当前位置： SCI文献检索 > DIGESTIVE DISEASES AND SCIENCES期刊下所有文献 > Current Concepts in Diabetes Mellitus and Chronic Liver Disease: Clinical Outcomes, Hepatitis C Virus Association, and Therapy.

Current Concepts in Diabetes Mellitus and Chronic Liver Disease: Clinical Outcomes, Hepatitis C Virus Association, and Therapy.

Abstract：

:Hereditary type 2 diabetes mellitus is a risk factor for chronic liver disease, and ~30 % of patients with liver cirrhosis develop diabetes. Diabetes mellitus has been associated with cirrhotic and non-cirrhotic hepatitis C virus liver infection, can aggravate the course the liver infection, and can induce a lower sustained response to antiviral treatment. Evidences that HCV may induce metabolic and autoimmune disturbances leading to hypobetalipoproteinemia, steatosis, insulin resistance, impaired glucose tolerance, thyroid disease, and gonadal dysfunction have been found. Prospective studies have demonstrated that diabetes increases the risk of liver complications and death in patients with cirrhosis. However, treatment of diabetes in these patients is complex, as antidiabetic drugs can promote hypoglycemia and lactic acidosis. There have been few therapeutic studies evaluating antidiabetic treatments in patients with liver cirrhosis published to date; thus, the optimal treatment for diabetes and the impact of treatment on morbidity and mortality are not clearly known. As numbers of patients with chronic liver disease and diabetes mellitus are increasing, largely because of the global epidemics of obesity and nonalcoholic fatty liver disease, evaluation of treatment options is becoming more important. This review discusses new concepts on hepatogenous diabetes, the diabetes mellitus–hepatitis C virus association, and clinical implications of diabetes mellitus in patients with chronic liver disease. In addition, the effectiveness and safety of old and new antidiabetic drugs, including incretin-based therapies, will be described.

journal_name

Dig Dis Sci

journal_title

Digestive diseases and sciences

authors

García-Compeán D,González-González JA,Lavalle-González FJ,González-Moreno EI,Villarreal-Pérez JZ,Maldonado-Garza HJ

doi

10.1007/s10620-015-3907-2

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

371-80

issue

2

eissn

0163-2116

issn

1573-2568

pii

10.1007/s10620-015-3907-2

journal_volume

61

pub_type

杂志文章,评审

相关文献

DIGESTIVE DISEASES AND SCIENCES文献大全
  • Nitric oxide as a modulator of intestinal water and electrolyte transport.

    abstract：:The role of nitric oxide in intestinal fluid and electrolyte secretion depends upon whether the conditions under study are physiological or pathophysiological. In physiological conditions, endogenous nitric oxide seems to be a proabsorptive molecule, based on the findings that nitric oxide synthase inhibitors reverse ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1023/a:1018887525293

    authors： Izzo AA,Mascolo N,Capasso F

    更新日期：1998-08-01 00:00:00

  • Effects of vasoactive intestinal polypeptide (VIP) on lower esophageal sphincter in awake baboons: comparison with glucagon and secretin.

    abstract：:The effects of vasoactive intestinal polypeptide (VIP), glucagon, and secretin on lower esophageal sphincter pressure were investigated in awake baboons. The three hormones were compared with respect to effect on (1) resting lower esophageal sphincter pressure and (2) maximal stimulatory response to pentagastrin. VIP ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01297119

    authors： Siegel SR,Brown FC,Castell DO,Johnson LF,Said SI

    更新日期：1979-05-01 00:00:00

  • Mechanical characteristics of distension-evoked peristaltic contractions in the esophagus of systemic sclerosis patients.

    abstract：BACKGROUND:Systemic sclerosis (SS) patients with severe esophageal affection have impaired peristalsis. However, motor function evaluated in vivo by manometry and fluoroscopy does not provide detailed information about the individual contraction cycles. AIMS:To apply, for the first time in gastrointestinal (GI) patien...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-011-1777-9

    authors： Gregersen H,Villadsen GE,Liao D

    更新日期：2011-12-01 00:00:00

  • Dabigatran Reduces Liver Fibrosis in Thioacetamide-Injured Rats.

