Acute myeloblastic leukemia following prolonged treatment of Crohn's disease with 6-mercaptopurine.

abstract：BACKGROUND:Approximately 233,898 individuals in the Veterans Affairs healthcare network are hepatitis C virus (HCV)-infected, making the Veterans Affairs the single largest provider of HCV care in the USA. Direct-acting antiviral treatment regimens for HCV offer high cure rates. However, these medications pose an enorm...

journal_title：Digestive diseases and sciences

authors： Maier MM,Zhou XH,Chapko M,Leipertz SL,Wang X,Beste LA

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Crohn's disease (CD) and ulcerative colitis (UC) are associated with considerable direct healthcare costs. There have been few comprehensive analyses of all IBD- and non-IBD comorbidities that determine direct costs in this population. METHODS:We used data from a validated cohort of patients with inflamma...

journal_title：Digestive diseases and sciences

authors： Cai W,Cagan A,He Z,Ananthakrishnan AN

更新日期：2020-05-20 00:00:00

abstract：:Hepatitis B virus (HBV) DNA integrates into the host DNA and shows a series of potentially oncogenetic properties, but HBV is not an acutely transforming virus, because HCC develops decades after infection. Other factors, namely cirrhosis, inflammation, alcohol intake, and viral superinfections, could promote the onco...

journal_title：Digestive diseases and sciences

authors： Verme G,Brunetto MR,Oliveri F,Baldi M,Forzani B,Piantino P,Ponzetto A,Bonino F

更新日期：1991-08-01 00:00:00

abstract：:One hundred sixty-two patients chronically ingesting ibuprofen, piroxicam, or naproxen for osteoarthritis, who had abdominal pain and an endoscopically proven gastric ulcer were evaluated for eight weeks in a randomized, double-blind trial comparing misoprostol (200 micrograms four times daily with meals and at bedtim...

journal_title：Digestive diseases and sciences

authors： Jaszewski R,Graham DY,Stromatt SC

更新日期：1992-12-01 00:00:00

abstract：:Previous studies showed that bile salts had a promoting effect on colon cancer development and this effect was inhibited by ursodeoxycholate (UDC). We recently found that both human colorectal adenomas and carcinomas were associated with a specific decrease in alkaline sphingomyelinase activity. In this work, we compa...

journal_title：Digestive diseases and sciences

authors： Duan RD,Cheng Y,Tauschel HD,Nilsson A

更新日期：1998-01-01 00:00:00

abstract：:Epidemiologic data have shown that cholecystectomy is associated with a moderately increased risk of esophageal adenocarcinoma. The study objective was to evaluate the role of refluxed bile. A total of 696 patients with upper gastrointestinal symptoms were included in the study, of whom 55 had a history of cholecystec...

journal_title：Digestive diseases and sciences

authors： Fein M,Bueter M,Sailer M,Fuchs KH

更新日期：2008-05-01 00:00:00

abstract：:Patients with gallstone disease have impaired gallbladder motility. Prostaglandins are thought to be important mediators of gallbladder hypomotility. We assessed the effect of aspirin, a prostaglandin inhibitor on gallbladder resting volume and ejection fraction according to a double-blind study protocol in 20 healthy...

journal_title：Digestive diseases and sciences

authors： Das A,Baijal SS,Saraswat VA

更新日期：1995-08-01 00:00:00

abstract：:Four patients with cold urticaria and six control subjects were studied. Gastric acid output was measured for 1 hr before and 1 hr after the immersion of both hands in ice cold water. The mean acid output fell in the control group by 16.3%. Acid output in the cold urticaria patients rose in each case following the col...

journal_title：Digestive diseases and sciences

authors： Lass N,Doron O,Gilat T

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND AND AIM:Despite the limitations of screening or early diagnosis of colorectal cancers (CRC), carcinoembryonic antigen (CEA) is frequently measured in practice and during health promotion programs. The aim of this study was to evaluate the role of colonoscopy in healthy individuals with elevated CEA levels. ...

journal_title：Digestive diseases and sciences

authors： Lee JH,Hong SP,Jeon TJ,Kang GH,Choi WC,Jeon SM,Moon CM,Park JJ,Cheon JH,Kim TI,Kim WH

更新日期：2011-08-01 00:00:00

abstract：:Management of pancreatic cystic lesions relies on patients' clinical presentation, imaging, and endoscopic ultrasound. Current research in basic science, radiology, and endoscopy is evolving and making progress in this condition which is relatively common in the general population. This review focuses on the recent en...

