Abstract:
:Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and visceral hypersensitivity. In this study, resting blood pressure and heart rate were recorded in 20 IBS patients and 23 controls. We assessed pain intensity and unpleasantness to visceral and cutaneous stimuli using rectal distension and immersion of the foot in hot water. Mean resting heart rate was higher in IBS patients compared to controls. IBS patients rated pain intensity and unpleasantness to visceral and cutaneous stimuli significantly higher than controls. In IBS patients, blood pressure was significantly inversely associated with visceral pain and only weakly and positively associated with cutaneous pain; there were no relationships in controls. Sex and anxiety did not explain these relationships. In conclusion, we found evidence suggestive of central autonomic dysregulation in IBS patients.
journal_name
Dig Dis Scijournal_title
Digestive diseases and sciencesauthors
Gupta V,Sheffield D,Verne GNdoi
10.1023/a:1016424007454subject
Has Abstractpub_date
2002-08-01 00:00:00pages
1716-22issue
8eissn
0163-2116issn
1573-2568journal_volume
47pub_type
杂志文章abstract::Fish oil (a very long chain triglycerides, VLCT) has received much attention because of its favorable metabolic properties; however, its effect on gastrointestinal function has not been studied. We investigated the effects of intraduodenally administered VLCT on gut-hormone release [cholecystokinin (CCK), neurotensin,...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1005594514399
更新日期:2000-09-01 00:00:00
abstract::On-demand therapy is effective for maintaining symptoms control in nonerosive gastroesophageal reflux disease (GERD). Our aim was to assess the clinical effectiveness of on-demand therapy with a proton pump inhibitor (PPI) in mild GERD (nonerosive and low-grade esophagitis), its impact on health-related quality of lif...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1023/b:ddas.0000034551.39324.c3
更新日期:2004-06-01 00:00:00
abstract::The effect of the race of the donor on organ donation and on the outcome of clinical liver transplantation has not been addressed previously. The aims of this study were to determine: (1) the number of organs donated by each of the major racial groups of the United States, (2) the outcome of transplantation of these o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01536746
更新日期:1990-11-01 00:00:00
abstract::Peutz-Jeghers syndrome (PJS) is an autosomal-dominant inherited disorder characterized by mucocutaneous pigmentation, hamartomatous polyposis of the gastrointestinal tract, and an increased risk for the development of both gastrointestinal and extraintestinal malignancies. Germline mutation of the STK11 gene, which en...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0837-x
更新日期:2010-04-01 00:00:00
abstract::Since the publication of the last extensive review of hepatitis vaccines, use of inactivated hepatitis A vaccines has been extended to high-risk regions of the United States and specific patient groups, such as those with chronic liver disease, and use of the recombinant hepatitis B vaccines has been recommended for o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1023/a:1015397807278
更新日期:2002-06-01 00:00:00
abstract::We examined the effect of interleukin-1beta (IL-1beta) on spontaneous and enhanced restoration (cell migration and proliferation) using an in vitro wound model comprising a confluent monolayer of rat gastric epithelial RGM1 cells. Repair of an artificial wound in a cell monolayer was found to be time- and concentratio...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018890419648
更新日期:1998-03-01 00:00:00
abstract::Musashi-1 (Msi-1), a mammalian neural RNA-binding protein, has been found to play important roles in the maintenance of stem cell states and differentiation in neural stem cells and mouse intestinal cells. We explored Msi-1 expression and its potential implications in the human stomach. Reverse transcription-PCR revea...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-007-9858-5
更新日期:2008-02-01 00:00:00
abstract::As recently described, Ki-1 anaplastic large cell lymphoma is a distinctive subtype of non-Hodgkin's lymphoma. We report a Ki-1 anaplastic large cell lymphoma of the duodenum in a 62-year-old man. He received modified CHOP therapy and was in complete remission at 18 months. To our knowledge, this is the first report o...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/BF02100125
更新日期:1996-12-01 00:00:00
abstract::The main objective of our studies has been to optimize the effects of monoclonal antibodies (MAbs) and other immunosuppressive reagents to enhance organ graft survival. One such agent is OKT3, a MAb that is directed against the CD3 component of the human T-cell receptor (TCR) complex. Treatment of a rejection episode ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,评审
doi:10.1007/BF02063942
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Given the rising epidemics of obesity and metabolic syndrome, nonalcoholic steatohepatitis (NASH) is now the most common cause of liver disease in the developed world. Effective treatment for NASH, either to reverse or prevent the progression of hepatic fibrosis, is currently lacking. AIM:To define the pred...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-014-3380-3
更新日期:2015-04-01 00:00:00
abstract::By using two-color immunofluorescence with fluorescein isothiocyanate (FITC) and phycoerythrin (PE)-labelled monoclonal antibodies and multiparameter flow cytometry, we investigated lamina propria lymphocyte subsets of patients with ulcerative colitis (UC) and Crohn's disease (CD). Leu-3/Leu-2 (CD4/CD8) ratio of lamin...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01296815
更新日期:1991-10-01 00:00:00
abstract::Papillary stenosis is an imprecisely defined clinical syndrome which eludes definitive diagnosis. In this study we evaluated 26 patients with suspected papillary stenosis by manometric examination of the sphincter of Oddi done during ERCP examination. Basal pressure in the sphincter of Oddi was elevated in 14 of the p...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01308431
更新日期:1979-03-01 00:00:00
abstract::Telomerase acitivity can be induced in human B lymphocytes by in vitro stimulation of their antigen receptors. To determine whether telomerase activity is induced in vivo, we analyzed telomerase activity in B lymphocytes from the mesenteric lymph nodes of patients with inflammatory bowel disease (IBD), whose lymph nod...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1026107429546
更新日期:2003-10-01 00:00:00
