Effect of age and disease on two drug binding proteins: albumin and alpha-1- acid glycoprotein.


:The influence of age and disease on serum albumin and alpha-1-acid glycoprotein was studied in 126 subjects (69 M, 57 F) presenting with tuberculosis and after recovery. Albumin concentration fell with age in both disease and healthy states, and alpha-1-acid glycoprotein concentration rose with age in the healthy state. Age-related differences were less marked in the disease state. During recovery from illness, serum albumin concentration rose and alpha-1-acid glycoprotein concentration fell. The mean concentration difference in the latter was lower in the older age groups. The clinical consequences of changes in binding protein concentrations as a result of ageing and disease need to be studied further for individual drugs.


Clin Biochem


Clinical biochemistry


Woo J,Chan HS,Or KH,Arumanayagam M




Has Abstract


1994-08-01 00:00:00














  • Tumor markers in the laboratory: closing the guideline-practice gap.

    abstract::Increasing interest in the use of tumor markers in the clinical management of cancer patients has encouraged development of guidelines by local, national and international groups. Such guidelines generally include recommendations about which markers are likely to be most helpful in given circumstances. Particular requ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Sturgeon CM

    更新日期:2001-07-01 00:00:00

  • Fluorometric and time-resolved immunofluorometric assays for protein-tyrosine phosphatase activity.

    abstract:OBJECTIVE:To develop sensitive nonisotopic assays for protein-tyrosine phosphatase (PTP) activity. METHODS:The fluorometric assay is based on the fact that phosphotyrosine but not tyrosine forms highly fluorescent complexes with Tb3+. Thus, PTP activity can be followed by measuring the decrease of fluorescence due to ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Galvan B,Christopoulos TK

    更新日期:1996-04-01 00:00:00

  • Purification of three major forms of beta-hCG from urine and production of polyclonal antibodies against them.

    abstract:OBJECTIVES:This study has been conducted to develop a proper and relatively simple method for purification of three major forms of beta-hCG from urine to use as clinical calibrators and also to produce anti-beta-hCG polyclonal antibodies against these purified forms. DESIGN AND METHODS:Major beta-hCG forms from urine ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Khademi F,Hamzehee K,Mostafaie A,Hajihossaini R

    更新日期:2009-09-01 00:00:00

  • Minor immunophilin binding of tacrolimus and sirolimus metabolites.

    abstract:OBJECTIVES:We have previously identified three minor immunophilins of molecular weights 37 kDa, 14 kDa, and 5-8 kDa capable of binding tacrolimus and sirolimus. DESIGN AND METHODS:When tested against pure preparations of five sirolimus metabolites, the 14 kDa protein had almost no cross-reactivity, the 37 kDa protein ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Davis DL,Murthy JN,Gallant-Haidner H,Yatscoff RW,Soldin SJ

    更新日期:2000-02-01 00:00:00

  • Water bath hyperthermia reduces stemness of colon cancer cells.

    abstract:OBJECTIVES:Researchers have proposed that cancer stem cells (CSCs) are the driving force of tumorigenesis, recurrence, and metastases, contributing to the failure of some cancer treatments. Water bath hyperthermia, a novel treatment for cancer, can be highly effective when combined with chemotherapy, radiotherapy, or i...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Gao F,Ye Y,Zhang Y,Yang J

    更新日期:2013-11-01 00:00:00

  • Reduction of pre-analytical errors in the clinical laboratory at the University Hospital of Korea through quality improvement activities.

    abstract:BACKGROUND:The clinical laboratory is responsible for reporting accurate and expeditious results. However, the pre-analytical phase is directly related to the procedure of specimen collection and is mostly out of the direct control of the laboratory; further, most pre-analytical errors are related to human factors. The...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Lee NY

    更新日期:2019-08-01 00:00:00

  • Evaluation of the Dupont aca bromocresol purple albumin method.

    abstract::The bromocresol purple (BCP) albumin method on the DuPont aca was evaluated by determining the accuracy and precision of the method. A split sample comparison was performed against the electroimmunoassay (EIA) method as well as the bromocresol green (BCG) method on the DuPont aca and the Technicon SMA 12/60. The BCP m...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Krahn J