    abstract：BACKGROUND:Liver fibrosis can progress to cirrhosis, hepatocellular carcinoma, or liver failure. Unfortunately, the antifibrotic agents are limited. Thrombin activates hepatic stellate cells (HSCs). Therefore, we investigated the effects of a direct thrombin inhibitor, dabigatran, on liver fibrosis. METHODS:Adult male...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-5311-1

    authors： Lee KC,Hsu WF,Hsieh YC,Chan CC,Yang YY,Huang YH,Hou MC,Lin HC

    更新日期：2019-01-01 00:00:00

  • Serum levels of soluble immune factors and pathogenesis of chronic hepatitis C, and their relation to therapeutic response to interferon-alpha.

    abstract：:To test the role of immune reactivity in the pathogenesis of hepatitis C, serum soluble immune factors were measured in a cohort of 57 patients with chronic hepatitis C, and in 20 healthy subjects. Levels of interleukin-1 beta, granulocyte-macrophage colony-stimulating factor, tumor necrosis factor-alpha, and interleu...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02087671

    authors： Quiroga JA,Martin J,Pardo M,Carreño V

    更新日期：1994-11-01 00:00:00

  • Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance.

    abstract：BACKGROUND AND AIM:Aberrant methylation of specific genes is frequent event in hepatocellular carcinoma (HCC). Our present study aims to explore the methylation levels of acid phosphatase locus 1 (ACP1), bone morphogenetic protein 4 (BMP4), and testis-specific protein, Y-encoded-like 5 (TSPYL5) and their potential clin...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-015-3878-3

    authors： Qiu X,Hu B,Huang Y,Deng Y,Wang X,Zheng F

    更新日期：2016-01-01 00:00:00

  • Possible mechanism of increase in gastric mucosal PGE2 and PGI2 generation induced by ecabet sodium, a novel gastroprotective agent.

    abstract：:The gastroprotective agent ecabet sodium (ecabet, 12-sulfodehydroabietic acid monosodium salt) increases the formation of prostaglandin (PG) E2 and I2 by gastric mucosa. In the present study, we examined the effect of ecabet on metabolism of arachidonic acid (AA) in rat gastric mucosal cells. Ecabet (0.1-10 mM) concen...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1018885005109

    authors： Kinoshita M,Tamaki H

    更新日期：1997-01-01 00:00:00

  • Pancreaticopleural fistula: report of two cases and review of the literature.

    abstract：:Pancreaticopleural fistulas are a rare complication of pancreatitis. We report two cases from our institution and review 37 cases of pancreaticopleural fistulas identified in the literature. Endoscopic retrograde cholangiopancreatography was more sensitive compared to computed tomography in demonstrating pancreaticopl...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-006-3073-7

    authors： Oh YS,Edmundowicz SA,Jonnalagadda SS,Azar RR

    更新日期：2006-01-01 00:00:00

  • Low acid output in Pima Indians. A possible cause for the rarity of duodenal ulcer in this population.

    abstract：:Duodenal ulcer has not been observed in full-heritage Pima Indians, while gastric cancer is relatively frequent. To investigate possible underlying factors for this phenomenon, we determined gastric acid output, gastric emptying rate, and plasma levels of gastrin, pepsinogen I, and pepsinogen II in apparently healthy ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01318419

    authors： Sasaki H,Nagulesparan M,Samloff IM,Straus E,Sievers ML,Dubois A

    更新日期：1984-09-01 00:00:00

  • Donor gender does not affect liver transplantation outcome in children.

