Evidence for autonomic dysregulation in the irritable bowel syndrome.

Abstract:

:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and visceral hypersensitivity. In this study, resting blood pressure and heart rate were recorded in 20 IBS patients and 23 controls. We assessed pain intensity and unpleasantness to visceral and cutaneous stimuli using rectal distension and immersion of the foot in hot water. Mean resting heart rate was higher in IBS patients compared to controls. IBS patients rated pain intensity and unpleasantness to visceral and cutaneous stimuli significantly higher than controls. In IBS patients, blood pressure was significantly inversely associated with visceral pain and only weakly and positively associated with cutaneous pain; there were no relationships in controls. Sex and anxiety did not explain these relationships. In conclusion, we found evidence suggestive of central autonomic dysregulation in IBS patients.

journal_name

Dig Dis Sci

authors

Gupta V,Sheffield D,Verne GN

doi

10.1023/a:1016424007454

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

1716-22

issue

8

eissn

0163-2116

issn

1573-2568

journal_volume

47

pub_type

杂志文章
  • Effects of very long chain versus long chain triglycerides on gastrointestinal motility and hormone release in humans.

    abstract::Fish oil (a very long chain triglycerides, VLCT) has received much attention because of its favorable metabolic properties; however, its effect on gastrointestinal function has not been studied. We investigated the effects of intraduodenally administered VLCT on gut-hormone release [cholecystokinin (CCK), neurotensin,...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1005594514399

    authors: Jonkers IJ,Ledeboer M,Steens J,Smelt AH,Masclee AA

    更新日期:2000-09-01 00:00:00

  • On-demand therapy with rabeprazole in nonerosive and erosive gastroesophageal reflux disease in clinical practice: effectiveness, health-related quality of life, and patient satisfaction.

    abstract::On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of lif...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1023/b:ddas.0000034551.39324.c3

    authors: Ponce J,Argüello L,Bastida G,Ponce M,Ortiz V,Garrigues V

    更新日期:2004-06-01 00:00:00

  • Effect of race upon organ donation and recipient survival in liver transplantation.

    abstract::The effect of the race of the donor on organ donation and on the outcome of clinical liver transplantation has not been addressed previously. The aims of this study were to determine: (1) the number of organs donated by each of the major racial groups of the United States, (2) the outcome of transplantation of these o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01536746

    authors: Pillay P,Van Thiel DH,Gavaler JS,Starzl TE

    更新日期:1990-11-01 00:00:00

  • A De Novo mutation of STK11 gene in a Chinese patient with Peutz-Jeghers syndrome.

    abstract::Peutz-Jeghers syndrome (PJS) is an autosomal-dominant inherited disorder characterized by mucocutaneous pigmentation, hamartomatous polyposis of the gastrointestinal tract, and an increased risk for the development of both gastrointestinal and extraintestinal malignancies. Germline mutation of the STK11 gene, which en...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0837-x

    authors: Gao Y,Zhang FM,Huang S,Wang X,Zhang P,Huang XD,Ji GZ,Fan ZN

    更新日期:2010-04-01 00:00:00

  • Hepatitis A, hepatitis B, and combination hepatitis vaccines for immunoprophylaxis: an update.

    abstract::Since the publication of the last extensive review of hepatitis vaccines, use of inactivated hepatitis A vaccines has been extended to high-risk regions of the United States and specific patient groups, such as those with chronic liver disease, and use of the recombinant hepatitis B vaccines has been recommended for o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1023/a:1015397807278

    authors: Koff RS

    更新日期:2002-06-01 00:00:00

  • Interleukin-1beta inhibits growth factor-stimulated restoration of wounded rat gastric epithelial cell monolayers.

    abstract::We examined the effect of interleukin-1beta (IL-1beta) on spontaneous and enhanced restoration (cell migration and proliferation) using an in vitro wound model comprising a confluent monolayer of rat gastric epithelial RGM1 cells. Repair of an artificial wound in a cell monolayer was found to be time- and concentratio...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018890419648

    authors: Nakamura E,Takahashi S,Matsui H,Okabe S

    更新日期:1998-03-01 00:00:00

  • Helicobacter pylori infection induces candidate stem cell marker Musashi-1 in the human gastric epithelium.

    abstract::Musashi-1 (Msi-1), a mammalian neural RNA-binding protein, has been found to play important roles in the maintenance of stem cell states and differentiation in neural stem cells and mouse intestinal cells. We explored Msi-1 expression and its potential implications in the human stomach. Reverse transcription-PCR revea...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-007-9858-5

    authors: Murata H,Tsuji S,Tsujii M,Nakamura T,Fu HY,Eguchi H,Asahi K,Okano H,Kawano S,Hayashi N

