当前位置： SCI文献检索 > CLINICAL BIOCHEMISTRY期刊下所有文献 > Analytical interference of 4-hydroxy-3-methoxymethamphetamine with the measurement of plasma free normetanephrine by ultra-high pressure liquid chromatography-tandem mass spectrometry.

Analytical interference of 4-hydroxy-3-methoxymethamphetamine with the measurement of plasma free normetanephrine by ultra-high pressure liquid chromatography-tandem mass spectrometry.

Abstract：

OBJECTIVES:The diagnosis of pheochromocytoma relies on the measurement of plasma free metanephrines assay whose reliability has been considerably improved by ultra-high pressure liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Here we report an analytical interference occurring between 4-hydroxy-3-methoxymethamphetamine (HMMA), a metabolite of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"), and normetanephrine (NMN) since they share a common pharmacophore resulting in the same product ion after fragmentation. DESIGN AND METHODS:Synthetic HMMA was spiked into plasma samples containing various concentrations of NMN and the intensity of the interference was determined by UPLC-MS/MS before and after improvement of the analytical method. RESULTS:Using a careful adjustment of chromatographic conditions including the change of the UPLC analytical column, we were able to distinguish both compounds. HMMA interference for NMN determination should be seriously considered since MDMA activates the sympathetic nervous system and if confounded with NMN may lead to false-positive tests when performing a differential diagnostic of pheochromocytoma.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Dunand M,Donzelli M,Rickli A,Hysek CM,Liechti ME,Grouzmann E

doi

10.1016/j.clinbiochem.2014.04.003

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

1121-3

issue

12

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(14)00172-6

journal_volume

47

pub_type

杂志文章

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