    abstract：:The liver is recognized as a sex hormone-responsive organ. Gender-specific differences in liver function are known to exist. Recently, a higher failure rate for organs transplanted in adults from female donors to male recipients has been reported. This increased failure rate of livers obtained from adult females and t...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01540167

    authors： Pillay P,Van Thiel DH,Gavaler JS,Starzl TE

    更新日期：1990-06-01 00:00:00

  • Slow gastric emptying induced by high fat content of meal accelerated by cisapride administered rectally.

    abstract：:The evaluation of agents potentially accelerating gastric emptying in gastric stasis syndromes is time-consuming. Since a previous study showed that emptying is slowed after antecedent fat ingestion and intravenous cisapride abolishes this effect, we investigated whether emptying delayed by fat incorporated into a mea...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF01307519

    authors： Stacher G,Granser GV,Bergmann H,Kugi A,Stacher-Janotta G,Höbart J

    更新日期：1991-09-01 00:00:00

  • Cost-effectiveness of chemoprevention with proton pump inhibitors in Barrett's esophagus.

    abstract：BACKGROUND:Proton pump inhibitors (PPIs) may reduce the risk of esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus. PPIs are prescribed for virtually all patients with Barrett's esophagus, irrespective of the presence of reflux symptoms, and represent a de facto chemopreventive agent in this populatio...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-014-3186-3

    authors： Sharaiha RZ,Freedberg DE,Abrams JA,Wang YC

    更新日期：2014-06-01 00:00:00

  • Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder.

    abstract：:Biliary mucin was regarded as a major contributing factor in formation of pigment stones as well as cholesterol ones. The aim of this study was to elucidate the mechanism of biliary mucin secretion in canine gallbladder epithelial (CGBE) cells treated by lipopolysaccharides (LPS) with special reference to cyclooxygena...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1023/a:1022832608466

    authors： Kim HJ,Lee SK,Kim MH,Seo DW,Min YI

    更新日期：2003-04-01 00:00:00

  • Changes in Serum Myostatin Levels in Alcoholic Hepatitis Correlate with Improvement in MELD.

    abstract：BACKGROUND:Alcoholic hepatitis (AH) is a serious clinical syndrome often associated with muscle wasting. Myostatin, a member of the transforming growth factor-β superfamily, has been studied in diseases with muscle wasting; however, the role of myostatin in AH is unknown. AIMS:To investigate the association between my...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-020-06632-5

    authors： Shamseddeen H,Madathanapalli A,Are VS,Shah VH,Sanyal AJ,Tang Q,Liang T,Gelow K,Zimmers TA,Chalasani N,Desai AP

    更新日期：2020-10-19 00:00:00

  • Xenon-inhalation computed tomography for noninvasive quantitative measurement of tissue blood flow in pancreatic tumor.

    abstract：BACKGROUND AND AIMS:The purpose of this prospective study was to demonstrate the ability to measure pancreatic tumor tissue blood flow (TBF) with a noninvasive method using xenon inhalation computed tomography (xenon-CT) and to correlate TBF with histological features, particularly microvascular density (MVD). METHODS...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章

    doi：10.1007/s10620-011-1915-4

    authors： Kubota M,Murakami T,Nagano H,Eguchi H,Marubashi S,Kobayashi S,Wada H,Tanemura M,Dono K,Nakamori S,Sakon M,Monden M,Mori M,Doki Y

    更新日期：2012-03-01 00:00:00

  • In Vitro and In Vivo Renoprotective Effects of Telbivudine in Chronic Hepatitis B Patients Receiving Nucleotide Analogue.

    abstract：AIM:Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. METHODS:In this prospective study, consecutive CHB patients on co...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-019-05717-0

    authors： Mak LY,Liu SH,Yap DY,Seto WK,Wong DK,Fung J,Chan TM,Lai CL,Yuen MF

    更新日期：2019-12-01 00:00:00

  • Organic anions and the diarrhea of inflammatory bowel disease.