    更新日期:2008-02-01 00:00:00

  • Case report: primary CD30 (Ki-1)-positive anaplastic large cell lymphoma of the duodenum.

    abstract::As recently described, Ki-1 anaplastic large cell lymphoma is a distinctive subtype of non-Hodgkin's lymphoma. We report a Ki-1 anaplastic large cell lymphoma of the duodenum in a 62-year-old man. He received modified CHOP therapy and was in complete remission at 18 months. To our knowledge, this is the first report o...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/BF02100125

    authors: Yoshikawa I,Murata I,Tanaka Y,Kanagawa K,Tabaru A,Itoh H,Otsuki M

    更新日期:1996-12-01 00:00:00

  • Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.

    abstract::The main objective of our studies has been to optimize the effects of monoclonal antibodies (MAbs) and other immunosuppressive reagents to enhance organ graft survival. One such agent is OKT3, a MAb that is directed against the CD3 component of the human T-cell receptor (TCR) complex. Treatment of a rejection episode ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,评审

    doi:10.1007/BF02063942

    authors: Alegre ML,Lenschow DJ,Bluestone JA

    更新日期:1995-01-01 00:00:00

  • Total body weight loss of ≥ 10 % is associated with improved hepatic fibrosis in patients with nonalcoholic steatohepatitis.

    abstract:BACKGROUND:Given the rising epidemics of obesity and metabolic syndrome, nonalcoholic steatohepatitis (NASH) is now the most common cause of liver disease in the developed world. Effective treatment for NASH, either to reverse or prevent the progression of hepatic fibrosis, is currently lacking. AIM:To define the pred...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-014-3380-3

    authors: Glass LM,Dickson RC,Anderson JC,Suriawinata AA,Putra J,Berk BS,Toor A

    更新日期:2015-04-01 00:00:00

  • Two-color immunofluorescence and flow cytometric analysis of lamina propria lymphocyte subsets in ulcerative colitis and Crohn's disease.

    abstract::By using two-color immunofluorescence with fluorescein isothiocyanate (FITC) and phycoerythrin (PE)-labelled monoclonal antibodies and multiparameter flow cytometry, we investigated lamina propria lymphocyte subsets of patients with ulcerative colitis (UC) and Crohn's disease (CD). Leu-3/Leu-2 (CD4/CD8) ratio of lamin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01296815

    authors: Senju M,Wu KC,Mahida YR,Jewell DP

    更新日期:1991-10-01 00:00:00

  • Biliary and pancreatic duct pressures measured by ERCP manometry in patients with suspected papillary stenosis.

    abstract::Papillary stenosis is an imprecisely defined clinical syndrome which eludes definitive diagnosis. In this study we evaluated 26 patients with suspected papillary stenosis by manometric examination of the sphincter of Oddi done during ERCP examination. Basal pressure in the sphincter of Oddi was elevated in 14 of the p...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01308431

    authors: Bar-Meir S,Geenen JE,Hogan WJ,Dodds WJ,Stewart ET,Arndorfer RC

    更新日期:1979-03-01 00:00:00

  • Strong telomerase activity of B lymphocyte from mesenteric lymph nodes of patients with inflammatory bowel disease.

    abstract::Telomerase acitivity can be induced in human B lymphocytes by in vitro stimulation of their antigen receptors. To determine whether telomerase activity is induced in vivo, we analyzed telomerase activity in B lymphocytes from the mesenteric lymph nodes of patients with inflammatory bowel disease (IBD), whose lymph nod...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1026107429546

    authors: Takagi S,Kinouchi Y,Chida M,Hiwatashi N,Noguchi M,Takahashi S,Shimosegawa T

    更新日期:2003-10-01 00:00:00

  • Accurate Identification of Fatty Liver Disease in Data Warehouse Utilizing Natural Language Processing.

    abstract:INTRODUCTION:Natural language processing is a powerful technique of machine learning capable of maximizing data extraction from complex electronic medical records. METHODS:We utilized this technique to develop algorithms capable of "reading" full-text radiology reports to accurately identify the presence of fatty live...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-017-4721-9

    authors: Redman JS,Natarajan Y,Hou JK,Wang J,Hanif M,Feng H,Kramer JR,Desiderio R,Xu H,El-Serag HB,Kanwal F

    更新日期:2017-10-01 00:00:00

  • Gastric acid inhibits antral phase III activity in duodenal ulcer patients.