    更新日期:1983-04-01 00:00:00

  • The use of proteomics for the assessment of clinical samples in research.

    abstract::Proteomics, the analysis of expressed proteins, has been an important developing area of research for the past two decades [Anderson, NG, Anderson, NL. Twenty years of two-dimensional electrophoresis: past, present and future. Electrophoresis 1996;17:443-453]. Advances in technology have led to a rapid increase in app...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Aldred S,Grant MM,Griffiths HR

    更新日期:2004-11-01 00:00:00

  • Method performance and clinical workflow outcomes associated with meconium and umbilical cord toxicology testing.

    abstract:OBJECTIVE:Neonatal abstinence syndrome (NAS) is a rising concern with unknown long-term effects. It is apparent that higher cost of care, impact on the community and reduced quality of life are associated with similar etiologies (e.g., fetal alcohol syndrome). Detection of drug exposure in utero allows for earlier inte...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Labardee RM,Swartzwelder JR,Gebhardt KE,Pardi JA,Dawsey AC,Brent Dixon R,Cotten SW

    更新日期:2017-12-01 00:00:00

  • B-type natriuretic peptide in pediatrics.

    abstract:OBJECTIVES:There has been growing interest in the use of serum B-type natriuretic peptide (BNP) and the N-terminal segment of its pro-hormone (NT-proBNP) as biomarkers for cardiac disease. The aim of this review is to summarize the current state of knowledge regarding BNP and NT-proBNP measurement in the pediatric popu...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Davis GK,Bamforth F,Sarpal A,Dicke F,Rabi Y,Lyon ME

    更新日期:2006-06-01 00:00:00

  • Precipitation method for separating and quantifying bone and liver alkaline phosphatase isoenzymes.

    abstract::We evaluated a method for quantifying bone isoenzyme of alkaline phosphatase (ALP) which utilizes wheat-germ lectin to precipitate this fraction. In precision studies, CVs ranged from 3.2 to 11.4% (within-day) and from 3.7 to 11.5% (day-to-day). The assay procedure was linear to 1100 U/L and was easily adapted to auto...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Burlina A,Plebani M,Secchiero S,Zaninotto M,Sciacovelli L

    更新日期:1991-10-01 00:00:00

  • Evaluation of Elecsys free triiodothyronine assay: relevance of age-related reference ranges.

    abstract:OBJECTIVE:This study aimed at evaluating Elecsys free triiodothyronine (FT3) assay performed on an Elecsys 2010 system, while paying special attention to age relationship in euthyroid subjects. DESIGN AND METHODS:FT3 levels were measured in 149 euthyroid control subjects aged between 2 and 92 years old, 33 hyperthyroi...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Sapin R,Schlienger JL,Goichot B,Gasser F,Grucker D

    更新日期:1998-07-01 00:00:00

  • The clinical relevance of imatinib plasma trough concentrations in chronic myeloid leukemia. A Belgian study.

    abstract::This retrospective multicenter study in patients with chronic myeloid leukemia in chronic phase was undertaken to confirm the clinical relevance of imatinib plasma concentrations monitoring in daily practice. Forty-one patients, with 47 imatinib plasma measurements, were analyzed during treatment with imatinib given a...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,多中心研究


    authors: Van Obbergh F,Knoops L,Devos T,Beguin Y,Graux C,Benghiat F,Kargar-Samani K,Bauwens D,Efira A,Dubois C,Springael C,Montfort L,Connerotte T,Capron A,Delannoy A,Wallemacq P

    更新日期:2017-05-01 00:00:00

  • Antioxidant status, lipid peroxidation and nitric oxide end products in patients of type 2 diabetes mellitus with nephropathy.

    abstract:OBJECTIVES:Oxidative stress is considered to be a unifying link between diabetes mellitus (DM) and its complications including nephropathy. The aim of the present study was to evaluate oxidative stress status in Asian Indian patients of type 2 DM with nephropathy. DESIGN AND METHODS:Serum levels of malondialdehyde (MD...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Bhatia S,Shukla R,Venkata Madhu S,Kaur Gambhir J,Madhava Prabhu K

    更新日期:2003-10-01 00:00:00

  • The effect of altered thyroid function on serum fructosamine concentrations.

