported in patients with chronic renal failure (CRF). The aim of this study was to investigate whether gastric myoelectrical activity was impaired in patients with CRF using electrogastrography. The electrogastrogram (EGG) was recorded in 24 symptomatic patien...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1018856112765
更新日期：1997-05-01 00:00:00
abstract：:Chemiluminescence (CL) analysis of monocytes and polymorphonuclear cells (PMNs) was performed on 13 patients with Crohn's disease (CD) and 10 healthy volunteers. The percentages of monocyte populations in mononuclear cells obtained from the patients with CD were greater than those from the healthy volunteers, but the ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01535990
更新日期：1988-08-01 00:00:00
abstract：:Cyclic vomiting syndrome is a disorder characterized by recurrent episodes of nausea and vomiting with complete resolution of symptoms between attacks. Nitric oxide plays a critical role in regulating several components of gastrointestinal mucosal defense and injury. Interleukin-6 has a wide variety of actions in the ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1010712703685
更新日期：2001-04-01 00:00:00
abstract：:Biliary mucin was regarded as a major contributing factor in formation of pigment stones as well as cholesterol ones. The aim of this study was to elucidate the mechanism of biliary mucin secretion in canine gallbladder epithelial (CGBE) cells treated by lipopolysaccharides (LPS) with special reference to cyclooxygena...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1022832608466
更新日期：2003-04-01 00:00:00
abstract：:By using two-color immunofluorescence with fluorescein isothiocyanate (FITC) and phycoerythrin (PE)-labelled monoclonal antibodies and multiparameter flow cytometry, we investigated lamina propria lymphocyte subsets of patients with ulcerative colitis (UC) and Crohn's disease (CD). Leu-3/Leu-2 (CD4/CD8) ratio of lamin...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296815
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND:There are sporadic reports in the literature in which radiologic liver and lung lesions found incidentally during follow-up metastatic surveillance were shown to be caused by toxocariasis. AIMS:The objective of the work discussed in this report was to identify common clinical and histopathological features ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-011-1833-5
更新日期：2012-01-01 00:00:00
abstract：UNLABELLED:There is a wide choice of fecal occult blood tests (FOBTs) for colorectal cancer screening. GOAL:To highlight the issues applicable when choosing a FOBT, in particular which FOBT is best suited to the range of screening scenarios. Four scenarios characterize the constraints and expectations of screening pro...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-014-3445-3
更新日期：2015-03-01 00:00:00
abstract：:Liver from neonatal rats injected with LD50 E. coli endotoxin was studied by light and electron microscopy. By 2 hr, there was margination and migration of polymorphonuclear leukocytes. Single cell necrosis was seen after 8 hr. At 16 hr, there were numerous necrotic foci in the mid-zonal region of hepatic lobules, as ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01318697
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:Given the rising epidemics of obesity and metabolic syndrome, nonalcoholic steatohepatitis (NASH) is now the most common cause of liver disease in the developed world. Effective treatment for NASH, either to reverse or prevent the progression of hepatic fibrosis, is currently lacking. AIM:To define the pred...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3380-3
更新日期：2015-04-01 00:00:00
abstract：:Small intestinal bacterial overgrowth (SIBO) has a high incidence in dogs and, as in humans, is difficult to diagnose. The aim of this study was to determine the diagnostic significance of serum unconjugated bile acid concentrations in dogs with bacterial overgrowth. Fasting sera were obtained from 23 dogs: 10 with cu...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005493416946
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:The performance characteristics of colonic sensation and motility measurements are unclear. AIM:To compare left colon compliance, tone, and sensation in males and females and to evaluate inter and intra-individual coefficients of variation (COV) in these measurements. METHODS:Data were acquired using stand...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-009-0772-x
更新日期：2010-03-01 00:00:00
abstract：:The purpose of the present study was to investigate the Helicobacter pylori eradication potency of combined amoxicillin-omeprazole treatment in patients with duodenal ulcer disease and to compare the efficacy of two omeprazole and amoxicillin doses concerning H. pylori eradication, ulcer healing, pain relief, and safe...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02088052
更新日期：1994-07-01 00:00:00