journal_title：Digestive diseases and sciences

authors： Bartel MJ,Raimondo M

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND AIM:The purpose of this study was to examine the association between celiac disease (CD) and prior respiratory syncytial virus (RSV) infection or any viral bronchiolitis. METHODS:This was a retrospective case-control study. During 2006-2008 small intestinal biopsy data were collected from Sweden's 28 pa...

journal_title：Digestive diseases and sciences

authors： Tjernberg AR,Ludvigsson JF

更新日期：2014-07-01 00:00:00

abstract：:Bleeding from esophagogastric varices is a potentially deadly complication in patients with hepatosplenic schistosomiasis. The aim of this study is to establish indicators of variceal bleeding. We studied 40 patients with compensated hepatosplenic schistosomiasis and varices, analyzing four endoscopic (variceal size, ...

journal_title：Digestive diseases and sciences

authors： Martins RD,Szejnfeld J,Lima FG,Ferrari AP

更新日期：2000-05-01 00:00:00

abstract：:Colonic mucus is decreased in a rat model of spastic constipation, and some types of water-insoluble dietary fiber increase colonic mucus when consumed by rats for several weeks. However, little is known about the effect of water-soluble dietary fiber on the colonic mucus. The aim of the present study was to investiga...

journal_title：Digestive diseases and sciences

authors： Shimotoyodome A,Meguro S,Hase T,Tokimitsu I,Sakata T

更新日期：2001-07-01 00:00:00

abstract：:Acid inhibition after proton pump inhibitors in children is variable, and to measure it by a noninvasive method may help to tailor treatment. To study gastric acid inhibition after a single dose of PPI, by measuring urinary acid output (UAO), which decreases as parietal cells release acid into the stomach during a mea...

journal_title：Digestive diseases and sciences

authors： Oderda G,Rapa A,Chiorboli E,Ronchi B,Zavallone A,Strigini L

更新日期：2002-08-01 00:00:00

abstract：:During topical dissolution of gallstones, solvent can escape to the duodenum causing toxic effects that have not yet been adequately quantified. We compared the local intestinal cytotoxic and systemic hepatotoxic effects of two gallstone solvents, methyl tert-butyl ether and ethyl propionate, on the rabbit's duodenum....

journal_title：Digestive diseases and sciences

authors： Clerici C,Gentili G,Zakko SF,Balò S,Miglietti M,Giansanti M,Modesto R,Guttermuth CF,Morelli A

更新日期：1997-03-01 00:00:00

abstract：:The synthetic substrate cholyl-PABA, developed by conjugating cholic acid with paraaminobenzoic acid, is hydrolyzed by the bacterial enzyme cholyl hydrolase to release free PABA. This study aimed to evaluate whether quantitating urinary excretion of PABA after oral administration of cholyl-PABA can detect small intest...

journal_title：Digestive diseases and sciences

authors： Bardhan PK,Feger A,Kogon M,Muller J,Gillessen D,Beglinger C,Gyr N

更新日期：2000-03-01 00:00:00

abstract：:Gastroparesis is characterized by delayed gastric emptying, with symptoms such as nausea, vomiting and abdominal pain, in the absence of mechanical obstruction. In most cases, it is idiopathic although diabetes mellitus is another leading cause. The physiology of gastric emptying is a complex process which is influenc...

journal_title：Digestive diseases and sciences

authors： Sullivan A,Temperley L,Ruban A

更新日期：2020-06-01 00:00:00

abstract：:Glycoprotein and glycolipid constituents were examined in purified microvillus and basolateral membranes isolated from rat small intestinal epithelial cells. SDS-polyacrylamide gel electrophoresis showed that the molecular weights of most of the major proteins from microvillus membranes were over 100 kD, whereas the m...

journal_title：Digestive diseases and sciences

authors： Morita A,Siddiqui B,Erickson RH,Kim YS

更新日期：1989-04-01 00:00:00

abstract：:Nearly all chronic anal fissures occur in the posterior midline of the anal canal. However, some of them are in the anterior midline and are rarely double or in the lateral anal walls. The aim of this study was to determine if the clinical, manometric and endosonographic characteristics in patients with chronic anal f...

journal_title：Digestive diseases and sciences

authors： Pascual M,Parés D,Pera M,Courtier R,Gil MJ,Puig S,Serrano A,Andreu M,Grande L

更新日期：2008-01-01 00:00:00

abstract：:To evaluate the frequency and type of gastroduodenal mucosal inflammatory changes in patients with symptomatic acid peptic disease and nonulcer dyspepsia, 100 patients with gastrointestinal symptoms indicative of acid peptic disease or dyspepsia and 10 control subjects were clinically evaluated and underwent radiograp...

