Effect of age and disease on two drug binding proteins: albumin and alpha-1- acid glycoprotein.

Abstract:

:The influence of age and disease on serum albumin and alpha-1-acid glycoprotein was studied in 126 subjects (69 M, 57 F) presenting with tuberculosis and after recovery. Albumin concentration fell with age in both disease and healthy states, and alpha-1-acid glycoprotein concentration rose with age in the healthy state. Age-related differences were less marked in the disease state. During recovery from illness, serum albumin concentration rose and alpha-1-acid glycoprotein concentration fell. The mean concentration difference in the latter was lower in the older age groups. The clinical consequences of changes in binding protein concentrations as a result of ageing and disease need to be studied further for individual drugs.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Woo J,Chan HS,Or KH,Arumanayagam M

doi

10.1016/0009-9120(94)90032-9

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

289-92

issue

4

eissn

0009-9120

issn

1873-2933

pii

0009-9120(94)90032-9

journal_volume

27

pub_type

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