    abstract::The effect of altered thyroid function on serum fructosamine concentrations was investigated in 31 untreated hyperthyroid patients, 18 short-term hypothyroid patients (i.e., 20 days after withdrawal of thyroid hormone suppressive therapy for thyroid cancer), 7 untreated long-term hypothyroid patients, and 25 age-match...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Cirillo R,Balzano S,Cossu E,Bartalena L,Solinas MP,Falcone M,Balestrieri A,Martino E

    更新日期:1988-06-01 00:00:00

  • Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as indicators of tubular damage in normoalbuminuric patients with type 2 diabetes.

    abstract:OBJECTIVES:Renal dysfunction has been reported in normoalbuminuric patients, demonstrating the necessity to improve the diagnostic and prognostic tools for diabetic kidney disease (DKD) investigation. Therefore, the aim of this study was to investigate whether the urinary levels of neutrophil gelatinase-associated lipo...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: de Carvalho JA,Tatsch E,Hausen BS,Bollick YS,Moretto MB,Duarte T,Duarte MM,Londero SW,Premaor MO,Comim FV,Delanghe JR,Moresco RN

    更新日期:2016-02-01 00:00:00

  • Timing of specimen collection is crucial in urine screening of drug dependent mothers and newborns.

    abstract::We compared results of urine drug analysis with clinical data and history to test the usefulness of peripartum drug screening and to establish guidelines for optimal testing. Urine from 28 mothers and 52 babies was analysed. Drugs not suspected by history were found in 10 mothers and six babies. Results assisted in th...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Halstead AC,Godolphin W,Lockitch G,Segal S

    更新日期:1988-01-01 00:00:00

  • An abnormal urinary excretion of glycine betaine may persist for years.

    abstract:OBJECTIVES:Does abnormal betaine excretion persist? DESIGN AND METHODS:Patients (10) with abnormal excretion in 1998 were recalled in 2005. Subsequent urine samples were collected on 4 days from persistently abnormal subjects. RESULTS:Half the 1998 abnormal patients were abnormal in 2005. Only 1/20 controls was abnor...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Lever M,Atkinson W,George PM,Chambers ST

    更新日期:2007-07-01 00:00:00

  • Chemokines and transplant outcome.

    abstract::Improving long-term management, life-quality and outcome of transplant recipients continues to be a challenge. The impact of highly chemoattractant proteins as chemokines on transplant outcome is undeniable. These immunoactive molecules are critical in a wide variety of physiological and pathological processes, such a...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Crescioli C

    更新日期:2016-03-01 00:00:00

  • Nonalcoholic steatohepatitis: recent advances from experimental models to clinical management.

    abstract::A condition defined as nonalcoholic fatty liver disease (NAFLD) is frequently found in humans. Deemed as a benign condition until recently, more emphasis is now put on the potential harmful evolution of the inflammatory form, that is, nonalcoholic steatohepatitis (NASH), toward end-stage liver disease. This review hig...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Portincasa P,Grattagliano I,Palmieri VO,Palasciano G

    更新日期:2005-03-01 00:00:00

  • Effects of hemoglobin variants on Hb A1c determinations using Bio-Rad columns.

    abstract::In the column chromatographic determination of Hb A1c, hemoglobin variants affect Hb A1c results and column patterns. Samples from several patients with hemoglobin variants were run on Bio-Rad Hb A1c columns to demonstrate these patterns. Columns should be examined during the run to detect the presence of Hb F which m...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Allen LC

    更新日期:1985-06-01 00:00:00

  • Serum retinol binding protein 4 in patients with familial partial lipodystrophy.

    abstract:OBJECTIVE:To determine Retinol Binding Protein 4 (RBP4) levels in patients with Familial Partial Lipodystrophy (FPLD). METHODS:Ten patients with FPLD and a control group (9 patients) were selected to participate in the study. RESULTS:RBP4-log levels were lower in patients with FPLD in comparison to control group (1.5...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Godoy-Matos AF,Moreira RO,MacDowell R,Bendet I,Mory PB,Moises RS

    更新日期:2009-07-01 00:00:00

  • Biochemical characterization of chitotriosidase enzyme: comparison between normal individuals and patients with Gaucher and with Niemann-Pick diseases.