journal_title：Digestive diseases and sciences

authors： Greenlaw R,Sheahan DG,DeLuca V,Miller D,Myerson D,Myerson P

更新日期：1980-09-01 00:00:00

abstract：:Various reports on the prevalence of gastroesophageal reflux disease (GERD) and uninvestigated dyspepsia have been conducted in Western countries. We sought to determine the frequency of GERD symptoms and uninvestigated dyspepsia in Korea. Telephone interviews were conducted with 1,044 individuals. Of all subjects, 7....

journal_title：Digestive diseases and sciences

authors： Yang SY,Lee OY,Bak YT,Jun DW,Lee SP,Lee SH,Park GT,Yoon BC,Choi HS,Hahm JS,Lee MH,Lee DH

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Current genetic research of nonalcoholic steatohepatitis (NASH) cirrhosis is limited by our ability to accurately identify cases on a large scale. Our objective was to develop and validate an electronic health record (EHR) algorithm to accurately identify cases of NASH cirrhosis in the EHR. METHODS...

journal_title：Digestive diseases and sciences

authors： Danford CJ,Lee JY,Strohbehn IA,Corey KE,Lai M

更新日期：2020-06-13 00:00:00

abstract：:The effect of insulin on the myoelectric activity of the small intestine was determined in conscious pigs. Animals were implanted with electrodes along the small intestine, a strain gage on the stomach and catheters in both saphenous arteries. Feeding modified the migrating myoelectric complex (MMC), a cyclic pattern ...

journal_title：Digestive diseases and sciences

authors： Rayner V,Weekes TE,Bruce JB

更新日期：1981-01-01 00:00:00

abstract：:Squamous cell carcinoma represents the most common primary malignant lesion of the esophagus (1). The initial manifestation of lymphosarcoma infrequently occurs in the gastrointestinal tract, and in one large series, there were no lymphosarcomas presenting in the esophagus (2). In the case described below, a primary h...

journal_title：Digestive diseases and sciences

authors： Berman MD,Falchuk KR,Trey C,Gramm HF

更新日期：1979-11-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) screening is a priority for the Veteran's Health Administration (VHA). Optimizing fecal occult blood testing (FOBT) is integral to CRC screening in health care systems. AIMS:The purpose of this study was to characterize the utilization of CRC testing in a large integrated health care...

journal_title：Digestive diseases and sciences

authors： Long MD,Lance T,Robertson D,Kahwati L,Kinsinger L,Fisher DA

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Barrett's esophagus (BE) is characterized by a distinct Th2-predominant cytokine profile. However, antigens that shift the immune response toward the Th2 profile are unknown. AIM:We examined the effects of rebamipide on the esophageal microbiome and BE development in a rat model. METHODS:BE was induced by ...

journal_title：Digestive diseases and sciences

authors： Kohata Y,Nakahara K,Tanigawa T,Yamagami H,Shiba M,Watanabe T,Tominaga K,Fujiwara Y,Arakawa T

更新日期：2015-09-01 00:00:00

abstract：:Biomagnetic measurements are based on the noninvasive recording of magnetic signals produced by biological sources such as nervous system and muscle. The aim of this study was to obtain multichannel magnetic field recordings from the human gastrointestinal tract and to localize the sources of these signals three-dimen...

journal_title：Digestive diseases and sciences

authors： Allescher HD,Abraham-Fuchs K,Dunkel RE,Classen M

更新日期：1998-04-01 00:00:00

abstract：INTRODUCTION:Stent placement in the distal duodenum can be difficult. We describe a case report of a 94-year-old man with metastatic pancreatic head cancer compressing the third and fourth portions of the duodenum, treated by endoscopic stent placement using a colonoscope. AREAS COVERED:A literature review highlighted...

journal_title：Digestive diseases and sciences

authors： Minervini A,Lauro A,Pagano N,Vaccari S,D'Andrea V,Marino IR,Cervellera M,Tonini V

更新日期：2019-09-01 00:00:00

abstract：:Bacterial infection remains a leading cause of mortality and morbidity for patients with cirrhosis, with hospitalization, alterations in the intestinal microbiota, and therapeutic drugs all implicated in its development. Bacterial infections also remain the most common precipitant of acute-on-chronic liver failure, wi...

journal_title：Digestive diseases and sciences

authors： Cannon MD,Martin P,Carrion AF

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Gastric intestinal metaplasia (GIM) is an accepted pathologic precursor to gastric adenocarcinoma (GAC). While surveillance of GIM in Europe and Asia is common, only limited recommendations related to endoscopic surveillance of GIM exist in the United States. AIM:To understand the clinical practice patterns...

journal_title：Digestive diseases and sciences

authors： Vance RB Jr,Kubiliun N,Dunbar KB

更新日期：2016-07-01 00:00:00