abstract：:The effect of ischemia-reperfusion and 48-hr fasting on apoptosis was characterized in rat gastric mucosa and compared to small intestinal mucosa. Under halothane anesthesia, the celiac artery or superior mesenteric artery in the rat was occluded for 60 min followed by reperfusion. Occlusion of the celiac artery reduc...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1005695031233
更新日期：2001-03-01 00:00:00
abstract：:Symptom scores, stool data, and the transit of a standard, solid meal were measured in 28 patients with irritable bowel syndrome (IBS) during baseline conditions and after five weeks of treatment with placebo and loperamide, given as a flexible dosage regime in the form of a double-blind, cross-over trial. All patient...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01296258
更新日期：1984-03-01 00:00:00
abstract：OBJECTIVE:The regulation of apoptosis of intestinal mucosal cells is important in maintenance of normal intestinal physiology. SUMMARY:Sphingosine-1-phosphate (S1P) has been shown to play a critical role in cellular protection to otherwise lethal stimuli in several nonintestinal tissues. METHODS:The current study det...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-008-0393-9
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND AND AIMS:The Gastroenterology Core Curriculum requires training in women's digestive disorders; however, requirements do not necessarily produce knowledge and competence. Our study goals were: (1) to compare perceptions of education, fellow-reported levels of competence, and attitudes towards training in wom...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-010-1532-7
更新日期：2011-03-01 00:00:00
abstract：:A large retrospective autopsy study of patients was analyzed to evaluate the major etiologic and pathologic factors contributing to fatal acute pancreatitis (AP). From an autopsy population of 50,227 patients, 405 cases were identified where AP was defined as the official primary cause of death. AP was classified acco...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/BF01308298
更新日期：1985-10-01 00:00:00
abstract：:Hereditary type 2 diabetes mellitus is a risk factor for chronic liver disease, and ~30 % of patients with liver cirrhosis develop diabetes. Diabetes mellitus has been associated with cirrhotic and non-cirrhotic hepatitis C virus liver infection, can aggravate the course the liver infection, and can induce a lower sus...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章,评审
doi：10.1007/s10620-015-3907-2
更新日期：2016-02-01 00:00:00
abstract：:We studied intraesophageal pressure changes in patients with symptoms of gastroesophageal reflux and an abnormal 24-hr pH monitoring record (N = 52). Our method was simultaneous esophageal manometry and pH monitoring. We observed a three-component esophageal manometric sequence (EMS). When this sequence recurred over ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01538066
更新日期：1989-09-01 00:00:00
abstract：:Both intracellular calcium ions and neural input are important in esophageal smooth muscle contraction. The aim of this study was to compare the effects of well-tolerated doses of the calcium-channel blocker, nifedipine (20 mg sublingually/buccally) with the anticholinergic, propantheline bromide (15 mg orally) and th...
journal_title：Digestive diseases and sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01318513
更新日期：1984-04-01 00:00:00
abstract：BACKGROUND:Accumulating evidence suggests that Foxp3+ regulatory T (Treg) cells act as inhibitory mediators of inflammation; however, the in vivo mechanism underlying this protection remains elusive in liver diseases. AIMS:To clarify the in vivo role of Foxp3+ Treg cells in liver fibrosis, we used the DEREG mouse, whi...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3438-2
更新日期：2015-07-01 00:00:00
abstract：:Interferon treatment of chronic hepatitis C virus infection is successful in a minority of patients. The sequence of the interferon sensitivity determining region (ISDR) of the NS5A protein may determine the outcome of therapy in patients infected with HCV genotype 1. To determine whether IFN treatment caused selectio...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1023/a:1010623417345
更新日期：2001-07-01 00:00:00
abstract：:Concentration and voltage dependence of Mg transport across the rat duodenum was measured in an Ussing chamber. Mucosa (m) to serosa (s) Mg flux exhibits a cellular fraction comparable to that found for Ca. Mg sm flux is purely diffusive and probably restricted to the paracellular pathway. At all concentrations betwee...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01296406
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. METHODS:We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. ...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/s10620-014-3102-x
更新日期：2014-08-01 00:00:00
abstract：:This study was designed to determine the effect of a newly synthesized benzimidazole derivative NC-1300-B on H+, K+-ATPase (proton pump) in the hog gastric mucosa and on the basal gastric acid secretion and necrotizing agent-induced gastric lesions in rats. NC-1300-B inhibited the proton pump in a concentration-depend...
journal_title：Digestive diseases and sciences
pub_type： 杂志文章
doi：10.1007/BF01536998
更新日期：1988-11-01 00:00:00