    abstract::Fourteen patients with duodenal ulcers and eight healthy volunteers were examined to measure interdigestive gastroduodenal motility and plasma motilin. In order to study the effects of gastric acid on the gastroduodenal motility, 20 mg of famotidine was administered intravenously. The motility index of the gastric ant...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF01295907

    authors: Kusano M,Sekiguchi T,Nishioka T,Kawamura O,Kikuchi K,Matsuzaki T,Horikoshi T

    更新日期:1993-05-01 00:00:00

  • Swallowing activity assessed by ambulatory impedance-pH monitoring predicts awake and asleep periods at night.

    abstract:INTRODUCTION:Voluntary muscle activity, including swallowing, decreases during the night. The association between nocturnal awakenings and swallowing activity is under-researched with limited information on the frequency of swallows during awake and asleep periods. AIM:The aim of this study was to assess nocturnal swa...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10620-012-2474-z

    authors: Pohl D,Arevalo F,Singh E,Freeman J,Tutuian R,Castell DO

    更新日期:2013-04-01 00:00:00

  • Reproducibility and performance characteristics of colonic compliance, tone, and sensory tests in healthy humans.

    abstract:BACKGROUND:The performance characteristics of colonic sensation and motility measurements are unclear. AIM:To compare left colon compliance, tone, and sensation in males and females and to evaluate inter and intra-individual coefficients of variation (COV) in these measurements. METHODS:Data were acquired using stand...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-009-0772-x

    authors: Odunsi ST,Camilleri M,Bharucha AE,Papathanasopoulos A,Busciglio I,Burton D,Zinsmeister AR

    更新日期:2010-03-01 00:00:00

  • Efficacy of Pregabalin and Antioxidants Combination in Reducing Pain in Chronic Pancreatitis: A Double Blind Randomized Trial.

    abstract:BACKGROUND:In patients with chronic pancreatitis (CP), pain relief is a dilemma. Antioxidants with pregabalin therapy have been reported to be useful. Hence, this study was carried out to determine the efficacy of the combination of antioxidant and pregabalin therapy in reducing pain in patients with CP. METHODS:This ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06711-7

    authors: Sureshkumar S,Omang A,Anandhi A,Rajesh BS,Abdulbasith KM,Vijayakumar C,Palanivel C,Pazhanivel M,Kate V

    更新日期:2020-11-18 00:00:00

  • "Deathgrip" esophagus: segmental aperistalsis following electrical injury.

    abstract::We report a case of documented transient segmental aperistalsis of the distal esophagus following an accidental electrical injury. There are no other reports in the literature demonstrating this phenomenon. A review of gastrointestinal injury secondary to electrical injury is presented. ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018834609306

    authors: Rubin BM,Doman DB,Goldberg HJ,Golding MI

    更新日期:1998-09-01 00:00:00

  • Infliximab Dose Escalation as an Effective Strategy for Managing Secondary Loss of Response in Ulcerative Colitis.

    abstract:BACKGROUND:The outcomes of infliximab dose escalation in ulcerative colitis (UC) have not been well evaluated. AIMS:To assess the short- and long-term outcomes of infliximab dose escalation in a cohort of patients with UC. METHODS:This was a multicenter, retrospective, cohort study. All consecutive UC patients who ha...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s10620-015-3735-4

    authors: Taxonera C,Barreiro-de Acosta M,Calvo M,Saro C,Bastida G,Martín-Arranz MD,Gisbert JP,García-Sánchez V,Marín-Jiménez I,Bermejo F,Chaparro M,Ponferrada Á,Martínez-Montiel MP,Pajares R,de Gracia C,Olivares D,Alba C,Mendoza

    更新日期:2015-10-01 00:00:00

  • New enema treatments for inflammatory bowel disease.

    abstract::Two new preparations are under clinical trial for use in the treatment of ulcerative proctitis and left-sided colitis. One is 5-aminosalicylate, a component of sulfasalazine. This substance has virtually no immunomodulating capabilities. Evidence for efficacy equal to that of sulfasalazine in acute colitis has been ob...

    journal_title:Digestive diseases and sciences

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01538136

    authors: Karp LC,Targan SR

    更新日期:1988-03-01 00:00:00

  • Medical residents' colorectal cancer screening may be dependent on ambulatory care education.