    abstract：:To determine if organic anions contribute to the diarrhea of inflammatory bowel disease, we measured osmolality, electrolytes, short-chain fatty acids, lactic acid, and some Krebs cycle anions in 24-hr fecal collections from 18 patients with chronic ulcerative colitis, 20 with Crohn's disease of the colon, and 16 norm...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01536987

    authors： Vernia P,Gnaedinger A,Hauck W,Breuer RI

    更新日期：1988-11-01 00:00:00

  • Predictors of mortality in patients with hepatocellular carcinoma undergoing transarterial chemoembolization.

    abstract：BACKGROUND/AIM:Transarterial chemoembolization (TACE) is the recommended treatment for patients with Barcelona stage B hepatocellular carcinoma; however, community practice varies from these American Association for the Study of Liver Diseases guidelines. In this study, we sought to assess factors determining outcome a...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-014-3247-7

    authors： Barman PM,Sharma P,Krishnamurthy V,Willatt J,McCurdy H,Moseley RH,Su GL

    更新日期：2014-11-01 00:00:00

  • Randomized, double-blind, placebo-controlled trial of eight-week course of recombinant alpha-interferon for chronic non-A, non-B hepatitis.

    abstract：:Forty-nine Japanese patients were enrolled in a randomized, placebo-controlled, double-blind trial of alpha-interferon for chronic non-A, non-B hepatitis: 24 patients received 3 million units of recombinant human alpha alpha-interferon (alpha-2a) thrice weekly for eight weeks, and 25 patients received placebo in a sim...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF01307512

    authors： Omata M,Ito Y,Yokosuka O,Imazeki F,Tagawa M,Takano S,Hosoda K,Tada M,Ohto M,Ito K

    更新日期：1991-09-01 00:00:00

  • Chemotactic activity in inflammatory bowel disease. Role of leukotriene B4.

    abstract：:An important histologic feature of inflammatory bowel disease (IBD) is infiltration of the colonic mucosa with neutrophils. To investigate the nature of the chemotactic agents responsible for this infiltration, colonic mucosa from three normals and nine patients with inflammatory bowel disease (seven ulcerative coliti...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF01296664

    authors： Lobos EA,Sharon P,Stenson WF

    更新日期：1987-12-01 00:00:00

  • Gallbladder motility, gallstones, and the surgeon.

    abstract：:Cholecystectomy is one of the commonest surgical procedures in the Western world, with more than half a million procedures performed annually in the United States alone. In recent years, studies of gallstone pathogenesis and gallbladder disease have increasingly focused on abnormal gallbladder motility in the pathogen...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,评审

    doi：10.1007/BF02063233

    authors： Patankar R,Ozmen MM,Bailey IS,Johnson CD

    更新日期：1995-11-01 00:00:00

  • Clinical impact of HAb18G/CD147 expression in esophageal squamous cell carcinoma.

    abstract：BACKGROUND:HAb18G/CD147 expression has been associated with many tumor invasion molecules, which play important roles in recurrence and poor differentiation of esophageal squamous cell carcinoma (ESCC). However, the clinical implications of HAb18G/CD147 in ESCC are still unclear. AIMS:In this study, we clarified the c...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-011-1812-x

    authors： Zhu S,Li Y,Mi L,Zhang Y,Zhang L,Gong L,Han X,Yao L,Lan M,Chen Z,Zhang W

    更新日期：2011-12-01 00:00:00

  • Does empiric esophageal dilation benefit dysphagia when endoscopy is normal?

    abstract：:Some patients referred for esophagogastroduodenoscopy (EGD) to evaluate symptoms of dysphagia have normal endoscopies. How best to manage these patients is unclear. We reviewed our experience with empiric esophageal dilation in this setting. Over a five-year period, 40 consecutive patients with esophageal dysphagia an...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02088225

    authors： Marshall JB,Chowdhury TA

    更新日期：1996-06-01 00:00:00

  • Changes in bowel function: pregnancy and the puerperium.