    abstract:OBJECTIVES:The aim of the present study was to establish the range of chitotriosidase (CT) activity in normal individuals, patients with Gaucher disease (GD) and Niemann-Pick disease (NPD), types A or B. The kinetics of CT in these three groups was also investigated. DESIGN AND METHODS:CT activity, as well as Km, Vmax...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wajner A,Michelin K,Burin MG,Pires RF,Pereira ML,Giugliani R,Coelho JC

    更新日期:2004-10-01 00:00:00

  • Soluble urokinase-type plasminogen activator receptor forms in plasma as markers of atherosclerotic plaque vulnerability.

    abstract:OBJECTIVES:: To test if circulating forms of the soluble urokinase-type plasminogen activator receptor (suPAR) are potential biomarkers of plaque vulnerability. DESIGN AND METHODS:: Plasma concentrations of suPAR(I-III), suPAR(II-III) and uPAR(I) were measured by time-resolved fluorescence immunoassays in Caucasian pa...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Olson FJ,Thurison T,Ryndel M,Høyer-Hansen G,Fagerberg B

    更新日期:2010-01-01 00:00:00

  • Dimethyl sulphoxide (DMSO) induced serum hyperosmolality.

    abstract::We describe a patient who received intravenous dimethyl sulphoxide (DMSO) (as part of an experimental protocol) to control increased intracranial pressure. The patient died of a brain abscess. She developed extreme serum hyperosmolality from the DMSO with the osmolality peaking at 717 mosmol/kg. DMSO may induce extrem...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Wolf P,Simon M

    更新日期:1983-08-01 00:00:00

  • Use of different chemical methods for acid phosphatase in cases of rape.

    abstract::Generally acid phosphatase (ACP) assay is used for testing cases of alleged rape. Comparison of three different chemical methods for Acid Phosphatase (Andersch's method with p-nitrophenyl-phosphate substrate and tartrate inhibitor (A-Tart), Roy's method with thymolphthalein phosphate substrate (R-TMP), and Babson's me...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Pragay DA,Casey SJ,Gotthelf J

    更新日期:1977-10-01 00:00:00

  • Soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid is inversely associated with disease severity of knee osteoarthritis.

    abstract:OBJECTIVES:The aim of this study was to measure soluble receptor for advanced glycation end products (sRAGE) in plasma and synovial fluid of knee osteoarthritis (OA) patients and to determine the correlation between sRAGE levels and disease severity. DESIGN AND METHODS:Thirty-six OA patients and 15 healthy controls we...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Chayanupatkul M,Honsawek S

    更新日期:2010-09-01 00:00:00

  • Evaluation and risk stratification of acute coronary syndromes using a low cut-off level of cardiac troponin T, combined with CK-MB mass determination.

    abstract:OBJECTIVES:To study the usefulness of combined cardiac Troponin T (cTnT) and CK-MB mass determinations in risk stratification of acute coronary syndromes. DESIGN AND METHODS:Blood samples for cTnT and CK-MB mass were collected at arrival and 4, 8, and 12-24 later in 301 consecutive patients with recent acute chest pai...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章


    authors: Solymoss BC,Bourassa MG,Fortier A,Théroux P

    更新日期:2004-04-01 00:00:00

  • miRNAs: their discovery, biogenesis and mechanism of action.

    abstract::The field of miRNA research is evolving at a very fast pace. Since their discovery almost 20years ago, miRNAs have proven to be of tremendous importance to normal physiological homeostasis as well as to the pathogenesis of major diseases such as cancer. Recent advances describe a key contribution for miRNAs in a wide ...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Tétreault N,De Guire V

    更新日期:2013-07-01 00:00:00

  • Pathophysiology, clinics, diagnosis and treatment of heart involvement in carbon monoxide poisoning.

    abstract::The toxicity of carbon monoxide has been recognized for long throughout history and is unquestionably the leading cause of unintentional poisoning deaths in the Western countries. The severity of poisoning is dependent upon environmental and human factor. The leading pathophysiological mechanism resides in the ability...

    journal_title:Clinical biochemistry

    pub_type: 杂志文章,评审


    authors: Lippi G,Rastelli G,Meschi T,Borghi L,Cervellin G

    更新日期:2012-11-01 00:00:00