abstract:INTRODUCTION:Natural language processing is a powerful technique of machine learning capable of maximizing data extraction from complex electronic medical records. METHODS:We utilized this technique to develop algorithms capable of "reading" full-text radiology reports to accurately identify the presence of fatty live...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-017-4721-9
更新日期:2017-10-01 00:00:00
abstract::Fourteen patients with duodenal ulcers and eight healthy volunteers were examined to measure interdigestive gastroduodenal motility and plasma motilin. In order to study the effects of gastric acid on the gastroduodenal motility, 20 mg of famotidine was administered intravenously. The motility index of the gastric ant...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF01295907
更新日期:1993-05-01 00:00:00
abstract:INTRODUCTION:Voluntary muscle activity, including swallowing, decreases during the night. The association between nocturnal awakenings and swallowing activity is under-researched with limited information on the frequency of swallows during awake and asleep periods. AIM:The aim of this study was to assess nocturnal swa...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/s10620-012-2474-z
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:The performance characteristics of colonic sensation and motility measurements are unclear. AIM:To compare left colon compliance, tone, and sensation in males and females and to evaluate inter and intra-individual coefficients of variation (COV) in these measurements. METHODS:Data were acquired using stand...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-009-0772-x
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:In patients with chronic pancreatitis (CP), pain relief is a dilemma. Antioxidants with pregabalin therapy have been reported to be useful. Hence, this study was carried out to determine the efficacy of the combination of antioxidant and pregabalin therapy in reducing pain in patients with CP. METHODS:This ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06711-7
更新日期:2020-11-18 00:00:00
abstract::We report a case of documented transient segmental aperistalsis of the distal esophagus following an accidental electrical injury. There are no other reports in the literature demonstrating this phenomenon. A review of gastrointestinal injury secondary to electrical injury is presented. ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018834609306
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:The outcomes of infliximab dose escalation in ulcerative colitis (UC) have not been well evaluated. AIMS:To assess the short- and long-term outcomes of infliximab dose escalation in a cohort of patients with UC. METHODS:This was a multicenter, retrospective, cohort study. All consecutive UC patients who ha...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章,多中心研究
doi:10.1007/s10620-015-3735-4
更新日期:2015-10-01 00:00:00
abstract::Two new preparations are under clinical trial for use in the treatment of ulcerative proctitis and left-sided colitis. One is 5-aminosalicylate, a component of sulfasalazine. This substance has virtually no immunomodulating capabilities. Evidence for efficacy equal to that of sulfasalazine in acute colitis has been ob...
journal_title:Digestive diseases and sciences
pub_type: 临床试验,杂志文章
doi:10.1007/BF01538136
更新日期:1988-03-01 00:00:00
abstract::Colorectal cancer results in significant morbidity and mortality in the United States. Screening is a critical component of cancer prevention. However, research has suggested that physicians may inconsistently adhere to surveillance guidelines. Since residency training can significantly impact upon future practice pat...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018837603989
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Patients with decompensated cirrhosis are at increased risk of mortality, even in absence of ACLF. The CLIF-C AD score (CLIF-C ADs) was proposed as a prognostic score but lacks sufficient validation. Our aim was to describe clinical characteristics and hospital evolution according to score groups an...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06791-5
更新日期:2021-01-03 00:00:00
abstract::The impact of depression (assessed by the Beck Depression Inventory) on quality of life and outcome was prospectively assessed in adult patients with cirrhosis. Patients with depression had significantly poorer perceived quality of life (P = 0.006), poorer adaptive coping (P = 0.001), and lower functional status, i.e....
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018898106656
更新日期:1997-07-01 00:00:00
abstract::The initiating mechanisms involved in colonic injury are currently unknown. The goal of the current study was to examine the role of the inflammatory mediators reactive oxygen metabolites and proteases in an ex vivo model of selective epithelial permeability. Rats were prepared with exteriorized colonic chambers to wh...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02209017
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Currently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model. METHODS:The rats underwent ...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-020-06055-2
更新日期:2020-09-01 00:00:00
abstract::The 1993 Milwaukee Cryptosporidium outbreak posed several questions regarding appropriate management and prognosis of inflammatory bowel disease patients acutely infected with this organism. We prospectively identified and monitored 12 patients with stable ulcerative colitis or Crohn's disease who suffered abrupt clin...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1023/a:1018828507990
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND AND AIM:Postoperative infection is not uncommon after hepatectomy. This study assessed the effectiveness of preoperative antibiotic prophylaxis in elective hepatectomy in a randomized clinical trial setting. METHODS:A total of 120 patients who were scheduled to undergo elective hepatectomy were equally rand...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-015-4008-y
更新日期:2016-06-01 00:00:00
abstract::The effect of smoking on interdigestive gastrointestinal motility is little studied but may play a role in gastrointestinal morbidity. We studied gastroduodenal motility in 10 volunteers (five smokers and five nonsmokers) using a water-perfused pressure catheter. A pH probe was placed in the duodenal bulb. Baseline mo...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/BF02220449
更新日期:1995-12-01 00:00:00
abstract::This study was done to examine the role of cyclooxygenase (COX) in lipopolysaccharide (LPS)-induced gastroprotection and gastric stasis. In conscious rats, LPS dose and time dependently increased gastric luminal fluid accumulation. LPS decreased blood flow (laser Doppler) and prevented gastric injury from acidified et...
journal_title:Digestive diseases and sciences
pub_type: 杂志文章
doi:10.1007/s10620-006-3203-2
更新日期:2006-04-01 00:00:00