    abstract：:Pregnancy is a time when women are susceptible to bowel habit perturbations. The purpose of this study was to provide new baseline data for a range of bowel habit parameters. Prospective 7-day bowel habit diaries were completed during each of the three trimesters of pregnancy and after birth. Sensations of incomplete ...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s10620-006-9538-x

    authors： Derbyshire EJ,Davies J,Detmar P

    更新日期：2007-02-01 00:00:00

  • Involvement of alpha(2)-adrenoceptors in the gastric protective effect of nitroglycerin against acidified ethanol-induced mucosal injury.

    abstract：:Clinical observations reveal that alcohol intake is associated with an increase in upper gastrointestinal hemorrhage requiring hospitalization and that nitroglycerin or long-acting nitrates lower this risk. Nitroglycerin, a gastric vasodilator that can increase gastric fluid volume, protects the rodent stomach against...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-006-9692-1

    authors： Leung FW,Chan CC

    更新日期：2007-11-01 00:00:00

  • Lipopolysaccharide binding protein is down-regulated during acute liver failure.

    abstract：BACKGROUND AND AIMS:Lipopolysaccharide binding protein (LBP) is involved in the modulation of acute liver injury and failure caused by acetaminophen (APAP). Although the biological activity of LBP is concentration dependent, little is known about its levels in acute liver failure. METHODS:Serum and hepatic LBP were me...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-012-2046-2

    authors： Su GL,Fontana RJ,Jinjuvadia K,Bayliss J,Wang SC

    更新日期：2012-04-01 00:00:00

  • Influence of cisapride on gastric emptying of solids and liquids monitored by 13C breath tests.

    abstract：:[13C]Acetate and [13C]octanoate breath tests were used to analyze the gastric emptying of liquids and solids in healthy controls and patients with functional dyspepsia both with and without cisapride. A standard test meal was labeled with either 150 mg [13C]acetate (liquid phase labeled in the water) or with 100 mg [1...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/BF02209007

    authors： Duan LP,Braden B,Caspary WF,Lembcke B

    更新日期：1995-10-01 00:00:00

  • Effectiveness of leukocyte interferon-alpha treatment in patients with chronic hepatitis C not responsive to recombinant interferon.

    abstract：:Twenty-four patients with chronic active HCV infection, nonresponders to a previous treatment cycle with recombinant interferon-alpha (r-IFNA), underwent retreatment with leukocyte (LE-) IFN-alpha. This was administered at the dose of 3 MU three times a week, for either six months (group A) or 12 months (group B). All...

    journal_title：Digestive diseases and sciences

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1023/a:1026693901012

    authors： Scotto G,Grimaldi M

    更新日期：1998-10-01 00:00:00

  • Diagnostic Ability of Endoscopic Bile Cytology Using a Newly Designed Biliary Scraper for Biliary Strictures.

    abstract：BACKGROUND:A new device with metallic wires for scrape cytology was developed. AIMS:To compare the diagnostic performance of scrape cytology and conventional cytology during endoscopic retrograde cholangiopancreatography for biliary strictures. METHODS:A total of 420 cases with biliary stricture underwent transpapill...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-018-5217-y

    authors： Nakahara K,Michikawa Y,Morita R,Suetani K,Morita N,Sato J,Tsuji K,Ikeda H,Matsunaga K,Watanabe T,Matsumoto N,Kobayashi S,Otsubo T,Itoh F

    更新日期：2019-01-01 00:00:00

  • Intestinal pH and gastrointestinal transit profiles in cystic fibrosis patients measured by wireless motility capsule.

    abstract：BACKGROUND AND AIMS:The effect of the cystic fibrosis transmembrane conductance regulator protein (CFTR) defect in pancreatic insufficient (PI) patients with cystic fibrosis (CF) on the gastrointestinal pH profile is poorly defined. Adequate and efficient neutralization of the gastric acidity in the duodenum is importa...

    journal_title：Digestive diseases and sciences

    pub_type： 杂志文章

    doi：10.1007/s10620-012-2209-1

    authors： Gelfond D,Ma C,Semler J,Borowitz D

    更新日期：2013-08-01 00:00:00