    abstract::Colorectal cancer results in significant morbidity and mortality in the United States. Screening is a critical component of cancer prevention. However, research has suggested that physicians may inconsistently adhere to surveillance guidelines. Since residency training can significantly impact upon future practice pat...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018837603989

    authors: Borum ML

    更新日期:1997-06-01 00:00:00

  • CLIF-C AD Score Predicts Development of Acute Decompensations and Survival in Hospitalized Cirrhotic Patients.

    abstract:BACKGROUND AND AIMS:Patients with decompensated cirrhosis are at increased risk of mortality, even in absence of ACLF. The CLIF-C AD score (CLIF-C ADs) was proposed as a prognostic score but lacks sufficient validation. Our aim was to describe clinical characteristics and hospital evolution according to score groups an...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06791-5

    authors: Baldin C,Piedade J,Guimarães L,Victor L,Duarte J,Veiga Z,Alcântara C,Fernandes F,Pereira JL,Pereira G

    更新日期:2021-01-03 00:00:00

  • Depression in patients with cirrhosis. Impact on outcome.

    abstract::The impact of depression (assessed by the Beck Depression Inventory) on quality of life and outcome was prospectively assessed in adult patients with cirrhosis. Patients with depression had significantly poorer perceived quality of life (P = 0.006), poorer adaptive coping (P = 0.001), and lower functional status, i.e....

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018898106656

    authors: Singh N,Gayowski T,Wagener MM,Marino IR

    更新日期:1997-07-01 00:00:00

  • Phorbol myristate acetate ex vivo model of enhanced colonic epithelial permeability. Reactive oxygen metabolite and protease independence.

    abstract::The initiating mechanisms involved in colonic injury are currently unknown. The goal of the current study was to examine the role of the inflammatory mediators reactive oxygen metabolites and proteases in an ex vivo model of selective epithelial permeability. Rats were prepared with exteriorized colonic chambers to wh...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02209017

    authors: Berin MC,Buell MG

    更新日期:1995-10-01 00:00:00

  • A Novel Method for the Prevention and Treatment of Small-for-Size Syndrome in Liver Transplantation.

    abstract:BACKGROUND:Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model. METHODS:The rats underwent ...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-020-06055-2

    authors: Feng Y,Han Z,Gu B,Li X,Wang B,Guo F,Praseedom RK,Wang F,Cheng H,Lucas A,Li Y,Chen H

    更新日期:2020-09-01 00:00:00

  • Cryptosporidiosis and inflammatory bowel disease. Experience from the Milwaukee outbreak.

    abstract::The 1993 Milwaukee Cryptosporidium outbreak posed several questions regarding appropriate management and prognosis of inflammatory bowel disease patients acutely infected with this organism. We prospectively identified and monitored 12 patients with stable ulcerative colitis or Crohn's disease who suffered abrupt clin...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1023/a:1018828507990

    authors: Manthey MW,Ross AB,Soergel KH

    更新日期:1997-08-01 00:00:00

  • Preoperative Antibiotic Prophylaxis Does Not Reduce the Risk of Postoperative Infectious Complications in Patients Undergoing Elective Hepatectomy.

    abstract:BACKGROUND AND AIM:Postoperative infection is not uncommon after hepatectomy. This study assessed the effectiveness of preoperative antibiotic prophylaxis in elective hepatectomy in a randomized clinical trial setting. METHODS:A total of 120 patients who were scheduled to undergo elective hepatectomy were equally rand...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-015-4008-y

    authors: Zhou YM,Chen ZY,Li XD,Xu DH,Su X,Li B

    更新日期:2016-06-01 00:00:00

  • Effects of smoking on interdigestive gastrointestinal motility.

    abstract::The effect of smoking on interdigestive gastrointestinal motility is little studied but may play a role in gastrointestinal morbidity. We studied gastroduodenal motility in 10 volunteers (five smokers and five nonsmokers) using a water-perfused pressure catheter. A pH probe was placed in the duodenal bulb. Baseline mo...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/BF02220449

    authors: McDonnell WM,Owyang C

    更新日期:1995-12-01 00:00:00

  • Effects of lipopolysaccharide on gastric stasis: role of cyclooxygenase.

    abstract::This study was done to examine the role of cyclooxygenase (COX) in lipopolysaccharide (LPS)-induced gastroprotection and gastric stasis. In conscious rats, LPS dose and time dependently increased gastric luminal fluid accumulation. LPS decreased blood flow (laser Doppler) and prevented gastric injury from acidified et...

    journal_title:Digestive diseases and sciences

    pub_type: 杂志文章

    doi:10.1007/s10620-006-3203-2

    authors: West SD,Suliburk JW,Smith GS,Mercer DW

    更新日期:2006-04-01 00:00:00